IGF1 pathway

No Pathway Network information available for IGF1 pathway

Pathways in the IGF1 pathway SuperPath

#	Name	Source	Genes
1	IGF1 pathway	PubChem	AKT1 BAD BCAR1 CRK CRKL GRB10 GRB2 HRAS IGF1R IRS1 IRS2 NCK2 PDPK1 PIK3CA PIK3R1 PRKCD PRKCZ PRKD1 PTK2 PTPN1 PTPN11 PXN RACK1 RAF1 RPS6KB1 SHC1 SOS1 YWHAE YWHAZ (see all 29) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PRKD1	Protein Kinase D1	Protein Coding	1
2	IGF1R	Insulin Like Growth Factor 1 Receptor	Protein Coding	1
3	GRB10	Growth Factor Receptor Bound Protein 10	Protein Coding	1
4	PRKCD	Protein Kinase C Delta	Protein Coding	1
5	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
6	BCAR1	BCAR1 Scaffold Protein, Cas Family Member	Protein Coding	1
7	PTPN1	Protein Tyrosine Phosphatase Non-Receptor Type 1	Protein Coding	1
8	PRKCZ	Protein Kinase C Zeta	Protein Coding	1
9	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
10	PXN	Paxillin	Protein Coding	1
11	RACK1	Receptor For Activated C Kinase 1	Protein Coding	1
12	NCK2	NCK Adaptor Protein 2	Protein Coding	1
13	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
14	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
15	YWHAZ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta	Protein Coding	1
16	YWHAE	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon	Protein Coding	1
17	CRKL	CRK Like Proto-Oncogene, Adaptor Protein	Protein Coding	1
18	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	1
19	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
20	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	1
21	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	1
22	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
23	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
24	IRS2	Insulin Receptor Substrate 2	Protein Coding	1
25	IRS1	Insulin Receptor Substrate 1	Protein Coding	1
26	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
27	SHC1	SHC Adaptor Protein 1	Protein Coding	1
28	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
29	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1

Disorders associated with IGF1 pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome 3	Enrichment	HRAS, PTPN11, RAF1, SOS1	9.22
2	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, PTPN11, RAF1, SOS1	7.65
3	Noonan syndrome 1	Enrichment	HRAS, PTPN11, RAF1, SOS1	6.84
4	Rasopathy	Enrichment	HRAS, PTPN11, RAF1, SOS1	6.61
5	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.88
6	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11, YWHAZ	4.58
7	Noonan syndrome with multiple lentigines	Enrichment	PTPN11, RAF1	4.58
8	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	4.18
9	Nevus, epidermal	Enrichment	HRAS, PIK3CA	4.04
10	Type 2 diabetes mellitus	Enrichment	IRS1, IRS2, PTPN1	4.02
11	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, RAF1	3.91
12	Arteriovenous malformation	Enrichment	HRAS, PIK3CA	3.80
13	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.80
14	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, PIK3CA	3.71
15	Lung non-small cell carcinoma	Enrichment	HRAS, PIK3CA	3.62
16	Meningioma	Enrichment	AKT1, PIK3CA	3.54
17	Lip and oral cavity carcinoma	Enrichment	HRAS, PIK3CA	3.54
18	Breast cancer	Enrichment	AKT1, PIK3CA, SHC1	3.27
19	Colorectal cancer	Enrichment	AKT1, PIK3CA, PIK3R1	3.08
20	Hydrops fetalis, nonimmune	Enrichment	HRAS, PTPN11	2.86
21	Bladder cancer	Enrichment	HRAS, PIK3CA	2.76
22	Non-immune hydrops fetalis	Enrichment	HRAS, PTPN11	2.70
23	Macrodactyly	Enrichment	PIK3CA	2.67
24	Proteus syndrome	Enrichment	AKT1	2.67
25	Metachondromatosis	Enrichment	PTPN11	2.67
26	Noonan syndrome 5	Enrichment	RAF1	2.67
27	Noonan syndrome 4	Enrichment	SOS1	2.67
28	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.67
29	Leopard syndrome 1	Enrichment	PTPN11	2.67
30	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.67
31	Cowden syndrome 5	Enrichment	PIK3CA	2.67
32	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.67
33	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.67
34	Short syndrome	Enrichment	PIK3R1	2.67
35	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.67
36	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.67
37	Leopard syndrome 2	Enrichment	RAF1	2.67
38	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.67
39	Cowden syndrome 6	Enrichment	AKT1	2.67
40	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.67
41	Congenital heart defects and ectodermal dysplasia	Enrichment	PRKD1	2.67
42	Trigonitis	Enrichment	RAF1	2.67
43	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.67
44	Hypospadias	Enrichment	PIK3CA	2.67
45	Rare venous malformation	Enrichment	PIK3CA	2.67
46	Diaphragmatic eventration	Enrichment	PIK3CA	2.67
47	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.67
48	Rare combined vascular malformation	Enrichment	PIK3CA	2.67
49	Cavernous lymphangioma	Enrichment	PIK3CA	2.67
50	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.67
51	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.67
52	Silver-russell syndrome due to maternal uniparental disomy of chromosome 7	Enrichment	GRB10	2.67
53	Malignant epithelial tumor of salivary glands	Enrichment	PRKD1	2.67
54	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.67
55	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.67
56	Distal 17p13.3 microdeletion syndrome	Enrichment	YWHAE	2.67
57	Macrodactyly of toe	Enrichment	PIK3CA	2.67
58	Malignant astrocytoma	Enrichment	PTPN11	2.67
59	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA	2.40
60	Fibromatosis, gingival, 1	Enrichment	SOS1	2.37
61	Costello syndrome	Enrichment	HRAS	2.37
62	Pulmonic stenosis	Enrichment	SOS1	2.37
63	Keratosis, seborrheic	Enrichment	PIK3CA	2.37
64	Noonan syndrome 8	Enrichment	PIK3CA	2.37
65	Werner syndrome	Enrichment	PTPN11	2.37
66	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.37
67	Wooly hair nevus	Enrichment	HRAS	2.37
68	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.19
69	Nuchal bleb, familial	Enrichment	SOS1	2.19
70	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.19
71	Miller-dieker lissencephaly syndrome	Enrichment	YWHAE	2.19
72	Chromosome 17p13.3, centromeric, duplication syndrome	Enrichment	YWHAE	2.19
73	Large congenital melanocytic nevus	Enrichment	HRAS	2.19
74	Immunodeficiency 14	Enrichment	PIK3R1	2.19
75	Spermatocytoma	Enrichment	HRAS	2.19
76	Growth delay due to insulin-like growth factor i resistance	Enrichment	IGF1R	2.19
77	Tricuspid valve insufficiency	Enrichment	PTPN11	2.19
78	Keratoacanthoma	Enrichment	PIK3CA	2.19
79	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	2.07
80	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.07
81	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	CRKL	2.07
82	Cerebrovascular disease	Enrichment	PIK3CA	2.07
83	Epidermolytic nevus	Enrichment	HRAS	2.07
84	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.07
85	Gingival fibromatosis	Enrichment	SOS1	2.07
86	Capillary malformations, congenital	Enrichment	PIK3CA	1.97
87	Insulin-like growth factor i	Enrichment	IGF1R	1.97
88	Lymphoma	Enrichment	PTPN11	1.97
89	Hemimegalencephaly	Enrichment	PIK3CA	1.97
90	Endometrial stromal sarcoma	Enrichment	YWHAE	1.97
91	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.89
92	Cowden syndrome 1	Enrichment	PIK3CA	1.89
93	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.89
94	Patent ductus arteriosus	Enrichment	PTPN11	1.89
95	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.89
96	Kidney clear cell sarcoma	Enrichment	YWHAE	1.89
97	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	1.83
98	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.83
99	Gallbladder cancer	Enrichment	PIK3CA	1.83
100	Pilomyxoid astrocytoma	Enrichment	RAF1	1.83
101	Follicular thyroid carcinoma	Enrichment	HRAS	1.83
102	Overgrowth syndrome	Enrichment	PIK3R1	1.83
103	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.72
104	Ovarian cancer	Enrichment	AKT1, PIK3CA	1.71
105	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.67
106	Pectus excavatum	Enrichment	PTPN11	1.63
107	Specific learning disability	Enrichment	PTPN11	1.63
108	Epicanthus	Enrichment	PTPN11	1.60
109	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.60
110	Congenital long qt syndrome	Enrichment	PTPN11	1.60
111	Aortic valve disease 1	Enrichment	SOS1	1.56
112	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	1.56
113	Nk-cell enteropathy	Enrichment	IGF1R	1.56
114	Microcephaly	Enrichment	IGF1R, PTPN11	1.55
115	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.53
116	Lynch syndrome	Enrichment	PIK3CA	1.50
117	Rhabdomyosarcoma	Enrichment	HRAS	1.47
118	Patent foramen ovale	Enrichment	PTPN11	1.42
119	Endometrial cancer	Enrichment	PIK3CA	1.36
120	Hepatocellular carcinoma	Enrichment	PIK3CA	1.34
121	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.30
122	Scoliosis	Enrichment	PTPN11	1.30
123	Strabismus	Enrichment	PTPN11	1.25
124	Prostate cancer	Enrichment	PIK3CA	1.22
125	Differentiated thyroid carcinoma	Enrichment	HRAS	1.22
126	Long qt syndrome 1	Enrichment	PTPN11	1.21
127	Lung cancer	Enrichment	PIK3CA	1.18
128	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.17
129	Left ventricular noncompaction	Enrichment	RAF1	1.14
130	Gastric cancer	Enrichment	PIK3CA	1.06
131	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.06
132	Thrombocytopenia	Enrichment	PTPN11	1.01
133	Autosomal dominant non-syndromic intellectual disability	Enrichment	YWHAZ	0.99
134	Hypertelorism	Enrichment	PIK3CA	0.98
135	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.97
136	Hereditary breast ovarian cancer syndrome	Enrichment	BCAR1	0.95
137	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.95
138	Dilated cardiomyopathy	Enrichment	RAF1	0.80
139	Autism spectrum disorder	Enrichment	PTPN11	0.68
140	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	0.61

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

IGF1 pathway

Pathway Network for IGF1 pathway

Member Pathways for IGF1 pathway

Pathways in the IGF1 pathway SuperPath

Associated Genes for IGF1 pathway

Associated Disorders for IGF1 pathway

Disorders associated with IGF1 pathway SuperPath

STRING Interaction Network for IGF1 pathway

Sources for IGF1 pathway