IL12 signaling mediated by STAT4

No Pathway Network information available for IL12 signaling mediated by STAT4

Pathways in the IL12 signaling mediated by STAT4 SuperPath

#	Name	Source	Genes
1	IL12 signaling mediated by STAT4	PubChem	CD247 CD28 CD3D CD3E CD3G CD4 CREBBP ETV5 FOS HLA-DRA IFNG IL13 IL18 IL18R1 IL18RAP IL2 IL2RA IRF1 JUN MAPK8 NFATC2 PIAS2 PRF1 STAT3 STAT4 TBX21 TGFB1 (see all 27) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ETV5	ETS Variant Transcription Factor 5	Protein Coding	1
2	TBX21	T-Box Transcription Factor 21	Protein Coding	1
3	HLA-DRA	Major Histocompatibility Complex, Class II, DR Alpha	Protein Coding	1
4	CD247	CD247 Molecule	Protein Coding	1
5	PRF1	Perforin 1	Protein Coding	1
6	STAT4	Signal Transducer And Activator Of Transcription 4	Protein Coding	1
7	IL13	Interleukin 13	Protein Coding	1
8	IL18RAP	Interleukin 18 Receptor Accessory Protein	Protein Coding	1
9	IL18R1	Interleukin 18 Receptor 1	Protein Coding	1
10	IL18	Interleukin 18	Protein Coding	1
11	CD3D	CD3 Delta Subunit Of T-Cell Receptor Complex	Protein Coding	1
12	CD3E	CD3 Epsilon Subunit Of T-Cell Receptor Complex	Protein Coding	1
13	CD3G	CD3 Gamma Subunit Of T-Cell Receptor Complex	Protein Coding	1
14	IFNG	Interferon Gamma	Protein Coding	1
15	IL2	Interleukin 2	Protein Coding	1
16	IL2RA	Interleukin 2 Receptor Subunit Alpha	Protein Coding	1
17	NFATC2	Nuclear Factor Of Activated T Cells 2	Protein Coding	1
18	CD28	CD28 Molecule	Protein Coding	1
19	CD4	CD4 Molecule	Protein Coding	1
20	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
21	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
22	IRF1	Interferon Regulatory Factor 1	Protein Coding	1
23	PIAS2	Protein Inhibitor Of Activated STAT 2	Protein Coding	1
24	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
25	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
26	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	1
27	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1

Disorders associated with IL12 signaling mediated by STAT4 SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD247, CD3D, CD3E	8.15
2	Oligoarticular juvenile idiopathic arthritis	Enrichment	CD247, IL2RA, STAT4	6.61
3	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	CD247, IL2RA, STAT4	6.61
4	Severe combined immunodeficiency	Enrichment	CD247, CD3D, CD3E, CD3G	6.31
5	Idiopathic aplastic anemia	Enrichment	IFNG, PRF1	4.42
6	Aplastic anemia	Enrichment	IFNG, PRF1	3.77
7	Diffuse large b-cell lymphoma	Enrichment	CREBBP, STAT3	3.19
8	Type 1 diabetes mellitus 10	Enrichment	IL2RA	2.70
9	Hemophagocytic lymphohistiocytosis, familial, 2	Enrichment	PRF1	2.70
10	Immunodeficiency 69	Enrichment	IFNG	2.70
11	Disabling pansclerotic morphea of childhood	Enrichment	STAT4	2.70
12	Okt4 epitope deficiency	Enrichment	CD4	2.70
13	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.70
14	Immunodeficiency 18	Enrichment	CD3E	2.70
15	Systemic lupus erythematosus 11	Enrichment	STAT4	2.70
16	Allergic rhinitis	Enrichment	IL13	2.70
17	Immunodeficiency 25	Enrichment	CD247	2.70
18	Graham little-piccardi-lassueur syndrome	Enrichment	HLA-DRA	2.70
19	Immunodeficiency 123 with hpv-related verrucosis	Enrichment	CD28	2.70
20	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.70
21	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.70
22	Immunodeficiency 79	Enrichment	CD4	2.70
23	Immunodeficiency 88	Enrichment	TBX21	2.70
24	Immunodeficiency 19, severe combined	Enrichment	CD3D	2.70
25	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.70
26	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.70
27	Immunodeficiency 19	Enrichment	CD3D	2.70
28	Menke-hennekam syndrome	Enrichment	CREBBP	2.70
29	Fatal post-viral neurodegenerative disorder	Enrichment	PRF1	2.70
30	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.70
31	Camurati-engelmann disease 1	Enrichment	TGFB1	2.40
32	Thumb deformity	Enrichment	CREBBP	2.40
33	Immunodeficiency 41 with lymphoproliferation and autoimmunity	Enrichment	IL2RA	2.40
34	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	2.40
35	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	2.40
36	Camurati-engelmann disease	Enrichment	TGFB1	2.40
37	Immunodeficiency 17	Enrichment	CD3G	2.40
38	Joint contractures, osteochondromas, and b-cell lymphoma	Enrichment	NFATC2	2.40
39	Immunodeficiency 117	Enrichment	IRF1	2.40
40	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.22
41	Asthma, nasal polyps, and aspirin intolerance	Enrichment	TBX21	2.22
42	Mycosis fungoides	Enrichment	CD28	2.22
43	Tuberous sclerosis 1	Enrichment	IFNG	2.22
44	Hepatitis c virus	Enrichment	IFNG	2.22
45	Tuberous sclerosis 2	Enrichment	IFNG	2.22
46	Tethered spinal cord syndrome	Enrichment	CREBBP	2.22
47	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	2.22
48	Hyper ige syndrome	Enrichment	STAT3	2.22
49	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	2.22
50	Saczary syndrome	Enrichment	CD28	2.22
51	Congenital generalized lipodystrophy	Enrichment	FOS	2.10
52	Pediatric systemic lupus erythematosus	Enrichment	STAT4	2.10
53	Breast cancer	Enrichment	IL2, JUN	2.01
54	Hemophagocytic lymphohistiocytosis, familial, 1	Enrichment	PRF1	2.00
55	Histiocytoid hemangioma	Enrichment	FOS	2.00
56	Rubinstein-taybi syndrome 1	Enrichment	CREBBP	1.92
57	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP	1.92
58	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.92
59	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.92
60	Hypertrichosis	Enrichment	CREBBP	1.92
61	Lymphoma, non-hodgkin, familial	Enrichment	PRF1	1.80
62	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.80
63	Asthma	Enrichment	IL13	1.66
64	Lung non-small cell carcinoma	Enrichment	IRF1	1.66
65	Acute promyelocytic leukemia	Enrichment	STAT3	1.59
66	Heart disease	Enrichment	CREBBP	1.56
67	Corpus callosum, agenesis of	Enrichment	CREBBP	1.53
68	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.53
69	Rare genetic intellectual disability	Enrichment	CREBBP	1.53
70	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.53
71	Human immunodeficiency virus type 1	Enrichment	IFNG	1.45
72	Behcet syndrome	Enrichment	STAT4	1.43
73	Cardiomyopathy, dilated, 1a	Enrichment	NFATC2	1.39
74	Autoinflammatory disease	Enrichment	PRF1	1.33
75	Scoliosis	Enrichment	CREBBP	1.33
76	Lung cancer	Enrichment	IRF1	1.21
77	Cystic fibrosis	Enrichment	TGFB1	1.21
78	Systemic lupus erythematosus	Enrichment	STAT4	1.13
79	Gastric cancer	Enrichment	IRF1	1.08
80	Myeloma, multiple	Enrichment	CREBBP	0.98
81	Autism	Enrichment	CREBBP	0.87
82	Congenital nervous system abnormality	Enrichment	CREBBP	0.72
83	Nervous system disease	Enrichment	CREBBP	0.72

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

IL12 signaling mediated by STAT4

Pathway Network for IL12 signaling mediated by STAT4

Member Pathways for IL12 signaling mediated by STAT4

Pathways in the IL12 signaling mediated by STAT4 SuperPath

Associated Genes for IL12 signaling mediated by STAT4

Associated Disorders for IL12 signaling mediated by STAT4

Disorders associated with IL12 signaling mediated by STAT4 SuperPath

STRING Interaction Network for IL12 signaling mediated by STAT4

Sources for IL12 signaling mediated by STAT4