Hypothetical craniofacial development pathway

No Pathway Network information available for Hypothetical craniofacial development pathway

Pathways in the Hypothetical craniofacial development pathway SuperPath

#	Name	Source	Genes
1	Hypothetical craniofacial development pathway	WikiPathways	ARHGAP29 IRF6 RHOA TFAP2A TGFB3 TP63 WNT1 (see all 7) (see less)
2	p63 transcription factor network	PubChem	TP63

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TP63	Tumor Protein P63	Protein Coding	2
2	ARHGAP29	Rho GTPase Activating Protein 29	Protein Coding	1
3	WNT1	Wnt Family Member 1	Protein Coding	1
4	TGFB3	Transforming Growth Factor Beta 3	Protein Coding	1
5	TFAP2A	Transcription Factor AP-2 Alpha	Protein Coding	1
6	RHOA	Ras Homolog Family Member A	Protein Coding	1
7	IRF6	Interferon Regulatory Factor 6	Protein Coding	1

Disorders associated with Hypothetical craniofacial development pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Cleft lip/palate	Enrichment	ARHGAP29, IRF6, TP63	7.51
2	Cleft lip and alveolus	Enrichment	IRF6, TP63	5.86
3	Cleft upper lip	Enrichment	IRF6, TP63	5.64
4	Rapp-hodgkin syndrome	Enrichment	TP63	4.13
5	Ankyloblepharon-ectodermal defects-cleft lip/palate	Enrichment	TP63	4.13
6	Split-hand/foot malformation 4	Enrichment	TP63	4.13
7	Ankyloblepharon filiforme adnatum and cleft palate	Enrichment	TP63	4.13
8	Adult syndrome	Enrichment	TP63	4.13
9	Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3	Enrichment	TP63	4.13
10	Limb-mammary syndrome	Enrichment	TP63	4.13
11	Premature ovarian failure 21	Enrichment	TP63	4.13
12	Orofacial cleft 8	Enrichment	TP63	4.13
13	Tp63-related disorders	Enrichment	TP63	4.13
14	Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1	Enrichment	TP63	3.83
15	Bladder exstrophy	Enrichment	TP63	3.83
16	Fissured tongue	Enrichment	TP63	3.83
17	Orofacial cleft 6	Enrichment	IRF6	3.29
18	Popliteal pterygium syndrome	Enrichment	IRF6	3.29
19	Bone mineral density quantitative trait locus 16	Enrichment	WNT1	3.29
20	Loeys-dietz syndrome 5	Enrichment	TGFB3	3.29
21	Irf6-related disorders	Enrichment	IRF6	3.29
22	Autosomal dominant popliteal pterygium syndrome	Enrichment	IRF6	3.29
23	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	3.29
24	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	3.29
25	Isolated split hand-split foot malformation	Enrichment	TP63	3.23
26	Premature menopause	Enrichment	TP63	3.02
27	Osteogenesis imperfecta, type xv	Enrichment	WNT1	2.99
28	Loeys-dietz syndrome 4	Enrichment	TGFB3	2.99
29	Esotropia	Enrichment	TFAP2A	2.99
30	Van der woude syndrome	Enrichment	IRF6	2.99
31	Lens subluxation	Enrichment	TFAP2A	2.99
32	Male infertility with spermatogenesis disorder	Enrichment	TP63	2.96
33	Van der woude syndrome 1	Enrichment	IRF6	2.81
34	Osteoporosis, juvenile	Enrichment	WNT1	2.81
35	Branchiooculofacial syndrome	Enrichment	TFAP2A	2.69
36	Arrhythmogenic right ventricular dysplasia, familial, 1	Enrichment	TGFB3	2.59
37	Amblyopia	Enrichment	TFAP2A	2.59
38	Arrhythmogenic right ventricular dysplasia 1	Enrichment	TGFB3	2.59
39	Branchiootorenal syndrome 1	Enrichment	TFAP2A	2.51
40	Hemihyperplasia, isolated	Enrichment	RHOA	2.51
41	Branchiootorenal syndrome	Enrichment	TFAP2A	2.44
42	Primary ovarian insufficiency	Enrichment	TP63	2.36
43	Loeys-dietz syndrome	Enrichment	TGFB3	2.33
44	Cat eye syndrome	Enrichment	TFAP2A	2.29
45	Epicanthus	Enrichment	TFAP2A	2.21
46	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	TGFB3	2.21
47	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	TGFB3	2.21
48	Osteogenesis imperfecta, type iv	Enrichment	WNT1	2.17
49	Osteoporosis	Enrichment	WNT1	2.14
50	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	TGFB3	2.14
51	Osteogenesis imperfecta, type iii	Enrichment	WNT1	2.11
52	Cleft palate, isolated	Enrichment	IRF6	2.06
53	Microphthalmia	Enrichment	TFAP2A	1.95
54	Tooth agenesis	Enrichment	IRF6	1.95
55	Brittle bone disorder	Enrichment	WNT1	1.93
56	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	TGFB3	1.65
57	Hypertelorism	Enrichment	TFAP2A	1.58

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Hypothetical craniofacial development pathway

Pathway Network for Hypothetical craniofacial development pathway

Member Pathways for Hypothetical craniofacial development pathway

Pathways in the Hypothetical craniofacial development pathway SuperPath

Associated Genes for Hypothetical craniofacial development pathway

Associated Disorders for Hypothetical craniofacial development pathway

Disorders associated with Hypothetical craniofacial development pathway SuperPath

STRING Interaction Network for Hypothetical craniofacial development pathway

Sources for Hypothetical craniofacial development pathway