IL-18 signaling pathway

No Pathway Network information available for IL-18 signaling pathway

Pathways in the IL-18 signaling pathway SuperPath

#	Name	Source	Genes
1	IL-18 signaling pathway	WikiPathways	ACACB BAX BID CASP3 CASP8 CEBPB CFLAR CHUK CSN2 CTNNB1 CYCS ELAVL1 FAS FASLG GATA1 GRIN2B GSK3B HSPB1 IKBKB IMP3 IRF1 LCK MAP2K7 MAP3K7 MAPK1 MAPK3 MAPK9 MEF2A NATP NCF1 NCF2 NFATC4 NFKB1 NFKBIA NOX1 PARP1 PIK3R1 PRKAA1 PRKCA PRKCB PRKCD PTEN RELA RPS6KB1 SLC12A3 SP1 TICAM2 TNF TNFRSF1A TP53 (see all 50) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NATP	N-Acetyltransferase Pseudogene	Pseudogene	1
2	CFLAR	CASP8 And FADD Like Apoptosis Regulator	Protein Coding	1
3	CASP8	Caspase 8	Protein Coding	1
4	CASP3	Caspase 3	Protein Coding	1
5	TP53	Tumor Protein P53	Protein Coding	1
6	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	1
7	TNF	Tumor Necrosis Factor	Protein Coding	1
8	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	1
9	SP1	Sp1 Transcription Factor	Protein Coding	1
10	SLC12A3	Solute Carrier Family 12 Member 3	Protein Coding	1
11	NCF1	Neutrophil Cytosolic Factor 1	Protein Coding	1
12	BID	BH3 Interacting Domain Death Agonist	Protein Coding	1
13	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	1
14	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
15	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	1
16	PTEN	Phosphatase And Tensin Homolog	Protein Coding	1
17	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	1
18	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
19	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
20	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
21	PRKCD	Protein Kinase C Delta	Protein Coding	1
22	PRKCB	Protein Kinase C Beta	Protein Coding	1
23	PRKCA	Protein Kinase C Alpha	Protein Coding	1
24	PRKAA1	Protein Kinase AMP-Activated Catalytic Subunit Alpha 1	Protein Coding	1
25	CYCS	Cytochrome C, Somatic	Protein Coding	1
26	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
27	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
28	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
29	NFATC4	Nuclear Factor Of Activated T Cells 4	Protein Coding	1
30	NCF2	Neutrophil Cytosolic Factor 2	Protein Coding	1
31	MEF2A	Myocyte Enhancer Factor 2A	Protein Coding	1
32	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
33	IRF1	Interferon Regulatory Factor 1	Protein Coding	1
34	FASLG	Fas Ligand	Protein Coding	1
35	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
36	FAS	Fas Cell Surface Death Receptor	Protein Coding	1
37	TICAM2	TIR Domain Containing Adaptor Molecule 2	Protein Coding	1
38	HSPB1	Heat Shock Protein Family B (Small) Member 1	Protein Coding	1
39	ACACB	Acetyl-CoA Carboxylase Beta	Protein Coding	1
40	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
41	GRIN2B	Glutamate Ionotropic Receptor NMDA Type Subunit 2B	Protein Coding	1
42	NOX1	NADPH Oxidase 1	Protein Coding	1
43	GATA1	GATA Binding Protein 1	Protein Coding	1
44	ELAVL1	ELAV Like RNA Binding Protein 1	Protein Coding	1
45	CTNNB1	Catenin Beta 1	Protein Coding	1
46	CSN2	Casein Beta	Protein Coding	1
47	PARP1	Poly(ADP-Ribose) Polymerase 1	Protein Coding	1
48	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
49	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	1
50	IMP3	IMP U3 Small Nucleolar Ribonucleoprotein 3	Protein Coding	1

Disorders associated with IL-18 signaling pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Acute megakaryocytic leukemia	Enrichment	GATA1, PTEN, TP53	6.33
2	Adult hepatocellular carcinoma	Enrichment	CASP8, CTNNB1, TP53	5.41
3	Lung cancer	Enrichment	CASP8, FAS, FASLG, IRF1	5.26
4	Granulomatous disease, chronic, autosomal recessive, 2	Enrichment	NCF1, NCF2	4.40
5	Nasopharyngeal carcinoma	Enrichment	NFKBIA, TP53	4.40
6	Hepatocellular carcinoma	Enrichment	CASP8, CTNNB1, TP53	4.16
7	Autoimmune lymphoproliferative syndrome	Enrichment	FAS, FASLG	4.10
8	Bladder cancer	Enrichment	CTNNB1, PTEN, TP53	3.79
9	Adrenocortical carcinoma	Enrichment	CTNNB1, TP53	3.70
10	Squamous cell carcinoma, head and neck	Enrichment	PTEN, TP53	3.56
11	Gallbladder cancer	Enrichment	CTNNB1, TP53	3.56
12	Colorectal cancer	Enrichment	BAX, CTNNB1, PIK3R1, TP53	3.54
13	Chronic granulomatous disease	Enrichment	NCF1, NCF2	3.33
14	Gastric cancer	Enrichment	IRF1, PTEN, TP53	3.28
15	Rhabdomyosarcoma	Enrichment	PTEN, TP53	2.81
16	Gliosarcoma	Enrichment	NFKBIA, TP53	2.81
17	Giant cell glioblastoma	Enrichment	NFKBIA, TP53	2.76
18	Behcet syndrome	Enrichment	FAS, TNFRSF1A	2.66
19	Diffuse large b-cell lymphoma	Enrichment	PTEN, TP53	2.66
20	Breast cancer	Enrichment	CASP8, PTEN, TP53	2.58
21	Hepatoblastoma	Enrichment	CTNNB1, TP53	2.57
22	Diamond-blackfan anemia 1	Enrichment	GATA1, TP53	2.49
23	Periodic fever, familial, autosomal dominant	Enrichment	TNFRSF1A	2.43
24	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.43
25	Vacterl association with hydrocephalus	Enrichment	PTEN	2.43
26	Anemia, congenital, nonspherocytic hemolytic, 9	Enrichment	GATA1	2.43
27	Thrombocytopenia, x-linked, with or without dyserythropoietic anemia	Enrichment	GATA1	2.43
28	Thrombocytopenia with beta-thalassemia, x-linked	Enrichment	GATA1	2.43
29	Caspase 8 deficiency	Enrichment	CASP8	2.43
30	Fetal encasement syndrome	Enrichment	CHUK	2.43
31	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.43
32	Developmental and epileptic encephalopathy 27	Enrichment	GRIN2B	2.43
33	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.43
34	Immunodeficiency 15b	Enrichment	IKBKB	2.43
35	Noonan syndrome 13	Enrichment	MAPK1	2.43
36	Immunodeficiency 15a	Enrichment	IKBKB	2.43
37	Short syndrome	Enrichment	PIK3R1	2.43
38	Bone marrow failure syndrome 5	Enrichment	TP53	2.43
39	Anemia, x-linked, with or without neutropenia and/or platelet abnormalities	Enrichment	GATA1	2.43
40	Papilloma of choroid plexus	Enrichment	TP53	2.43
41	Basal cell carcinoma 7	Enrichment	TP53	2.43
42	Anaplastic thyroid carcinoma	Enrichment	TP53	2.43
43	Papillary tumor of the pineal region	Enrichment	PTEN	2.43
44	Thrombocytopenia 4	Enrichment	CYCS	2.43
45	Coronary artery disease, autosomal dominant, 1	Enrichment	MEF2A	2.43
46	Charcot-marie-tooth disease, axonal, type 2f	Enrichment	HSPB1	2.43
47	Intellectual developmental disorder, autosomal dominant 6, with or without seizures	Enrichment	GRIN2B	2.43
48	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.43
49	Multiple sclerosis 5	Enrichment	TNFRSF1A	2.43
50	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.43
51	Glioma susceptibility 2	Enrichment	PTEN	2.43
52	Ductal carcinoma in situ	Enrichment	TP53	2.43
53	Immunodeficiency 22	Enrichment	LCK	2.43
54	Tnf receptor-associated periodic fever syndrome	Enrichment	TNFRSF1A	2.43
55	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.43
56	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.43
57	Acute megakaryoblastic leukemia in children with down syndrome	Enrichment	GATA1	2.43
58	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.43
59	Adenoid ameloblastoma	Enrichment	CTNNB1	2.43
60	Thrombocytopenia with congenital dyserythropoietic anemia	Enrichment	GATA1	2.43
61	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.43
62	Grin2b-related neurodevelopmental disorder	Enrichment	GRIN2B	2.43
63	Choroid plexus cancer	Enrichment	TP53	2.43
64	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.43
65	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.43
66	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	2.43
67	Microcystic stromal tumor	Enrichment	CTNNB1	2.43
68	Prostate cancer	Enrichment	PTEN, TP53	2.29
69	Ovarian cancer	Enrichment	CTNNB1, PTEN, TP53	2.22
70	Severe combined immunodeficiency	Enrichment	IKBKB, LCK	2.18
71	Myeloproliferative syndrome, transient	Enrichment	GATA1	2.13
72	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.13
73	Granulomatous disease, chronic, autosomal recessive, 1	Enrichment	NCF1	2.13
74	Porphyria, congenital erythropoietic	Enrichment	GATA1	2.13
75	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.13
76	Cervical cancer	Enrichment	TP53	2.13
77	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.13
78	Neuronopathy, distal hereditary motor, autosomal dominant 3	Enrichment	HSPB1	2.13
79	Lymphoma, hodgkin, classic	Enrichment	TP53	2.13
80	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.13
81	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.13
82	Immunodeficiency 127	Enrichment	TNF	2.13
83	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	2.13
84	Rela fusion-positive ependymoma	Enrichment	RELA	2.13
85	Acute basophilic leukemia	Enrichment	GATA1	2.13
86	Congenital fibrosarcoma	Enrichment	TP53	2.13
87	Li-fraumeni syndrome 1	Enrichment	TP53	2.13
88	Sarcoma	Enrichment	TP53	2.13
89	Ectodermal dysplasia and immune deficiency	Enrichment	NFKBIA	2.13
90	Cervix carcinoma	Enrichment	TP53	2.13
91	Hodgkin's lymphoma	Enrichment	TP53	2.13
92	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.13
93	Intermittent hydrarthrosis	Enrichment	TNFRSF1A	2.13
94	Vacterl with hydrocephalus	Enrichment	PTEN	2.13
95	Immunodeficiency 117	Enrichment	IRF1	2.13
96	Teratoma	Enrichment	CTNNB1	2.13
97	Common variable immunodeficiency 12	Enrichment	NFKB1	2.13
98	Juvenile polyposis of infancy	Enrichment	PTEN	2.13
99	Hypokalemia	Enrichment	SLC12A3	2.13
100	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.13
101	Diamond-blackfan anemia	Enrichment	GATA1, TP53	2.11
102	Microcephaly	Enrichment	CTNNB1, GRIN2B, MAPK1	1.98
103	Desmoid disease, hereditary	Enrichment	CTNNB1	1.96
104	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	FASLG	1.96
105	Osteogenic sarcoma	Enrichment	TP53	1.96
106	Psoriatic arthritis	Enrichment	TNF	1.96
107	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3R1	1.96
108	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.96
109	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.96
110	Anus, imperforate	Enrichment	CTNNB1	1.96
111	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.96
112	Desmoid tumor	Enrichment	CTNNB1	1.96
113	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.96
114	Anaplastic astrocytoma	Enrichment	TP53	1.96
115	Frontometaphyseal dysplasia	Enrichment	MAP3K7	1.96
116	Immunodeficiency 14	Enrichment	PIK3R1	1.96
117	Squamous cell carcinoma	Enrichment	TP53	1.96
118	T-cell acute lymphoblastic leukemia	Enrichment	BAX	1.96
119	Adenocarcinoma	Enrichment	TP53	1.96
120	Migraine without aura	Enrichment	TNF	1.96
121	Laryngeal squamous cell carcinoma	Enrichment	PTEN	1.96
122	Bone osteosarcoma	Enrichment	TP53	1.96
123	Vogt-koyanagi-harada disease	Enrichment	FAS	1.96
124	Hereditary breast carcinoma	Enrichment	PTEN, TP53	1.94
125	Thrombocytopenia	Enrichment	CYCS, GATA1	1.87
126	Small cell cancer of the lung	Enrichment	TP53	1.83
127	Down syndrome	Enrichment	GATA1	1.83
128	Granulomatous disease, chronic, x-linked	Enrichment	NCF1	1.83
129	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.83
130	Astigmatism	Enrichment	GRIN2B	1.83
131	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.83
132	Pilomatrixoma	Enrichment	CTNNB1	1.83
133	Alazami syndrome	Enrichment	CTNNB1	1.83
134	Lung sarcomatoid carcinoma	Enrichment	TP53	1.83
135	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.83
136	Craniopharyngioma	Enrichment	CTNNB1	1.83
137	Cerebral malaria	Enrichment	TNF	1.83
138	Glioma	Enrichment	PTEN	1.83
139	Hereditary breast ovarian cancer syndrome	Enrichment	PTEN, TP53	1.76
140	Neuronopathy, distal hereditary motor, autosomal dominant 2	Enrichment	HSPB1	1.74
141	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.74
142	Gitelman syndrome	Enrichment	SLC12A3	1.74
143	Rhabdomyosarcoma 2	Enrichment	TP53	1.74
144	Macrocephaly/autism syndrome	Enrichment	PTEN	1.74
145	Lymphoma	Enrichment	TP53	1.74
146	Hemangioma	Enrichment	PTEN	1.74
147	Vascular dementia	Enrichment	TNF	1.74
148	Autosomal thrombocytopenia with normal platelets	Enrichment	CYCS	1.74
149	Hemimegalencephaly	Enrichment	PTEN	1.74
150	Sleep disorder	Enrichment	GRIN2B	1.74
151	Li-fraumeni syndrome	Enrichment	TP53	1.66
152	Cowden syndrome 1	Enrichment	PTEN	1.66
153	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.66
154	Breast adenocarcinoma	Enrichment	TP53	1.66
155	Esophageal cancer	Enrichment	TP53	1.59
156	Thyroid cancer, nonmedullary, 2	Enrichment	PTEN	1.59
157	Essential thrombocythemia	Enrichment	TP53	1.59
158	Bartter disease	Enrichment	SLC12A3	1.59
159	Common variable immunodeficiency	Enrichment	NFKB1	1.59
160	Follicular thyroid carcinoma	Enrichment	PTEN	1.59
161	Overgrowth syndrome	Enrichment	PIK3R1	1.59
162	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.59
163	Glioma susceptibility 1	Enrichment	TP53	1.54
164	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.54
165	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.54
166	Cardiomyopathy, familial hypertrophic, 4	Enrichment	NCF1	1.49
167	Charge syndrome	Enrichment	TNFRSF1A	1.49
168	Primary hyperaldosteronism	Enrichment	TP53	1.49
169	Cowden syndrome	Enrichment	PTEN	1.49
170	Leukemia, chronic lymphocytic	Enrichment	TP53	1.44
171	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.44
172	Melanoma	Enrichment	PTEN	1.44
173	Familial colorectal cancer	Enrichment	TP53	1.44
174	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.44
175	Asthma	Enrichment	TNF	1.40
176	Meningioma, familial	Enrichment	PTEN	1.40
177	Myelodysplastic syndrome	Enrichment	TP53	1.40
178	Lung non-small cell carcinoma	Enrichment	IRF1	1.40
179	Uterine corpus cancer	Enrichment	PTEN	1.40
180	Specific learning disability	Enrichment	MAPK1	1.40
181	Meningioma	Enrichment	PTEN	1.36
182	Lip and oral cavity carcinoma	Enrichment	TP53	1.36
183	Alzheimer's disease	Enrichment	TNF	1.33
184	Protein-deficiency anemia	Enrichment	GATA1	1.33
185	Multiple sclerosis	Enrichment	TNFRSF1A	1.30
186	Medulloblastoma	Enrichment	CTNNB1	1.30
187	Lung cancer susceptibility 3	Enrichment	TP53	1.30
188	Congenital nervous system abnormality	Enrichment	CTNNB1, PTEN	1.24
189	Nervous system disease	Enrichment	CTNNB1, PTEN	1.24
190	Polycystic liver disease	Enrichment	CTNNB1	1.22
191	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	1.22
192	Autism spectrum disorder	Enrichment	GRIN2B, PTEN	1.21
193	Heart, malformation of	Enrichment	MAPK1	1.19
194	Williams-beuren syndrome	Enrichment	NCF1	1.15
195	Craniosynostosis	Enrichment	GRIN2B	1.15
196	Endometrial cancer	Enrichment	PTEN	1.13
197	Malaria	Enrichment	TNF	1.09
198	Autoinflammatory disease	Enrichment	TNFRSF1A	1.07
199	Scoliosis	Enrichment	GRIN2B	1.07
200	Inherited cancer-predisposing syndrome	Enrichment	PTEN, TP53	1.07
201	Pancreatic cancer	Enrichment	TP53	1.05
202	Systemic lupus erythematosus	Enrichment	TNF	0.87
203	Cerebral palsy	Enrichment	GRIN2B	0.87
204	Leukemia, acute myeloid	Enrichment	TP53	0.86
205	Epilepsy	Enrichment	GRIN2B	0.86
206	Charcot-marie-tooth disease	Enrichment	HSPB1	0.85
207	West syndrome	Enrichment	GRIN2B	0.82
208	Autosomal dominant non-syndromic intellectual disability	Enrichment	GRIN2B	0.77
209	Myeloma, multiple	Enrichment	TP53	0.73
210	Complex neurodevelopmental disorder	Enrichment	GRIN2B	0.43

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

IL-18 signaling pathway

Pathway Network for IL-18 signaling pathway

Member Pathways for IL-18 signaling pathway

Pathways in the IL-18 signaling pathway SuperPath

Associated Genes for IL-18 signaling pathway

Associated Disorders for IL-18 signaling pathway

Disorders associated with IL-18 signaling pathway SuperPath

STRING Interaction Network for IL-18 signaling pathway

Sources for IL-18 signaling pathway