IL27-mediated signaling events

Pathway network for the IL27-mediated signaling events SuperPath

Sources:

PubChem
R&D Systems
Sino Biological

Pathways in the IL27-mediated signaling events SuperPath

#	Name	Source	Genes
1	IL27-mediated signaling events	PubChem	EBI3 GATA3 IFNG IL12A IL12B IL12RB1 IL12RB2 IL17A IL18 IL1B IL2 IL27 IL27RA IL6 IL6ST JAK1 JAK2 STAT1 STAT2 STAT3 STAT4 STAT5A TBX21 TGFB1 TNF TYK2 (see all 26) (see less)
2	Th1 Differentiation	R&D Systems	CD28 CD3E CD4 CD80 CD86 EBI3 FOS FOSB FOSL1 GATA3 HLA-DRA IFNG IFNGR1 IFNGR2 IL10 IL12A IL12B IL12RB1 IL12RB2 IL18 IL18R1 IL18RAP IL2 IL27 IL27RA IL6ST JAK1 JAK2 JUN JUNB JUND LTA STAT1 STAT3 STAT4 STAT5A STAT5B TBX21 TLR1 TLR10 TLR2 TLR3 TLR4 TLR5 TLR6 TLR7 TLR8 TLR9 TNF TYK2 (see all 50) (see less)
3	IL12 signaling pathway	Sino Biological	CDK5R1 EBI3 GATA3 IFNG IL12A IL12B IL12RB1 IL12RB2 IL17A IL17F IL21 IL23R IL27 IL27RA IL6ST JAK1 JAK2 RORC STAT1 STAT3 STAT4 STAT5A STAT5B TYK2 (see all 24) (see less)

Gene overlap in member pathways for IL27-mediated signaling events SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	IL27RA	Interleukin 27 Receptor Subunit Alpha	Protein Coding	3
2	IL27	Interleukin 27	Protein Coding	3
3	EBI3	Epstein-Barr Virus Induced 3	Protein Coding	3
4	IL12RB2	Interleukin 12 Receptor Subunit Beta 2	Protein Coding	3
5	IL12B	Interleukin 12B	Protein Coding	3
6	IL12A	Interleukin 12A	Protein Coding	3
7	STAT4	Signal Transducer And Activator Of Transcription 4	Protein Coding	3
8	IL12RB1	Interleukin 12 Receptor Subunit Beta 1	Protein Coding	3
9	IL6ST	Interleukin 6 Cytokine Family Signal Transducer	Protein Coding	3
10	IFNG	Interferon Gamma	Protein Coding	3
11	GATA3	GATA Binding Protein 3	Protein Coding	3
12	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	3
13	JAK2	Janus Kinase 2	Protein Coding	3
14	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	3
15	TYK2	Tyrosine Kinase 2	Protein Coding	3
16	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	3
17	JAK1	Janus Kinase 1	Protein Coding	3
18	TBX21	T-Box Transcription Factor 21	Protein Coding	2
19	IL17A	Interleukin 17A	Protein Coding	2
20	IL18	Interleukin 18	Protein Coding	2
21	IL2	Interleukin 2	Protein Coding	2
22	TNF	Tumor Necrosis Factor	Protein Coding	2
23	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	2
24	STAT2	Signal Transducer And Activator Of Transcription 2	Protein Coding	1
25	IL1B	Interleukin 1 Beta	Protein Coding	1
26	IL6	Interleukin 6	Protein Coding	1
27	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
28	TLR1	Toll Like Receptor 1	Protein Coding	1
29	TLR2	Toll Like Receptor 2	Protein Coding	1
30	TLR3	Toll Like Receptor 3	Protein Coding	1
31	TLR4	Toll Like Receptor 4	Protein Coding	1
32	TLR5	Toll Like Receptor 5	Protein Coding	1
33	TLR6	Toll Like Receptor 6	Protein Coding	1
34	TLR7	Toll Like Receptor 7	Protein Coding	1
35	TLR9	Toll Like Receptor 9	Protein Coding	1
36	TLR8	Toll Like Receptor 8	Protein Coding	1
37	TLR10	Toll Like Receptor 10	Protein Coding	1
38	HLA-DRA	Major Histocompatibility Complex, Class II, DR Alpha	Protein Coding	1
39	CD3E	CD3 Epsilon Subunit Of T-Cell Receptor Complex	Protein Coding	1
40	CD4	CD4 Molecule	Protein Coding	1
41	CD28	CD28 Molecule	Protein Coding	1
42	CD80	CD80 Molecule	Protein Coding	1
43	CD86	CD86 Molecule	Protein Coding	1
44	IL18R1	Interleukin 18 Receptor 1	Protein Coding	1
45	IL18RAP	Interleukin 18 Receptor Accessory Protein	Protein Coding	1
46	IFNGR1	Interferon Gamma Receptor 1	Protein Coding	1
47	IFNGR2	Interferon Gamma Receptor 2	Protein Coding	1
48	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
49	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
50	JUNB	JunB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
51	JUND	JunD Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
52	FOSB	FosB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
53	FOSL1	FOS Like 1, AP-1 Transcription Factor Subunit	Protein Coding	1
54	IL10	Interleukin 10	Protein Coding	1
55	LTA	Lymphotoxin Alpha	Protein Coding	1
56	CDK5R1	Cyclin Dependent Kinase 5 Regulatory Subunit 1	Protein Coding	1
57	IL17F	Interleukin 17F	Protein Coding	1
58	IL21	Interleukin 21	Protein Coding	1
59	IL23R	Interleukin 23 Receptor	Protein Coding	1
60	RORC	RAR Related Orphan Receptor C	Protein Coding	1

Disorders associated with IL27-mediated signaling events SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, JAK2, STAT3	8.31
2	Behcet syndrome	Enrichment	IFNGR1, IL10, IL12A, STAT4, TLR4	8.21
3	Systemic lupus erythematosus	Enrichment	IL10, STAT4, TLR7, TNF	4.91
4	Human immunodeficiency virus type 1	Enrichment	IFNG, IL10, TLR3	4.43
5	Psoriatic arthritis	Enrichment	LTA, TNF	4.40
6	Chronic mucocutaneous candidiasis	Enrichment	IL17F, STAT1	4.35
7	Primary biliary cholangitis	Enrichment	IL12A, IL12RB1	3.97
8	Histiocytoid hemangioma	Enrichment	FOS, FOSB	3.88
9	Acute promyelocytic leukemia	Enrichment	STAT3, STAT5B	3.64
10	Rheumatoid arthritis	Enrichment	IL10, TLR1	3.33
11	Immunodeficiency 35	Enrichment	TYK2	2.75
12	Immunodeficiency 30	Enrichment	IL12RB1	2.75
13	Candidiasis, familial, 6	Enrichment	IL17F	2.75
14	Immunodeficiency 69	Enrichment	IFNG	2.75
15	Stuve-wiedemann syndrome 2	Enrichment	IL6ST	2.75
16	Hyper-ige syndrome 4a, autosomal dominant, with recurrent infections	Enrichment	IL6ST	2.75
17	Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant	Enrichment	STAT5B	2.75
18	Disabling pansclerotic morphea of childhood	Enrichment	STAT4	2.75
19	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.75
20	Systemic lupus erythematosus 11	Enrichment	STAT4	2.75
21	Immunodeficiency 42	Enrichment	RORC	2.75
22	Psoriasis 7	Enrichment	IL23R	2.75
23	Immunodeficiency 31a	Enrichment	STAT1	2.75
24	Immunodeficiency 29	Enrichment	IL12B	2.75
25	Inflammatory bowel disease 17	Enrichment	IL23R	2.75
26	Immunodeficiency 31b	Enrichment	STAT1	2.75
27	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.75
28	Hyper-ige syndrome 4b, autosomal recessive, with recurrent infections	Enrichment	IL6ST	2.75
29	Immunodeficiency 94 with autoinflammation and dysmorphic facies	Enrichment	IL6ST	2.75
30	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.75
31	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.75
32	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.75
33	Pseudo-torch syndrome 3	Enrichment	STAT2	2.72
34	Immunodeficiency 88	Enrichment	TBX21	2.72
35	Multisystem inflammatory syndrome in children	Enrichment	TLR3, TLR6	2.53
36	Hypoparathyroidism, sensorineural deafness, and renal dysplasia syndrome	Enrichment	GATA3	2.45
37	Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive	Enrichment	STAT5B	2.45
38	Thrombocythemia 3	Enrichment	JAK2	2.45
39	Immunodeficiency 31c	Enrichment	STAT1	2.45
40	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.45
41	B-lymphoblastic leukemia/lymphoma with hyperdiploidy	Enrichment	GATA3	2.45
42	Hypoparathyroidism-deafness-renal disease syndrome	Enrichment	GATA3	2.45
43	Polycythemia	Enrichment	JAK2	2.45
44	Lymphomatoid papulosis	Enrichment	TYK2	2.45
45	Autosomal dominant nonsyndromic deafness	Enrichment	GATA3	2.45
46	Hypereosinophilic syndrome	Enrichment	JAK2	2.45
47	Laron syndrome with immunodeficiency	Enrichment	STAT5B	2.45
48	Primary cutaneous anaplastic large cell lymphoma	Enrichment	TYK2	2.45
49	Leprosy 3	Enrichment	TLR2	2.43
50	Helicobacter pylori infection	Enrichment	IFNGR1	2.43
51	Legionnaire disease	Enrichment	TLR5	2.43
52	Leprosy 4	Enrichment	LTA	2.43
53	Immunodeficiency 83 viral infections	Enrichment	TLR3	2.43
54	Leprosy 5	Enrichment	TLR1	2.43
55	Immunodeficiency 27a	Enrichment	IFNGR1	2.43
56	Immunodeficiency 74, covid19-related, x-linked	Enrichment	TLR7	2.43
57	Okt4 epitope deficiency	Enrichment	CD4	2.43
58	Systemic lupus erythematosus 1	Enrichment	TLR5	2.43
59	Graft-versus-host disease	Enrichment	IL10	2.43
60	X-linked immunodeficiency 74	Enrichment	TLR7	2.43
61	Systemic lupus erythematosus 17	Enrichment	TLR7	2.43
62	Immunodeficiency 18	Enrichment	CD3E	2.43
63	Immunodeficiency 27b	Enrichment	IFNGR1	2.43
64	Graham little-piccardi-lassueur syndrome	Enrichment	HLA-DRA	2.43
65	Melioidosis	Enrichment	TLR5	2.43
66	Macular degeneration, age-related, 10	Enrichment	TLR4	2.43
67	Immunodeficiency 123 with hpv-related verrucosis	Enrichment	CD28	2.43
68	Immunodeficiency 79	Enrichment	CD4	2.43
69	Autosomal dominant mendelian susceptibility to mycobacterial diseases due to partial ifngammar2 deficiency	Enrichment	IFNGR2	2.43
70	Camurati-engelmann disease 1	Enrichment	TGFB1	2.42
71	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	2.42
72	Immunodeficiency 127	Enrichment	TNF	2.42
73	Camurati-engelmann disease	Enrichment	TGFB1	2.42
74	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.28
75	Takayasu arteritis	Enrichment	IL12B	2.28
76	Polycythemia vera	Enrichment	JAK2	2.28
77	Tuberous sclerosis 1	Enrichment	IFNG	2.28
78	Stuve-wiedemann syndrome 1	Enrichment	IL6ST	2.28
79	Hepatitis c virus	Enrichment	IFNG	2.28
80	Tuberous sclerosis 2	Enrichment	IFNG	2.28
81	Hyper ige syndrome	Enrichment	STAT3	2.28
82	Immunodeficiency, common variable, 11	Enrichment	IL21	2.28
83	End stage renal disease	Enrichment	GATA3	2.28
84	Stüve-wiedemann syndrome	Enrichment	IL6ST	2.28
85	Asthma, nasal polyps, and aspirin intolerance	Enrichment	TBX21	2.24
86	Migraine without aura	Enrichment	TNF	2.24
87	Immunodeficiency 44	Enrichment	STAT2	2.24
88	Erythrocytosis, familial, 1	Enrichment	JAK2	2.15
89	Budd-chiari syndrome	Enrichment	JAK2	2.15
90	Pediatric systemic lupus erythematosus	Enrichment	STAT4	2.15
91	Leprosy 1	Enrichment	TLR6	2.13
92	Kaposi sarcoma	Enrichment	IL6	2.12
93	Cerebral malaria	Enrichment	TNF	2.12
94	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	2.12
95	Myeloproliferative neoplasm	Enrichment	JAK2	2.05
96	Idiopathic aplastic anemia	Enrichment	IFNG	2.05
97	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	2.02
98	Vascular dementia	Enrichment	TNF	2.02
99	Mycosis fungoides	Enrichment	CD28	1.96
100	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	TLR8	1.96
101	Immunodeficiency 28	Enrichment	IFNGR2	1.96
102	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD3E	1.96
103	Saczary syndrome	Enrichment	CD28	1.96
104	Type 1 diabetes mellitus	Enrichment	IL6	1.94
105	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.94
106	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.94
107	Myelofibrosis	Enrichment	JAK2	1.91
108	Essential thrombocythemia	Enrichment	JAK2	1.91
109	Oligoarticular juvenile idiopathic arthritis	Enrichment	STAT4	1.91
110	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	STAT4	1.91
111	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.85
112	Anemia, autoimmune hemolytic	Enrichment	TLR8	1.83
113	Congenital generalized lipodystrophy	Enrichment	FOS	1.83
114	Hepatitis b	Enrichment	IFNGR1	1.83
115	Pseudomyogenic hemangioendothelioma	Enrichment	FOSB	1.83
116	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.80
117	Inflammatory bowel disease 1	Enrichment	IL6	1.77
118	Aplastic anemia	Enrichment	IFNG	1.76
119	Herpes simplex virus encephalitis	Enrichment	TLR3	1.74
120	Asthma	Enrichment	TNF	1.68
121	Alzheimer's disease	Enrichment	TNF	1.61
122	Breast cancer	Enrichment	IL2, JUN	1.51
123	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.48
124	Arteriovenous malformations of the brain	Enrichment	IL6	1.45
125	Malaria	Enrichment	TNF	1.36
126	Cakut	Enrichment	GATA3	1.23
127	Cystic fibrosis	Enrichment	TGFB1	1.22
128	Leukemia, acute myeloid	Enrichment	JAK2	1.16
129	Type 2 diabetes mellitus	Enrichment	IL6	1.11
130	Myocardial infarction	Enrichment	LTA	1.11
131	Gastric cancer	Enrichment	IL1B	1.10
132	Primary ovarian insufficiency	Enrichment	JAK2	1.00
133	Severe combined immunodeficiency	Enrichment	CD3E	0.94
134	Colorectal cancer	Enrichment	TLR2	0.56

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

IL27-mediated signaling events

Pathway Network for IL27-mediated signaling events

Pathway network for the IL27-mediated signaling events SuperPath

Member Pathways for IL27-mediated signaling events

Pathways in the IL27-mediated signaling events SuperPath

Gene overlap in member pathways for IL27-mediated signaling events SuperPath

Associated Genes for IL27-mediated signaling events

Associated Disorders for IL27-mediated signaling events

Disorders associated with IL27-mediated signaling events SuperPath

STRING Interaction Network for IL27-mediated signaling events

Sources for IL27-mediated signaling events