Human Early Embryo Development
Pathways in the Human Early Embryo Development SuperPath
| # | Name | Source | Genes |
|---|---|---|---|
| 1 | Human Early Embryo Development | QIAGEN | |
| 2 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | Reactome |
Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways
| # | Symbol | Description | Category | # Related Pathways |
|---|---|---|---|---|
| 1 | NANOG | Nanog Homeobox | Protein Coding | 2 |
| 2 | POU5F1 | POU Class 5 Homeobox 1 | Protein Coding | 2 |
| 3 | SOX2 | SRY-Box Transcription Factor 2 | Protein Coding | 2 |
| 4 | ASCL2 | Achaete-Scute Family BHLH Transcription Factor 2 | Protein Coding | 1 |
| 5 | BMP4 | Bone Morphogenetic Protein 4 | Protein Coding | 1 |
| 6 | GCM1 | Glial Cells Missing Transcription Factor 1 | Protein Coding | 1 |
| 7 | ID2 | Inhibitor Of DNA Binding 2 | Protein Coding | 1 |
Disorders associated with Human Early Embryo Development SuperPath
according to GeneCards Suite gene sharing
| # | Disorder | Type | Genes | Score |
|---|---|---|---|---|
| 1 | Microphthalmia, syndromic 6 | Enrichment | BMP4 | 3.29 |
| 2 | Orofacial cleft 11 | Enrichment | BMP4 | 3.29 |
| 3 | Microphthalmia, syndromic 3 | Enrichment | SOX2 | 3.05 |
| 4 | Nanophthalmos | Enrichment | SOX2 | 2.61 |
| 5 | Septooptic dysplasia | Enrichment | SOX2 | 2.58 |
| 6 | Anterior segment dysgenesis 5 | Enrichment | BMP4 | 2.51 |
| 7 | Macs syndrome | Enrichment | SOX2 | 2.35 |
| 8 | Microphthalmia | Enrichment | SOX2 | 2.31 |
| 9 | Peters-plus syndrome | Enrichment | BMP4 | 2.29 |
| 10 | Stickler syndrome | Enrichment | BMP4 | 2.29 |
| 11 | Renal hypodysplasia/aplasia 3 | Enrichment | BMP4 | 2.21 |
| 12 | Cleft lip/palate | Enrichment | BMP4 | 2.14 |
