IL-17 Family Signaling Pathways

Pathway network for the IL-17 Family Signaling Pathways SuperPath

Sources:

R&D Systems
Sino Biological
GeneGo (Thomson Reuters)
WikiPathways

Pathways in the IL-17 Family Signaling Pathways SuperPath

#	Name	Source	Genes
1	IL-17 Family Signaling Pathways	R&D Systems	CEBPB CEBPD CHUK FOS FOSB FOSL1 FOSL2 GSK3B IKBKB IKBKE IKBKG IL17A IL17B IL17C IL17D IL17F IL17RA IL17RB IL17RC IL17RD IL17RE IL25 JUN JUNB JUND MAP3K7 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE REL RELA RELB TRAF3 TRAF3IP2 TRAF6 (see all 43) (see less)
2	IL17 signaling pathway	Sino Biological	CASP10 CASP2 CASP3 CASP6 CASP7 CASP8 CASP9 CCL2 CCL20 CCL7 CEBPA CEBPB CEBPD CEBPE CEBPZ CSF2 CSF3 CXCL1 CXCL10 CXCL2 CXCL5 CXCL8 ELAVL1 FADD GSK3B HSP90AA1 HSP90AB1 HSP90B1 IKBKB IKBKE IL17A IL17B IL17C IL17D IL17F IL17RA IL17RB IL17RC IL17RE IL25 IL6 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 MMP1 MMP13 MMP3 MMP9 NFKB1 NFKBIA NFKBIB PTGS2 REL RELA RELB SRSF1 TAB1 TBK1 TNF TRADD TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 USP25 (see all 80) (see less)
3	Mucin expression in CF via IL-6, IL-17 signaling pathways	GeneGo (Thomson Reuters)	ATF2 CFTR CHUK FOS FOSB FOSL1 FOSL2 IKBKB IKBKG IL17A IL17F IL17RA IL17RC IL6 IL6R IL6ST JAK2 JUN JUNB JUND MAP3K7 MAPK1 MAPK3 MUC5AC MUC5B NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE REL RELA RELB RORC SP1 STAT3 TLR2 TLR5 TRAF3IP2 TRAF6 (see all 40) (see less)
4	IL-17 signaling pathway	WikiPathways	AKT1 CEBPB CEBPD GSK3B IKBKB IKBKG IL17A IL17B IL17C IL17D IL17F IL17RA IL17RB IL17RC IL17RD IL17RE IL25 JAK1 JAK2 MAP3K14 MAP3K7 MAPK1 MAPK3 NFKB1 NFKBIB RELA SP1 STAT3 TRAF3 TRAF3IP2 TRAF6 (see all 31) (see less)

Gene overlap in member pathways for IL-17 Family Signaling Pathways SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	IL17A	Interleukin 17A	Protein Coding	4
2	IL17F	Interleukin 17F	Protein Coding	4
3	IL17RA	Interleukin 17 Receptor A	Protein Coding	4
4	IL17RC	Interleukin 17 Receptor C	Protein Coding	4
5	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	4
6	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	4
7	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	4
8	NFKBIB	NFKB Inhibitor Beta	Protein Coding	4
9	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	4
10	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	4
11	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	4
12	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	4
13	TRAF3IP2	TRAF3 Interacting Protein 2	Protein Coding	3
14	TRAF3	TNF Receptor Associated Factor 3	Protein Coding	3
15	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	3
16	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	3
17	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	3
18	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	3
19	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	3
20	CEBPD	CCAAT Enhancer Binding Protein Delta	Protein Coding	3
21	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	3
22	IL17B	Interleukin 17B	Protein Coding	3
23	IL17RB	Interleukin 17 Receptor B	Protein Coding	3
24	IL17C	Interleukin 17C	Protein Coding	3
25	IL17RE	Interleukin 17 Receptor E	Protein Coding	3
26	IL17D	Interleukin 17D	Protein Coding	3
27	IL25	Interleukin 25	Protein Coding	3
28	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	2
29	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	2
30	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	2
31	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	2
32	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
33	FOSB	FosB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
34	FOSL1	FOS Like 1, AP-1 Transcription Factor Subunit	Protein Coding	2
35	FOSL2	FOS Like 2, AP-1 Transcription Factor Subunit	Protein Coding	2
36	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
37	JUNB	JunB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
38	JUND	JunD Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
39	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	2
40	IKBKE	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon	Protein Coding	2
41	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	2
42	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	2
43	IL17RD	Interleukin 17 Receptor D	Protein Coding	2
44	IL6	Interleukin 6	Protein Coding	2
45	JAK2	Janus Kinase 2	Protein Coding	2
46	SP1	Sp1 Transcription Factor	Protein Coding	2
47	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	2
48	CASP10	Caspase 10	Protein Coding	1
49	CASP2	Caspase 2	Protein Coding	1
50	CASP3	Caspase 3	Protein Coding	1
51	CASP6	Caspase 6	Protein Coding	1
52	CASP7	Caspase 7	Protein Coding	1
53	CASP8	Caspase 8	Protein Coding	1
54	CASP9	Caspase 9	Protein Coding	1
55	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	1
56	CCL20	C-C Motif Chemokine Ligand 20	Protein Coding	1
57	CCL7	C-C Motif Chemokine Ligand 7	Protein Coding	1
58	CEBPA	CCAAT Enhancer Binding Protein Alpha	Protein Coding	1
59	CEBPE	CCAAT Enhancer Binding Protein Epsilon	Protein Coding	1
60	CEBPZ	CCAAT Enhancer Binding Protein Zeta	Protein Coding	1
61	CSF2	Colony Stimulating Factor 2	Protein Coding	1
62	CSF3	Colony Stimulating Factor 3	Protein Coding	1
63	CXCL1	C-X-C Motif Chemokine Ligand 1	Protein Coding	1
64	CXCL10	C-X-C Motif Chemokine Ligand 10	Protein Coding	1
65	CXCL2	C-X-C Motif Chemokine Ligand 2	Protein Coding	1
66	CXCL5	C-X-C Motif Chemokine Ligand 5	Protein Coding	1
67	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	1
68	ELAVL1	ELAV Like RNA Binding Protein 1	Protein Coding	1
69	FADD	Fas Associated Via Death Domain	Protein Coding	1
70	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	1
71	HSP90AB1	Heat Shock Protein 90 Alpha Family Class B Member 1	Protein Coding	1
72	HSP90B1	Heat Shock Protein 90 Beta Family Member 1	Protein Coding	1
73	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
74	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	1
75	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
76	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1
77	MAP2K5	Mitogen-Activated Protein Kinase Kinase 5	Protein Coding	1
78	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	1
79	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	1
80	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
81	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
82	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
83	MMP1	Matrix Metallopeptidase 1	Protein Coding	1
84	MMP13	Matrix Metallopeptidase 13	Protein Coding	1
85	MMP3	Matrix Metallopeptidase 3	Protein Coding	1
86	MMP9	Matrix Metallopeptidase 9	Protein Coding	1
87	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	1
88	SRSF1	Serine And Arginine Rich Splicing Factor 1	Protein Coding	1
89	TAB1	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1	Protein Coding	1
90	TBK1	TANK Binding Kinase 1	Protein Coding	1
91	TNF	Tumor Necrosis Factor	Protein Coding	1
92	TRADD	TNFRSF1A Associated Via Death Domain	Protein Coding	1
93	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	1
94	TRAF4	TNF Receptor Associated Factor 4	Protein Coding	1
95	TRAF5	TNF Receptor Associated Factor 5	Protein Coding	1
96	USP25	Ubiquitin Specific Peptidase 25	Protein Coding	1
97	CFTR	CF Transmembrane Conductance Regulator	Protein Coding	1
98	ATF2	Activating Transcription Factor 2	Protein Coding	1
99	IL6R	Interleukin 6 Receptor	Protein Coding	1
100	IL6ST	Interleukin 6 Cytokine Family Signal Transducer	Protein Coding	1
101	MUC5AC	Mucin 5AC, Oligomeric Mucus/Gel-Forming	Protein Coding	1
102	RORC	RAR Related Orphan Receptor C	Protein Coding	1
103	TLR2	Toll Like Receptor 2	Protein Coding	1
104	TLR5	Toll Like Receptor 5	Protein Coding	1
105	MUC5B	Mucin 5B, Oligomeric Mucus/Gel-Forming	Protein Coding	1
106	JAK1	Janus Kinase 1	Protein Coding	1
107	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
108	MAP3K14	Mitogen-Activated Protein Kinase Kinase Kinase 14	Protein Coding	1

Disorders associated with IL-17 Family Signaling Pathways SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Chronic mucocutaneous candidiasis	Enrichment	IL17F, IL17RA, IL17RC, TRAF3IP2	9.45
2	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, JAK2, STAT3	7.97
3	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	5.07
4	Metaphyseal anadysplasia	Enrichment	MMP13, MMP9	4.46
5	Histiocytoid hemangioma	Enrichment	FOS, FOSB	4.07
6	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	3.75
7	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1, MAP2K2	3.69
8	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1, MAP2K2	3.69
9	Herpes simplex virus encephalitis	Enrichment	TBK1, TRAF3	3.47
10	Proteus syndrome	Enrichment	AKT1	2.64
11	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.64
12	Incontinentia pigmenti	Enrichment	IKBKG	2.64
13	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.64
14	Candidiasis, familial, 6	Enrichment	IL17F	2.64
15	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.64
16	Immunodeficiency 15b	Enrichment	IKBKB	2.64
17	Noonan syndrome 13	Enrichment	MAPK1	2.64
18	Immunodeficiency 15a	Enrichment	IKBKB	2.64
19	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.64
20	Immunodeficiency 132a	Enrichment	TRAF3	2.64
21	Immunodeficiency 132b	Enrichment	TRAF3	2.64
22	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.64
23	Cowden syndrome 6	Enrichment	AKT1	2.64
24	Hypogonadotropic hypogonadism 18 with or without anosmia	Enrichment	IL17RD	2.64
25	Candidiasis, familial, 9	Enrichment	IL17RC	2.64
26	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.64
27	Psoriasis	Enrichment	IL17RA	2.64
28	Immunodeficiency 112	Enrichment	MAP3K14	2.64
29	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.64
30	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.64
31	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.64
32	Nik deficiency	Enrichment	MAP3K14	2.64
33	Leprosy 3	Enrichment	TLR2	2.53
34	Legionnaire disease	Enrichment	TLR5	2.53
35	Fetal encasement syndrome	Enrichment	CHUK	2.53
36	Stuve-wiedemann syndrome 2	Enrichment	IL6ST	2.53
37	Hyper-ige syndrome 4a, autosomal dominant, with recurrent infections	Enrichment	IL6ST	2.53
38	Immunodeficiency 92	Enrichment	REL	2.53
39	Systemic lupus erythematosus 1	Enrichment	TLR5	2.53
40	Immunodeficiency 42	Enrichment	RORC	2.53
41	Interleukin 6, serum level of, quantitative trait locus	Enrichment	IL6R	2.53
42	Soluble interleukin-6 receptor, serum level of, quantitative trait locus	Enrichment	IL6R	2.53
43	Hyper-ige syndrome 5, autosomal recessive, with recurrent infections	Enrichment	IL6R	2.53
44	Melioidosis	Enrichment	TLR5	2.53
45	Hyper-ige syndrome 4b, autosomal recessive, with recurrent infections	Enrichment	IL6ST	2.53
46	Immunodeficiency 94 with autoinflammation and dysmorphic facies	Enrichment	IL6ST	2.53
47	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.53
48	Immunodeficiency 53	Enrichment	RELB	2.53
49	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.53
50	Aquagenic palmoplantar keratoderma	Enrichment	CFTR	2.53
51	Aplasia cutis-enamel dysplasia syndrome	Enrichment	FOSL2	2.53
52	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.53
53	Extrinsic allergic alveolitis	Enrichment	MUC5B	2.53
54	Noonan syndrome and noonan-related syndrome	Enrichment	MAP2K1, MAP2K2	2.46
55	Immunodeficiency 33	Enrichment	IKBKG	2.34
56	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.34
57	Thrombocythemia 3	Enrichment	JAK2	2.34
58	Immunodeficiency 51	Enrichment	IL17RA	2.34
59	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.34
60	Rela fusion-positive ependymoma	Enrichment	RELA	2.34
61	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.34
62	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.34
63	Polycythemia	Enrichment	JAK2	2.34
64	Hypereosinophilic syndrome	Enrichment	JAK2	2.34
65	Common variable immunodeficiency 12	Enrichment	NFKB1	2.34
66	Discoid lupus erythematosus	Enrichment	TRAF3IP2	2.34
67	Spermatogenic failure, y-linked, 2	Enrichment	CFTR	2.23
68	Panbronchiolitis, diffuse	Enrichment	MUC5B	2.23
69	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.23
70	Immunodeficiency, common variable, 10	Enrichment	NFKB2	2.23
71	Immunodeficiency 108 with autoinflammation	Enrichment	CEBPE	2.23
72	Caspase 8 deficiency	Enrichment	CASP8	2.23
73	Melorheostosis, isolated	Enrichment	MAP2K1	2.23
74	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.23
75	Autoimmune lymphoproliferative syndrome, type iia	Enrichment	CASP10	2.23
76	Melorheostosis	Enrichment	MAP2K1	2.23
77	Coronary heart disease 6	Enrichment	MMP3	2.23
78	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.23
79	Immunodeficiency 90 with encephalopathy, functional hyposplenia, and hepatic dysfunction	Enrichment	FADD	2.23
80	Autoinflammation with arthritis and vasculitis	Enrichment	TBK1	2.23
81	Corticobasal syndrome	Enrichment	TBK1	2.23
82	Encephalopathy, acute, infection-induced 8	Enrichment	TBK1	2.23
83	Intellectual developmental disorder, autosomal recessive 80, with variant lissencephaly	Enrichment	CASP2	2.23
84	Epilepsy, idiopathic generalized 19	Enrichment	USP25	2.23
85	Cebpe-associated autoinflammation-immunodeficiency-neutrophil dysfunction syndrome	Enrichment	CEBPE	2.23
86	Acute myeloid leukemia with mutated cebpa	Enrichment	CEBPA	2.23
87	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.16
88	Polycythemia vera	Enrichment	JAK2	2.16
89	Psoriasis 13	Enrichment	TRAF3IP2	2.16
90	Hyper ige syndrome	Enrichment	STAT3	2.16
91	Candidiasis, familial, 8	Enrichment	TRAF3IP2	2.16
92	Frontometaphyseal dysplasia	Enrichment	MAP3K7	2.16
93	Noonan syndrome 1	Enrichment	MAP2K1, MAP2K2	2.10
94	Stuve-wiedemann syndrome 1	Enrichment	IL6ST	2.05
95	Nuchal bleb, familial	Enrichment	CFTR	2.05
96	Nasopharyngeal carcinoma	Enrichment	NFKBIA	2.05
97	Stüve-wiedemann syndrome	Enrichment	IL6ST	2.05
98	Erythrocytosis, familial, 1	Enrichment	JAK2	2.04
99	Budd-chiari syndrome	Enrichment	JAK2	2.04
100	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.04
101	Rasopathy	Enrichment	MAP2K1, MAP2K2	1.99
102	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	1.94
103	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.94
104	Myeloproliferative neoplasm	Enrichment	JAK2	1.94
105	Kaposi sarcoma	Enrichment	IL6	1.93
106	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.93
107	Congenital generalized lipodystrophy	Enrichment	FOS	1.93
108	Idiopathic bronchiectasis	Enrichment	CFTR	1.93
109	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	1.93
110	Pseudomyogenic hemangioendothelioma	Enrichment	FOSB	1.93
111	Metaphyseal dysplasia, spahr type	Enrichment	MMP13	1.93
112	Specific granule deficiency 1	Enrichment	CEBPE	1.93
113	Spondyloepimetaphyseal dysplasia, missouri type	Enrichment	MMP13	1.93
114	Neurodevelopmental disorder with dysmorphic facies and behavioral abnormalities	Enrichment	SRSF1	1.93
115	Immunodeficiency 127	Enrichment	TNF	1.93
116	Recessive dystrophic epidermolysis bullosa	Enrichment	MMP1	1.93
117	Frontotemporal dementia and/or amyotrophic lateral sclerosis 4	Enrichment	TBK1	1.93
118	Metaphyseal anadysplasia 2	Enrichment	MMP9	1.93
119	Tafro syndrome	Enrichment	MAP2K2	1.93
120	Oculootodental syndrome	Enrichment	FADD	1.93
121	Specific granule deficiency	Enrichment	CEBPE	1.93
122	Breast adenocarcinoma	Enrichment	AKT1	1.87
123	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.83
124	Myelofibrosis	Enrichment	JAK2	1.80
125	Essential thrombocythemia	Enrichment	JAK2	1.80
126	Type 1 diabetes mellitus	Enrichment	IL6	1.76
127	Pulmonary fibrosis	Enrichment	MUC5B	1.76
128	Langerhans cell histiocytosis	Enrichment	MAP2K1	1.75
129	Psoriatic arthritis	Enrichment	TNF	1.75
130	Migraine without aura	Enrichment	TNF	1.75
131	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.74
132	Coronary heart disease 5	Enrichment	IKBKG	1.69
133	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.69
134	Cowden syndrome	Enrichment	AKT1	1.69
135	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.65
136	Autoimmune lymphoproliferative syndrome	Enrichment	CASP10	1.63
137	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.63
138	Cerebral malaria	Enrichment	TNF	1.63
139	Specific learning disability	Enrichment	MAPK1	1.60
140	Bronchiectasis with or without elevated sweat chloride 1	Enrichment	CFTR	1.58
141	Vas deferens, congenital bilateral aplasia of	Enrichment	CFTR	1.58
142	Inflammatory bowel disease 1	Enrichment	IL6	1.58
143	Meningioma	Enrichment	AKT1	1.57
144	Vascular dementia	Enrichment	TNF	1.54
145	Inherited acute myeloid leukemia	Enrichment	CEBPA	1.54
146	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	CEBPA	1.54
147	Acute promyelocytic leukemia	Enrichment	STAT3	1.53
148	Heart, malformation of	Enrichment	MAPK1	1.39
149	Hereditary chronic pancreatitis	Enrichment	CFTR	1.39
150	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1	1.39
151	Motor neuron disease	Enrichment	TBK1	1.39
152	Arteriovenous malformations of the brain	Enrichment	IL17RD	1.37
153	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.37
154	Lynch syndrome	Enrichment	CFTR	1.36
155	Gliosarcoma	Enrichment	NFKBIA	1.34
156	Lymphoma, non-hodgkin, familial	Enrichment	CASP10	1.34
157	Lennox-gastaut syndrome	Enrichment	MAPK10	1.34
158	Pancreatitis, hereditary	Enrichment	CFTR	1.31
159	Interstitial lung disease 2	Enrichment	MUC5B	1.31
160	Giant cell glioblastoma	Enrichment	NFKBIA	1.31
161	Multisystem inflammatory syndrome in children	Enrichment	TRAF3	1.31
162	Malaria	Enrichment	IKBKG	1.29
163	Kallmann syndrome	Enrichment	IL17RD	1.29
164	Arteriovenous malformation	Enrichment	MAP2K1	1.29
165	Adult hepatocellular carcinoma	Enrichment	CASP8	1.29
166	Progressive non-fluent aphasia	Enrichment	TBK1	1.29
167	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	TBK1	1.24
168	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1	1.24
169	Asthma	Enrichment	TNF	1.20
170	Lung non-small cell carcinoma	Enrichment	MAP2K1	1.20
171	Severe combined immunodeficiency	Enrichment	IKBKB	1.14
172	Alzheimer's disease	Enrichment	TNF	1.13
173	Severe covid-19	Enrichment	MUC5B	1.09
174	Leukemia, acute myeloid	Enrichment	JAK2	1.06
175	Cystic fibrosis	Enrichment	CFTR	1.04
176	Male infertility	Enrichment	CFTR	1.02
177	Hereditary breast carcinoma	Enrichment	AKT1	1.02
178	Human immunodeficiency virus type 1	Enrichment	CCL2	1.00
179	Type 2 diabetes mellitus	Enrichment	IL6	0.93
180	Hepatocellular carcinoma	Enrichment	CASP8	0.91
181	Primary ovarian insufficiency	Enrichment	JAK2	0.90
182	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	CFTR	0.82
183	Breast cancer	Enrichment	AKT1	0.80
184	Lung cancer	Enrichment	CASP8	0.76
185	Colorectal cancer	Enrichment	AKT1	0.74
186	Systemic lupus erythematosus	Enrichment	TNF	0.69
187	Ovarian cancer	Enrichment	AKT1	0.68
188	Gastric cancer	Enrichment	CASP10	0.65
189	Microcephaly	Enrichment	MAPK1	0.61
190	Myeloma, multiple	Enrichment	TRAF5	0.55
191	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	TBK1	0.54
192	Autism spectrum disorder	Enrichment	MAP2K1	0.32
193	Inherited cancer-predisposing syndrome	Enrichment	CEBPA	0.26

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

IL-17 Family Signaling Pathways

Pathway Network for IL-17 Family Signaling Pathways

Pathway network for the IL-17 Family Signaling Pathways SuperPath

Member Pathways for IL-17 Family Signaling Pathways

Pathways in the IL-17 Family Signaling Pathways SuperPath

Gene overlap in member pathways for IL-17 Family Signaling Pathways SuperPath

Associated Genes for IL-17 Family Signaling Pathways

Associated Disorders for IL-17 Family Signaling Pathways

Disorders associated with IL-17 Family Signaling Pathways SuperPath

STRING Interaction Network for IL-17 Family Signaling Pathways

Sources for IL-17 Family Signaling Pathways