Hypothesized pathways in pathogenesis of cardiovascular disease

No Pathway Network information available for Hypothesized pathways in pathogenesis of cardiovascular disease

Pathways in the Hypothesized pathways in pathogenesis of cardiovascular disease SuperPath

#	Name	Source	Genes
1	Hypothesized pathways in pathogenesis of cardiovascular disease	WikiPathways	AGTR1 ANGPT2 CCN2 ENG FBN1 FBN2 FBN3 FLNA LTBP1 LTBP2 MAPK1 MAPK14 MAPK3 MAPK8 NR2C2 POSTN RUNX2 SERPINE1 SHC1 SMAD2 SMAD3 SMAD4 TGFBR1 TGFBR2 TGFBR3 (see all 25) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RUNX2	RUNX Family Transcription Factor 2	Protein Coding	1
2	FBN3	Fibrillin 3	Protein Coding	1
3	NR2C2	Nuclear Receptor Subfamily 2 Group C Member 2	Protein Coding	1
4	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	1
5	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	1
6	SHC1	SHC Adaptor Protein 1	Protein Coding	1
7	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
8	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
9	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
10	SERPINE1	Serpin Family E Member 1	Protein Coding	1
11	SMAD4	SMAD Family Member 4	Protein Coding	1
12	SMAD3	SMAD Family Member 3	Protein Coding	1
13	SMAD2	SMAD Family Member 2	Protein Coding	1
14	LTBP2	Latent Transforming Growth Factor Beta Binding Protein 2	Protein Coding	1
15	LTBP1	Latent Transforming Growth Factor Beta Binding Protein 1	Protein Coding	1
16	ANGPT2	Angiopoietin 2	Protein Coding	1
17	FLNA	Filamin A	Protein Coding	1
18	FBN2	Fibrillin 2	Protein Coding	1
19	FBN1	Fibrillin 1	Protein Coding	1
20	ENG	Endoglin	Protein Coding	1
21	AGTR1	Angiotensin II Receptor Type 1	Protein Coding	1
22	CCN2	Cellular Communication Network Factor 2	Protein Coding	1
23	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
24	POSTN	Periostin	Protein Coding	1
25	TGFBR3	Transforming Growth Factor Beta Receptor 3	Protein Coding	1

Disorders associated with Hypothesized pathways in pathogenesis of cardiovascular disease SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Marfan syndrome	Enrichment	FBN1, FBN2, LTBP2, TGFBR1, TGFBR2	16.00
2	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	FBN1, FBN2, FLNA, SMAD2, SMAD3, SMAD4, TGFBR1, TGFBR2	11.27
3	Loeys-dietz syndrome	Enrichment	FBN1, SMAD2, SMAD3, TGFBR1, TGFBR2	10.91
4	Loeys-dietz syndrome 1	Enrichment	SMAD2, TGFBR1, TGFBR2	8.26
5	Aortic aneurysm	Enrichment	FBN1, SMAD3, TGFBR1	7.66
6	Loeys-dietz syndrome 2	Enrichment	TGFBR1, TGFBR2	5.49
7	Ehlers-danlos syndrome	Enrichment	FBN2, SMAD3, TGFBR2	5.28
8	Contractural arachnodactyly, congenital	Enrichment	FBN1, FBN2	5.01
9	Weill-marchesani syndrome 1	Enrichment	FBN1, LTBP2	5.01
10	Weill-marchesani syndrome	Enrichment	FBN1, LTBP2	4.71
11	Connective tissue disease	Enrichment	FBN1, SMAD3, TGFBR2	4.58
12	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	ENG, SMAD4	4.49
13	Familial cerebral saccular aneurysm	Enrichment	ENG, TGFBR3	4.49
14	Hereditary hemorrhagic telangiectasia	Enrichment	ENG, SMAD4	4.17
15	Familial thoracic aortic aneurysm and dissection	Enrichment	FBN1, SMAD3	3.93
16	Pectus excavatum	Enrichment	FBN1, TGFBR1	3.75
17	Aortic aneurysm, familial thoracic 1	Enrichment	FBN1, SMAD3	3.53
18	Ectopia lentis 1, isolated, autosomal dominant	Enrichment	FBN1	2.73
19	Microspherophakia and/or megalocornea, with ectopia lentis and with or without secondary glaucoma	Enrichment	LTBP2	2.73
20	Otopalatodigital syndrome, type i	Enrichment	FLNA	2.73
21	Intestinal pseudoobstruction, neuronal, chronic idiopathic, x-linked	Enrichment	FLNA	2.73
22	Glaucoma 3, primary congenital, d	Enrichment	LTBP2	2.73
23	Multiple self-healing squamous epithelioma	Enrichment	TGFBR1	2.73
24	Weill-marchesani syndrome 2	Enrichment	FBN1	2.73
25	Geleophysic dysplasia 2	Enrichment	FBN1	2.73
26	Protrusio acetabuli	Enrichment	FBN1	2.73
27	Weill-marchesani syndrome 3	Enrichment	LTBP2	2.73
28	Noonan syndrome 13	Enrichment	MAPK1	2.73
29	Macular degeneration, early-onset	Enrichment	FBN2	2.73
30	Terminal osseous dysplasia	Enrichment	FLNA	2.73
31	Fg syndrome 2	Enrichment	FLNA	2.73
32	Lymphoplasmacytic lymphoma	Enrichment	FBN1	2.73
33	Plasminogen activator inhibitor-1 deficiency	Enrichment	SERPINE1	2.73
34	Otopalatodigital syndrome spectrum disorder	Enrichment	FLNA	2.73
35	Colorectal cancer, hereditary nonpolyposis, type 6	Enrichment	TGFBR2	2.73
36	Loeys-dietz syndrome 6	Enrichment	SMAD2	2.73
37	Cutis laxa, autosomal recessive, type iie	Enrichment	LTBP1	2.73
38	X-linked ehlers-danlos syndrome	Enrichment	FLNA	2.73
39	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	2.73
40	Heritable thoracic aortic disease	Enrichment	SMAD4	2.73
41	Glaucoma secondary to spherophakia/ectopia lentis and megalocornea	Enrichment	LTBP2	2.73
42	Congenital plasminogen activator inhibitor type 1 deficiency	Enrichment	SERPINE1	2.73
43	Neonatal marfan syndrome	Enrichment	FBN1	2.73
44	X-linked keloid scarring-reduced joint mobility-increased optic cup-to-disc ratio syndrome	Enrichment	FLNA	2.73
45	Acromicric dysplasia	Enrichment	FBN1	2.43
46	Metaphyseal dysplasia with maxillary hypoplasia with or without brachydactyly	Enrichment	RUNX2	2.43
47	Myhre syndrome	Enrichment	SMAD4	2.43
48	Visceral neuropathy, familial, 1, autosomal recessive	Enrichment	FLNA	2.43
49	Stiff skin syndrome	Enrichment	FBN1	2.43
50	Kyphomelic dysplasia	Enrichment	CCN2	2.43
51	Otopalatodigital syndrome, type ii	Enrichment	FLNA	2.43
52	Melnick-needles syndrome	Enrichment	FLNA	2.43
53	Frontometaphyseal dysplasia 1	Enrichment	FLNA	2.43
54	Pulmonary arteriovenous fistulas	Enrichment	ENG	2.43
55	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	2.43
56	Microvascular complications of diabetes 5	Enrichment	TGFBR2	2.43
57	Beaulieu-boycott-innes syndrome	Enrichment	FBN1	2.43
58	Loeys-dietz syndrome 3	Enrichment	SMAD3	2.43
59	Spondyloepimetaphyseal dysplasia, li-shao-li type	Enrichment	CCN2	2.43
60	Cardiac valvular dysplasia, x-linked	Enrichment	FLNA	2.43
61	Aortic dissection	Enrichment	FBN1	2.43
62	Marfanoid-progeroid-lipodystrophy syndrome	Enrichment	FBN1	2.43
63	Lymphatic malformation 10	Enrichment	ANGPT2	2.43
64	Lens subluxation	Enrichment	FBN1	2.43
65	Cleidocranial dysplasia 1	Enrichment	RUNX2	2.26
66	Prune belly syndrome	Enrichment	FLNA	2.26
67	Achondroplasia	Enrichment	FBN1	2.26
68	Mccune-albright syndrome	Enrichment	FBN1	2.26
69	Juvenile polyposis syndrome	Enrichment	SMAD4	2.26
70	Exfoliation syndrome	Enrichment	LTBP2	2.26
71	Arterial tortuosity syndrome	Enrichment	FLNA	2.26
72	Periventricular nodular heterotopia 1	Enrichment	FLNA	2.26
73	Congenital short bowel syndrome	Enrichment	FLNA	2.26
74	Autosomal recessive cutis laxa type i	Enrichment	LTBP1	2.26
75	Isolated ectopia lentis	Enrichment	FBN1	2.26
76	Frontometaphyseal dysplasia	Enrichment	FLNA	2.26
77	Cleidocranial dysplasia	Enrichment	RUNX2	2.26
78	Geleophysic dysplasia	Enrichment	FBN1	2.26
79	Glaucoma 3, primary infantile, b	Enrichment	LTBP2	2.13
80	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.13
81	Mitral valve insufficiency	Enrichment	FBN1	2.13
82	Pseudomyogenic hemangioendothelioma	Enrichment	SERPINE1	2.13
83	Polycystic liver disease 1 with or without kidney cysts	Enrichment	FBN1	2.04
84	Arthrogryposis, renal dysfunction, and cholestasis 1	Enrichment	FBN1	2.04
85	Microcephaly 1, primary, autosomal recessive	Enrichment	ANGPT2	2.04
86	Goldberg-shprintzen syndrome	Enrichment	FBN1	2.04
87	Polycystic liver disease 1	Enrichment	FBN1	2.04
88	Juvenile glaucoma	Enrichment	LTBP2	2.04
89	Diffuse cutaneous systemic sclerosis	Enrichment	CCN2	2.04
90	Glaucoma, primary open angle	Enrichment	LTBP2	1.96
91	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	ENG	1.96
92	Renal tubular dysgenesis	Enrichment	AGTR1	1.96
93	Inguinal hernia	Enrichment	FBN1	1.96
94	Patent ductus arteriosus	Enrichment	FLNA	1.96
95	Limited scleroderma	Enrichment	CCN2	1.96
96	Classic ehlers-danlos syndrome	Enrichment	TGFBR1	1.96
97	Esophageal cancer	Enrichment	TGFBR2	1.89
98	Glaucoma 3, primary congenital, a	Enrichment	LTBP2	1.89
99	Brugada syndrome 1	Enrichment	FBN1	1.89
100	Gallbladder cancer	Enrichment	SMAD4	1.89
101	Fanconi anemia, complementation group c	Enrichment	FLNA	1.83
102	Orthostatic intolerance	Enrichment	FBN1	1.83
103	Stroke, ischemic	Enrichment	FBN1	1.74
104	Melanoma	Enrichment	FBN1	1.74
105	Heritable pulmonary arterial hypertension	Enrichment	ENG	1.70
106	Specific learning disability	Enrichment	MAPK1	1.70
107	Diaphragmatic hernia, congenital	Enrichment	FBN1	1.63
108	Pulmonary hypertension, primary, 1	Enrichment	ENG	1.63
109	Periventricular nodular heterotopia	Enrichment	FLNA	1.59
110	Myopia	Enrichment	FBN1	1.56
111	Lynch syndrome	Enrichment	TGFBR2	1.56
112	Perrault syndrome 1	Enrichment	FBN1	1.54
113	Hypertension, essential	Enrichment	AGTR1	1.51
114	Cleft palate, isolated	Enrichment	FLNA	1.51
115	Heart, malformation of	Enrichment	MAPK1	1.49
116	Patent foramen ovale	Enrichment	FLNA	1.49
117	Arteriovenous malformations of the brain	Enrichment	ENG	1.46
118	Scoliosis	Enrichment	FBN1	1.36
119	Pancreatic cancer	Enrichment	SMAD4	1.35
120	Non-immune hydrops fetalis	Enrichment	ANGPT2	1.25
121	Primary autosomal recessive microcephaly	Enrichment	ANGPT2	1.24
122	Fetal akinesia deformation sequence 1	Enrichment	FBN2	1.18
123	Systemic lupus erythematosus	Enrichment	ENG	1.16
124	Myopathy	Enrichment	FBN1	1.15
125	Gastric cancer	Enrichment	SMAD4	1.12
126	Nephrotic syndrome	Enrichment	RUNX2	1.12
127	Thrombocytopenia	Enrichment	SMAD4	1.07
128	Breast cancer	Enrichment	SHC1	0.89
129	Dilated cardiomyopathy	Enrichment	FBN1	0.86
130	Colorectal cancer	Enrichment	SMAD4	0.83
131	Microcephaly	Enrichment	MAPK1	0.69
132	Inherited cancer-predisposing syndrome	Enrichment	SMAD4	0.66

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Hypothesized pathways in pathogenesis of cardiovascular disease

Pathway Network for Hypothesized pathways in pathogenesis of cardiovascular disease

Member Pathways for Hypothesized pathways in pathogenesis of cardiovascular disease

Pathways in the Hypothesized pathways in pathogenesis of cardiovascular disease SuperPath

Associated Genes for Hypothesized pathways in pathogenesis of cardiovascular disease

Associated Disorders for Hypothesized pathways in pathogenesis of cardiovascular disease

Disorders associated with Hypothesized pathways in pathogenesis of cardiovascular disease SuperPath

STRING Interaction Network for Hypothesized pathways in pathogenesis of cardiovascular disease

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