Homologous DNA Pairing and Strand Exchange

Pathway network for the Homologous DNA Pairing and Strand Exchange SuperPath

Sources:

Reactome
PubChem

Pathways in the Homologous DNA Pairing and Strand Exchange SuperPath

#	Name	Source	Genes
1	Homologous DNA Pairing and Strand Exchange	Reactome	ATM ATR ATRIP BARD1 BLM BRCA1 BRCA2 BRIP1 CHEK1 DNA2 EXO1 HUS1 KAT5 MRE11 NBN PALB2 RAD1 RAD17 RAD50 RAD51 RAD51AP1 RAD51B RAD51C RAD51D RAD9A RAD9B RBBP8 RFC2 RFC3 RFC4 RFC5 RHNO1 RMI1 RMI2 RPA1 RPA2 RPA3 SEM1 TOP3A TOPBP1 WRN XRCC2 XRCC3 (see all 43) (see less)
2	HDR through Homologous Recombination (HRR)	Reactome	ATM ATR ATRIP BARD1 BLM BRCA1 BRCA2 BRIP1 CHEK1 DNA2 EME1 EME2 EXO1 FIGNL1 FIRRM GEN1 HUS1 KAT5 MRE11 MUS81 NBN PALB2 PCNA POLD1 POLD2 POLD3 POLD4 POLE POLE2 POLE3 POLE4 POLH POLK RAD1 RAD17 RAD50 RAD51 RAD51AP1 RAD51B RAD51C RAD51D RAD9A RAD9B RBBP8 RFC1 RFC2 RFC3 RFC4 RFC5 RHNO1 RMI1 RMI2 RPA1 RPA2 RPA3 RPS27A RTEL1 SEM1 SLX1A SLX1B SLX4 SPIDR TOP3A TOPBP1 UBA52 UBB UBC WRN XRCC2 XRCC3 (see all 70) (see less)
3	Diseases of DNA repair	Reactome	ATM ATR ATRIP BARD1 BLM BRCA1 BRCA2 BRIP1 DNA2 EXO1 HUS1 KAT5 MLH1 MRE11 MSH2 MSH3 MSH6 MUTYH NBN NEIL1 NEIL3 NTHL1 OGG1 PALB2 PMS2 RAD1 RAD17 RAD50 RAD51 RAD51AP1 RAD51B RAD51C RAD51D RAD9A RAD9B RBBP8 RFC2 RFC3 RFC4 RFC5 RHNO1 RMI1 RMI2 RPA1 RPA2 RPA3 SEM1 TOP3A TOPBP1 WRN XRCC2 (see all 51) (see less)
4	Fanconi anemia pathway	PubChem	ATM ATR ATRIP BHLHE40 BLM BRCA1 BRCA2 BRIP1 CENPS CENPS-CORT CHEK1 FAAP100 FAAP24 FAN1 FANCA FANCB FANCC FANCD2 FANCE FANCF FANCG FANCI FANCL FANCM H2AX HES1 HUS1 MRE11 NBN PALB2 RAD1 RAD17 RAD50 RAD9A RFC2 RFC3 RFC4 RFC5 RMI1 RPA1 RPA2 TOP3A TOPBP1 UBE2T USP1 WDR48 XRCC3 (see all 47) (see less)
5	Defective homologous recombination repair (HRR) due to BRCA2 loss of function	Reactome	ATM ATR ATRIP BARD1 BLM BRCA1 BRCA2 BRIP1 DNA2 EXO1 HUS1 KAT5 MRE11 NBN PALB2 RAD1 RAD17 RAD50 RAD51 RAD51AP1 RAD51B RAD51C RAD51D RAD9A RAD9B RBBP8 RFC2 RFC3 RFC4 RFC5 RHNO1 RMI1 RMI2 RPA1 RPA2 RPA3 SEM1 TOP3A TOPBP1 WRN XRCC2 (see all 41) (see less)
6	Diseases of DNA Double-Strand Break Repair	Reactome	ATM ATR ATRIP BARD1 BLM BRCA1 BRCA2 BRIP1 DNA2 EXO1 HUS1 KAT5 MRE11 NBN PALB2 RAD1 RAD17 RAD50 RAD51 RAD51AP1 RAD51B RAD51C RAD51D RAD9A RAD9B RBBP8 RFC2 RFC3 RFC4 RFC5 RHNO1 RMI1 RMI2 RPA1 RPA2 RPA3 SEM1 TOP3A TOPBP1 WRN XRCC2 (see all 41) (see less)
7	Fanconi Anemia Pathway	Reactome	ATR ATRIP CENPS CENPS-CORT CENPX DCLRE1A DCLRE1B EME1 EME2 ERCC1 ERCC4 FAAP100 FAAP20 FAAP24 FAN1 FANCA FANCB FANCC FANCD2 FANCE FANCF FANCG FANCI FANCL FANCM MUS81 POLN RPA1 RPA2 RPA3 RPS27A SLX1A SLX1B SLX4 UBA52 UBB UBC UBE2T USP1 WDR48 (see all 40) (see less)
8	Presynaptic phase of homologous DNA pairing and strand exchange	Reactome	ATM ATR ATRIP BARD1 BLM BRCA1 BRCA2 BRIP1 CHEK1 DNA2 EXO1 HUS1 KAT5 MRE11 NBN RAD1 RAD17 RAD50 RAD51 RAD51B RAD51C RAD51D RAD9A RAD9B RBBP8 RFC2 RFC3 RFC4 RFC5 RHNO1 RMI1 RMI2 RPA1 RPA2 RPA3 SEM1 TOP3A TOPBP1 WRN XRCC2 (see all 40) (see less)
9	HDR through Single Strand Annealing (SSA)	Reactome	ABL1 ATM ATR ATRIP BARD1 BLM BRCA1 BRIP1 DNA2 ERCC1 ERCC4 EXO1 HUS1 KAT5 MRE11 NBN RAD1 RAD17 RAD50 RAD51 RAD52 RAD9A RAD9B RBBP8 RFC2 RFC3 RFC4 RFC5 RHNO1 RMI1 RMI2 RPA1 RPA2 RPA3 TOP3A TOPBP1 WRN (see all 37) (see less)
10	Impaired BRCA2 binding to RAD51	Reactome	ATM ATR ATRIP BARD1 BLM BRCA1 BRCA2 BRIP1 DNA2 EXO1 HUS1 KAT5 MRE11 NBN RAD1 RAD17 RAD50 RAD51 RAD9A RAD9B RBBP8 RFC2 RFC3 RFC4 RFC5 RHNO1 RMI1 RMI2 RPA1 RPA2 RPA3 SEM1 TOP3A TOPBP1 WRN (see all 35) (see less)
11	Diseases of Base Excision Repair	Reactome	MUTYH NEIL1 NEIL3 NTHL1 OGG1
12	Defective Base Excision Repair Associated with NEIL1	Reactome	NEIL1

Gene overlap in member pathways for Homologous DNA Pairing and Strand Exchange SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ATR	ATR Checkpoint Kinase	Protein Coding	10
2	RPA1	Replication Protein A1	Protein Coding	10
3	RPA2	Replication Protein A2	Protein Coding	10
4	ATRIP	ATR Interacting Protein	Protein Coding	10
5	RAD50	RAD50 Double Strand Break Repair Protein	Protein Coding	9
6	TOPBP1	DNA Topoisomerase II Binding Protein 1	Protein Coding	9
7	HUS1	HUS1 Checkpoint Clamp Component	Protein Coding	9
8	MRE11	MRE11 Double Strand Break Repair Nuclease	Protein Coding	9
9	NBN	Nibrin	Protein Coding	9
10	ATM	ATM Serine/Threonine Kinase	Protein Coding	9
11	RAD1	RAD1 Checkpoint DNA Exonuclease	Protein Coding	9
12	RAD9A	RAD9 Checkpoint Clamp Component A	Protein Coding	9
13	RAD17	RAD17 Checkpoint Clamp Loader Component	Protein Coding	9
14	RFC2	Replication Factor C Subunit 2	Protein Coding	9
15	RFC3	Replication Factor C Subunit 3	Protein Coding	9
16	RFC4	Replication Factor C Subunit 4	Protein Coding	9
17	RFC5	Replication Factor C Subunit 5	Protein Coding	9
18	RPA3	Replication Protein A3	Protein Coding	9
19	BLM	BLM RecQ Like Helicase	Protein Coding	9
20	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	9
21	TOP3A	DNA Topoisomerase III Alpha	Protein Coding	9
22	RMI1	RecQ Mediated Genome Instability 1	Protein Coding	9
23	BRIP1	BRCA1 Interacting DNA Helicase 1	Protein Coding	9
24	KAT5	Lysine Acetyltransferase 5	Protein Coding	8
25	RMI2	RecQ Mediated Genome Instability 2	Protein Coding	8
26	RAD9B	RAD9 Checkpoint Clamp Component B	Protein Coding	8
27	DNA2	DNA Replication Helicase/Nuclease 2	Protein Coding	8
28	BARD1	BRCA1 Associated RING Domain 1	Protein Coding	8
29	RAD51	RAD51 Recombinase	Protein Coding	8
30	RBBP8	RB Binding Protein 8, Endonuclease	Protein Coding	8
31	BRCA2	BRCA2 DNA Repair Associated	Protein Coding	8
32	WRN	WRN RecQ Like Helicase	Protein Coding	8
33	RHNO1	RAD9-HUS1-RAD1 Interacting Nuclear Orphan 1	Protein Coding	8
34	EXO1	Exonuclease 1	Protein Coding	8
35	SEM1	SEM1 26S Proteasome Subunit	Protein Coding	7
36	RAD51C	RAD51 Paralog C	Protein Coding	6
37	RAD51B	RAD51 Paralog B	Protein Coding	6
38	RAD51D	RAD51 Paralog D	Protein Coding	6
39	XRCC2	X-Ray Repair Cross Complementing 2	Protein Coding	6
40	PALB2	Partner And Localizer Of BRCA2	Protein Coding	6
41	RAD51AP1	RAD51 Associated Protein 1	Protein Coding	5
42	CHEK1	Checkpoint Kinase 1	Protein Coding	4
43	XRCC3	X-Ray Repair Cross Complementing 3	Protein Coding	3
44	NEIL1	Nei Like DNA Glycosylase 1	Protein Coding	3
45	EME1	Essential Meiotic Structure-Specific Endonuclease 1	Protein Coding	2
46	EME2	Essential Meiotic Structure-Specific Endonuclease Subunit 2	Protein Coding	2
47	SLX1A	Structure-Specific Endonuclease Subunit SLX1A	Protein Coding	2
48	RPS27A	Ribosomal Protein S27a	Protein Coding	2
49	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	2
50	UBB	Ubiquitin B	Protein Coding	2
51	UBC	Ubiquitin C	Protein Coding	2
52	SLX1B	Structure-Specific Endonuclease Subunit SLX1B	Protein Coding	2
53	MUS81	MUS81 Structure-Specific Endonuclease Subunit	Protein Coding	2
54	SLX4	SLX4 Structure-Specific Endonuclease Subunit	Protein Coding	2
55	MUTYH	MutY DNA Glycosylase	Protein Coding	2
56	NTHL1	Nth Like DNA Glycosylase 1	Protein Coding	2
57	OGG1	8-Oxoguanine DNA Glycosylase	Protein Coding	2
58	NEIL3	Nei Like DNA Glycosylase 3	Protein Coding	2
59	FAN1	FANCD2 And FANCI Associated Nuclease 1	Protein Coding	2
60	FANCM	FA Complementation Group M	Protein Coding	2
61	FAAP100	FA Core Complex Associated Protein 100	Protein Coding	2
62	FANCG	FA Complementation Group G	Protein Coding	2
63	FANCC	FA Complementation Group C	Protein Coding	2
64	FANCE	FA Complementation Group E	Protein Coding	2
65	FAAP24	FA Core Complex Associated Protein 24	Protein Coding	2
66	CENPS	Centromere Protein S	Protein Coding	2
67	CENPS-CORT	CENPS-CORT Readthrough	Protein Coding	2
68	FANCL	FA Complementation Group L	Protein Coding	2
69	FANCI	FA Complementation Group I	Protein Coding	2
70	FANCB	FA Complementation Group B	Protein Coding	2
71	FANCA	FA Complementation Group A	Protein Coding	2
72	FANCD2	FA Complementation Group D2	Protein Coding	2
73	FANCF	FA Complementation Group F	Protein Coding	2
74	UBE2T	Ubiquitin Conjugating Enzyme E2 T	Protein Coding	2
75	USP1	Ubiquitin Specific Peptidase 1	Protein Coding	2
76	WDR48	WD Repeat Domain 48	Protein Coding	2
77	ERCC1	ERCC Excision Repair 1, Endonuclease Non-Catalytic Subunit	Protein Coding	2
78	ERCC4	ERCC Excision Repair 4, Endonuclease Catalytic Subunit	Protein Coding	2
79	POLD3	DNA Polymerase Delta 3, Accessory Subunit	Protein Coding	1
80	SPIDR	Scaffold Protein Involved In DNA Repair	Protein Coding	1
81	GEN1	GEN1 Holliday Junction 5'' Flap Endonuclease	Protein Coding	1
82	PCNA	Proliferating Cell Nuclear Antigen	Protein Coding	1
83	POLK	DNA Polymerase Kappa	Protein Coding	1
84	RTEL1	Regulator Of Telomere Elongation Helicase 1	Protein Coding	1
85	POLE3	DNA Polymerase Epsilon 3, Accessory Subunit	Protein Coding	1
86	POLD1	DNA Polymerase Delta 1, Catalytic Subunit	Protein Coding	1
87	POLD2	DNA Polymerase Delta 2, Accessory Subunit	Protein Coding	1
88	POLE	DNA Polymerase Epsilon, Catalytic Subunit	Protein Coding	1
89	POLE2	DNA Polymerase Epsilon 2, Accessory Subunit	Protein Coding	1
90	POLH	DNA Polymerase Eta	Protein Coding	1
91	FIRRM	FIGNL1 Interacting Regulator Of Recombination And Mitosis	Protein Coding	1
92	POLE4	DNA Polymerase Epsilon 4, Accessory Subunit	Protein Coding	1
93	POLD4	DNA Polymerase Delta 4, Accessory Subunit	Protein Coding	1
94	RFC1	Replication Factor C Subunit 1	Protein Coding	1
95	FIGNL1	Fidgetin Like 1	Protein Coding	1
96	MSH6	MutS Homolog 6	Protein Coding	1
97	MLH1	MutL Homolog 1	Protein Coding	1
98	MSH2	MutS Homolog 2	Protein Coding	1
99	MSH3	MutS Homolog 3	Protein Coding	1
100	PMS2	PMS1 Homolog 2, Mismatch Repair System Component	Protein Coding	1
101	BHLHE40	Basic Helix-Loop-Helix Family Member E40	Protein Coding	1
102	HES1	Hes Family BHLH Transcription Factor 1	Protein Coding	1
103	H2AX	H2A.X Variant Histone	Protein Coding	1
104	FAAP20	FA Core Complex Associated Protein 20	Protein Coding	1
105	CENPX	Centromere Protein X	Protein Coding	1
106	POLN	DNA Polymerase Nu	Protein Coding	1
107	DCLRE1B	DNA Cross-Link Repair 1B	Protein Coding	1
108	DCLRE1A	DNA Cross-Link Repair 1A	Protein Coding	1
109	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	1
110	RAD52	RAD52 DNA Repair Protein	Protein Coding	1

Disorders associated with Homologous DNA Pairing and Strand Exchange SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Breast cancer	Enrichment	ATM, BARD1, BLM, BRCA1, BRCA2, BRIP1, MRE11, NBN, PALB2, RAD50, RAD51, RAD51C, RAD51D, XRCC2, XRCC3	16.00
2	Ovarian cancer	Enrichment	ATM, BARD1, BLM, BRCA1, BRCA2, BRIP1, MRE11, NBN, PALB2, RAD50, RAD51C, RAD51D, WRN	16.00
3	Pancreatic cancer	Enrichment	ATM, BRCA1, BRCA2, BRIP1, NBN, PALB2, RBBP8	16.00
4	Gastric cancer	Enrichment	ATM, BARD1, BRCA1, BRCA2, BRIP1, NBN, PALB2, RAD51C, RAD51D	16.00
5	Hereditary breast ovarian cancer syndrome	Enrichment	ATM, BARD1, BLM, BRCA1, BRCA2, BRIP1, MRE11, NBN, PALB2, RAD50, RAD51, RAD51B, RAD51C, RAD51D, XRCC2	16.00
6	Colorectal cancer	Enrichment	ATM, BLM, BRCA1, BRCA2, BRIP1, MLH1, MSH2, MSH6, MUTYH, PALB2, PMS2, RAD51D, RMI1	16.00
7	Lynch syndrome 1	Enrichment	ATM, MLH1, MSH2, MSH6, PALB2, PMS2, RAD51D	16.00
8	Prostate cancer	Enrichment	ATM, BRCA1, BRCA2, MSH6, NBN, PALB2, RAD51D	16.00
9	Breast-ovarian cancer, familial 1	Enrichment	ATM, BRCA1, BRCA2, BRIP1, MSH2, NBN, PALB2, RAD51C, RAD51D	16.00
10	Endometrial cancer	Enrichment	ATM, BARD1, BLM, BRCA1, BRCA2, MLH1, MSH2, MSH3, MSH6, MUTYH, PMS2, RAD51C	16.00
11	Hereditary breast carcinoma	Enrichment	ATM, BARD1, BLM, BRCA1, BRCA2, BRIP1, MLH1, MSH2, MSH6, MUTYH, NBN, PALB2, RAD50, RAD51, RAD51D	16.00
12	Uterine corpus cancer	Enrichment	ATM, BRCA1, BRCA2, BRIP1, MSH2, MSH6, PALB2, RAD51C	16.00
13	Fanconi anemia, complementation group a	Enrichment	BRCA1, BRCA2, BRIP1, FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, PALB2, UBE2T	16.00
14	Inherited cancer-predisposing syndrome	Enrichment	ATM, BARD1, BLM, BRCA1, BRCA2, BRIP1, MRE11, NBN, RAD50, RAD51B, RAD51C, RAD51D, XRCC2	11.18
15	Colonic benign neoplasm	Enrichment	ATM, MLH1, MRE11, MUTYH, PALB2	10.09
16	Mismatch repair cancer syndrome 1	Enrichment	MLH1, MSH2, MSH6, PMS2	9.72
17	Rhabdomyosarcoma	Enrichment	BRCA1, BRCA2, MSH2, MSH6, PMS2	8.59
18	Seckel syndrome	Enrichment	ATR, ATRIP, DNA2, RBBP8	7.44
19	Lynch syndrome 4	Enrichment	MSH2, MSH6, PMS2	6.70
20	Familial colorectal cancer type x	Enrichment	ATM, BRCA2, POLD1, POLE	6.68
21	Lynch syndrome	Enrichment	MLH1, MSH2, MSH6, PMS2	6.63
22	Breast-ovarian cancer, familial 2	Enrichment	BRCA1, BRCA2, PMS2	6.30
23	Familial colorectal cancer	Enrichment	MLH1, MSH2, MUTYH	5.23
24	Diffuse midline glioma, h3 k27m-mutant	Enrichment	BRCA2, BRIP1	5.19
25	Microcephaly, growth restriction, and increased sister chromatid exchange 2	Enrichment	RMI2, TOP3A	5.19
26	Inflammatory breast carcinoma	Enrichment	BRCA1, BRCA2	5.19
27	Bilateral breast cancer	Enrichment	BRCA1, BRCA2	5.19
28	Neuroendocrine tumor of pancreas	Enrichment	BRCA2, PALB2	5.05
29	Muir-torre syndrome	Enrichment	MLH1, MSH2	4.86
30	Hereditary site-specific ovarian cancer syndrome	Enrichment	RAD51C, RAD51D	4.60
31	Polyposis syndrome, hereditary mixed, 1	Enrichment	BRCA1, BRCA2	4.41
32	Cholangiocarcinoma	Enrichment	BRCA1, BRCA2	4.41
33	Nijmegen breakage syndrome-like disorder	Enrichment	MRE11, RAD50	4.41
34	Diffuse large b-cell lymphoma	Enrichment	BRCA2, NBN, PMS2	4.33
35	Chordoma	Enrichment	BRCA2, PALB2	4.27
36	Bladder cancer	Enrichment	ATM, BRCA1, BRCA2	4.26
37	Hepatoblastoma	Enrichment	BARD1, BRCA2, MSH2	4.20
38	Hepatocellular carcinoma	Enrichment	NBN, PMS2, RAD50	4.13
39	Polymerase proofreading-related polyposis	Enrichment	POLD1, POLE	4.11
40	Fanconi anemia, complementation group d2	Enrichment	BRIP1, FANCD2	3.93
41	Glioblastoma	Enrichment	ATM, MSH2	3.86
42	Congenital disorder of deglycosylation 2	Enrichment	NEIL1	3.83
43	Isolated growth hormone deficiency, type ia	Enrichment	BRCA2, DNA2	3.75
44	Clear cell renal cell carcinoma	Enrichment	ATM, OGG1	3.69
45	Lung cancer	Enrichment	BRCA1, MLH1, PALB2	3.64
46	Tracheoesophageal fistula with or without esophageal atresia	Enrichment	BRCA2, BRIP1	3.64
47	Fanconi anemia, complementation group c	Enrichment	DCLRE1B, FANCC	3.63
48	Isolated tracheo-esophageal fistula	Enrichment	BRCA2, BRIP1	3.54
49	Familial adenomatous polyposis 3	Enrichment	NTHL1	3.43
50	Myeloma, multiple	Enrichment	ATM, BARD1, BRCA2	3.40
51	Premature menopause	Enrichment	ERCC1, NBN	3.26
52	Medulloblastoma	Enrichment	BRCA2, WRN	3.24
53	Familial adenomatous polyposis 2	Enrichment	MUTYH	3.13
54	Pituitary stalk interruption syndrome	Enrichment	FANCA, FANCG	3.12
55	Esophageal atresia/tracheoesophageal fistula	Enrichment	BRCA2, BRIP1	2.97
56	Spastic paraplegia 7, autosomal recessive	Enrichment	MUTYH	2.96
57	Renal cell carcinoma, nonpapillary	Enrichment	ATM, OGG1	2.85
58	Pilomatrixoma	Enrichment	MUTYH	2.83
59	Gliosarcoma	Enrichment	ATM, MSH2	2.79
60	Giant cell glioblastoma	Enrichment	ATM, MSH2	2.74
61	Familial adenomatous polyposis 1	Enrichment	MUTYH	2.73
62	Hereditary clear cell renal cell carcinoma	Enrichment	OGG1	2.59
63	Palmoplantar keratoderma, punctate type ii	Enrichment	BRCA1	2.59
64	Bloom syndrome	Enrichment	BLM	2.59
65	Seckel syndrome 2	Enrichment	RBBP8	2.59
66	Fanconi anemia, complementation group j	Enrichment	BRIP1	2.59
67	Glioma susceptibility 3	Enrichment	BRCA2	2.59
68	Seckel syndrome 1	Enrichment	ATR	2.59
69	Mirror movements 2	Enrichment	RAD51	2.59
70	Seckel syndrome 8	Enrichment	DNA2	2.59
71	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 6	Enrichment	RPA1	2.59
72	Fanconi anemia, complementation group r	Enrichment	RAD51	2.59
73	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 6	Enrichment	DNA2	2.59
74	Infant-type hemispheric glioma	Enrichment	BRCA1	2.59
75	Pancreatic cancer 2	Enrichment	BRCA2	2.59
76	Jawad syndrome	Enrichment	RBBP8	2.59
77	Ataxia-telangiectasia-like disorder 1	Enrichment	MRE11	2.59
78	Cutaneous telangiectasia and cancer syndrome, familial	Enrichment	ATR	2.59
79	Endometrial serous adenocarcinoma	Enrichment	ATM	2.59
80	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 5	Enrichment	TOP3A	2.59
81	Rothmund-thomson syndrome, type 4	Enrichment	DNA2	2.59
82	Morimoto-ryu-malicdan neuromuscular syndrome	Enrichment	RFC4	2.59
83	B-cell non-hodgkin lymphoma	Enrichment	ATM	2.59
84	Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome	Enrichment	ATR	2.59
85	Primary peritoneal carcinoma	Enrichment	BRCA1	2.59
86	Cerebrooculofacioskeletal syndrome 4	Enrichment	ERCC1	2.56
87	Xfe progeroid syndrome	Enrichment	ERCC4	2.56
88	Fanconi anemia, complementation group p	Enrichment	SLX4	2.53
89	Fanconi anemia, complementation group t	Enrichment	UBE2T	2.53
90	Fanconi anemia, complementation group g	Enrichment	FANCG	2.53
91	Fanconi anemia, complementation group b	Enrichment	FANCB	2.53
92	Spermatogenic failure 28	Enrichment	FANCM	2.53
93	Premature ovarian failure 15	Enrichment	FANCM	2.53
94	Dyskeratosis congenita, autosomal recessive 8	Enrichment	DCLRE1B	2.53
95	Fanconi anemia, complementation group l	Enrichment	FANCL	2.53
96	Autosomal recessive spastic paraplegia type 60	Enrichment	WDR48	2.53
97	Fanconi anemia, complementation group x	Enrichment	FAAP100	2.53
98	Fanconi anemia, complementation group u	Enrichment	XRCC2	2.53
99	Premature ovarian failure 17	Enrichment	XRCC2	2.53
100	Spermatogenic failure 50	Enrichment	XRCC2	2.53
101	Oocyte/zygote/embryo maturation arrest 21	Enrichment	CHEK1	2.53
102	Basal cell carcinoma	Enrichment	PALB2	2.52
103	Lynch syndrome 2	Enrichment	MLH1	2.42
104	Mismatch repair cancer syndrome 2	Enrichment	MSH2	2.42
105	Mismatch repair cancer syndrome 4	Enrichment	PMS2	2.42
106	Rectal benign neoplasm	Enrichment	MSH2	2.42
107	Pituitary cancer	Enrichment	PMS2	2.42
108	Ascending colon cancer	Enrichment	MSH2	2.42
109	Ovarian cyst	Enrichment	MSH2	2.42
110	Rothmund-thomson syndrome, type 2	Enrichment	DNA2	2.29
111	Neurodevelopmental disorder with dysmorphic facies, sleep disturbance, and brain abnormalities	Enrichment	KAT5	2.29
112	Fanconi anemia, complementation group s	Enrichment	BRCA1	2.29
113	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	2.29
114	Werner syndrome	Enrichment	WRN	2.29
115	Pancreatic cancer 4	Enrichment	BRCA1	2.29
116	Ovarian cancer 1	Enrichment	BRIP1	2.29
117	High grade glioma	Enrichment	ATM	2.29
118	Fanconi anemia, complementation group d1	Enrichment	BRCA2	2.29
119	T-cell prolymphocytic leukemia	Enrichment	ATM	2.29
120	Peritoneum cancer	Enrichment	BRCA1	2.29
121	Cystic fibrosis with helicobacter pylori gastritis, megaloblastic anemia, and impaired intellectual development	Enrichment	POLE	2.29
122	Colorectal cancer 10	Enrichment	POLD1	2.29
123	Colorectal cancer 12	Enrichment	POLE	2.29
124	Immunodeficiency 120	Enrichment	POLD1	2.29
125	Mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome	Enrichment	POLD1	2.29
126	Ataxia-telangiectasia-like disorder 2	Enrichment	PCNA	2.29
127	Ovarian dysgenesis 9	Enrichment	SPIDR	2.29
128	Immunodeficiency 122	Enrichment	POLD3	2.29
129	Xeroderma pigmentosum, complementation group f	Enrichment	ERCC4	2.26
130	Congenital heart defects and skeletal malformations syndrome	Enrichment	ABL1	2.26
131	Fanconi anemia, complementation group q	Enrichment	ERCC4	2.26
132	Xeroderma pigmentosum group f	Enrichment	ERCC4	2.26
133	Ovarian germ cell cancer	Enrichment	FANCM	2.23
134	Vacterl association, x-linked, with or without hydrocephalus	Enrichment	FANCL	2.23
135	Fanconi anemia, complementation group i	Enrichment	FANCI	2.23
136	Interstitial nephritis, karyomegalic	Enrichment	FAN1	2.23
137	Intellectual developmental disorder, x-linked, syndromic, pilorge type	Enrichment	FANCB	2.23
138	Fanconi anemia, complementation group e	Enrichment	FANCE	2.23
139	Vacterl with hydrocephalus	Enrichment	FANCB	2.23
140	Malignant germ cell tumor of ovary	Enrichment	FANCM	2.23
141	Submucosal cleft palate	Enrichment	UBB	2.23
142	Cleft hard palate	Enrichment	UBB	2.23
143	Short stature, microcephaly, and endocrine dysfunction	Enrichment	XRCC2	2.23
144	Fanconi anemia, complementation group n	Enrichment	PALB2	2.22
145	Pancreatic cancer 3	Enrichment	PALB2	2.22
146	Melanoma, cutaneous malignant 6	Enrichment	XRCC3	2.20
147	Burkitt lymphoma	Enrichment	PMS2	2.12
148	Mismatch repair cancer syndrome 3	Enrichment	MSH6	2.12
149	Ataxia-telangiectasia	Enrichment	ATM	2.11
150	Vasculopathy, retinal, with cerebral leukoencephalopathy and systemic manifestations	Enrichment	ATRIP	2.11
151	Nijmegen breakage syndrome	Enrichment	NBN	2.11
152	Polycythemia vera	Enrichment	ATM	2.11
153	Chilblain lupus 1	Enrichment	ATRIP	2.11
154	Tumor predisposition syndrome 1	Enrichment	BRCA2	2.11
155	Koolen-de vries syndrome	Enrichment	ATM	2.11
156	Chilblain lupus	Enrichment	ATRIP	2.11
157	Adenocarcinoma	Enrichment	ATM	2.11
158	Bap1 tumor predisposition syndrome	Enrichment	BRCA2	2.11
159	Childhood apraxia of speech	Enrichment	RFC3	2.11
160	T-cell acute lymphoblastic leukemia	Enrichment	ABL1	2.09
161	Retinoblastoma	Enrichment	FANCM	2.05
162	Uvula, bifid	Enrichment	UBB	2.05
163	Cleft soft palate	Enrichment	UBB	2.05
164	Fanconi anemia, complementation group f	Enrichment	FANCF	2.05
165	Cutis laxa, autosomal recessive, type ib	Enrichment	MUS81	2.05
166	Breast-ovarian cancer, familial 3	Enrichment	RAD51C	2.05
167	Breast-ovarian cancer, familial 4	Enrichment	RAD51D	2.05
168	Fanconi anemia, complementation group o	Enrichment	RAD51C	2.05
169	Breast-ovarian cancer, familial 5	Enrichment	PALB2	2.04
170	Mirror movements 1	Enrichment	RAD51	1.99
171	Ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia	Enrichment	MRE11	1.99
172	Aicardi-goutieres syndrome 1	Enrichment	ATRIP	1.99
173	Mantle cell lymphoma	Enrichment	ATM	1.99
174	Thrombotic microangiopathy	Enrichment	ATRIP	1.99
175	Oculomotor apraxia	Enrichment	ATM	1.99
176	Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies	Enrichment	POLE	1.99
177	Neurodevelopmental disorder with hypotonia, speech delay, and dysmorphic facies	Enrichment	POLK	1.99
178	Dyskeratosis congenita, autosomal recessive 5	Enrichment	RTEL1	1.99
179	Cerebellar ataxia, neuropathy, and vestibular areflexia syndrome	Enrichment	RFC1	1.99
180	Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, genital anomalies, and immunodeficiency	Enrichment	POLE	1.99
181	Autosomal dominant dyskeratosis congenita 4	Enrichment	RTEL1	1.99
182	Facial dysmorphism, immunodeficiency, livedo, and short stature	Enrichment	POLE	1.99
183	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 3	Enrichment	RTEL1	1.99
184	Hutchinson-gilford progeria syndrome	Enrichment	ERCC4	1.96
185	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	ABL1	1.96
186	Primary ovarian insufficiency	Enrichment	ERCC1, NBN	1.95
187	Lynch syndrome 5	Enrichment	MSH6	1.95
188	Familial adenomatous polyposis 4	Enrichment	MSH3	1.95
189	Cellular ependymoma	Enrichment	MSH2	1.95
190	Tanycytic ependymoma	Enrichment	MSH2	1.95
191	Papillary ependymoma	Enrichment	MSH2	1.95
192	Intellectual developmental disorder with dysmorphic facies and behavioral abnormalities	Enrichment	MSH6	1.95
193	Colon adenocarcinoma	Enrichment	MSH6	1.95
194	Clear cell ependymoma	Enrichment	MSH2	1.95
195	Erythrocytosis, familial, 2	Enrichment	FANCD2	1.93
196	Spastic paraplegia 47, autosomal recessive	Enrichment	DCLRE1B	1.93
197	Combined oxidative phosphorylation deficiency 32	Enrichment	EME2	1.93
198	Vacterl association	Enrichment	FANCL	1.93
199	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	CHEK1	1.93
200	Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1	Enrichment	ATRIP	1.89
201	Vascular dementia	Enrichment	ATRIP	1.89
202	Cockayne syndrome a	Enrichment	ERCC4	1.87
203	Autosomal recessive cerebellar ataxia	Enrichment	ERCC4	1.87
204	Xeroderma pigmentosum-cockayne syndrome complex	Enrichment	ERCC4	1.87
205	Vater/vacterl association	Enrichment	FANCL	1.83
206	Von hippel-lindau syndrome	Enrichment	FANCD2	1.83
207	Gaucher disease, type i	Enrichment	MSH6	1.83
208	Benign ependymoma	Enrichment	MSH2	1.83
209	Kabuki syndrome 1	Enrichment	BRCA2	1.81
210	Dyskeratosis congenita, x-linked	Enrichment	RTEL1	1.81
211	Cockayne syndrome b	Enrichment	ERCC1	1.79
212	Cerebrooculofacioskeletal syndrome 1	Enrichment	ERCC1	1.79
213	Renal cell carcinoma, papillary, 1	Enrichment	ATM	1.75
214	Lymphoma	Enrichment	PMS2	1.73
215	Leukemia, chronic myeloid	Enrichment	ABL1	1.72
216	Cockayne syndrome	Enrichment	ERCC4	1.72
217	Moyamoya angiopathy	Enrichment	ABL1	1.72
218	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	ABL1	1.72
219	Isolated split hand-split foot malformation	Enrichment	SEM1	1.69
220	Mitochondrial dna depletion syndrome 4a	Enrichment	FANCI	1.69
221	Epilepsy, progressive myoclonic, 4, with or without renal failure	Enrichment	RTEL1	1.69
222	Combined oxidative phosphorylation deficiency 24	Enrichment	RTEL1	1.69
223	Polydactyly	Enrichment	BRCA2	1.64
224	Leukemia, acute lymphoblastic 3	Enrichment	ERCC4	1.61
225	Leukemia, chronic lymphocytic	Enrichment	ATM	1.59
226	Aplastic anemia	Enrichment	NBN	1.59
227	Aicardi-goutieres syndrome	Enrichment	ATRIP	1.59
228	Immune deficiency disease	Enrichment	ATM	1.55
229	Leukemia, acute lymphoblastic	Enrichment	NBN	1.55
230	Xeroderma pigmentosum, variant type	Enrichment	ERCC4	1.53
231	Pulmonary fibrosis	Enrichment	RTEL1	1.51
232	Hoyeraal-hreidarsson syndrome	Enrichment	RTEL1	1.51
233	Lip and oral cavity carcinoma	Enrichment	ABL1	1.49
234	Neural tube defects	Enrichment	RAD9B	1.48
235	Periventricular nodular heterotopia	Enrichment	BRCA1	1.45
236	Cataract	Enrichment	WRN	1.45
237	Heart disease	Enrichment	ABL1	1.43
238	Wilms tumor 1	Enrichment	BRCA2	1.42
239	Cardiomyopathy, familial hypertrophic, 9	Enrichment	PMS2	1.39
240	Male infertility with spermatogenesis disorder	Enrichment	FANCM	1.36
241	Microcephaly	Enrichment	ABL1, NBN	1.35
242	Williams-beuren syndrome	Enrichment	RFC2	1.30
243	Lissencephaly	Enrichment	NBN	1.28
244	Combined immunodeficiency	Enrichment	POLD1	1.26
245	Combined t cell and b cell immunodeficiency	Enrichment	POLD1	1.26
246	Combined t and b cell immunodeficiency	Enrichment	POLD1	1.26
247	Azoospermia	Enrichment	FANCM	1.24
248	46 xx gonadal dysgenesis	Enrichment	SPIDR	1.22
249	Precursor t-cell acute lymphoblastic leukemia	Enrichment	ABL1	1.22
250	Cardiomyopathy, dilated, 1g	Enrichment	PMS2	1.10
251	Interstitial lung disease 2	Enrichment	RTEL1	1.07
252	Parkinson's disease	Enrichment	RFC1	1.03
253	Dyskeratosis congenita	Enrichment	RTEL1	1.03
254	Systemic lupus erythematosus	Enrichment	ATRIP	1.02
255	Cerebral palsy	Enrichment	BRCA2	1.02
256	Type 2 diabetes mellitus	Enrichment	WRN	0.99
257	Leukemia, acute myeloid	Enrichment	FANCD2	0.95
258	Parkinson disease, late-onset	Enrichment	RFC1	0.93
259	Spastic ataxia	Enrichment	ERCC4	0.87
260	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	FANCM	0.82
261	Leigh syndrome, nuclear	Enrichment	EME2	0.73
262	Leigh disease	Enrichment	EME2	0.70
263	Mitochondrial disease	Enrichment	TOP3A	0.69
264	Hereditary retinal dystrophy	Enrichment	ATRIP	0.27
265	Fundus dystrophy	Enrichment	ATRIP	0.27

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Homologous DNA Pairing and Strand Exchange

Pathway Network for Homologous DNA Pairing and Strand Exchange

Pathway network for the Homologous DNA Pairing and Strand Exchange SuperPath

Member Pathways for Homologous DNA Pairing and Strand Exchange

Pathways in the Homologous DNA Pairing and Strand Exchange SuperPath

Gene overlap in member pathways for Homologous DNA Pairing and Strand Exchange SuperPath

Associated Genes for Homologous DNA Pairing and Strand Exchange

Associated Disorders for Homologous DNA Pairing and Strand Exchange

Disorders associated with Homologous DNA Pairing and Strand Exchange SuperPath

STRING Interaction Network for Homologous DNA Pairing and Strand Exchange

Sources for Homologous DNA Pairing and Strand Exchange