IL-1 Family Signaling Pathways

Pathway network for the IL-1 Family Signaling Pathways SuperPath

Sources:

R&D Systems
Sino Biological
GeneGo (Thomson Reuters)
WikiPathways
Reactome

Pathways in the IL-1 Family Signaling Pathways SuperPath

#	Name	Source	Genes
1	IL-1 Family Signaling Pathways	R&D Systems	ATF2 CHUK FOS FOSB FOSL1 FOSL2 IKBKB IKBKE IKBKG IL18 IL18BP IL18R1 IL18RAP IL1A IL1B IL1F10 IL1R1 IL1R2 IL1RAP IL1RL1 IL1RL2 IL1RN IL33 IL36A IL36B IL36G IL36RN IL37 IRAK1 IRAK2 IRAK4 JUN JUNB JUND MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 MYD88 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE REL RELA RELB SIGIRR TAB1 TAB2 TRAF6 (see all 61) (see less)
2	Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways	R&D Systems	ARHGEF12 ATF2 BCL10 BLNK BTK CALM1 CARD9 CD209 CHUK CLEC12A CLEC4A CLEC4C CLEC4E CLEC6A CLEC7A CNKSR1 CREBBP EP300 FCER1G FOS FOSB FOSL1 IKBKB IKBKE IKBKG JUN JUNB JUND KRAS KSR1 LSP1 MALT1 MAP2K1 MAP2K2 MAP3K14 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 MYD88 NFATC1 NFATC2 NFATC3 NFATC4 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE PLCG2 PPP3CA PPP3R1 PRKCD PTPN11 PTPN6 RAF1 REL RELA RELB RHOA SRC SYK TLR8 TLR9 (see all 69) (see less)
3	IL1 signaling pathway	Sino Biological	ATF1 ATF2 ATF3 ATF4 ATF5 ATF6 ATF6B FOS IKBKB IKBKE IL18 IL18BP IL18R1 IL18RAP IL1A IL1B IL1F10 IL1R1 IL1RAP IL1RL1 IL1RL2 IL1RN IL33 IL36A IL36B IL36G IL36RN IL37 IRAK1 IRAK2 IRAK3 IRAK4 JDP2 JUN JUNB JUND MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 MYD88 NFKB1 NFKBIA NFKBIB REL RELA RELB TAB1 TRAF6 (see all 62) (see less)
4	Mucin expression in CF via TLRs, EGFR signaling pathways	GeneGo (Thomson Reuters)	ATF2 CFTR CHUK EGFR FOS FOSB FOSL1 FOSL2 GRB2 HRAS IKBKB IL6 IRAK1 IRAK2 IRAK4 JUN JUNB JUND MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K14 MAP3K7 MAPK1 MAPK10 MAPK14 MAPK3 MAPK8 MAPK9 MUC2 MUC5AC MUC5B MYD88 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE PRKCD RAF1 REL RELA RELB RPS6KA1 SHC1 SOS1 SOS2 SP1 SRC TAB1 TAB2 TGFA TIRAP TLR2 TLR5 TRAF6 (see all 60) (see less)
5	Immune response IL-1 signaling pathway	GeneGo (Thomson Reuters)	ATF2 CHUK CP CXCL8 ECSIT EDN1 F3 FOS FOSB FOSL1 FOSL2 HMOX1 IKBKB IKBKG IL1A IL1B IL1R1 IL1RAP IL6 IRAK1 IRAK4 IRF1 JUN JUNB JUND MAP2K3 MAP2K4 MAP2K6 MAP3K1 MAP3K14 MAP3K7 MAPK10 MAPK14 MAPK8 MAPK9 MYD88 NFKB1 NFKBIA NFKBIB NFKBIE NOS2 PTGS2 RELA SERPINE1 STAT1 TAB1 TAB2 TNF TOLLIP TRAF6 UBA52 UBB UBC UBE2N UBE2V1 (see all 55) (see less)
6	Interleukin-1 (IL-1) structural pathway	WikiPathways	ATF2 CHUK EIF4E ELK1 FOS IKBKB IL1A IL1R1 IL1RAP IRAK1 IRAK2 IRAK4 IRF7 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K14 MAP3K7 MAP3K8 MAPK1 MAPK11 MAPK14 MAPK3 MAPK9 MAPKAPK2 MBP MKNK1 MKNK2 MYD88 RELA RPS6KA5 SAFB TAB1 TAB2 TAB3 TANK TOLLIP TRAF6 (see all 42) (see less)
7	Interleukin-36 pathway	Reactome	IL1F10 IL1RAP IL1RL2 IL36A IL36B IL36G IL36RN (see all 7) (see less)
8	Interleukin-33 signaling	Reactome	IL1RAP IL1RL1 IL33

Gene overlap in member pathways for IL-1 Family Signaling Pathways SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	IL1RAP	Interleukin 1 Receptor Accessory Protein	Protein Coding	6
2	MYD88	MYD88 Innate Immune Signal Transduction Adaptor	Protein Coding	6
3	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	6
4	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	6
5	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	6
6	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	6
7	ATF2	Activating Transcription Factor 2	Protein Coding	6
8	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	6
9	IRAK4	Interleukin 1 Receptor Associated Kinase 4	Protein Coding	5
10	IRAK1	Interleukin 1 Receptor Associated Kinase 1	Protein Coding	5
11	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	5
12	TAB1	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1	Protein Coding	5
13	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	5
14	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	5
15	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	5
16	NFKBIB	NFKB Inhibitor Beta	Protein Coding	5
17	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	5
18	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	5
19	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	5
20	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	5
21	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	5
22	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	5
23	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	5
24	JUNB	JunB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	5
25	JUND	JunD Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	5
26	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	5
27	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	5
28	IL1A	Interleukin 1 Alpha	Protein Coding	4
29	IL1R1	Interleukin 1 Receptor Type 1	Protein Coding	4
30	IRAK2	Interleukin 1 Receptor Associated Kinase 2	Protein Coding	4
31	TAB2	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 2	Protein Coding	4
32	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	4
33	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	4
34	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	4
35	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	4
36	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	4
37	FOSB	FosB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	4
38	FOSL1	FOS Like 1, AP-1 Transcription Factor Subunit	Protein Coding	4
39	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	4
40	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	4
41	MAP3K14	Mitogen-Activated Protein Kinase Kinase Kinase 14	Protein Coding	4
42	IL1B	Interleukin 1 Beta	Protein Coding	3
43	IL33	Interleukin 33	Protein Coding	3
44	IL36RN	Interleukin 36 Receptor Antagonist	Protein Coding	3
45	IL36A	Interleukin 36 Alpha	Protein Coding	3
46	IL36B	Interleukin 36 Beta	Protein Coding	3
47	IL36G	Interleukin 36 Gamma	Protein Coding	3
48	IL1F10	Interleukin 1 Family Member 10	Protein Coding	3
49	IL1RL1	Interleukin 1 Receptor Like 1	Protein Coding	3
50	IL1RL2	Interleukin 1 Receptor Like 2	Protein Coding	3
51	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	3
52	IKBKE	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon	Protein Coding	3
53	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	3
54	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	3
55	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	3
56	FOSL2	FOS Like 2, AP-1 Transcription Factor Subunit	Protein Coding	3
57	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	3
58	IL1RN	Interleukin 1 Receptor Antagonist	Protein Coding	2
59	IL18	Interleukin 18	Protein Coding	2
60	IL18BP	Interleukin 18 Binding Protein	Protein Coding	2
61	IL37	Interleukin 37	Protein Coding	2
62	IL18R1	Interleukin 18 Receptor 1	Protein Coding	2
63	IL18RAP	Interleukin 18 Receptor Accessory Protein	Protein Coding	2
64	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	2
65	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	2
66	PRKCD	Protein Kinase C Delta	Protein Coding	2
67	IL6	Interleukin 6	Protein Coding	2
68	TOLLIP	Toll Interacting Protein	Protein Coding	2
69	IL1R2	Interleukin 1 Receptor Type 2	Protein Coding	1
70	SIGIRR	Single Ig And TIR Domain Containing	Protein Coding	1
71	CD209	CD209 Molecule	Protein Coding	1
72	LSP1	Lymphocyte Specific Protein 1	Protein Coding	1
73	KSR1	Kinase Suppressor Of Ras 1	Protein Coding	1
74	CNKSR1	Connector Enhancer Of Kinase Suppressor Of Ras 1	Protein Coding	1
75	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
76	ARHGEF12	Rho Guanine Nucleotide Exchange Factor 12	Protein Coding	1
77	RHOA	Ras Homolog Family Member A	Protein Coding	1
78	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	1
79	EP300	EP300 Lysine Acetyltransferase	Protein Coding	1
80	CLEC7A	C-Type Lectin Domain Containing 7A	Protein Coding	1
81	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	1
82	CLEC4E	C-Type Lectin Domain Family 4 Member E	Protein Coding	1
83	FCER1G	Fc Epsilon Receptor Ig	Protein Coding	1
84	CLEC6A	C-Type Lectin Domain Containing 6A	Protein Coding	1
85	PLCG2	Phospholipase C Gamma 2	Protein Coding	1
86	BCL10	BCL10 Immune Signaling Adaptor	Protein Coding	1
87	CARD9	Caspase Recruitment Domain Family Member 9	Protein Coding	1
88	MALT1	MALT1 Paracaspase	Protein Coding	1
89	CALM1	Calmodulin 1	Protein Coding	1
90	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	1
91	PPP3R1	Protein Phosphatase 3 Regulatory Subunit B, Alpha	Protein Coding	1
92	NFATC1	Nuclear Factor Of Activated T Cells 1	Protein Coding	1
93	NFATC2	Nuclear Factor Of Activated T Cells 2	Protein Coding	1
94	NFATC3	Nuclear Factor Of Activated T Cells 3	Protein Coding	1
95	NFATC4	Nuclear Factor Of Activated T Cells 4	Protein Coding	1
96	CLEC4C	C-Type Lectin Domain Family 4 Member C	Protein Coding	1
97	BLNK	B Cell Linker	Protein Coding	1
98	BTK	Bruton Tyrosine Kinase	Protein Coding	1
99	TLR9	Toll Like Receptor 9	Protein Coding	1
100	CLEC4A	C-Type Lectin Domain Family 4 Member A	Protein Coding	1
101	PTPN6	Protein Tyrosine Phosphatase Non-Receptor Type 6	Protein Coding	1
102	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
103	TLR8	Toll Like Receptor 8	Protein Coding	1
104	CLEC12A	C-Type Lectin Domain Family 12 Member A	Protein Coding	1
105	ATF1	Activating Transcription Factor 1	Protein Coding	1
106	ATF3	Activating Transcription Factor 3	Protein Coding	1
107	ATF4	Activating Transcription Factor 4	Protein Coding	1
108	ATF5	Activating Transcription Factor 5	Protein Coding	1
109	ATF6	Activating Transcription Factor 6	Protein Coding	1
110	ATF6B	Activating Transcription Factor 6 Beta	Protein Coding	1
111	IRAK3	Interleukin 1 Receptor Associated Kinase 3	Protein Coding	1
112	JDP2	Jun Dimerization Protein 2	Protein Coding	1
113	MAP2K5	Mitogen-Activated Protein Kinase Kinase 5	Protein Coding	1
114	CFTR	CF Transmembrane Conductance Regulator	Protein Coding	1
115	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
116	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
117	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
118	MUC2	Mucin 2, Oligomeric Mucus/Gel-Forming	Protein Coding	1
119	MUC5AC	Mucin 5AC, Oligomeric Mucus/Gel-Forming	Protein Coding	1
120	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	1
121	SHC1	SHC Adaptor Protein 1	Protein Coding	1
122	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
123	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	1
124	SP1	Sp1 Transcription Factor	Protein Coding	1
125	TGFA	Transforming Growth Factor Alpha	Protein Coding	1
126	TLR2	Toll Like Receptor 2	Protein Coding	1
127	TLR5	Toll Like Receptor 5	Protein Coding	1
128	TIRAP	TIR Domain Containing Adaptor Protein	Protein Coding	1
129	MUC5B	Mucin 5B, Oligomeric Mucus/Gel-Forming	Protein Coding	1
130	CP	Ceruloplasmin	Protein Coding	1
131	EDN1	Endothelin 1	Protein Coding	1
132	F3	Coagulation Factor III, Tissue Factor	Protein Coding	1
133	HMOX1	Heme Oxygenase 1	Protein Coding	1
134	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	1
135	IRF1	Interferon Regulatory Factor 1	Protein Coding	1
136	NOS2	Nitric Oxide Synthase 2	Protein Coding	1
137	SERPINE1	Serpin Family E Member 1	Protein Coding	1
138	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	1
139	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
140	TNF	Tumor Necrosis Factor	Protein Coding	1
141	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	1
142	UBB	Ubiquitin B	Protein Coding	1
143	UBC	Ubiquitin C	Protein Coding	1
144	UBE2N	Ubiquitin Conjugating Enzyme E2 N	Protein Coding	1
145	UBE2V1	Ubiquitin Conjugating Enzyme E2 V1	Protein Coding	1
146	ECSIT	ECSIT Signaling Integrator	Protein Coding	1
147	RPS6KA5	Ribosomal Protein S6 Kinase A5	Protein Coding	1
148	MKNK1	MAPK Interacting Serine/Threonine Kinase 1	Protein Coding	1
149	MBP	Myelin Basic Protein	Protein Coding	1
150	IRF7	Interferon Regulatory Factor 7	Protein Coding	1
151	EIF4E	Eukaryotic Translation Initiation Factor 4E	Protein Coding	1
152	MAP3K8	Mitogen-Activated Protein Kinase Kinase Kinase 8	Protein Coding	1
153	TANK	TRAF Family Member Associated NFKB Activator	Protein Coding	1
154	SAFB	Scaffold Attachment Factor B	Protein Coding	1
155	MAPKAPK2	MAPK Activated Protein Kinase 2	Protein Coding	1
156	MKNK2	MAPK Interacting Serine/Threonine Kinase 2	Protein Coding	1
157	TAB3	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 3	Protein Coding	1
158	ELK1	ETS Transcription Factor ELK1	Protein Coding	1

Disorders associated with IL-1 Family Signaling Pathways SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome 1	Enrichment	HRAS, MAP2K1, MAP2K2, RAF1, SOS1, SOS2	9.24
2	Rasopathy	Enrichment	HRAS, MAP2K1, MAP2K2, RAF1, SOS1, SOS2	8.91
3	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, MAP2K1, MAP2K2, RAF1, SOS1	8.38
4	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS, MAP2K1, MAP2K2	6.30
5	Cardiofaciocutaneous syndrome	Enrichment	KRAS, MAP2K1, MAP2K2	6.30
6	Noonan syndrome 3	Enrichment	HRAS, RAF1, SOS1	5.55
7	Transient predisposition to invasive pyogenic bacterial infection	Enrichment	IRAK4, MYD88	5.03
8	Lung non-small cell carcinoma	Enrichment	EGFR, HRAS, MAP2K1	4.88
9	Immunodeficiency 33	Enrichment	IKBKG, IRAK4	4.79
10	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	4.79
11	Nuchal bleb, familial	Enrichment	CFTR, SOS1	4.24
12	Pseudomyogenic hemangioendothelioma	Enrichment	FOSB, SERPINE1	4.02
13	Malaria	Enrichment	IKBKG, NOS2, TNF	3.98
14	Diffuse large b-cell lymphoma	Enrichment	BTK, CREBBP, MYD88	3.94
15	Noonan syndrome with multiple lentigines	Enrichment	PTPN11, RAF1	3.82
16	Histiocytoid hemangioma	Enrichment	FOS, FOSB	3.80
17	Lymphoma, mucosa-associated lymphoid type	Enrichment	BCL10, MALT1	3.60
18	Rubinstein-taybi syndrome 1	Enrichment	CREBBP, EP300	3.42
19	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP, EP300	3.42
20	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	3.40
21	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, MAP2K1	3.28
22	Pilomyxoid astrocytoma	Enrichment	KRAS, RAF1	3.28
23	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, RAF1	3.28
24	Arteriovenous malformation	Enrichment	HRAS, MAP2K1	3.17
25	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1	3.07
26	Psoriasis 14, pustular	Enrichment	IL36RN	2.99
27	Lip and oral cavity carcinoma	Enrichment	EGFR, HRAS	2.91
28	Specific learning disability	Enrichment	MAPK1, PTPN11	2.87
29	Aortic valve disease 1	Enrichment	SOS1, TAB2	2.84
30	Juvenile myelomonocytic leukemia	Enrichment	KRAS, PTPN11	2.79
31	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1, SOS1	2.77
32	Gliosarcoma	Enrichment	EGFR, NFKBIA	2.65
33	Giant cell glioblastoma	Enrichment	EGFR, NFKBIA	2.60
34	Rare genetic intellectual disability	Enrichment	CREBBP, EP300	2.59
35	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.51
36	Immunodeficiency 68	Enrichment	MYD88	2.51
37	Macroglobulinemia, waldenstrom 1	Enrichment	MYD88	2.51
38	Melorheostosis, isolated	Enrichment	MAP2K1	2.51
39	Immunodeficiency 39 viral infections	Enrichment	IRF7	2.51
40	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.51
41	Fetal encasement syndrome	Enrichment	CHUK	2.51
42	46,xy sex reversal 6	Enrichment	MAP3K1	2.51
43	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.51
44	Immunodeficiency 15b	Enrichment	IKBKB	2.51
45	Noonan syndrome 13	Enrichment	MAPK1	2.51
46	Immunodeficiency 15a	Enrichment	IKBKB	2.51
47	Autism 19	Enrichment	EIF4E	2.51
48	Immunodeficiency 39	Enrichment	IRF7	2.51
49	Chronic recurrent multifocal osteomyelitis 3	Enrichment	IL1R1	2.51
50	Melorheostosis	Enrichment	MAP2K1	2.51
51	Immunodeficiency 67	Enrichment	IRAK4	2.51
52	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.51
53	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.51
54	Immunodeficiency 112	Enrichment	MAP3K14	2.51
55	Waldenstram macroglobulinemia	Enrichment	MYD88	2.51
56	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.51
57	Nik deficiency	Enrichment	MAP3K14	2.51
58	Polyvalvular heart disease syndrome	Enrichment	TAB2	2.51
59	Arteriovenous malformations of the brain	Enrichment	EGFR, IL6	2.50
60	Incontinentia pigmenti	Enrichment	IKBKG	2.39
61	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.39
62	Aceruloplasminemia	Enrichment	CP	2.39
63	Auriculocondylar syndrome 3	Enrichment	EDN1	2.39
64	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.39
65	Plasminogen activator inhibitor-1 deficiency	Enrichment	SERPINE1	2.39
66	Question mark ears, isolated	Enrichment	EDN1	2.39
67	Immunodeficiency 31a	Enrichment	STAT1	2.39
68	Immunodeficiency 31b	Enrichment	STAT1	2.39
69	Heme oxygenase 1 deficiency	Enrichment	HMOX1	2.39
70	Aplasia cutis-enamel dysplasia syndrome	Enrichment	FOSL2	2.39
71	Congenital plasminogen activator inhibitor type 1 deficiency	Enrichment	SERPINE1	2.39
72	Leprosy 3	Enrichment	TLR2	2.35
73	Legionnaire disease	Enrichment	TLR5	2.35
74	Noonan syndrome 5	Enrichment	RAF1	2.35
75	Noonan syndrome 4	Enrichment	SOS1	2.35
76	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.35
77	Bacteremia 1	Enrichment	TIRAP	2.35
78	Noonan syndrome 9	Enrichment	SOS2	2.35
79	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.35
80	Immunodeficiency 92	Enrichment	REL	2.35
81	Systemic lupus erythematosus 1	Enrichment	TLR5	2.35
82	Leopard syndrome 2	Enrichment	RAF1	2.35
83	Melioidosis	Enrichment	TLR5	2.35
84	Thrombocytopenia 6	Enrichment	SRC	2.35
85	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.35
86	Immunodeficiency 53	Enrichment	RELB	2.35
87	Trigonitis	Enrichment	RAF1	2.35
88	Aquagenic palmoplantar keratoderma	Enrichment	CFTR	2.35
89	Extrinsic allergic alveolitis	Enrichment	MUC5B	2.35
90	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.35
91	Chronic recurrent multifocal osteomyelitis 2, with periostitis and pustulosis	Enrichment	IL1RN	2.35
92	Microvascular complications of diabetes 4	Enrichment	IL1RN	2.35
93	Hepatitis, fulminant viral	Enrichment	IL18BP	2.35
94	Inflammatory bowel disease 31, autosomal recessive	Enrichment	IL37	2.35
95	Inflammatory bowel disease	Enrichment	IL37	2.35
96	Asthma-related traits 5	Enrichment	IRAK3	2.34
97	Achromatopsia 7	Enrichment	ATF6	2.34
98	Metachondromatosis	Enrichment	PTPN11	2.29
99	Immunodeficiency 103 fungal infections	Enrichment	CARD9	2.29
100	Oculoectodermal syndrome	Enrichment	KRAS	2.29
101	Leopard syndrome 1	Enrichment	PTPN11	2.29
102	Immunodeficiency 82 with systemic inflammation	Enrichment	SYK	2.29
103	Developmental and epileptic encephalopathy 91	Enrichment	PPP3CA	2.29
104	Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development	Enrichment	PPP3CA	2.29
105	Isolated growth hormone deficiency type iii	Enrichment	BTK	2.29
106	Candidiasis, familial, 4	Enrichment	CLEC7A	2.29
107	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.29
108	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.29
109	Dengue virus	Enrichment	CD209	2.29
110	Immunodeficiency 12	Enrichment	MALT1	2.29
111	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.29
112	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.29
113	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.29
114	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.29
115	Sezary's disease	Enrichment	BCL10	2.29
116	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.29
117	Colitis	Enrichment	SYK	2.29
118	Congenital pulmonary airway malformation	Enrichment	KRAS	2.29
119	Vegetative pyoderma gangrenosum	Enrichment	PTPN6	2.29
120	Bullous pyoderma gangrenosum	Enrichment	PTPN6	2.29
121	Pustular pyoderma gangrenosum	Enrichment	PTPN6	2.29
122	Menke-hennekam syndrome	Enrichment	CREBBP	2.29
123	Classic pyoderma gangrenosum	Enrichment	PTPN6	2.29
124	Mucosa-associated lymphoma	Enrichment	BCL10	2.29
125	Malignant astrocytoma	Enrichment	PTPN11	2.29
126	Autoinflammatory disease	Enrichment	IL1RN, IL36RN	2.29
127	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.21
128	Rela fusion-positive ependymoma	Enrichment	RELA	2.21
129	Congenital dyserythropoietic anemia	Enrichment	IRAK4	2.21
130	Congenital heart defects, multiple types, 2	Enrichment	TAB2	2.21
131	Cardiac anomalies-short stature-joint hypermobility-facial dysmorphism syndrome	Enrichment	TAB2	2.21
132	Tafro syndrome	Enrichment	MAP2K2	2.21
133	Scoliosis	Enrichment	CREBBP, PTPN11	2.18
134	Bladder cancer	Enrichment	EGFR, HRAS	2.14
135	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.09
136	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.09
137	Hermansky-pudlak syndrome 3	Enrichment	CP	2.09
138	Immunodeficiency 31c	Enrichment	STAT1	2.09
139	Immunodeficiency 127	Enrichment	TNF	2.09
140	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.09
141	Immunodeficiency 117	Enrichment	IRF1	2.09
142	Common variable immunodeficiency 12	Enrichment	NFKB1	2.09
143	Submucosal cleft palate	Enrichment	UBB	2.09
144	Cleft hard palate	Enrichment	UBB	2.09
145	Fibromatosis, gingival, 1	Enrichment	SOS1	2.05
146	Costello syndrome	Enrichment	HRAS	2.05
147	Spermatogenic failure, y-linked, 2	Enrichment	CFTR	2.05
148	Panbronchiolitis, diffuse	Enrichment	MUC5B	2.05
149	Pulmonic stenosis	Enrichment	SOS1	2.05
150	Immunodeficiency, common variable, 10	Enrichment	NFKB2	2.05
151	Wooly hair nevus	Enrichment	HRAS	2.05
152	Pelvic organ prolapse	Enrichment	TAB2	2.03
153	Langerhans cell histiocytosis	Enrichment	MAP2K1	2.03
154	Frontometaphyseal dysplasia	Enrichment	MAP3K7	2.03
155	Colorectal cancer	Enrichment	BCL10, EP300, SRC	2.01
156	Long qt syndrome 1	Enrichment	CALM1, PTPN11	1.99
157	Thumb deformity	Enrichment	CREBBP	1.99
158	Isolated growth hormone deficiency, type iii, with agammaglobulinemia	Enrichment	BTK	1.99
159	Agammaglobulinemia 4, autosomal recessive	Enrichment	BLNK	1.99
160	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	1.99
161	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	1.99
162	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS	1.99
163	Immunodeficiency 37	Enrichment	BCL10	1.99
164	Aspergillosis	Enrichment	CLEC7A	1.99
165	Long qt syndrome 14	Enrichment	CALM1	1.99
166	Agammaglobulinemia, x-linked	Enrichment	BTK	1.99
167	Werner syndrome	Enrichment	PTPN11	1.99
168	Menke-hennekam syndrome 2	Enrichment	EP300	1.99
169	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	1.99
170	Agammaglobulinemia 4	Enrichment	BLNK	1.99
171	Joint contractures, osteochondromas, and b-cell lymphoma	Enrichment	NFATC2	1.99
172	Arthritis	Enrichment	SYK	1.99
173	Non-immune hydrops fetalis	Enrichment	KRAS, PTPN11	1.97
174	Systemic lupus erythematosus	Enrichment	IRAK1, TNF	1.96
175	Uvula, bifid	Enrichment	UBB	1.92
176	Psoriatic arthritis	Enrichment	TNF	1.92
177	Cleft soft palate	Enrichment	UBB	1.92
178	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.92
179	Migraine without aura	Enrichment	TNF	1.92
180	Severe combined immunodeficiency	Enrichment	IKBKB, MALT1	1.91
181	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.91
182	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.91
183	Congenital generalized lipodystrophy	Enrichment	FOS	1.91
184	Pediatric systemic lupus erythematosus	Enrichment	IRAK1	1.91
185	Gastric cancer	Enrichment	IL1B, IRF1	1.88
186	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	1.88
187	Large congenital melanocytic nevus	Enrichment	HRAS	1.88
188	Spermatocytoma	Enrichment	HRAS	1.88
189	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	1.88
190	Melanoma of soft tissue	Enrichment	ATF1	1.86
191	Mesothelioma, malignant	Enrichment	BCL10	1.82
192	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	TLR8	1.82
193	Agammaglobulinemia 1, autosomal recessive	Enrichment	BTK	1.82
194	Neutrophilic dermatosis, acute febrile	Enrichment	PTPN6	1.82
195	Agammaglobulinemia 1	Enrichment	BTK	1.82
196	Tethered spinal cord syndrome	Enrichment	CREBBP	1.82
197	T-cell acute lymphoblastic leukemia	Enrichment	BCL10	1.82
198	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	1.82
199	Tricuspid valve insufficiency	Enrichment	PTPN11	1.82
200	Testicular cancer	Enrichment	BCL10	1.82
201	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	1.81
202	Kaposi sarcoma	Enrichment	IL6	1.79
203	Auriculocondylar syndrome 1	Enrichment	EDN1	1.79
204	Cerebral malaria	Enrichment	TNF	1.79
205	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	1.79
206	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	1.76
207	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.76
208	Epidermolytic nevus	Enrichment	HRAS	1.76
209	Idiopathic bronchiectasis	Enrichment	CFTR	1.76
210	Gingival fibromatosis	Enrichment	SOS1	1.76
211	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.76
212	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.70
213	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.70
214	Vascular dementia	Enrichment	TNF	1.70
215	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.69
216	Anemia, autoimmune hemolytic	Enrichment	TLR8	1.69
217	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.69
218	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS	1.69
219	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.69
220	Pilocytic astrocytoma	Enrichment	KRAS	1.69
221	Type 1 diabetes mellitus	Enrichment	IL6	1.62
222	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.62
223	Microcephaly	Enrichment	EP300, MAPK1, PTPN11	1.61
224	Thrombocytopenia	Enrichment	PTPN11, SRC	1.61
225	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.60
226	Follicular lymphoma	Enrichment	BCL10	1.60
227	Lymphoma	Enrichment	PTPN11	1.60
228	Cowden syndrome 1	Enrichment	EGFR	1.58
229	Pulmonary fibrosis	Enrichment	MUC5B	1.58
230	Lung squamous cell carcinoma	Enrichment	EGFR	1.58
231	Hemihyperplasia, isolated	Enrichment	RHOA	1.52
232	Testicular germ cell tumor	Enrichment	BCL10	1.52
233	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.52
234	Patent ductus arteriosus	Enrichment	PTPN11	1.52
235	Breast adenocarcinoma	Enrichment	KRAS	1.52
236	Hypertrichosis	Enrichment	CREBBP	1.52
237	Nevus, epidermal	Enrichment	HRAS	1.51
238	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	1.51
239	Myelofibrosis	Enrichment	SRC	1.51
240	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.51
241	Follicular thyroid carcinoma	Enrichment	HRAS	1.51
242	Lennox-gastaut syndrome	Enrichment	MAPK10	1.50
243	Myeloma, multiple	Enrichment	CREBBP, KRAS	1.48
244	Migraine with or without aura 1	Enrichment	TAB2	1.47
245	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.47
246	Leukemia, chronic myeloid	Enrichment	KRAS	1.45
247	Gallbladder cancer	Enrichment	KRAS	1.45
248	Inflammatory bowel disease 1	Enrichment	IL6	1.44
249	Coronary heart disease 5	Enrichment	IKBKG	1.44
250	Bronchiectasis with or without elevated sweat chloride 1	Enrichment	CFTR	1.41
251	Vas deferens, congenital bilateral aplasia of	Enrichment	CFTR	1.41
252	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.40
253	Neurodegeneration with brain iron accumulation	Enrichment	CP	1.40
254	Lymphoma, non-hodgkin, familial	Enrichment	BCL10	1.40
255	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.40
256	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1	1.40
257	Breast cancer	Enrichment	JUN, SHC1	1.36
258	Asthma	Enrichment	TNF	1.36
259	Achromatopsia	Enrichment	ATF6	1.35
260	Charge syndrome	Enrichment	EP300	1.35
261	Dilated cardiomyopathy	Enrichment	RAF1, TAB2	1.31
262	Autosomal non-syndromic agammaglobulinemia	Enrichment	BLNK	1.30
263	Pulmonary disease, chronic obstructive	Enrichment	HMOX1	1.29
264	Alzheimer's disease	Enrichment	TNF	1.29
265	Heart, malformation of	Enrichment	MAPK1	1.27
266	Patent foramen ovale	Enrichment	TAB2	1.27
267	Pectus excavatum	Enrichment	PTPN11	1.26
268	Immune deficiency disease	Enrichment	SYK	1.26
269	Combined immunodeficiency	Enrichment	MALT1	1.26
270	Combined t cell and b cell immunodeficiency	Enrichment	MALT1	1.26
271	Combined t and b cell immunodeficiency	Enrichment	MALT1	1.26
272	Hermansky-pudlak syndrome	Enrichment	CP	1.23
273	Epicanthus	Enrichment	PTPN11	1.23
274	Congenital long qt syndrome	Enrichment	PTPN11	1.23
275	Osteoporosis	Enrichment	SRC	1.22
276	Lung cancer susceptibility 3	Enrichment	EGFR	1.22
277	Hereditary chronic pancreatitis	Enrichment	CFTR	1.22
278	Hermansky-pudlak syndrome 1	Enrichment	CP	1.20
279	Lynch syndrome	Enrichment	CFTR	1.19
280	Rhabdomyosarcoma	Enrichment	HRAS	1.16
281	Heart disease	Enrichment	CREBBP	1.16
282	Pancreatitis, hereditary	Enrichment	CFTR	1.14
283	Interstitial lung disease 2	Enrichment	MUC5B	1.14
284	Ovarian cancer	Enrichment	EGFR, MAP3K1	1.13
285	Polydactyly, postaxial, type a1	Enrichment	EP300	1.13
286	Corpus callosum, agenesis of	Enrichment	CREBBP	1.13
287	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.13
288	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.13
289	Human immunodeficiency virus type 1	Enrichment	CD209	1.06
290	Tooth agenesis	Enrichment	TGFA	1.03
291	Lung cancer	Enrichment	MAP3K8	1.02
292	Multisystem inflammatory syndrome in children	Enrichment	IRAK3	1.02
293	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.00
294	Cardiomyopathy, dilated, 1a	Enrichment	NFATC2	0.99
295	Autism spectrum disorder	Enrichment	MAP2K1, PTPN11	0.97
296	Hydrops fetalis, nonimmune	Enrichment	HRAS	0.96
297	Pancreatic cancer	Enrichment	KRAS	0.92
298	Severe covid-19	Enrichment	MUC5B	0.92
299	Differentiated thyroid carcinoma	Enrichment	HRAS	0.92
300	Cystic fibrosis	Enrichment	HMOX1	0.91
301	Strabismus	Enrichment	PTPN11	0.89
302	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.87
303	Male infertility	Enrichment	CFTR	0.85
304	Left ventricular noncompaction	Enrichment	RAF1	0.84
305	Long qt syndrome	Enrichment	CALM1	0.83
306	Type 2 diabetes mellitus	Enrichment	IL6	0.80
307	Leukemia, acute myeloid	Enrichment	KRAS	0.73
308	Hypertrophic cardiomyopathy	Enrichment	PTPN11	0.71
309	Hereditary breast carcinoma	Enrichment	KRAS	0.70
310	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.68
311	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	CFTR	0.66
312	Autosomal dominant non-syndromic intellectual disability	Enrichment	PPP3CA	0.65
313	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	0.61
314	Undetermined early-onset epileptic encephalopathy	Enrichment	PPP3CA	0.60
315	Cone-rod dystrophy 2	Enrichment	ATF6	0.57
316	Autism	Enrichment	CREBBP	0.51
317	Congenital nervous system abnormality	Enrichment	CREBBP	0.38
318	Nervous system disease	Enrichment	CREBBP	0.38
319	Inherited cancer-predisposing syndrome	Enrichment	EGFR	0.35
320	Hereditary retinal dystrophy	Enrichment	ATF6	0.13
321	Fundus dystrophy	Enrichment	ATF6	0.13

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

IL-1 Family Signaling Pathways

Pathway Network for IL-1 Family Signaling Pathways

Pathway network for the IL-1 Family Signaling Pathways SuperPath

Member Pathways for IL-1 Family Signaling Pathways

Pathways in the IL-1 Family Signaling Pathways SuperPath

Gene overlap in member pathways for IL-1 Family Signaling Pathways SuperPath

Associated Genes for IL-1 Family Signaling Pathways

Associated Disorders for IL-1 Family Signaling Pathways

Disorders associated with IL-1 Family Signaling Pathways SuperPath

STRING Interaction Network for IL-1 Family Signaling Pathways

Sources for IL-1 Family Signaling Pathways