IFN-gamma pathway

No Pathway Network information available for IFN-gamma pathway

Pathways in the IFN-gamma pathway SuperPath

#	Name	Source	Genes
1	IFN-gamma pathway	PubChem	AKT1 CASP1 CBL CEBPB CRKL DAPK1 IFNG IFNGR1 IL1B IRF1 IRF9 JAK1 JAK2 MAP2K1 MAP3K1 MAP3K11 MAPK3 MTOR PIAS1 PIAS4 PIK3CA PIK3R1 PRKCD PTGES2 PTPN11 PTPN2 RAPGEF1 SMAD7 SOCS1 STAT1 STAT3 (see all 31) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	DAPK1	Death Associated Protein Kinase 1	Protein Coding	1
2	PTGES2	Prostaglandin E Synthase 2	Protein Coding	1
3	PTPN2	Protein Tyrosine Phosphatase Non-Receptor Type 2	Protein Coding	1
4	IFNGR1	Interferon Gamma Receptor 1	Protein Coding	1
5	IL1B	Interleukin 1 Beta	Protein Coding	1
6	CASP1	Caspase 1	Protein Coding	1
7	IFNG	Interferon Gamma	Protein Coding	1
8	MAP3K11	Mitogen-Activated Protein Kinase Kinase Kinase 11	Protein Coding	1
9	SMAD7	SMAD Family Member 7	Protein Coding	1
10	SOCS1	Suppressor Of Cytokine Signaling 1	Protein Coding	1
11	RAPGEF1	Rap Guanine Nucleotide Exchange Factor 1	Protein Coding	1
12	PRKCD	Protein Kinase C Delta	Protein Coding	1
13	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
14	PIAS4	Protein Inhibitor Of Activated STAT 4	Protein Coding	1
15	IRF1	Interferon Regulatory Factor 1	Protein Coding	1
16	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
17	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	1
18	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
19	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
20	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
21	CBL	Cbl Proto-Oncogene	Protein Coding	1
22	CRKL	CRK Like Proto-Oncogene, Adaptor Protein	Protein Coding	1
23	JAK2	Janus Kinase 2	Protein Coding	1
24	IRF9	Interferon Regulatory Factor 9	Protein Coding	1
25	PIAS1	Protein Inhibitor Of Activated STAT 1	Protein Coding	1
26	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
27	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
28	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
29	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	1
30	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
31	JAK1	Janus Kinase 1	Protein Coding	1

Disorders associated with IFN-gamma pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, JAK2, STAT3	7.97
2	Lung non-small cell carcinoma	Enrichment	IRF1, MAP2K1, PIK3CA	5.75
3	Noonan syndrome and noonan-related syndrome	Enrichment	CBL, MAP2K1, PTPN11	5.32
4	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.82
5	Noonan syndrome 1	Enrichment	CBL, MAP2K1, PTPN11	4.73
6	Rasopathy	Enrichment	CBL, MAP2K1, PTPN11	4.57
7	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL, PTPN11	4.52
8	Myeloproliferative neoplasm	Enrichment	CBL, JAK2	4.30
9	Hemimegalencephaly	Enrichment	MTOR, PIK3CA	4.30
10	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	4.12
11	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1, PIK3CA	3.98
12	Overgrowth syndrome	Enrichment	MTOR, PIK3R1	3.98
13	Gastric cancer	Enrichment	IL1B, IRF1, PIK3CA	3.90
14	Arteriovenous malformation	Enrichment	MAP2K1, PIK3CA	3.74
15	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.74
16	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1, PIK3CA	3.65
17	Juvenile myelomonocytic leukemia	Enrichment	CBL, PTPN11	3.48
18	Meningioma	Enrichment	AKT1, PIK3CA	3.48
19	Diffuse large b-cell lymphoma	Enrichment	SOCS1, STAT3	3.07
20	Colorectal cancer	Enrichment	AKT1, PIK3CA, PIK3R1	3.00
21	Ovarian cancer	Enrichment	AKT1, MAP3K1, PIK3CA	2.81
22	Macrodactyly	Enrichment	PIK3CA	2.64
23	Proteus syndrome	Enrichment	AKT1	2.64
24	Metachondromatosis	Enrichment	PTPN11	2.64
25	Helicobacter pylori infection	Enrichment	IFNGR1	2.64
26	Melorheostosis, isolated	Enrichment	MAP2K1	2.64
27	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.64
28	Leopard syndrome 1	Enrichment	PTPN11	2.64
29	Cowden syndrome 5	Enrichment	PIK3CA	2.64
30	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.64
31	46,xy sex reversal 6	Enrichment	MAP3K1	2.64
32	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.64
33	Immunodeficiency 27a	Enrichment	IFNGR1	2.64
34	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.64
35	Immunodeficiency 69	Enrichment	IFNG	2.64
36	Short syndrome	Enrichment	PIK3R1	2.64
37	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.64
38	Immunodeficiency 27b	Enrichment	IFNGR1	2.64
39	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.64
40	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.64
41	Melorheostosis	Enrichment	MAP2K1	2.64
42	Immunodeficiency 31a	Enrichment	STAT1	2.64
43	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.64
44	Cowden syndrome 6	Enrichment	AKT1	2.64
45	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.64
46	Colorectal cancer 3	Enrichment	SMAD7	2.64
47	Immunodeficiency 31b	Enrichment	STAT1	2.64
48	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.64
49	Immunodeficiency 65 viral infections	Enrichment	IRF9	2.64
50	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.64
51	Hypospadias	Enrichment	PIK3CA	2.64
52	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.64
53	Rare venous malformation	Enrichment	PIK3CA	2.64
54	Diaphragmatic eventration	Enrichment	PIK3CA	2.64
55	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.64
56	Rare combined vascular malformation	Enrichment	PIK3CA	2.64
57	Cavernous lymphangioma	Enrichment	PIK3CA	2.64
58	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.64
59	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.64
60	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.64
61	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.64
62	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.64
63	Macrodactyly of toe	Enrichment	PIK3CA	2.64
64	Malignant astrocytoma	Enrichment	PTPN11	2.64
65	Lung cancer	Enrichment	IRF1, PIK3CA	2.62
66	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA	2.35
67	Ovarian germ cell cancer	Enrichment	CBL	2.34
68	Keratosis, seborrheic	Enrichment	PIK3CA	2.34
69	Noonan syndrome 8	Enrichment	PIK3CA	2.34
70	Thrombocythemia 3	Enrichment	JAK2	2.34
71	Immunodeficiency 31c	Enrichment	STAT1	2.34
72	Werner syndrome	Enrichment	PTPN11	2.34
73	Cebalid syndrome	Enrichment	MTOR	2.34
74	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.34
75	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.34
76	Smith-kingsmore syndrome	Enrichment	MTOR	2.34
77	Polycythemia	Enrichment	JAK2	2.34
78	Hypereosinophilic syndrome	Enrichment	JAK2	2.34
79	Immunodeficiency 117	Enrichment	IRF1	2.34
80	Malignant germ cell tumor of ovary	Enrichment	CBL	2.34
81	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.16
82	Immune thrombocytopenia	Enrichment	SOCS1	2.16
83	Polycythemia vera	Enrichment	JAK2	2.16
84	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.16
85	Tuberous sclerosis 1	Enrichment	IFNG	2.16
86	Langerhans cell histiocytosis	Enrichment	MAP2K1	2.16
87	Hepatitis c virus	Enrichment	IFNG	2.16
88	Tuberous sclerosis 2	Enrichment	IFNG	2.16
89	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.16
90	Autoinflammatory syndrome, familial, with or without immunodeficiency	Enrichment	SOCS1	2.16
91	Hyper ige syndrome	Enrichment	STAT3	2.16
92	Immunodeficiency 14	Enrichment	PIK3R1	2.16
93	Tricuspid valve insufficiency	Enrichment	PTPN11	2.16
94	Keratoacanthoma	Enrichment	PIK3CA	2.16
95	Erythrocytosis, familial, 1	Enrichment	JAK2	2.04
96	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1	2.04
97	Anemia, autoimmune hemolytic	Enrichment	SOCS1	2.04
98	Budd-chiari syndrome	Enrichment	JAK2	2.04
99	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.04
100	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	CRKL	2.04
101	Focal cortical dysplasia, type ii	Enrichment	MTOR	2.04
102	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1	2.04
103	Hepatitis b	Enrichment	IFNGR1	2.04
104	Cerebrovascular disease	Enrichment	PIK3CA	2.04
105	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	2.04
106	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.04
107	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	2.04
108	Capillary malformations, congenital	Enrichment	PIK3CA	1.94
109	Lymphoma	Enrichment	PTPN11	1.94
110	Aggressive systemic mastocytosis	Enrichment	CBL	1.94
111	Idiopathic aplastic anemia	Enrichment	IFNG	1.94
112	Breast cancer	Enrichment	AKT1, PIK3CA	1.90
113	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.87
114	Cowden syndrome 1	Enrichment	PIK3CA	1.87
115	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.87
116	Patent ductus arteriosus	Enrichment	PTPN11	1.87
117	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.87
118	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.87
119	Nevus, epidermal	Enrichment	PIK3CA	1.80
120	Myelofibrosis	Enrichment	JAK2	1.80
121	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.80
122	Noonan syndrome 3	Enrichment	PTPN11	1.80
123	Essential thrombocythemia	Enrichment	JAK2	1.80
124	Gallbladder cancer	Enrichment	PIK3CA	1.80
125	Oligoarticular juvenile idiopathic arthritis	Enrichment	PTPN2	1.80
126	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	PTPN2	1.80
127	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.74
128	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.69
129	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.69
130	Aplastic anemia	Enrichment	IFNG	1.65
131	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.65
132	Pectus excavatum	Enrichment	PTPN11	1.60
133	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.60
134	Specific learning disability	Enrichment	PTPN11	1.60
135	Autism spectrum disorder	Enrichment	MAP2K1, PTPN11	1.59
136	Epicanthus	Enrichment	PTPN11	1.57
137	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.57
138	Congenital long qt syndrome	Enrichment	PTPN11	1.57
139	Acute promyelocytic leukemia	Enrichment	STAT3	1.53
140	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1	1.50
141	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.47
142	Lynch syndrome	Enrichment	PIK3CA	1.47
143	Rare genetic intellectual disability	Enrichment	MTOR	1.47
144	Rhabdomyosarcoma	Enrichment	CBL	1.44
145	Human immunodeficiency virus type 1	Enrichment	IFNG	1.39
146	Patent foramen ovale	Enrichment	PTPN11	1.39
147	Behcet syndrome	Enrichment	IFNGR1	1.37
148	Endometrial cancer	Enrichment	PIK3CA	1.33
149	Hepatocellular carcinoma	Enrichment	PIK3CA	1.31
150	Scoliosis	Enrichment	PTPN11	1.27
151	Hydrops fetalis, nonimmune	Enrichment	PTPN11	1.24
152	Strabismus	Enrichment	PTPN11	1.22
153	Bladder cancer	Enrichment	PIK3CA	1.19
154	Prostate cancer	Enrichment	PIK3CA	1.19
155	Long qt syndrome 1	Enrichment	PTPN11	1.18
156	Non-immune hydrops fetalis	Enrichment	PTPN11	1.16
157	Nephronophthisis	Enrichment	PIAS1	1.14
158	Systemic lupus erythematosus	Enrichment	SOCS1	1.07
159	Leukemia, acute myeloid	Enrichment	JAK2	1.06
160	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.03
161	Thrombocytopenia	Enrichment	PTPN11	0.98
162	Hypertelorism	Enrichment	PIK3CA	0.95
163	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.92
164	Primary ovarian insufficiency	Enrichment	JAK2	0.90
165	Microcephaly	Enrichment	PTPN11	0.61
166	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	0.58

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

IFN-gamma pathway

Pathway Network for IFN-gamma pathway

Member Pathways for IFN-gamma pathway

Pathways in the IFN-gamma pathway SuperPath

Associated Genes for IFN-gamma pathway

Associated Disorders for IFN-gamma pathway

Disorders associated with IFN-gamma pathway SuperPath

STRING Interaction Network for IFN-gamma pathway

Sources for IFN-gamma pathway