IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)

Sources:

#	Name	Source	Genes
1	IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	Reactome	CHUK IKBKB IKBKG
2	Nod-like receptor (NLR) signaling pathway	WikiPathways	CD40 CHUK EPHB2 ERBIN IKBKB IKBKG MAP3K7 MAPK8 RELA (see all 9) (see less)
3	Brain-derived neurotrophic factor (BDNF) signaling pathway	WikiPathways	CHUK CYFIP1 IKBKB IKBKG
4	IKBKB deficiency causes SCID	Reactome	CHUK IKBKB IKBKG

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	4
2	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	4
3	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	4
4	CD40	CD40 Molecule	Protein Coding	1
5	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	1
6	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
7	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
8	ERBIN	Erbb2 Interacting Protein	Protein Coding	1
9	EPHB2	EPH Receptor B2	Protein Coding	1
10	CYFIP1	Cytoplasmic FMR1 Interacting Protein 1	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Immune deficiency disease	Direct
2	Severe combined immunodeficiency	Direct
3	Incontinentia pigmenti	Enrichment	IKBKG	3.53
4	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	3.53
5	Fetal encasement syndrome	Enrichment	CHUK	3.53
6	Immunodeficiency 15b	Enrichment	IKBKB	3.53
7	Immunodeficiency 15a	Enrichment	IKBKB	3.53
8	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	3.53
9	Bartsocas-papas syndrome 2	Enrichment	CHUK	3.53
10	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	3.53
11	Immunodeficiency 33	Enrichment	IKBKG	3.23
12	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG	3.23
13	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	3.23
14	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	3.18
15	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	3.18
16	Prostate cancer/brain cancer susceptibility	Enrichment	EPHB2	3.18
17	Immunodeficiency with hyper-igm, type 3	Enrichment	CD40	3.18
18	Bleeding disorder, platelet-type, 22	Enrichment	EPHB2	3.18
19	Autosomal dominant combined immunodeficiency due to erbin deficiency	Enrichment	ERBIN	3.18
20	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.88
21	Rela fusion-positive ependymoma	Enrichment	RELA	2.88
22	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	2.83
23	Frontometaphyseal dysplasia	Enrichment	MAP3K7	2.70
24	Coronary heart disease 5	Enrichment	IKBKG	2.58
25	Malaria	Enrichment	IKBKG	2.17
26	Prostate cancer	Enrichment	EPHB2	1.72

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)