HOP Signaling

No Pathway Network information available for HOP Signaling

Pathways in the HOP Signaling SuperPath

#	Name	Source	Genes
1	HOP Signaling	QIAGEN	ACTC1 GATA4 MYOCD NKX2-5 NPPA SRF (see all 6) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ACTC1	Actin Alpha Cardiac Muscle 1	Protein Coding	1
2	GATA4	GATA Binding Protein 4	Protein Coding	1
3	MYOCD	Myocardin	Protein Coding	1
4	NKX2-5	NK2 Homeobox 5	Protein Coding	1
5	NPPA	Natriuretic Peptide A	Protein Coding	1
6	SRF	Serum Response Factor	Protein Coding	1

Disorders associated with HOP Signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Patent foramen ovale	Enrichment	ACTC1, GATA4, NKX2-5	7.41
2	Familial atrial fibrillation	Enrichment	GATA4, NKX2-5, NPPA	7.01
3	Heart disease	Enrichment	GATA4, NKX2-5	4.83
4	Tetralogy of fallot	Enrichment	GATA4, NKX2-5	4.28
5	Left ventricular noncompaction	Enrichment	ACTC1, NKX2-5	4.02
6	Atrial septal defect 7 with or without atrioventricular conduction defects	Enrichment	NKX2-5	3.35
7	Hypothyroidism, congenital, nongoitrous, 5	Enrichment	NKX2-5	3.35
8	Atrioventricular septal defect 4	Enrichment	GATA4	3.35
9	Megabladder, congenital	Enrichment	MYOCD	3.35
10	Atrial septal defect 2	Enrichment	GATA4	3.35
11	Ventricular septal defect 3	Enrichment	NKX2-5	3.35
12	Testicular anomalies with or without congenital heart disease	Enrichment	GATA4	3.35
13	Hypoplastic left heart syndrome 2	Enrichment	NKX2-5	3.35
14	8p23.1 microdeletion syndrome	Enrichment	GATA4	3.35
15	Aortic arch interruption	Enrichment	NKX2-5	3.35
16	Atrial heart septal defect 7	Enrichment	NKX2-5	3.35
17	Partial atrioventricular septal defect with ventricular hypoplasia	Enrichment	GATA4	3.35
18	Dilated cardiomyopathy	Enrichment	ACTC1, NKX2-5	3.29
19	Cardiomyopathy, dilated, 1r	Enrichment	ACTC1	3.05
20	Cardiomyopathy, familial hypertrophic, 11	Enrichment	ACTC1	3.05
21	Atrial fibrillation, familial, 6	Enrichment	NPPA	3.05
22	Atrial septal defect 5	Enrichment	ACTC1	3.05
23	46,xy sex reversal 3	Enrichment	GATA4	3.05
24	Familial isolated congenital asplenia	Enrichment	NKX2-5	3.05
25	Deletion 5q35	Enrichment	NKX2-5	3.05
26	Isolated atrial standstill	Enrichment	NPPA	3.05
27	Prune belly syndrome	Enrichment	MYOCD	2.88
28	Atrial standstill 2	Enrichment	NPPA	2.88
29	Hereditary progressive cardiac conduction defect	Enrichment	NKX2-5	2.75
30	Transposition of the great arteries	Enrichment	GATA4	2.75
31	Ventricular septal defect 1	Enrichment	GATA4	2.66
32	Congenital heart defects, multiple types, 4	Enrichment	GATA4	2.66
33	Persistent truncus arteriosus	Enrichment	NKX2-5	2.66
34	Conotruncal heart malformations	Enrichment	NKX2-5	2.58
35	Double outlet right ventricle	Enrichment	NKX2-5	2.58
36	Hypothyroidism, congenital, nongoitrous, 2	Enrichment	NKX2-5	2.51
37	Hypoplastic left heart syndrome	Enrichment	NKX2-5	2.45
38	Atrial heart septal defect	Enrichment	NKX2-5	2.31
39	Interatrial communication	Enrichment	NKX2-5	2.31
40	Aortic valve disease 1	Enrichment	NKX2-5	2.24
41	Aortic aneurysm, familial thoracic 1	Enrichment	GATA4	2.21
42	46,xy partial gonadal dysgenesis	Enrichment	GATA4	2.21
43	Heart, malformation of	Enrichment	GATA4	2.10
44	Familial hypertrophic cardiomyopathy	Enrichment	ACTC1	1.84
45	Distal arthrogryposis	Enrichment	ACTC1	1.73
46	Hypertrophic cardiomyopathy	Enrichment	ACTC1	1.72
47	Familial isolated dilated cardiomyopathy	Enrichment	ACTC1	1.63
48	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	GATA4	1.61

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for HOP Signaling

Member Pathways for HOP Signaling

Pathways in the HOP Signaling SuperPath

Associated Genes for HOP Signaling

Associated Disorders for HOP Signaling

Disorders associated with HOP Signaling SuperPath

STRING Interaction Network for HOP Signaling

Sources for HOP Signaling