HSF1-dependent transactivation

Pathway network for the HSF1-dependent transactivation SuperPath

Sources:

Reactome

Pathways in the HSF1-dependent transactivation SuperPath

#	Name	Source	Genes
1	HSF1-dependent transactivation	Reactome	AKT1S1 CAMK2A CAMK2B CAMK2D CAMK2G CREBBP CRYAB DNAJB1 EP300 FKBP4 HSBP1 HSF1 HSP90AA1 HSP90AB1 HSPA1A HSPA1B HSPA1L HSPA2 HSPA8 HSPB8 MLST8 MTOR PTGES3 RPTOR (see all 24) (see less)
2	Attenuation phase	Reactome	CREBBP DNAJB1 EP300 FKBP4 HSBP1 HSF1 HSP90AA1 HSP90AB1 HSPA1A HSPA1B HSPA1L HSPA2 HSPA8 PTGES3 (see all 14) (see less)
3	Viral RNP Complexes in the Host Cell Nucleus	Reactome	HSPA1A HSPA1B

Gene overlap in member pathways for HSF1-dependent transactivation SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	HSPA1A	Heat Shock Protein Family A (Hsp70) Member 1A	Protein Coding	3
2	HSPA1B	Heat Shock Protein Family A (Hsp70) Member 1B	Protein Coding	3
3	PTGES3	Prostaglandin E Synthase 3	Protein Coding	2
4	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	2
5	EP300	EP300 Lysine Acetyltransferase	Protein Coding	2
6	FKBP4	FKBP Prolyl Isomerase 4	Protein Coding	2
7	HSBP1	Heat Shock Factor Binding Protein 1	Protein Coding	2
8	HSF1	Heat Shock Transcription Factor 1	Protein Coding	2
9	HSPA1L	Heat Shock Protein Family A (Hsp70) Member 1 Like	Protein Coding	2
10	HSPA2	Heat Shock Protein Family A (Hsp70) Member 2	Protein Coding	2
11	HSPA8	Heat Shock Protein Family A (Hsp70) Member 8	Protein Coding	2
12	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	2
13	HSP90AB1	Heat Shock Protein 90 Alpha Family Class B Member 1	Protein Coding	2
14	DNAJB1	DnaJ Heat Shock Protein Family (Hsp40) Member B1	Protein Coding	2
15	CRYAB	Crystallin Alpha B	Protein Coding	1
16	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
17	HSPB8	Heat Shock Protein Family B (Small) Member 8	Protein Coding	1
18	RPTOR	Regulatory Associated Protein Of MTOR Complex 1	Protein Coding	1
19	MLST8	MTOR Associated Protein MLST8	Protein Coding	1
20	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	1
21	CAMK2B	Calcium/Calmodulin Dependent Protein Kinase II Beta	Protein Coding	1
22	CAMK2D	Calcium/Calmodulin Dependent Protein Kinase II Delta	Protein Coding	1
23	CAMK2G	Calcium/Calmodulin Dependent Protein Kinase II Gamma	Protein Coding	1
24	AKT1S1	AKT1 Substrate 1	Protein Coding	1

Disorders associated with HSF1-dependent transactivation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Influenza	Direct
2	Rare genetic intellectual disability	Enrichment	CREBBP, EP300, MTOR	5.66
3	Rubinstein-taybi syndrome 1	Enrichment	CREBBP, EP300	4.83
4	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP, EP300	4.83
5	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.99
6	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.99
7	Menke-hennekam syndrome	Enrichment	CREBBP	2.99
8	Cardiomyopathy, dilated, 1ii	Enrichment	CRYAB	2.75
9	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	2.75
10	Intellectual developmental disorder, autosomal dominant 54	Enrichment	CAMK2B	2.75
11	Myopathy, myofibrillar, 2b, infantile-onset	Enrichment	CRYAB	2.75
12	Charcot-marie-tooth disease, axonal, type 2l	Enrichment	HSPB8	2.75
13	Myopathy, myofibrillar, 2a, adult-onset	Enrichment	CRYAB	2.75
14	Myopathy, myofibrillar, 13, with rimmed vacuoles	Enrichment	HSPB8	2.75
15	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	2.75
16	Intellectual developmental disorder, autosomal dominant 59	Enrichment	CAMK2G	2.75
17	Autosomal dominant distal axonal motor neuropathy-myofibrillar myopathy syndrome	Enrichment	HSPB8	2.75
18	Thumb deformity	Enrichment	CREBBP	2.69
19	Menke-hennekam syndrome 2	Enrichment	EP300	2.69
20	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	2.69
21	Fibrolamellar carcinoma	Enrichment	DNAJB1	2.69
22	Tethered spinal cord syndrome	Enrichment	CREBBP	2.51
23	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	2.51
24	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2A, CAMK2B	2.46
25	Cardiomyopathy, familial restrictive, 1	Enrichment	CRYAB	2.45
26	Cebalid syndrome	Enrichment	MTOR	2.45
27	Cataract 16, multiple types	Enrichment	CRYAB	2.45
28	Smith-kingsmore syndrome	Enrichment	MTOR	2.45
29	Rubinstein-taybi syndrome 2	Enrichment	EP300	2.29
30	Distal myopathy	Enrichment	HSPB8	2.28
31	Hypertrichosis	Enrichment	CREBBP	2.21
32	Focal cortical dysplasia, type ii	Enrichment	MTOR	2.15
33	Myopathy, autophagic vacuolar, infantile-onset	Enrichment	HSPB8	2.15
34	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	2.15
35	Autism	Enrichment	CAMK2G, CREBBP	2.15
36	Neuronopathy, distal hereditary motor, autosomal dominant 2	Enrichment	HSPB8	2.05
37	Hemimegalencephaly	Enrichment	MTOR	2.05
38	Charge syndrome	Enrichment	EP300	2.03
39	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.91
40	Overgrowth syndrome	Enrichment	MTOR	1.91
41	Early-onset posterior polar cataract	Enrichment	CRYAB	1.85
42	Heart disease	Enrichment	CREBBP	1.84
43	Congenital nervous system abnormality	Enrichment	CAMK2B, CREBBP	1.83
44	Nervous system disease	Enrichment	CAMK2B, CREBBP	1.83
45	Polydactyly, postaxial, type a1	Enrichment	EP300	1.81
46	Corpus callosum, agenesis of	Enrichment	CREBBP	1.81
47	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.81
48	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.81
49	Early-onset lamellar cataract	Enrichment	CRYAB	1.71
50	Diffuse large b-cell lymphoma	Enrichment	CREBBP	1.71
51	Microcephaly	Enrichment	CAMK2B, EP300	1.70
52	Scoliosis	Enrichment	CREBBP	1.61
53	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.58
54	Early-onset nuclear cataract	Enrichment	CRYAB	1.50
55	Myeloma, multiple	Enrichment	CREBBP	1.25
56	Dystonia	Enrichment	CAMK2B	1.22
57	Colorectal cancer	Enrichment	EP300	1.06
58	Familial isolated dilated cardiomyopathy	Enrichment	CRYAB	1.05

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

HSF1-dependent transactivation

Pathway Network for HSF1-dependent transactivation

Pathway network for the HSF1-dependent transactivation SuperPath

Member Pathways for HSF1-dependent transactivation

Pathways in the HSF1-dependent transactivation SuperPath

Gene overlap in member pathways for HSF1-dependent transactivation SuperPath

Associated Genes for HSF1-dependent transactivation

Associated Disorders for HSF1-dependent transactivation

Disorders associated with HSF1-dependent transactivation SuperPath

STRING Interaction Network for HSF1-dependent transactivation

Sources for HSF1-dependent transactivation