IL-2 Gene Expression in Activated and Quiescent T-Cells

No Pathway Network information available for IL-2 Gene Expression in Activated and Quiescent T-Cells

Pathways in the IL-2 Gene Expression in Activated and Quiescent T-Cells SuperPath

#	Name	Source	Genes
1	IL-2 Gene Expression in Activated and Quiescent T-Cells	QIAGEN	CD247 CD28 CD3D CD3E CD3G CD80 LAT MAPK1 MAPK10 MAPK3 MAPK8 MAPK9 NFAT5 NFATC1 NFATC2 NFATC3 NFATC4 NFKB1 SMAD2 SMAD3 SMAD4 TGFB1 TGFB2 TGFBR1 TGFBR2 TOB1 (see all 26) (see less)
2	TOB in T-Cell Signaling	QIAGEN	CCNA1 CCNA2 CCND1 CCNE1 CCNE2 CD247 CD28 CD3D CD3E CD3G CD80 CDKN1B LEFTY2 RB1 SMAD2 SMAD3 SMAD4 TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TOB1 (see all 23) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CD28	CD28 Molecule	Protein Coding	2
2	CD3D	CD3 Delta Subunit Of T-Cell Receptor Complex	Protein Coding	2
3	CD3E	CD3 Epsilon Subunit Of T-Cell Receptor Complex	Protein Coding	2
4	CD3G	CD3 Gamma Subunit Of T-Cell Receptor Complex	Protein Coding	2
5	CD247	CD247 Molecule	Protein Coding	2
6	CD80	CD80 Molecule	Protein Coding	2
7	SMAD2	SMAD Family Member 2	Protein Coding	2
8	SMAD3	SMAD Family Member 3	Protein Coding	2
9	SMAD4	SMAD Family Member 4	Protein Coding	2
10	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	2
11	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	2
12	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	2
13	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	2
14	TOB1	Transducer Of ERBB2, 1	Protein Coding	2
15	LAT	Linker For Activation Of T Cells	Protein Coding	1
16	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
17	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
18	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
19	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
20	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
21	NFAT5	Nuclear Factor Of Activated T Cells 5	Protein Coding	1
22	NFATC1	Nuclear Factor Of Activated T Cells 1	Protein Coding	1
23	NFATC2	Nuclear Factor Of Activated T Cells 2	Protein Coding	1
24	NFATC3	Nuclear Factor Of Activated T Cells 3	Protein Coding	1
25	NFATC4	Nuclear Factor Of Activated T Cells 4	Protein Coding	1
26	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
27	CCNA1	Cyclin A1	Protein Coding	1
28	CCNA2	Cyclin A2	Protein Coding	1
29	CCND1	Cyclin D1	Protein Coding	1
30	CCNE1	Cyclin E1	Protein Coding	1
31	CCNE2	Cyclin E2	Protein Coding	1
32	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1
33	LEFTY2	Left-Right Determination Factor 2	Protein Coding	1
34	RB1	RB Transcriptional Corepressor 1	Protein Coding	1
35	TGFB3	Transforming Growth Factor Beta 3	Protein Coding	1

Disorders associated with IL-2 Gene Expression in Activated and Quiescent T-Cells SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Loeys-dietz syndrome	Enrichment	SMAD2, SMAD3, TGFB2, TGFBR1, TGFBR2	16.00
2	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD2, SMAD3, SMAD4, TGFB2, TGFB3, TGFBR1, TGFBR2	11.58
3	Loeys-dietz syndrome 1	Enrichment	SMAD2, TGFBR1, TGFBR2	8.37
4	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD247, CD3D, CD3E	8.37
5	Severe combined immunodeficiency	Enrichment	CD247, CD3D, CD3E, CD3G	6.60
6	Marfan syndrome	Enrichment	TGFB2, TGFBR1, TGFBR2	6.29
7	Loeys-dietz syndrome 2	Enrichment	TGFBR1, TGFBR2	5.56
8	Loeys-dietz syndrome 4	Enrichment	TGFB2, TGFB3	5.56
9	Ehlers-danlos syndrome	Enrichment	SMAD3, TGFB2, TGFBR2	5.39
10	Aortic aneurysm	Enrichment	SMAD3, TGFBR1	4.78
11	Connective tissue disease	Enrichment	SMAD3, TGFBR2	2.88
12	Inherited cancer-predisposing syndrome	Enrichment	CDKN1B, RB1, SMAD4	2.86
13	Multiple self-healing squamous epithelioma	Enrichment	TGFBR1	2.77
14	Immunodeficiency 18	Enrichment	CD3E	2.77
15	Immunodeficiency 25	Enrichment	CD247	2.77
16	Camurati-engelmann disease 2	Enrichment	TGFB2	2.77
17	Neuroendocrine tumor	Enrichment	CDKN1B	2.77
18	Colorectal cancer, hereditary nonpolyposis, type 6	Enrichment	TGFBR2	2.77
19	Loeys-dietz syndrome 6	Enrichment	SMAD2	2.77
20	Immunodeficiency 123 with hpv-related verrucosis	Enrichment	CD28	2.77
21	Loeys-dietz syndrome 5	Enrichment	TGFB3	2.77
22	Trilateral retinoblastoma	Enrichment	RB1	2.77
23	Immunodeficiency 19, severe combined	Enrichment	CD3D	2.77
24	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	2.77
25	Heritable thoracic aortic disease	Enrichment	SMAD4	2.77
26	Immunodeficiency 19	Enrichment	CD3D	2.77
27	Lung oat cell carcinoma	Enrichment	RB1	2.77
28	Noonan syndrome 13	Enrichment	MAPK1	2.72
29	Inflammatory bowel disease-recurrent sinopulmonary infections syndrome	Enrichment	NFAT5	2.72
30	Myhre syndrome	Enrichment	SMAD4	2.47
31	Camurati-engelmann disease 1	Enrichment	TGFB1	2.47
32	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	2.47
33	Microvascular complications of diabetes 5	Enrichment	TGFBR2	2.47
34	Chromosome 13q14 deletion syndrome	Enrichment	RB1	2.47
35	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	2.47
36	Loeys-dietz syndrome 3	Enrichment	SMAD3	2.47
37	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	2.47
38	Camurati-engelmann disease	Enrichment	TGFB1	2.47
39	Immunodeficiency 17	Enrichment	CD3G	2.47
40	Familial retinoblastoma	Enrichment	RB1	2.47
41	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.42
42	Immunodeficiency 52	Enrichment	LAT	2.42
43	Joint contractures, osteochondromas, and b-cell lymphoma	Enrichment	NFATC2	2.42
44	Common variable immunodeficiency 12	Enrichment	NFKB1	2.42
45	Retinoblastoma	Enrichment	RB1	2.29
46	Juvenile polyposis syndrome	Enrichment	SMAD4	2.29
47	Mycosis fungoides	Enrichment	CD28	2.29
48	Osteogenic sarcoma	Enrichment	RB1	2.29
49	Woolly hair, autosomal recessive 3	Enrichment	RB1	2.29
50	Hypotrichosis 8	Enrichment	RB1	2.29
51	Squamous cell carcinoma	Enrichment	RB1	2.29
52	Bone osteosarcoma	Enrichment	RB1	2.29
53	Saczary syndrome	Enrichment	CD28	2.29
54	Small cell cancer of the lung	Enrichment	RB1	2.17
55	Lynch syndrome 4	Enrichment	RB1	2.17
56	Mantle cell lymphoma	Enrichment	CCND1	2.17
57	Primary hyperparathyroidism	Enrichment	CDKN1B	2.17
58	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.12
59	Arrhythmogenic right ventricular dysplasia, familial, 1	Enrichment	TGFB3	2.07
60	Von hippel-lindau syndrome	Enrichment	CCND1	2.07
61	Arrhythmogenic right ventricular dysplasia 1	Enrichment	TGFB3	2.07
62	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	2.07
63	Colorectal cancer	Enrichment	CCND1, SMAD4	2.03
64	Atrial septal defect 1	Enrichment	TGFB2	1.99
65	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.99
66	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.99
67	Classic ehlers-danlos syndrome	Enrichment	TGFBR1	1.99
68	Esophageal cancer	Enrichment	TGFBR2	1.93
69	Multiple endocrine neoplasia, type i	Enrichment	CDKN1B	1.93
70	Gallbladder cancer	Enrichment	SMAD4	1.93
71	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	1.93
72	Oligoarticular juvenile idiopathic arthritis	Enrichment	CD247	1.93
73	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	CD247	1.93
74	Ovarian cancer	Enrichment	CDKN1B, RB1	1.90
75	Common variable immunodeficiency	Enrichment	NFKB1	1.87
76	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.82
77	Lennox-gastaut syndrome	Enrichment	MAPK10	1.82
78	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.77
79	Pectus excavatum	Enrichment	TGFBR1	1.73
80	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.72
81	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	TGFB3	1.70
82	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	TGFB3	1.70
83	Lip and oral cavity carcinoma	Enrichment	RB1	1.70
84	Specific learning disability	Enrichment	MAPK1	1.68
85	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	1.63
86	Lung cancer susceptibility 3	Enrichment	RB1	1.63
87	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	TGFB3	1.63
88	Lynch syndrome	Enrichment	TGFBR2	1.60
89	Heart, malformation of	Enrichment	MAPK1	1.47
90	Visceral heterotaxy	Enrichment	LEFTY2	1.44
91	Cardiomyopathy, dilated, 1a	Enrichment	NFATC2	1.40
92	Pancreatic cancer	Enrichment	SMAD4	1.38
93	Bladder cancer	Enrichment	RB1	1.32
94	Cystic fibrosis	Enrichment	TGFB1	1.28
95	Gastric cancer	Enrichment	SMAD4	1.15
96	Thrombocytopenia	Enrichment	SMAD4	1.11
97	Myeloma, multiple	Enrichment	CCND1	1.04
98	Microcephaly	Enrichment	MAPK1	0.68

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

IL-2 Gene Expression in Activated and Quiescent T-Cells

Pathway Network for IL-2 Gene Expression in Activated and Quiescent T-Cells

Member Pathways for IL-2 Gene Expression in Activated and Quiescent T-Cells

Pathways in the IL-2 Gene Expression in Activated and Quiescent T-Cells SuperPath

Associated Genes for IL-2 Gene Expression in Activated and Quiescent T-Cells

Associated Disorders for IL-2 Gene Expression in Activated and Quiescent T-Cells

Disorders associated with IL-2 Gene Expression in Activated and Quiescent T-Cells SuperPath

STRING Interaction Network for IL-2 Gene Expression in Activated and Quiescent T-Cells

Sources for IL-2 Gene Expression in Activated and Quiescent T-Cells