Host-pathogen interaction of human coronaviruses - interferon induction

Pathway network for the Host-pathogen interaction of human coronaviruses - interferon induction SuperPath

Sources:

WikiPathways
PharmGKB

Pathways in the Host-pathogen interaction of human coronaviruses - interferon induction SuperPath

#	Name	Source	Genes
1	Host-pathogen interaction of human coronaviruses - interferon induction	WikiPathways	CHUK EIF2AK2 FOS IFIH1 IFNAR1 IFNAR2 IKBKB IKBKE IKBKG IRF3 IRF9 JAK1 JUN MAP3K7 MAPK14 MAPK8 MAVS MYD88 NFKB1 NFKBIA OAS1 OAS2 OAS3 RIGI RIPK1 STAT1 STAT2 TBK1 TICAM1 TLR7 TRAF3 TRAF6 TYK2 (see all 33) (see less)
2	Type I interferon induction and signaling during SARS-CoV-2 infection	WikiPathways	EIF2AK2 IFNAR1 IFNAR2 IKBKE IRF3 IRF7 IRF9 JAK1 MYD88 OAS1 OAS2 OAS3 STAT1 STAT2 TBK1 TLR2 TLR3 TLR4 TLR6 TLR7 TLR9 TMPRSS2 TRAF3 TRAF6 TREML4 TYK2 (see all 26) (see less)
3	Peginterferon alpha-2a/Peginterferon alpha-2b Pathway (Hepatocyte), Pharmacodynamics	PharmGKB	ADAR EIF2AK2 IFNA2 IFNAR1 IFNAR2 IFNL3 IFNLR1 IL10RB IRF3 IRF7 IRF9 JAK1 MAVS MX1 OAS1 PIAS1 RIGI SOCS3 STAT1 STAT2 TYK2 USP18 (see all 22) (see less)
4	SARS coronavirus and innate immunity	WikiPathways	ACE2 IFIH1 IFNAR1 IFNAR2 IFNB1 IRF3 IRF9 MAVS RIGI STAT1 STAT2 TICAM1 TRAF3 TYK2 (see all 14) (see less)
5	Induction of autophagy and toll-like receptor signaling pathways by graphene oxide	WikiPathways	IRF3 MYD88 TLR4 TLR9 TRAF6

Gene overlap in member pathways for Host-pathogen interaction of human coronaviruses - interferon induction SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	IRF3	Interferon Regulatory Factor 3	Protein Coding	5
2	TYK2	Tyrosine Kinase 2	Protein Coding	4
3	STAT2	Signal Transducer And Activator Of Transcription 2	Protein Coding	4
4	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	4
5	IFNAR2	Interferon Alpha And Beta Receptor Subunit 2	Protein Coding	4
6	IFNAR1	Interferon Alpha And Beta Receptor Subunit 1	Protein Coding	4
7	IRF9	Interferon Regulatory Factor 9	Protein Coding	4
8	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	3
9	TRAF3	TNF Receptor Associated Factor 3	Protein Coding	3
10	EIF2AK2	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2	Protein Coding	3
11	OAS1	2''-5''-Oligoadenylate Synthetase 1	Protein Coding	3
12	MYD88	MYD88 Innate Immune Signal Transduction Adaptor	Protein Coding	3
13	JAK1	Janus Kinase 1	Protein Coding	3
14	RIGI	RNA Sensor RIG-I	Protein Coding	3
15	MAVS	Mitochondrial Antiviral Signaling Protein	Protein Coding	3
16	IFIH1	Interferon Induced With Helicase C Domain 1	Protein Coding	2
17	TLR7	Toll Like Receptor 7	Protein Coding	2
18	OAS3	2''-5''-Oligoadenylate Synthetase 3	Protein Coding	2
19	OAS2	2''-5''-Oligoadenylate Synthetase 2	Protein Coding	2
20	TBK1	TANK Binding Kinase 1	Protein Coding	2
21	TICAM1	TIR Domain Containing Adaptor Molecule 1	Protein Coding	2
22	IKBKE	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon	Protein Coding	2
23	TLR4	Toll Like Receptor 4	Protein Coding	2
24	TLR9	Toll Like Receptor 9	Protein Coding	2
25	IRF7	Interferon Regulatory Factor 7	Protein Coding	2
26	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	1
27	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	1
28	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
29	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
30	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
31	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
32	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
33	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
34	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
35	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
36	RIPK1	Receptor Interacting Serine/Threonine Kinase 1	Protein Coding	1
37	TREML4	Triggering Receptor Expressed On Myeloid Cells Like 4	Protein Coding	1
38	TMPRSS2	Transmembrane Serine Protease 2	Protein Coding	1
39	TLR6	Toll Like Receptor 6	Protein Coding	1
40	TLR2	Toll Like Receptor 2	Protein Coding	1
41	TLR3	Toll Like Receptor 3	Protein Coding	1
42	IL10RB	Interleukin 10 Receptor Subunit Beta	Protein Coding	1
43	MX1	MX Dynamin Like GTPase 1	Protein Coding	1
44	ADAR	Adenosine Deaminase RNA Specific	Protein Coding	1
45	PIAS1	Protein Inhibitor Of Activated STAT 1	Protein Coding	1
46	IFNA2	Interferon Alpha 2	Protein Coding	1
47	USP18	Ubiquitin Specific Peptidase 18	Protein Coding	1
48	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	1
49	IFNL3	Interferon Lambda 3	Protein Coding	1
50	IFNLR1	Interferon Lambda Receptor 1	Protein Coding	1
51	ACE2	Angiotensin Converting Enzyme 2	Protein Coding	1
52	IFNB1	Interferon Beta 1	Protein Coding	1

Disorders associated with Host-pathogen interaction of human coronaviruses - interferon induction SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Multisystem inflammatory syndrome in children	Enrichment	IFIH1, IFNAR2, IFNB1, IRF3, TRAF3	10.53
2	Herpes simplex virus encephalitis	Enrichment	TBK1, TLR3, TRAF3	7.21
3	Singleton-merten syndrome	Enrichment	IFIH1, RIGI	6.00
4	Immunodeficiency 44	Enrichment	IFNAR2, STAT2	5.53
5	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	5.24
6	Hepatitis b	Enrichment	IFNAR2, IL10RB	4.82
7	Immunodeficiency 68	Enrichment	MYD88	3.43
8	Macroglobulinemia, waldenstrom 1	Enrichment	MYD88	3.43
9	Encephalopathy, acute, infection-induced 7	Enrichment	IRF3	3.43
10	Macular degeneration, age-related, 10	Enrichment	TLR4	3.43
11	Waldenstram macroglobulinemia	Enrichment	MYD88	3.43
12	Transient predisposition to invasive pyogenic bacterial infection	Enrichment	MYD88	3.13
13	Immunodeficiency 35	Enrichment	TYK2	2.99
14	Singleton-merten syndrome 1	Enrichment	IFIH1	2.99
15	Encephalopathy, acute, infection-induced 6	Enrichment	TICAM1	2.99
16	Pseudo-torch syndrome 3	Enrichment	STAT2	2.99
17	Immunodeficiency 106 viral infections	Enrichment	IFNAR1	2.99
18	Immunodeficiency 95	Enrichment	IFIH1	2.99
19	Immunodeficiency 132a	Enrichment	TRAF3	2.99
20	Type 1 diabetes mellitus 19	Enrichment	IFIH1	2.99
21	Immunodeficiency 132b	Enrichment	TRAF3	2.99
22	Immunodeficiency 31a	Enrichment	STAT1	2.99
23	Immunodeficiency 31b	Enrichment	STAT1	2.99
24	Singleton-merten syndrome 2	Enrichment	RIGI	2.99
25	Immunodeficiency 65 viral infections	Enrichment	IRF9	2.99
26	Aicardi-goutieres syndrome 7	Enrichment	IFIH1	2.99
27	Dermatitis, atopic, 4	Enrichment	SOCS3	2.79
28	Immunodeficiency 39 viral infections	Enrichment	IRF7	2.79
29	Leukoencephalopathy, developmental delay, and episodic neurologic regression syndrome	Enrichment	EIF2AK2	2.79
30	Immunodeficiency 39	Enrichment	IRF7	2.79
31	Immunodeficiency 100 with pulmonary alveolar proteinosis and hypogammaglobulinemia	Enrichment	OAS1	2.79
32	Dystonia 33	Enrichment	EIF2AK2	2.79
33	Pseudo-torch syndrome 2	Enrichment	USP18	2.79
34	Infantile-onset pulmonary alveolar proteinosis-hypogammaglobulinemia	Enrichment	OAS1	2.79
35	Adar-related hereditary spastic paraplegia	Enrichment	ADAR	2.79
36	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.79
37	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	2.73
38	Leprosy 3	Enrichment	TLR2	2.72
39	Immunodeficiency 83 viral infections	Enrichment	TLR3	2.72
40	Immunodeficiency 74, covid19-related, x-linked	Enrichment	TLR7	2.72
41	X-linked immunodeficiency 74	Enrichment	TLR7	2.72
42	Systemic lupus erythematosus 17	Enrichment	TLR7	2.72
43	Autoinflammation with arthritis and vasculitis	Enrichment	TBK1	2.72
44	Corticobasal syndrome	Enrichment	TBK1	2.72
45	Encephalopathy, acute, infection-induced 8	Enrichment	TBK1	2.72
46	Immunodeficiency 45	Enrichment	IFNAR2	2.69
47	Immunodeficiency 31c	Enrichment	STAT1	2.69
48	Lymphomatoid papulosis	Enrichment	TYK2	2.69
49	Basal ganglia disease	Enrichment	IFIH1	2.69
50	Primary cutaneous anaplastic large cell lymphoma	Enrichment	TYK2	2.69
51	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.61
52	Incontinentia pigmenti	Enrichment	IKBKG	2.61
53	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.61
54	Fetal encasement syndrome	Enrichment	CHUK	2.61
55	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.61
56	Immunodeficiency 15b	Enrichment	IKBKB	2.61
57	Immunodeficiency 15a	Enrichment	IKBKB	2.61
58	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.61
59	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.61
60	Autoinflammation with episodic fever and lymphadenopathy	Enrichment	RIPK1	2.61
61	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.61
62	Dyschromatosis symmetrica hereditaria	Enrichment	ADAR	2.49
63	Aicardi-goutieres syndrome 6	Enrichment	ADAR	2.49
64	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.49
65	Symmetrical dyschromatosis of extremities	Enrichment	ADAR	2.49
66	Frontotemporal dementia and/or amyotrophic lateral sclerosis 4	Enrichment	TBK1	2.42
67	Leprosy 1	Enrichment	TLR6	2.42
68	Hepatitis c virus	Enrichment	IFNL3	2.31
69	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1	2.31
70	Torsion dystonia 1	Enrichment	EIF2AK2	2.31
71	Inflammatory bowel disease 25	Enrichment	IL10RB	2.31
72	Immunodeficiency 33	Enrichment	IKBKG	2.31
73	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.31
74	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.31
75	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.31
76	Immunodeficiency 57 with autoinflammation	Enrichment	RIPK1	2.31
77	Common variable immunodeficiency 12	Enrichment	NFKB1	2.31
78	Spastic diplegia	Enrichment	IFIH1	2.29
79	Chronic mucocutaneous candidiasis	Enrichment	STAT1	2.21
80	Familial infantile bilateral striatal necrosis	Enrichment	ADAR	2.19
81	Behcet syndrome	Enrichment	TLR4	2.16
82	Diffuse large b-cell lymphoma	Enrichment	MYD88	2.16
83	Nasopharyngeal carcinoma	Enrichment	NFKBIA	2.14
84	Frontometaphyseal dysplasia	Enrichment	MAP3K7	2.14
85	Aicardi-goutiares syndrome	Enrichment	IFIH1	2.03
86	Inflammatory bowel disease 25, autosomal recessive	Enrichment	IL10RB	2.01
87	Il10-related early-onset inflammatory bowel disease	Enrichment	IL10RB	2.01
88	Congenital generalized lipodystrophy	Enrichment	FOS	2.01
89	Aicardi-goutieres syndrome	Enrichment	IFIH1	1.99
90	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.92
91	Histiocytoid hemangioma	Enrichment	FOS	1.92
92	Motor neuron disease	Enrichment	TBK1	1.87
93	Common variable immunodeficiency	Enrichment	NFKB1	1.77
94	Progressive non-fluent aphasia	Enrichment	TBK1	1.77
95	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	TBK1	1.72
96	Coronary heart disease 5	Enrichment	IKBKG	1.66
97	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.62
98	Immune deficiency disease	Enrichment	RIPK1	1.58
99	Human immunodeficiency virus type 1	Enrichment	TLR3	1.47
100	Gliosarcoma	Enrichment	NFKBIA	1.42
101	Giant cell glioblastoma	Enrichment	NFKBIA	1.39
102	Severe covid-19	Enrichment	IL10RB	1.34
103	Nephronophthisis	Enrichment	PIAS1	1.28
104	Malaria	Enrichment	IKBKG	1.26
105	Systemic lupus erythematosus	Enrichment	TLR7	1.14
106	Severe combined immunodeficiency	Enrichment	IKBKB	1.11
107	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	TBK1	0.98
108	Hereditary breast ovarian cancer syndrome	Enrichment	RIPK1	0.90
109	Colorectal cancer	Enrichment	ADAR	0.88
110	Breast cancer	Enrichment	JUN	0.78

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Host-pathogen interaction of human coronaviruses - interferon induction

Pathway Network for Host-pathogen interaction of human coronaviruses - interferon induction

Pathway network for the Host-pathogen interaction of human coronaviruses - interferon induction SuperPath

Member Pathways for Host-pathogen interaction of human coronaviruses - interferon induction

Pathways in the Host-pathogen interaction of human coronaviruses - interferon induction SuperPath

Gene overlap in member pathways for Host-pathogen interaction of human coronaviruses - interferon induction SuperPath

Associated Genes for Host-pathogen interaction of human coronaviruses - interferon induction

Associated Disorders for Host-pathogen interaction of human coronaviruses - interferon induction

Disorders associated with Host-pathogen interaction of human coronaviruses - interferon induction SuperPath

STRING Interaction Network for Host-pathogen interaction of human coronaviruses - interferon induction

Sources for Host-pathogen interaction of human coronaviruses - interferon induction