IL-10 Pathway

No Pathway Network information available for IL-10 Pathway

Pathways in the IL-10 Pathway SuperPath

#	Name	Source	Genes
1	IL-10 Pathway	QIAGEN	BCL2L1 BLVRA CCND1 CCND2 CCND3 CD14 CDKN2D HMOX1 IL10 IL10RA IL10RB IL1A IL1B IL6 JAK1 MAP2K6 MAPK11 MAPK12 MAPK13 MAPK14 MAPKAPK2 MYC NFKB1 PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PIM1 SOCS3 STAT3 TIA1 TLR4 TNF TYK2 (see all 35) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	BCL2L1	BCL2 Like 1	Protein Coding	1
2	BLVRA	Biliverdin Reductase A	Protein Coding	1
3	CCND1	Cyclin D1	Protein Coding	1
4	CCND2	Cyclin D2	Protein Coding	1
5	CCND3	Cyclin D3	Protein Coding	1
6	CD14	CD14 Molecule	Protein Coding	1
7	CDKN2D	Cyclin Dependent Kinase Inhibitor 2D	Protein Coding	1
8	HMOX1	Heme Oxygenase 1	Protein Coding	1
9	IL10	Interleukin 10	Protein Coding	1
10	IL10RA	Interleukin 10 Receptor Subunit Alpha	Protein Coding	1
11	IL10RB	Interleukin 10 Receptor Subunit Beta	Protein Coding	1
12	IL1A	Interleukin 1 Alpha	Protein Coding	1
13	IL1B	Interleukin 1 Beta	Protein Coding	1
14	IL6	Interleukin 6	Protein Coding	1
15	JAK1	Janus Kinase 1	Protein Coding	1
16	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	1
17	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	1
18	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	1
19	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	1
20	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
21	MAPKAPK2	MAPK Activated Protein Kinase 2	Protein Coding	1
22	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
23	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
24	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	1
25	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
26	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
27	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	1
28	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	1
29	PIM1	Pim-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
30	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	1
31	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
32	TIA1	TIA1 Cytotoxic Granule Associated RNA Binding Protein	Protein Coding	1
33	TLR4	Toll Like Receptor 4	Protein Coding	1
34	TNF	Tumor Necrosis Factor	Protein Coding	1
35	TYK2	Tyrosine Kinase 2	Protein Coding	1

Disorders associated with IL-10 Pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Il10-related early-onset inflammatory bowel disease	Enrichment	IL10, IL10RA, IL10RB	6.50
2	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, STAT3	4.71
3	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	CCND2, PIK3R2	4.41
4	Behcet syndrome	Enrichment	IL10, TLR4	2.97
5	Immunodeficiency 35	Enrichment	TYK2	2.59
6	Dermatitis, atopic, 4	Enrichment	SOCS3	2.59
7	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3	Enrichment	CCND2	2.59
8	Hyperbiliverdinemia	Enrichment	BLVRA	2.59
9	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.59
10	Short syndrome	Enrichment	PIK3R1	2.59
11	Graft-versus-host disease	Enrichment	IL10	2.59
12	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.59
13	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.59
14	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.59
15	Macular degeneration, age-related, 10	Enrichment	TLR4	2.59
16	Heme oxygenase 1 deficiency	Enrichment	HMOX1	2.59
17	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.59
18	Amyotrophic lateral sclerosis 26 with or without frontotemporal dementia	Enrichment	TIA1	2.59
19	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.59
20	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.59
21	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.59
22	Systemic lupus erythematosus	Enrichment	IL10, TNF	2.35
23	Burkitt lymphoma	Enrichment	MYC	2.29
24	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	2.29
25	Inflammatory bowel disease 28, autosomal recessive	Enrichment	IL10RA	2.29
26	Welander distal myopathy	Enrichment	TIA1	2.29
27	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.29
28	Immunodeficiency 127	Enrichment	TNF	2.29
29	Inflammatory bowel disease 28	Enrichment	IL10RA	2.29
30	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.29
31	Lymphomatoid papulosis	Enrichment	TYK2	2.29
32	Common variable immunodeficiency 12	Enrichment	NFKB1	2.29
33	Primary cutaneous anaplastic large cell lymphoma	Enrichment	TYK2	2.29
34	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.11
35	Psoriatic arthritis	Enrichment	TNF	2.11
36	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3R1	2.11
37	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.11
38	Hyper ige syndrome	Enrichment	STAT3	2.11
39	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	2.11
40	Inflammatory bowel disease 25	Enrichment	IL10RB	2.11
41	Immunodeficiency 14	Enrichment	PIK3R1	2.11
42	Migraine without aura	Enrichment	TNF	2.11
43	Myeloma, multiple	Enrichment	CCND1, PIK3R2	2.04
44	Kaposi sarcoma	Enrichment	IL6	1.99
45	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3R2	1.99
46	Mantle cell lymphoma	Enrichment	CCND1	1.99
47	Hepatitis b	Enrichment	IL10RB	1.99
48	Cerebral malaria	Enrichment	TNF	1.99
49	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	1.99
50	Von hippel-lindau syndrome	Enrichment	CCND1	1.89
51	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.89
52	Vascular dementia	Enrichment	TNF	1.89
53	Type 1 diabetes mellitus	Enrichment	IL6	1.81
54	Inflammatory bowel disease 25, autosomal recessive	Enrichment	IL10RB	1.81
55	Common variable immunodeficiency	Enrichment	NFKB1	1.75
56	Overgrowth syndrome	Enrichment	PIK3R1	1.75
57	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.69
58	Colorectal cancer	Enrichment	CCND1, PIK3R1	1.68
59	Rheumatoid arthritis	Enrichment	IL10	1.64
60	Inflammatory bowel disease 1	Enrichment	IL6	1.64
61	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.59
62	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.59
63	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.59
64	Asthma	Enrichment	TNF	1.55
65	Pulmonary disease, chronic obstructive	Enrichment	HMOX1	1.48
66	Acute promyelocytic leukemia	Enrichment	STAT3	1.48
67	Alzheimer's disease	Enrichment	TNF	1.48
68	Human immunodeficiency virus type 1	Enrichment	IL10	1.34
69	Arteriovenous malformations of the brain	Enrichment	IL6	1.32
70	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.32
71	Malaria	Enrichment	TNF	1.24
72	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	1.24
73	Severe covid-19	Enrichment	IL10RB	1.14
74	Cystic fibrosis	Enrichment	HMOX1	1.10
75	Type 2 diabetes mellitus	Enrichment	IL6	0.99
76	Gastric cancer	Enrichment	IL1B	0.98

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for IL-10 Pathway

Member Pathways for IL-10 Pathway

Pathways in the IL-10 Pathway SuperPath

Associated Genes for IL-10 Pathway

Associated Disorders for IL-10 Pathway

Disorders associated with IL-10 Pathway SuperPath

STRING Interaction Network for IL-10 Pathway

Sources for IL-10 Pathway