IL12-mediated signaling events

No Pathway Network information available for IL12-mediated signaling events

Pathways in the IL12-mediated signaling events SuperPath

#	Name	Source	Genes
1	IL12-mediated signaling events	PubChem	ATF2 B2M CCL3 CCL4 CCL4L1 CCR5 CD247 CD3D CD3E CD3G CD4 CD8A CD8B EOMES FASLG FOS GADD45B GADD45G GZMA GZMB HLA-A HLA-DRA HLX IFNG IL12A IL12B IL12RB1 IL12RB2 IL18 IL18R1 IL18RAP IL1B IL1R1 IL2 IL2RA IL2RB IL2RG IL4 JAK2 LCK MAP2K3 MAPK14 MTOR NFKB1 NFKB2 NOS2 RAB7A RELA RELB RIPK2 SOCS1 SPHK2 STAT1 STAT3 STAT4 STAT5A STAT6 TBX21 TYK2 (see all 59) (see less)
2	Immune response IL-12-induced IFN-gamma production	GeneGo (Thomson Reuters)	ATF2 CD247 CD3D CD3E CD3G CHUK ETV5 GADD45B GADD45G IFNG IKBKB IL12A IL12B IL12RB1 IL12RB2 IL18 IL18R1 IRAK1 JAK2 JUN MAP2K3 MAP2K4 MAP2K6 MAP3K14 MAP3K4 MAPK10 MAPK14 MAPK8 MAPK9 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NOS2 REL RELA RELB STAT3 STAT4 TBX21 TRA TRAC TRAF6 TRAJ18 TRAV24 TRB TRBV11-1 TRBV11-2 TRBV11-3 TRBV17 TYK2 (see all 52) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GADD45G	Growth Arrest And DNA Damage Inducible Gamma	Protein Coding	2
2	TBX21	T-Box Transcription Factor 21	Protein Coding	2
3	CD247	CD247 Molecule	Protein Coding	2
4	GADD45B	Growth Arrest And DNA Damage Inducible Beta	Protein Coding	2
5	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	2
6	IL12RB2	Interleukin 12 Receptor Subunit Beta 2	Protein Coding	2
7	IL12B	Interleukin 12B	Protein Coding	2
8	IL12A	Interleukin 12A	Protein Coding	2
9	STAT4	Signal Transducer And Activator Of Transcription 4	Protein Coding	2
10	IL12RB1	Interleukin 12 Receptor Subunit Beta 1	Protein Coding	2
11	IL18R1	Interleukin 18 Receptor 1	Protein Coding	2
12	IL18	Interleukin 18	Protein Coding	2
13	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	2
14	CD3D	CD3 Delta Subunit Of T-Cell Receptor Complex	Protein Coding	2
15	CD3E	CD3 Epsilon Subunit Of T-Cell Receptor Complex	Protein Coding	2
16	CD3G	CD3 Gamma Subunit Of T-Cell Receptor Complex	Protein Coding	2
17	IFNG	Interferon Gamma	Protein Coding	2
18	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	2
19	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	2
20	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	2
21	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	2
22	ATF2	Activating Transcription Factor 2	Protein Coding	2
23	JAK2	Janus Kinase 2	Protein Coding	2
24	TYK2	Tyrosine Kinase 2	Protein Coding	2
25	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	2
26	NOS2	Nitric Oxide Synthase 2	Protein Coding	2
27	HLX	H2.0 Like Homeobox	Protein Coding	1
28	CCR5	C-C Motif Chemokine Receptor 5	Protein Coding	1
29	GZMA	Granzyme A	Protein Coding	1
30	CCL4	C-C Motif Chemokine Ligand 4	Protein Coding	1
31	CCL4L1	C-C Motif Chemokine Ligand 4 Like 1	Protein Coding	1
32	CCL3	C-C Motif Chemokine Ligand 3	Protein Coding	1
33	HLA-DRA	Major Histocompatibility Complex, Class II, DR Alpha	Protein Coding	1
34	EOMES	Eomesodermin	Protein Coding	1
35	IL4	Interleukin 4	Protein Coding	1
36	IL2RG	Interleukin 2 Receptor Subunit Gamma	Protein Coding	1
37	IL2RB	Interleukin 2 Receptor Subunit Beta	Protein Coding	1
38	IL18RAP	Interleukin 18 Receptor Accessory Protein	Protein Coding	1
39	IL1R1	Interleukin 1 Receptor Type 1	Protein Coding	1
40	IL1B	Interleukin 1 Beta	Protein Coding	1
41	STAT6	Signal Transducer And Activator Of Transcription 6	Protein Coding	1
42	CD8A	CD8 Subunit Alpha	Protein Coding	1
43	IL2	Interleukin 2	Protein Coding	1
44	IL2RA	Interleukin 2 Receptor Subunit Alpha	Protein Coding	1
45	CD8B	CD8 Subunit Beta	Protein Coding	1
46	HLA-A	Major Histocompatibility Complex, Class I, A	Protein Coding	1
47	B2M	Beta-2-Microglobulin	Protein Coding	1
48	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
49	CD4	CD4 Molecule	Protein Coding	1
50	RIPK2	Receptor Interacting Serine/Threonine Kinase 2	Protein Coding	1
51	FASLG	Fas Ligand	Protein Coding	1
52	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
53	SOCS1	Suppressor Of Cytokine Signaling 1	Protein Coding	1
54	GZMB	Granzyme B	Protein Coding	1
55	SPHK2	Sphingosine Kinase 2	Protein Coding	1
56	RAB7A	RAB7A, Member RAS Oncogene Family	Protein Coding	1
57	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	1
58	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
59	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
60	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
61	ETV5	ETS Variant Transcription Factor 5	Protein Coding	1
62	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
63	IRAK1	Interleukin 1 Receptor Associated Kinase 1	Protein Coding	1
64	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
65	MAP3K4	Mitogen-Activated Protein Kinase Kinase Kinase 4	Protein Coding	1
66	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
67	NFKBIB	NFKB Inhibitor Beta	Protein Coding	1
68	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	1
69	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
70	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
71	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
72	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	1
73	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	1
74	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1
75	TRA	T Cell Receptor Alpha Locus	Protein Coding	1
76	TRB	T Cell Receptor Beta Locus	Protein Coding	1
77	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	1
78	MAP3K14	Mitogen-Activated Protein Kinase Kinase Kinase 14	Protein Coding	1
79	TRBV17	T Cell Receptor Beta Variable 17 (Non-Functional)	Protein Coding	1
80	TRBV11-3	T Cell Receptor Beta Variable 11-3	Protein Coding	1
81	TRBV11-2	T Cell Receptor Beta Variable 11-2	Protein Coding	1
82	TRBV11-1	T Cell Receptor Beta Variable 11-1	Protein Coding	1
83	TRAV24	T Cell Receptor Alpha Variable 24	Protein Coding	1
84	TRAJ18	T Cell Receptor Alpha Joining 18	Protein Coding	1
85	TRAC	T Cell Receptor Alpha Constant	Protein Coding	1

Disorders associated with IL12-mediated signaling events SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Oligoarticular juvenile idiopathic arthritis	Enrichment	CD247, IL2RA, IL2RB, STAT4	7.95
2	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	CD247, IL2RA, IL2RB, STAT4	7.95
3	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD247, CD3D, CD3E	7.27
4	Severe combined immunodeficiency	Enrichment	CD247, CD3D, CD3E, CD3G, IKBKB	6.83
5	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK2, STAT3	4.37
6	Immunodeficiency 7	Enrichment	TRA, TRAC	4.37
7	Hepatitis c virus	Enrichment	CCR5, IFNG	4.25
8	Human immunodeficiency virus type 1	Enrichment	CCL3, CCR5, IFNG	4.22
9	Pediatric systemic lupus erythematosus	Enrichment	IRAK1, STAT4	4.07
10	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	3.52
11	Primary biliary cholangitis	Enrichment	IL12A, IL12RB1	3.29
12	Behcet syndrome	Enrichment	IL12A, STAT4	2.63
13	Diffuse large b-cell lymphoma	Enrichment	SOCS1, STAT3	2.52
14	Precursor t-cell acute lymphoblastic leukemia	Enrichment	TRA, TRB	2.46
15	Immunodeficiency 35	Enrichment	TYK2	2.42
16	Immunodeficiency 30	Enrichment	IL12RB1	2.42
17	Fetal encasement syndrome	Enrichment	CHUK	2.42
18	Immunodeficiency 15b	Enrichment	IKBKB	2.42
19	Immunodeficiency 69	Enrichment	IFNG	2.42
20	Immunodeficiency 15a	Enrichment	IKBKB	2.42
21	Immunodeficiency 92	Enrichment	REL	2.42
22	Disabling pansclerotic morphea of childhood	Enrichment	STAT4	2.42
23	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.42
24	Immunodeficiency 18	Enrichment	CD3E	2.42
25	Systemic lupus erythematosus 11	Enrichment	STAT4	2.42
26	Immunodeficiency 25	Enrichment	CD247	2.42
27	Immunodeficiency 29	Enrichment	IL12B	2.42
28	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.42
29	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.42
30	Immunodeficiency 53	Enrichment	RELB	2.42
31	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.42
32	Immunodeficiency 88	Enrichment	TBX21	2.42
33	Immunodeficiency 19, severe combined	Enrichment	CD3D	2.42
34	Immunodeficiency 112	Enrichment	MAP3K14	2.42
35	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.42
36	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.42
37	Immunodeficiency 19	Enrichment	CD3D	2.42
38	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.42
39	Nik deficiency	Enrichment	MAP3K14	2.42
40	Type 1 diabetes mellitus 10	Enrichment	IL2RA	2.36
41	Immunodeficiency 116	Enrichment	CD8A	2.36
42	Immunodeficiency 43	Enrichment	B2M	2.36
43	Hyper-ige syndrome 6, autosomal dominant, with recurrent infections	Enrichment	STAT6	2.36
44	Immunodeficiency 63 with lymphoproliferation and autoimmunity	Enrichment	IL2RB	2.36
45	Charcot-marie-tooth disease, axonal, type 2b	Enrichment	RAB7A	2.36
46	Okt4 epitope deficiency	Enrichment	CD4	2.36
47	Charcot-marie-tooth disease type 2b	Enrichment	RAB7A	2.36
48	Dialysis-related amyloidosis	Enrichment	B2M	2.36
49	Chronic recurrent multifocal osteomyelitis 3	Enrichment	IL1R1	2.36
50	Birdshot chorioretinopathy	Enrichment	HLA-A	2.36
51	Immunodeficiency 31a	Enrichment	STAT1	2.36
52	Graham little-piccardi-lassueur syndrome	Enrichment	HLA-DRA	2.36
53	Immunodeficiency 31b	Enrichment	STAT1	2.36
54	Type 1 diabetes mellitus 22	Enrichment	CCR5	2.36
55	Immunodeficiency 22	Enrichment	LCK	2.36
56	Immunodeficiency 79	Enrichment	CD4	2.36
57	Amyloidosis, hereditary systemic 6	Enrichment	B2M	2.36
58	Diaphragmatic hernia-short bowel-asplenia syndrome	Enrichment	HLX	2.36
59	Microcephaly-polymicrogyria-corpus callosum agenesis syndrome	Enrichment	EOMES	2.36
60	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.12
61	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.12
62	Immunodeficiency, common variable, 10	Enrichment	NFKB2	2.12
63	Thrombocythemia 3	Enrichment	JAK2	2.12
64	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.12
65	Rela fusion-positive ependymoma	Enrichment	RELA	2.12
66	Ectodermal dysplasia and immune deficiency	Enrichment	NFKBIA	2.12
67	Trypsinogen deficiency	Enrichment	TRB	2.12
68	Immunodeficiency 17	Enrichment	CD3G	2.12
69	Polycythemia	Enrichment	JAK2	2.12
70	Lymphomatoid papulosis	Enrichment	TYK2	2.12
71	Hypereosinophilic syndrome	Enrichment	JAK2	2.12
72	Common variable immunodeficiency 12	Enrichment	NFKB1	2.12
73	Primary cutaneous anaplastic large cell lymphoma	Enrichment	TYK2	2.12
74	Hemangiopericytoma, malignant	Enrichment	STAT6	2.06
75	West nile virus	Enrichment	CCR5	2.06
76	Severe cutaneous adverse reaction	Enrichment	HLA-A	2.06
77	Immunodeficiency 41 with lymphoproliferation and autoimmunity	Enrichment	IL2RA	2.06
78	Immunodeficiency 31c	Enrichment	STAT1	2.06
79	Cebalid syndrome	Enrichment	MTOR	2.06
80	Smith-kingsmore syndrome	Enrichment	MTOR	2.06
81	Systemic lupus erythematosus	Enrichment	IRAK1, STAT4	2.01
82	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	1.94
83	Asthma, nasal polyps, and aspirin intolerance	Enrichment	TBX21	1.94
84	Takayasu arteritis	Enrichment	IL12B	1.94
85	Polycythemia vera	Enrichment	JAK2	1.94
86	Tuberous sclerosis 1	Enrichment	IFNG	1.94
87	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.94
88	Tuberous sclerosis 2	Enrichment	IFNG	1.94
89	Hyper ige syndrome	Enrichment	STAT3	1.94
90	Immune thrombocytopenia	Enrichment	SOCS1	1.89
91	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	FASLG	1.89
92	Severe combined immunodeficiency, x-linked	Enrichment	IL2RG	1.89
93	Combined immunodeficiency, x-linked	Enrichment	IL2RG	1.89
94	Autoinflammatory syndrome, familial, with or without immunodeficiency	Enrichment	SOCS1	1.89
95	Erythrocytosis, familial, 1	Enrichment	JAK2	1.82
96	Budd-chiari syndrome	Enrichment	JAK2	1.82
97	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.82
98	Anemia, autoimmune hemolytic	Enrichment	SOCS1	1.76
99	Autoimmune lymphoproliferative syndrome	Enrichment	FASLG	1.76
100	Focal cortical dysplasia, type ii	Enrichment	MTOR	1.76
101	Congenital generalized lipodystrophy	Enrichment	FOS	1.76
102	Immunodeficiency by defective expression of mhc class i	Enrichment	B2M	1.76
103	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	1.76
104	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	1.72
105	Vitamin d-dependent rickets, type 2a	Enrichment	TRB	1.72
106	Myeloproliferative neoplasm	Enrichment	JAK2	1.72
107	Idiopathic aplastic anemia	Enrichment	IFNG	1.72
108	Amyloidosis, hereditary systemic 2	Enrichment	B2M	1.67
109	Histiocytoid hemangioma	Enrichment	FOS	1.67
110	Hemimegalencephaly	Enrichment	MTOR	1.67
111	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.59
112	Myelofibrosis	Enrichment	JAK2	1.58
113	Essential thrombocythemia	Enrichment	JAK2	1.58
114	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.52
115	Overgrowth syndrome	Enrichment	MTOR	1.52
116	Lennox-gastaut syndrome	Enrichment	MAPK10	1.52
117	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.52
118	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.47
119	Lymphoma, non-hodgkin, familial	Enrichment	B2M	1.46
120	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.42
121	Aplastic anemia	Enrichment	IFNG	1.42
122	Omenn syndrome	Enrichment	IL2RG	1.37
123	Combined immunodeficiency	Enrichment	IL2RG	1.33
124	Ichthyosis	Enrichment	IL2RB	1.33
125	Combined t cell and b cell immunodeficiency	Enrichment	IL2RG	1.33
126	Combined t and b cell immunodeficiency	Enrichment	IL2RG	1.33
127	Acute promyelocytic leukemia	Enrichment	STAT3	1.31
128	Hereditary chronic pancreatitis	Enrichment	TRB	1.28
129	Gliosarcoma	Enrichment	NFKBIA	1.22
130	Pancreatitis, hereditary	Enrichment	TRB	1.20
131	Giant cell glioblastoma	Enrichment	NFKBIA	1.20
132	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.20
133	Rare genetic intellectual disability	Enrichment	MTOR	1.20
134	Malaria	Enrichment	NOS2	1.07
135	Severe covid-19	Enrichment	HLA-A	0.92
136	Lung cancer	Enrichment	FASLG	0.88
137	Leukemia, acute myeloid	Enrichment	JAK2	0.85
138	Gastric cancer	Enrichment	IL1B	0.77
139	Primary ovarian insufficiency	Enrichment	JAK2	0.69
140	Breast cancer	Enrichment	JUN	0.60

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

IL12-mediated signaling events

Pathway Network for IL12-mediated signaling events

Member Pathways for IL12-mediated signaling events

Pathways in the IL12-mediated signaling events SuperPath

Associated Genes for IL12-mediated signaling events

Associated Disorders for IL12-mediated signaling events

Disorders associated with IL12-mediated signaling events SuperPath

STRING Interaction Network for IL12-mediated signaling events

Sources for IL12-mediated signaling events