IL-9 Signaling Pathways

Pathway network for the IL-9 Signaling Pathways SuperPath

Sources:

R&D Systems
QIAGEN
GeneGo (Thomson Reuters)
Reactome

Pathways in the IL-9 Signaling Pathways SuperPath

#	Name	Source	Genes
1	IL-9 Signaling Pathways	R&D Systems	AKT1 AKT2 AKT3 ARAF BAD BRAF FOXO1 FOXO3 FOXO4 GRB2 GSK3A GSK3B IL2RG IL9 IL9R IRS1 IRS2 JAK1 JAK3 KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 PDPK1 PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 RAF1 RPS6KB1 SHC1 SOS1 SOS2 STAT1 STAT3 STAT5A STAT5B (see all 40) (see less)
2	Adipocytokines and Insulin Signaling	R&D Systems	ADIPOQ AKT1 AKT2 AKT3 ANGPTL2 ARAF BRAF CBL CRK EIF2S2 ELK1 FOS FOSB FOSL1 FOXO1 GRB2 GSK3A GSK3B GYS1 IL6 INS INSR IRS1 IRS2 ITLN1 JUN JUNB JUND KRAS LEP MAP2K1 MAP2K2 MAPK1 MAPK3 MAX MTOR MYC NAMPT PDPK1 PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCI PRKCQ PRKCZ PTEN PTPN11 RAF1 RAPGEF1 RBP4 RETN RHOQ RPS6 RPS6KB1 SERPINA12 SHC1 SLC2A4 SORBS1 SOS1 SOS2 TNF (see all 73) (see less)
3	IL-4 Pathway	QIAGEN	AKT1 ARAF BAD BCL2 BRAF ELK1 FCER2 FES GRB2 GSK3A GSK3B HBG1 HBG2 HLA-DMA HLA-DMB HLA-DOA HLA-DOB HLA-DPA1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 HRAS IL4 IL4R IRS1 IRS2 JAK1 JAK3 KRAS MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAPK1 MAPK3 MRAS NFKB1 NRAS PDPK1 PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PTEN RAF1 RPS6KB1 RRAS RRAS2 SOCS1 SOCS2 SOCS3 SOCS4 SOCS5 SOS1 SOS2 STAT6 (see all 64) (see less)
4	Development Thrombopoietin-regulated cell processes	GeneGo (Thomson Reuters)	AKT1 AKT2 AKT3 ATF1 BAD BIRC5 BRAF CBL CCNA2 CCND1 CDKN1A CDKN1B CREB1 CRKL ELK1 FOS FOXO1 FYN GRB2 GSK3A GSK3B HRAS IRS2 JAK2 JUN MAP2K1 MAPK1 MAPK3 MPL MYC PDPK1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PRKCA PRKCZ RAC1 RAF1 RAP1A RAPGEF1 RPS6KA3 RPS6KB1 SHC1 SOS1 SOS2 THPO VAV1 (see all 50) (see less)
5	Immune response IL-9 signaling pathway	GeneGo (Thomson Reuters)	BCL3 CHUK CISH GRB2 HRAS IKBKB IL22 IL2RG IL9 IL9R IRS1 IRS2 JAK1 JAK3 MAP2K1 MAP2K2 MAP3K14 MAPK1 MAPK3 NFKB1 NFKBIA NFKBIB NFKBIE PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 RAF1 RELA RPS6KA1 SHC1 SOCS2 SOCS3 SOS1 SOS2 STAT1 STAT3 STAT5A STAT5B TNF TNFRSF1A TRADD TRAF2 (see all 45) (see less)
6	IL-4 Signaling Pathways	R&D Systems	AKT1 AKT2 AKT3 ARAF BAD BRAF FOXO1 FOXO3 FOXO4 GRB2 GSK3A GSK3B IL13RA1 IL2RG IL4 IL4R IRS1 IRS2 JAK1 JAK3 KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 PDPK1 PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 RAF1 RPS6KB1 SHC1 SOS1 SOS2 STAT5A STAT5B STAT6 TYK2 (see all 41) (see less)
7	IL-2 Signaling Pathways	R&D Systems	AKT1 AKT2 AKT3 ARAF BAD BRAF FOXO1 FOXO3 FOXO4 GRB2 GSK3A GSK3B IL2 IL2RA IL2RB IL2RG IRS1 IRS2 JAK1 JAK3 KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 PDPK1 PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 RAF1 RPS6KB1 SHC1 SOS1 SOS2 STAT1 STAT3 STAT5A STAT5B (see all 41) (see less)
8	IL-21 Signaling Pathways	R&D Systems	AKT1 AKT2 AKT3 ARAF BAD BRAF FOXO1 FOXO3 FOXO4 GRB2 GSK3A GSK3B IL21 IL21R IL2RG IRS1 IRS2 JAK1 JAK3 KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 PDPK1 PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 RAF1 RPS6KB1 SHC1 SOS1 SOS2 STAT1 STAT3 STAT5A STAT5B (see all 40) (see less)
9	IL-7 Signaling Pathways	R&D Systems	AKT1 AKT2 AKT3 ARAF BAD BRAF FOXO1 FOXO3 FOXO4 GRB2 GSK3A GSK3B IL2RG IL7 IL7R IRS1 IRS2 JAK1 JAK3 KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 PDPK1 PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 RAF1 RPS6KB1 SHC1 SOS1 SOS2 STAT1 STAT3 STAT5A STAT5B (see all 40) (see less)
10	IL-15 Signaling Pathways	R&D Systems	AKT1 AKT2 AKT3 ARAF BAD BRAF FOXO1 FOXO3 FOXO4 GRB2 GSK3A GSK3B IL15 IL15RA IL2RB IL2RG IRS1 IRS2 JAK1 JAK3 KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 PDPK1 PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 RAF1 RPS6KB1 SHC1 SOS1 SOS2 STAT3 STAT5A STAT5B (see all 40) (see less)
11	Common Cytokine Receptor Gamma-Chain Family Signaling Pathways	R&D Systems	AKT1 AKT2 AKT3 ARAF BAD BRAF FOXO1 FOXO3 FOXO4 GRB2 GSK3A GSK3B IL2RG IRS1 IRS2 JAK1 JAK3 KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 PDPK1 PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 RAF1 RPS6KB1 SHC1 SOS1 SOS2 STAT1 STAT3 STAT5B STAT6 (see all 38) (see less)
12	IL-9 Pathway	QIAGEN	BCL3 CISH GZMA IL9 IL9R IRS2 JAK1 JAK3 LTA NFKB1 PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 SOCS1 SOCS2 SOCS3 SOCS5 SOCS6 STAT1 STAT3 STAT5A STAT5B TNF TNFRSF1A TNFRSF1B (see all 27) (see less)
13	Interleukin-9 signaling	Reactome	IL2RG IL9 IL9R JAK1 JAK3 STAT1 STAT3 STAT5A STAT5B (see all 9) (see less)

Gene overlap in member pathways for IL-9 Signaling Pathways SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	12
2	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	12
3	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	12
4	IRS2	Insulin Receptor Substrate 2	Protein Coding	12
5	JAK1	Janus Kinase 1	Protein Coding	11
6	JAK3	Janus Kinase 3	Protein Coding	11
7	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	11
8	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	11
9	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	11
10	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	11
11	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	11
12	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	11
13	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	11
14	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	10
15	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	10
16	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	10
17	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	10
18	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	10
19	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	10
20	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	10
21	GSK3A	Glycogen Synthase Kinase 3 Alpha	Protein Coding	10
22	IRS1	Insulin Receptor Substrate 1	Protein Coding	10
23	SHC1	SHC Adaptor Protein 1	Protein Coding	10
24	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	10
25	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	10
26	IL2RG	Interleukin 2 Receptor Subunit Gamma	Protein Coding	9
27	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	9
28	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	9
29	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	9
30	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	9
31	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	9
32	FOXO1	Forkhead Box O1	Protein Coding	9
33	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	9
34	ARAF	A-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	9
35	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	8
36	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	8
37	FOXO3	Forkhead Box O3	Protein Coding	7
38	FOXO4	Forkhead Box O4	Protein Coding	7
39	IL9	Interleukin 9	Protein Coding	4
40	IL9R	Interleukin 9 Receptor	Protein Coding	4
41	ELK1	ETS Transcription Factor ELK1	Protein Coding	3
42	TNF	Tumor Necrosis Factor	Protein Coding	3
43	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	3
44	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	3
45	SOCS2	Suppressor Of Cytokine Signaling 2	Protein Coding	3
46	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	3
47	STAT6	Signal Transducer And Activator Of Transcription 6	Protein Coding	3
48	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	2
49	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
50	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
51	PTEN	Phosphatase And Tensin Homolog	Protein Coding	2
52	PRKCA	Protein Kinase C Alpha	Protein Coding	2
53	PRKCZ	Protein Kinase C Zeta	Protein Coding	2
54	CBL	Cbl Proto-Oncogene	Protein Coding	2
55	RAPGEF1	Rap Guanine Nucleotide Exchange Factor 1	Protein Coding	2
56	IL4	Interleukin 4	Protein Coding	2
57	IL4R	Interleukin 4 Receptor	Protein Coding	2
58	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	2
59	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	2
60	SOCS1	Suppressor Of Cytokine Signaling 1	Protein Coding	2
61	SOCS5	Suppressor Of Cytokine Signaling 5	Protein Coding	2
62	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	2
63	BCL3	BCL3 Transcription Coactivator	Protein Coding	2
64	CISH	Cytokine Inducible SH2 Containing Protein	Protein Coding	2
65	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	2
66	IL2RB	Interleukin 2 Receptor Subunit Beta	Protein Coding	2
67	INS	Insulin	Protein Coding	1
68	INSR	Insulin Receptor	Protein Coding	1
69	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
70	MAX	MYC Associated Transcriptional Regulator X	Protein Coding	1
71	JUNB	JunB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
72	JUND	JunD Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
73	FOSB	FosB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
74	FOSL1	FOS Like 1, AP-1 Transcription Factor Subunit	Protein Coding	1
75	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
76	RPS6	Ribosomal Protein S6	Protein Coding	1
77	PRKCB	Protein Kinase C Beta	Protein Coding	1
78	PRKCG	Protein Kinase C Gamma	Protein Coding	1
79	PRKCE	Protein Kinase C Epsilon	Protein Coding	1
80	PRKCD	Protein Kinase C Delta	Protein Coding	1
81	PRKCI	Protein Kinase C Iota	Protein Coding	1
82	PRKCQ	Protein Kinase C Theta	Protein Coding	1
83	EIF2S2	Eukaryotic Translation Initiation Factor 2 Subunit Beta	Protein Coding	1
84	GYS1	Glycogen Synthase 1	Protein Coding	1
85	SORBS1	Sorbin And SH3 Domain Containing 1	Protein Coding	1
86	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	1
87	RHOQ	Ras Homolog Family Member Q	Protein Coding	1
88	SLC2A4	Solute Carrier Family 2 Member 4	Protein Coding	1
89	PRKAA1	Protein Kinase AMP-Activated Catalytic Subunit Alpha 1	Protein Coding	1
90	PRKAA2	Protein Kinase AMP-Activated Catalytic Subunit Alpha 2	Protein Coding	1
91	PRKAB1	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1	Protein Coding	1
92	PRKAB2	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 2	Protein Coding	1
93	ADIPOQ	Adiponectin, C1Q And Collagen Domain Containing	Protein Coding	1
94	ANGPTL2	Angiopoietin Like 2	Protein Coding	1
95	IL6	Interleukin 6	Protein Coding	1
96	LEP	Leptin	Protein Coding	1
97	ITLN1	Intelectin 1	Protein Coding	1
98	NAMPT	Nicotinamide Phosphoribosyltransferase	Protein Coding	1
99	RETN	Resistin	Protein Coding	1
100	RBP4	Retinol Binding Protein 4	Protein Coding	1
101	SERPINA12	Serpin Family A Member 12	Protein Coding	1
102	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
103	FCER2	Fc Epsilon Receptor II	Protein Coding	1
104	FES	FES Proto-Oncogene, Tyrosine Kinase	Protein Coding	1
105	HBG1	Hemoglobin Subunit Gamma 1	Protein Coding	1
106	HBG2	Hemoglobin Subunit Gamma 2	Protein Coding	1
107	HLA-DMA	Major Histocompatibility Complex, Class II, DM Alpha	Protein Coding	1
108	HLA-DMB	Major Histocompatibility Complex, Class II, DM Beta	Protein Coding	1
109	HLA-DOA	Major Histocompatibility Complex, Class II, DO Alpha	Protein Coding	1
110	HLA-DOB	Major Histocompatibility Complex, Class II, DO Beta	Protein Coding	1
111	HLA-DPA1	Major Histocompatibility Complex, Class II, DP Alpha 1	Protein Coding	1
112	HLA-DQA1	Major Histocompatibility Complex, Class II, DQ Alpha 1	Protein Coding	1
113	HLA-DQA2	Major Histocompatibility Complex, Class II, DQ Alpha 2	Protein Coding	1
114	HLA-DQB1	Major Histocompatibility Complex, Class II, DQ Beta 1	Protein Coding	1
115	HLA-DRA	Major Histocompatibility Complex, Class II, DR Alpha	Protein Coding	1
116	HLA-DRB1	Major Histocompatibility Complex, Class II, DR Beta 1	Protein Coding	1
117	HLA-DRB3	Major Histocompatibility Complex, Class II, DR Beta 3	Protein Coding	1
118	HLA-DRB4	Major Histocompatibility Complex, Class II, DR Beta 4	Protein Coding	1
119	HLA-DRB5	Major Histocompatibility Complex, Class II, DR Beta 5	Protein Coding	1
120	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
121	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1
122	MAP2K5	Mitogen-Activated Protein Kinase Kinase 5	Protein Coding	1
123	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	1
124	MRAS	Muscle RAS Oncogene Homolog	Protein Coding	1
125	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	1
126	RRAS	RAS Related	Protein Coding	1
127	RRAS2	RAS Related 2	Protein Coding	1
128	SOCS4	Suppressor Of Cytokine Signaling 4	Protein Coding	1
129	BIRC5	Baculoviral IAP Repeat Containing 5	Protein Coding	1
130	ATF1	Activating Transcription Factor 1	Protein Coding	1
131	CCND1	Cyclin D1	Protein Coding	1
132	CCNA2	Cyclin A2	Protein Coding	1
133	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
134	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1
135	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
136	CRKL	CRK Like Proto-Oncogene, Adaptor Protein	Protein Coding	1
137	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
138	JAK2	Janus Kinase 2	Protein Coding	1
139	MPL	MPL Proto-Oncogene, Thrombopoietin Receptor	Protein Coding	1
140	RAC1	Rac Family Small GTPase 1	Protein Coding	1
141	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	1
142	RPS6KA3	Ribosomal Protein S6 Kinase A3	Protein Coding	1
143	THPO	Thrombopoietin	Protein Coding	1
144	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	1
145	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
146	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
147	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
148	NFKBIB	NFKB Inhibitor Beta	Protein Coding	1
149	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	1
150	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
151	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	1
152	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	1
153	TRADD	TNFRSF1A Associated Via Death Domain	Protein Coding	1
154	MAP3K14	Mitogen-Activated Protein Kinase Kinase Kinase 14	Protein Coding	1
155	IL22	Interleukin 22	Protein Coding	1
156	IL13RA1	Interleukin 13 Receptor Subunit Alpha 1	Protein Coding	1
157	TYK2	Tyrosine Kinase 2	Protein Coding	1
158	IL2	Interleukin 2	Protein Coding	1
159	IL2RA	Interleukin 2 Receptor Subunit Alpha	Protein Coding	1
160	IL21	Interleukin 21	Protein Coding	1
161	IL21R	Interleukin 21 Receptor	Protein Coding	1
162	IL7	Interleukin 7	Protein Coding	1
163	IL7R	Interleukin 7 Receptor	Protein Coding	1
164	IL15	Interleukin 15	Protein Coding	1
165	IL15RA	Interleukin 15 Receptor Subunit Alpha	Protein Coding	1
166	GZMA	Granzyme A	Protein Coding	1
167	LTA	Lymphotoxin Alpha	Protein Coding	1
168	SOCS6	Suppressor Of Cytokine Signaling 6	Protein Coding	1
169	TNFRSF1B	TNF Receptor Superfamily Member 1B	Protein Coding	1

Disorders associated with IL-9 Signaling Pathways SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rasopathy	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2, RAF1, SOS1, SOS2	16.00
2	Noonan syndrome 1	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2, RAF1, SOS1, SOS2	11.81
3	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2, RAF1, SOS1	11.34
4	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	10.13
5	Cardiofaciocutaneous syndrome	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	10.13
6	Lung non-small cell carcinoma	Enrichment	BRAF, HRAS, KRAS, MAP2K1, NRAS	9.03
7	Type 2 diabetes mellitus	Enrichment	AKT2, IL6, INSR, IRS1, IRS2, RETN, SLC2A4	8.64
8	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF, HRAS, NRAS, PTEN	7.81
9	Noonan syndrome 3	Enrichment	HRAS, KRAS, RAF1, SOS1	7.81
10	Follicular thyroid carcinoma	Enrichment	BRAF, HRAS, NRAS, PTEN	7.81
11	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, HRAS, NRAS, RAF1	7.51
12	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1, NRAS	7.00
13	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA, PIK3R2	6.73
14	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	6.40
15	Noonan syndrome with multiple lentigines	Enrichment	BRAF, PTPN11, RAF1	6.22
16	Pilomyxoid astrocytoma	Enrichment	BRAF, KRAS, RAF1	6.15
17	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, STAT3	5.93
18	Hemimegalencephaly	Enrichment	AKT3, MTOR, PTEN	5.83
19	Essential thrombocythemia	Enrichment	JAK2, MPL, THPO	5.79
20	Arteriovenous malformation	Enrichment	HRAS, MAP2K1, PIK3CA	5.55
21	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS	5.46
22	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1, PIK3CA	5.39
23	Pulmonic stenosis	Enrichment	BRAF, SOS1	5.12
24	Immunodeficiency 31c	Enrichment	IL21R, STAT1	5.07
25	Differentiated thyroid carcinoma	Enrichment	BRAF, HRAS, KRAS, NRAS	5.01
26	Lip and oral cavity carcinoma	Enrichment	BRAF, HRAS, PIK3CA	4.99
27	Psoriatic arthritis	Enrichment	LTA, TNF	4.94
28	Congenital amegakaryocytic thrombocytopenia	Enrichment	MPL, THPO	4.88
29	Colorectal cancer	Enrichment	AKT1, BRAF, CCND1, PIK3CA, PIK3R1	4.79
30	Diffuse large b-cell lymphoma	Enrichment	BRAF, FOXO1, STAT3	4.72
31	Myeloma, multiple	Enrichment	BRAF, IL7R, KRAS, PIK3R2	4.67
32	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS, RRAS	4.67
33	Celiac disease 1	Enrichment	HLA-DQA1, HLA-DQB1	4.66
34	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	4.66
35	Bullous pemphigoid	Enrichment	HLA-DQB1, HLA-DRB1	4.66
36	Pediatric multiple sclerosis	Enrichment	HLA-DQB1, HLA-DRB1	4.66
37	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	4.64
38	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	4.64
39	Acute promyelocytic leukemia	Enrichment	STAT3, STAT5B	4.52
40	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.49
41	Dyskeratosis congenita, autosomal dominant 6	Enrichment	MPL, THPO	4.40
42	Melanoma of soft tissue	Enrichment	ATF1, CREB1	4.40
43	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	4.34
44	Breast cancer	Enrichment	AKT1, JUN, KRAS, PTEN, SHC1	4.30
45	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	4.18
46	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	CRKL, MAPK1	4.10
47	Breast adenocarcinoma	Enrichment	AKT1, KRAS	3.94
48	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	3.88
49	Idiopathic achalasia	Enrichment	HLA-DQA1, HLA-DQB1	3.88
50	Hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome	Enrichment	HBG1, HBG2	3.88
51	Myeloproliferative neoplasm	Enrichment	CBL, JAK2	3.88
52	Arteriovenous malformations of the brain	Enrichment	BRAF, IL6, KRAS	3.87
53	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, MAP2K1	3.80
54	Gallbladder cancer	Enrichment	BRAF, KRAS	3.80
55	Bladder cancer	Enrichment	CDKN1A, HRAS, PIK3CA	3.79
56	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL, PTPN11	3.77
57	Oligoarticular juvenile idiopathic arthritis	Enrichment	IL2RA, IL2RB	3.73
58	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	IL2RA, IL2RB	3.73
59	Narcolepsy 2	Enrichment	HLA-DQB1, HLA-DRB1	3.66
60	Follicular lymphoma	Enrichment	BCL2, HLA-DRB1	3.66
61	Hereditary persistence of fetal hemoglobin-sickle cell disease syndrome	Enrichment	HBG1, HBG2	3.66
62	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A, CDKN1B	3.56
63	Myelofibrosis	Enrichment	JAK2, MPL	3.56
64	Histiocytoid hemangioma	Enrichment	FOS, FOSB	3.55
65	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	3.47
66	Omenn syndrome	Enrichment	IL2RG, IL7R	3.42
67	Type 1 diabetes mellitus	Enrichment	IL6, INS	3.37
68	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	3.34
69	Ventricular septal defect	Enrichment	BRAF, RPS6KA3	3.33
70	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.33
71	Nk-cell enteropathy	Enrichment	JAK3, PIK3CB	3.23
72	Overgrowth syndrome	Enrichment	MTOR, PIK3R1	3.23
73	Fetal hemoglobin quantitative trait locus 1	Enrichment	HBG1, HBG2	3.22
74	Narcolepsy 1	Enrichment	HLA-DQB1, HLA-DRB1	3.22
75	Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant	Enrichment	STAT5B	3.18
76	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	3.18
77	Immunodeficiency 31a	Enrichment	STAT1	3.18
78	Immunodeficiency 31b	Enrichment	STAT1	3.18
79	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	3.18
80	T-b+ severe combined immunodeficiency due to jak3 deficiency	Enrichment	JAK3	3.18
81	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	3.18
82	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	3.18
83	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	3.18
84	Lung cancer susceptibility 3	Enrichment	BRAF, KRAS	3.17
85	Specific learning disability	Enrichment	MAPK1, RPS6KA3	3.14
86	Meningioma	Enrichment	AKT1, PIK3CA	3.07
87	Malaria	Enrichment	CISH, TNF	3.03
88	Melanoma	Enrichment	BRAF, PTEN	3.02
89	Inflammatory bowel disease 1	Enrichment	IL6, PRKCQ	3.00
90	Hereditary breast carcinoma	Enrichment	AKT1, KRAS, PTEN	2.94
91	Ovarian cancer	Enrichment	AKT1, KRAS, PTEN, RRAS2	2.88
92	Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive	Enrichment	STAT5B	2.88
93	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.88
94	Laron syndrome with immunodeficiency	Enrichment	STAT5B	2.88
95	Rhabdomyosarcoma	Enrichment	CBL, HRAS	2.81
96	Multiple sclerosis	Enrichment	HLA-DQB1, HLA-DRB1	2.72
97	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	JAK3	2.70
98	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.70
99	Severe combined immunodeficiency, x-linked	Enrichment	IL2RG	2.70
100	Combined immunodeficiency, x-linked	Enrichment	IL2RG	2.70
101	Hyper ige syndrome	Enrichment	STAT3	2.70
102	Periodic fever, familial, autosomal dominant	Enrichment	TNFRSF1A	2.70
103	Leprosy 4	Enrichment	LTA	2.70
104	Dermatitis, atopic, 4	Enrichment	SOCS3	2.70
105	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.70
106	Short syndrome	Enrichment	PIK3R1	2.70
107	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.70
108	Multiple sclerosis 5	Enrichment	TNFRSF1A	2.70
109	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.70
110	Tnf receptor-associated periodic fever syndrome	Enrichment	TNFRSF1A	2.70
111	Adenosine deaminase deficiency	Enrichment	JAK3	2.58
112	Systemic lupus erythematosus	Enrichment	SOCS1, TNF	2.57
113	Proteus syndrome	Enrichment	AKT1	2.55
114	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.55
115	Oculoectodermal syndrome	Enrichment	KRAS	2.55
116	Pallister-killian syndrome	Enrichment	ARAF	2.55
117	Noonan syndrome 5	Enrichment	RAF1	2.55
118	Noonan syndrome 4	Enrichment	SOS1	2.55
119	Melorheostosis, isolated	Enrichment	MAP2K1	2.55
120	Noonan syndrome 7	Enrichment	BRAF	2.55
121	Leopard syndrome 3	Enrichment	BRAF	2.55
122	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.55
123	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.55
124	Noonan syndrome 9	Enrichment	SOS2	2.55
125	Noonan syndrome 13	Enrichment	MAPK1	2.55
126	Hyper-ige syndrome 6, autosomal dominant, with recurrent infections	Enrichment	STAT6	2.55
127	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.55
128	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.55
129	Lymphangioma	Enrichment	BRAF	2.55
130	Phace association	Enrichment	BRAF	2.55
131	Melorheostosis	Enrichment	MAP2K1	2.55
132	Leopard syndrome 2	Enrichment	RAF1	2.55
133	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.55
134	Cowden syndrome 6	Enrichment	AKT1	2.55
135	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.55
136	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.55
137	Trigonitis	Enrichment	RAF1	2.55
138	Capillary hemangioma	Enrichment	AKT3	2.55
139	Congenital pulmonary airway malformation	Enrichment	KRAS	2.55
140	Syringocystadenoma papilliferum	Enrichment	BRAF	2.55
141	Ganglioglioma	Enrichment	BRAF	2.55
142	Nongerminomatous germ cell tumor	Enrichment	BRAF	2.55
143	Phace syndrome	Enrichment	BRAF	2.55
144	Classic hairy cell leukemia	Enrichment	BRAF	2.55
145	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.55
146	Immunodeficiency 130 with hpv-related verrucosis	Enrichment	IL7	2.53
147	T-b+ severe combined immunodeficiency due to il-7ralpha deficiency	Enrichment	IL7R	2.53
148	Immunodeficiency 63 with lymphoproliferation and autoimmunity	Enrichment	IL2RB	2.53
149	Immunodeficiency 35	Enrichment	TYK2	2.52
150	Type 1 diabetes mellitus 10	Enrichment	IL2RA	2.52
151	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	JAK3	2.48
152	Macrodactyly	Enrichment	PIK3CA	2.48
153	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.48
154	Cowden syndrome 5	Enrichment	PIK3CA	2.48
155	Fetal encasement syndrome	Enrichment	CHUK	2.48
156	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.48
157	Immunodeficiency 15b	Enrichment	IKBKB	2.48
158	Immunodeficiency 15a	Enrichment	IKBKB	2.48
159	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.48
160	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.48
161	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.48
162	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.48
163	Hypospadias	Enrichment	PIK3CA	2.48
164	Immunodeficiency 112	Enrichment	MAP3K14	2.48
165	Rare venous malformation	Enrichment	PIK3CA	2.48
166	Diaphragmatic eventration	Enrichment	PIK3CA	2.48
167	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.48
168	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.48
169	Rare combined vascular malformation	Enrichment	PIK3CA	2.48
170	Cavernous lymphangioma	Enrichment	PIK3CA	2.48
171	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.48
172	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.48
173	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.48
174	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.48
175	Macrodactyly of toe	Enrichment	PIK3CA	2.48
176	Nik deficiency	Enrichment	MAP3K14	2.48
177	Lung cancer	Enrichment	BRAF, KRAS	2.44
178	Coffin-lowry syndrome	Enrichment	RPS6KA3	2.43
179	Thrombocythemia 2	Enrichment	MPL	2.43
180	Amegakaryocytic thrombocytopenia, congenital, 1	Enrichment	MPL	2.43
181	Amegakaryocytic thrombocytopenia, congenital, 2	Enrichment	THPO	2.43
182	Intellectual developmental disorder, x-linked 19	Enrichment	RPS6KA3	2.43
183	Neuroendocrine tumor	Enrichment	CDKN1B	2.43
184	Hereditary thrombocytosis with transverse limb defect	Enrichment	THPO	2.43
185	Thrombocytopenia 9	Enrichment	THPO	2.43
186	Symptomatic form of coffin-lowry syndrome in female carriers	Enrichment	RPS6KA3	2.43
187	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.43
188	Chronic mucocutaneous candidiasis	Enrichment	STAT1	2.40
189	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	2.40
190	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.40
191	Immunodeficiency 127	Enrichment	TNF	2.40
192	Intermittent hydrarthrosis	Enrichment	TNFRSF1A	2.40
193	Common variable immunodeficiency 12	Enrichment	NFKB1	2.40
194	Severe combined immunodeficiency	Enrichment	IL7R, JAK3	2.37
195	Vacterl association with hydrocephalus	Enrichment	PTEN	2.33
196	Melanosis, neurocutaneous	Enrichment	NRAS	2.33
197	Noonan syndrome 6	Enrichment	NRAS	2.33
198	Noonan syndrome 11	Enrichment	MRAS	2.33
199	Papillary tumor of the pineal region	Enrichment	PTEN	2.33
200	Pulmonary alveolar proteinosis, acquired	Enrichment	HLA-DRB1	2.33
201	Graham little-piccardi-lassueur syndrome	Enrichment	HLA-DRA	2.33
202	Glioma susceptibility 2	Enrichment	PTEN	2.33
203	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	2.33
204	Hemoglobinopathy toms river	Enrichment	HBG2	2.33
205	Neurocutaneous melanocytosis	Enrichment	NRAS	2.33
206	Permanent neonatal diabetes mellitus	Enrichment	STAT3	2.28
207	Metachondromatosis	Enrichment	PTPN11	2.27
208	Donohue syndrome	Enrichment	INSR	2.27
209	Hyperinsulinemic hypoglycemia, familial, 5	Enrichment	INSR	2.27
210	Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities	Enrichment	INSR	2.27
211	Diabetes mellitus, insulin-resistant, with acanthosis nigricans	Enrichment	INSR	2.27
212	Leopard syndrome 1	Enrichment	PTPN11	2.27
213	Microphthalmia/coloboma 10	Enrichment	RBP4	2.27
214	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.27
215	Spinocerebellar ataxia 14	Enrichment	PRKCG	2.27
216	Polydactyly-macrocephaly syndrome	Enrichment	MAX	2.27
217	Hereditary palmoplantar keratoderma, gamborg-nielsen type	Enrichment	SERPINA12	2.27
218	Malignant astrocytoma	Enrichment	PTPN11	2.27
219	Fibromatosis, gingival, 1	Enrichment	SOS1	2.25
220	Hemangiopericytoma, malignant	Enrichment	STAT6	2.25
221	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.25
222	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.25
223	Senior-loken syndrome 7	Enrichment	AKT3	2.25
224	Immune system disease	Enrichment	PIK3CD	2.25
225	Bardet-biedl syndrome 16	Enrichment	AKT3	2.25
226	Tafro syndrome	Enrichment	MAP2K2	2.25
227	Immunodeficiency 56	Enrichment	IL21R	2.23
228	Immunodeficiency 104, severe combined	Enrichment	IL7R	2.23
229	Multiple sclerosis 3	Enrichment	IL7R	2.23
230	Immune thrombocytopenia	Enrichment	SOCS1	2.22
231	Mycosis fungoides	Enrichment	TNFRSF1B	2.22
232	Autoinflammatory syndrome, familial, with or without immunodeficiency	Enrichment	SOCS1	2.22
233	Bacteremia 2	Enrichment	CISH	2.22
234	Migraine without aura	Enrichment	TNF	2.22
235	Saczary syndrome	Enrichment	TNFRSF1B	2.22
236	Lymphomatoid papulosis	Enrichment	TYK2	2.22
237	Primary cutaneous anaplastic large cell lymphoma	Enrichment	TYK2	2.22
238	Immunodeficiency 41 with lymphoproliferation and autoimmunity	Enrichment	IL2RA	2.22
239	Costello syndrome	Enrichment	HRAS	2.18
240	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.18
241	Keratosis, seborrheic	Enrichment	PIK3CA	2.18
242	Noonan syndrome 8	Enrichment	PIK3CA	2.18
243	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.18
244	Rela fusion-positive ependymoma	Enrichment	RELA	2.18
245	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.18
246	Ectodermal dysplasia and immune deficiency	Enrichment	NFKBIA	2.18
247	Wooly hair nevus	Enrichment	HRAS	2.18
248	Combined immunodeficiency	Enrichment	IL2RG	2.14
249	Combined t cell and b cell immunodeficiency	Enrichment	IL2RG	2.14
250	Combined t and b cell immunodeficiency	Enrichment	IL2RG	2.14
251	Burkitt lymphoma	Enrichment	MYC	2.13
252	Ovarian germ cell cancer	Enrichment	CBL	2.13
253	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.13
254	Thrombocythemia 3	Enrichment	JAK2	2.13
255	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	2.13
256	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.13
257	Polycythemia	Enrichment	JAK2	2.13
258	Hypereosinophilic syndrome	Enrichment	JAK2	2.13
259	Malignant germ cell tumor of ovary	Enrichment	CBL	2.13
260	Anemia, autoimmune hemolytic	Enrichment	SOCS1	2.10
261	Tuberculosis	Enrichment	CISH	2.10
262	Cerebral malaria	Enrichment	TNF	2.10
263	Severe covid-19	Enrichment	HLA-DQB1, JAK3	2.09
264	Ataxia-telangiectasia	Enrichment	BRAF	2.08
265	Nuchal bleb, familial	Enrichment	SOS1	2.08
266	Tethered spinal cord syndrome	Enrichment	BRAF	2.08
267	Immunodeficiency, common variable, 11	Enrichment	IL21	2.05
268	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	2.03
269	Creutzfeldt-jakob disease	Enrichment	HLA-DQB1	2.03
270	Sarcoidosis 1	Enrichment	HLA-DRB1	2.03
271	Cyanosis, transient neonatal	Enrichment	HBG2	2.03
272	Noonan syndrome 12	Enrichment	RRAS2	2.03
273	Intravascular large b-cell lymphoma	Enrichment	BCL2	2.03
274	Vacterl with hydrocephalus	Enrichment	PTEN	2.03
275	Juvenile polyposis of infancy	Enrichment	PTEN	2.03
276	Vascular dementia	Enrichment	TNF	2.00
277	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.00
278	Nasopharyngeal carcinoma	Enrichment	NFKBIA	2.00
279	Spermatocytoma	Enrichment	HRAS	2.00
280	Keratoacanthoma	Enrichment	PIK3CA	2.00
281	Hyperinsulinemic hypoglycemia, familial, 4	Enrichment	INSR	1.97
282	Maturity-onset diabetes of the young, type 10	Enrichment	INS	1.97
283	Retinal dystrophy, iris coloboma, and comedogenic acne syndrome	Enrichment	RBP4	1.97
284	Hyperproinsulinemia	Enrichment	INS	1.97
285	Werner syndrome	Enrichment	PTPN11	1.97
286	Cebalid syndrome	Enrichment	MTOR	1.97
287	Glycogen storage disease 0, muscle	Enrichment	GYS1	1.97
288	Diabetes mellitus, permanent neonatal, 4	Enrichment	INS	1.97
289	Smith-kingsmore syndrome	Enrichment	MTOR	1.97
290	Progressive retinal dystrophy due to retinol transport defect	Enrichment	RBP4	1.97
291	Glycogen storage disease due to muscle and heart glycogen synthase deficiency	Enrichment	GYS1	1.97
292	Thrombocythemia 1	Enrichment	THPO	1.96
293	Polycythemia vera	Enrichment	JAK2	1.96
294	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	1.96
295	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.95
296	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	1.95
297	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.95
298	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.95
299	Craniopharyngioma	Enrichment	BRAF	1.95
300	Pilocytic astrocytoma	Enrichment	KRAS	1.95
301	Newborn respiratory distress syndrome	Enrichment	BRAF	1.95
302	Gingival fibromatosis	Enrichment	SOS1	1.95
303	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.95
304	Inherited epidermodysplasia verruciformis	Enrichment	IL7	1.93
305	Cerebrovascular disease	Enrichment	PIK3CA	1.88
306	Epidermolytic nevus	Enrichment	HRAS	1.88
307	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.88
308	Thrombocytopenia	Enrichment	MPL, THPO	1.87
309	Common variable immunodeficiency	Enrichment	NFKB1	1.86
310	Rhabdomyosarcoma 2	Enrichment	FOXO1	1.86
311	Laryngeal squamous cell carcinoma	Enrichment	PTEN	1.85
312	Adult-onset myasthenia gravis	Enrichment	HLA-DQA1	1.85
313	Delta beta-thalassemia	Enrichment	HBG1	1.85
314	Vogt-koyanagi-harada disease	Enrichment	HLA-DRB1	1.85
315	Erythrocytosis, familial, 1	Enrichment	JAK2	1.83
316	Budd-chiari syndrome	Enrichment	JAK2	1.83
317	Congenital generalized lipodystrophy	Enrichment	FOS	1.83
318	Mantle cell lymphoma	Enrichment	CCND1	1.83
319	Primary hyperparathyroidism	Enrichment	CDKN1B	1.83
320	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	1.82
321	Hypertelorism	Enrichment	PIK3CA, RPS6KA3	1.80
322	Type 1 diabetes mellitus 2	Enrichment	INS	1.79
323	Adiponectin deficiency	Enrichment	ADIPOQ	1.79
324	Tricuspid valve insufficiency	Enrichment	PTPN11	1.79
325	Capillary malformations, congenital	Enrichment	PIK3CA	1.78
326	Wilms tumor 5	Enrichment	BRAF	1.78
327	Lung squamous cell carcinoma	Enrichment	KRAS	1.78
328	Gastric cancer	Enrichment	KRAS, PTEN	1.76
329	Charge syndrome	Enrichment	TNFRSF1A	1.75
330	Von hippel-lindau syndrome	Enrichment	CCND1	1.74
331	Aggressive systemic mastocytosis	Enrichment	CBL	1.74
332	Temporal arteritis	Enrichment	HLA-DRB1	1.73
333	Systemic-onset juvenile idiopathic arthritis	Enrichment	HLA-DRB1	1.73
334	Glioma	Enrichment	PTEN	1.73
335	Megacolon	Enrichment	AKT3	1.71
336	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.70
337	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.70
338	Cowden syndrome 1	Enrichment	PIK3CA	1.70
339	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.70
340	Autism spectrum disorder	Enrichment	MAP2K1, PTEN, PTPN11	1.68
341	Dilated cardiomyopathy	Enrichment	BRAF, RAF1	1.68
342	Kaposi sarcoma	Enrichment	IL6	1.67
343	Focal cortical dysplasia, type ii	Enrichment	MTOR	1.67
344	Leptin deficiency or dysfunction	Enrichment	LEP	1.67
345	Neonatal diabetes mellitus	Enrichment	INS	1.67
346	Hereditary ataxia	Enrichment	PRKCG	1.67
347	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	1.67
348	Pseudomyogenic hemangioendothelioma	Enrichment	FOSB	1.67
349	Asthma	Enrichment	TNF	1.66
350	Lymphoma, non-hodgkin, familial	Enrichment	BRAF	1.65
351	Macrocephaly/autism syndrome	Enrichment	PTEN	1.63
352	Hemangioma	Enrichment	PTEN	1.63
353	Acute megakaryocytic leukemia	Enrichment	PTEN	1.63
354	Diffuse cutaneous systemic sclerosis	Enrichment	HLA-DRB1	1.63
355	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.60
356	Primary hyperaldosteronism	Enrichment	BRAF	1.60
357	Alzheimer's disease	Enrichment	TNF	1.59
358	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.57
359	Lymphoma	Enrichment	PTPN11	1.57
360	Polymicrogyria	Enrichment	AKT3	1.56
361	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS, PTEN	1.56
362	Granulomatosis with polyangiitis	Enrichment	HLA-DPA1	1.55
363	Limited scleroderma	Enrichment	HLA-DRB1	1.55
364	Gastroesophageal reflux	Enrichment	RPS6KA3	1.54
365	Orthostatic intolerance	Enrichment	RPS6KA3	1.54
366	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.53
367	Patent ductus arteriosus	Enrichment	PTPN11	1.50
368	46,xy disorder of sex development	Enrichment	INSR	1.50
369	Ichthyosis	Enrichment	IL2RB	1.50
370	Squamous cell carcinoma, head and neck	Enrichment	PTEN	1.49
371	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.49
372	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.49
373	Inherited cancer-predisposing syndrome	Enrichment	MAX, PTEN, PTPN11	1.47
374	Aortic valve disease 1	Enrichment	SOS1	1.45
375	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.44
376	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.43
377	Behcet syndrome	Enrichment	TNFRSF1A	1.43
378	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.41
379	Wilms tumor 1	Enrichment	BRAF	1.38
380	Lynch syndrome	Enrichment	KRAS	1.38
381	Myocardial infarction	Enrichment	LTA	1.37
382	Melanoma, cutaneous malignant 1	Enrichment	BRAF	1.33
383	Dandy-walker syndrome	Enrichment	BRAF	1.33
384	Autoinflammatory disease	Enrichment	TNFRSF1A	1.33
385	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	1.33
386	Heart, malformation of	Enrichment	MAPK1	1.31
387	Meningioma, familial	Enrichment	PTEN	1.29
388	Uterine corpus cancer	Enrichment	PTEN	1.29
389	Gliosarcoma	Enrichment	NFKBIA	1.29
390	Giant cell glioblastoma	Enrichment	NFKBIA	1.26
391	Pectus excavatum	Enrichment	PTPN11	1.24
392	Glycogen storage disease	Enrichment	GYS1	1.24
393	Diabetes mellitus	Enrichment	INS	1.24
394	Protein-deficiency anemia	Enrichment	NRAS	1.22
395	Epicanthus	Enrichment	PTPN11	1.20
396	Congenital long qt syndrome	Enrichment	PTPN11	1.20
397	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.19
398	Endometrial cancer	Enrichment	PIK3CA	1.17
399	Microphthalmia/coloboma 12	Enrichment	RBP4	1.17
400	Pancreatic cancer	Enrichment	KRAS	1.17
401	Hepatocellular carcinoma	Enrichment	PIK3CA	1.15
402	Pheochromocytoma	Enrichment	MAX	1.14
403	Coloboma of macula	Enrichment	RBP4	1.11
404	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.11
405	Anterior segment dysgenesis	Enrichment	RBP4	1.11
406	Rare genetic intellectual disability	Enrichment	MTOR	1.11
407	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	1.09
408	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.08
409	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.05
410	Prostate cancer	Enrichment	PIK3CA	1.04
411	Patent foramen ovale	Enrichment	PTPN11	1.03
412	Left ventricular noncompaction	Enrichment	RAF1	1.03
413	Macs syndrome	Enrichment	RBP4	0.99
414	Maturity-onset diabetes of the young	Enrichment	INS	0.99
415	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	MAX	0.97
416	Microphthalmia	Enrichment	RBP4	0.95
417	Scoliosis	Enrichment	PTPN11	0.92
418	Non-syndromic x-linked intellectual disability	Enrichment	RPS6KA3	0.90
419	Strabismus	Enrichment	PTPN11	0.87
420	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.86
421	Microcephaly	Enrichment	MAPK1, PTPN11	0.85
422	Long qt syndrome 1	Enrichment	PTPN11	0.83
423	Eye disease	Enrichment	RBP4	0.76
424	Primary ovarian insufficiency	Enrichment	JAK2	0.71
425	Hypertrophic cardiomyopathy	Enrichment	PTPN11	0.68
426	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.58
427	Congenital nervous system abnormality	Enrichment	PTEN	0.40
428	Nervous system disease	Enrichment	PTEN	0.40
429	Hereditary retinal dystrophy	Enrichment	RBP4	0.10
430	Fundus dystrophy	Enrichment	RBP4	0.10

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

IL-9 Signaling Pathways

Pathway Network for IL-9 Signaling Pathways

Pathway network for the IL-9 Signaling Pathways SuperPath

Member Pathways for IL-9 Signaling Pathways

Pathways in the IL-9 Signaling Pathways SuperPath

Gene overlap in member pathways for IL-9 Signaling Pathways SuperPath

Associated Genes for IL-9 Signaling Pathways

Associated Disorders for IL-9 Signaling Pathways

Disorders associated with IL-9 Signaling Pathways SuperPath

STRING Interaction Network for IL-9 Signaling Pathways

Sources for IL-9 Signaling Pathways