IL2 signaling events mediated by STAT5

Pathway network for the IL2 signaling events mediated by STAT5 SuperPath

Sources:

PubChem
Reactome

Pathways in the IL2 signaling events mediated by STAT5 SuperPath

#	Name	Source	Genes
1	IL2 signaling events mediated by STAT5	PubChem	BCL2 BCL2L1 CCNA2 CCND2 CCND3 CDK6 ELF1 FASLG FOXP3 GAB2 GRB2 IL2 IL2RA IL2RB IL2RG IL4 JAK1 JAK3 LCK LTA MYC PIK3CA PIK3R1 PRF1 PTPN11 SHC1 SOS1 SP1 STAT5A STAT5B (see all 30) (see less)
2	IL2-mediated signaling events	PubChem	BCL2 CDK2 CISH DOK2 FOS FYN GAB2 GRB2 IFNG IKZF3 IL2 IL2RA IL2RB IL2RG IRS1 JAK1 JAK3 JUN LCK MAP2K1 MAPK14 MAPK3 MAPKAPK2 MYC PIK3CA PIK3R1 PRKCB PRKCE PTK2B PTPN11 RAF1 RASA1 RHOA SHC1 SOCS1 SOCS2 SOCS3 SOS1 STAM STAT1 STAT3 STAT5A STAT5B SYK (see all 44) (see less)
3	IL2 signaling events mediated by PI3K	PubChem	AKT1 BCL2 BCL2L1 E2F1 EIF3A FOXO3 GAB2 GRB2 HSP90AA1 IL2 IL2RA IL2RB IL2RG JAK1 JAK3 LCK MTOR MYB MYC NFATC2 NFKB1 PIK3CA PIK3R1 PRKCZ PTPN11 RAC1 RELA RPS6 RPS6KB1 SGMS1 SHC1 SMPD1 SOS1 TERT UGCG (see all 35) (see less)
4	Interleukin-2 signaling	Reactome	IL2 IL2RA IL2RB IL2RG JAK1 JAK3 LCK PTK2B SHC1 STAT5A STAT5B SYK (see all 12) (see less)

Gene overlap in member pathways for IL2 signaling events mediated by STAT5 SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	IL2RG	Interleukin 2 Receptor Subunit Gamma	Protein Coding	4
2	IL2RB	Interleukin 2 Receptor Subunit Beta	Protein Coding	4
3	JAK3	Janus Kinase 3	Protein Coding	4
4	IL2	Interleukin 2	Protein Coding	4
5	IL2RA	Interleukin 2 Receptor Subunit Alpha	Protein Coding	4
6	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	4
7	SHC1	SHC Adaptor Protein 1	Protein Coding	4
8	JAK1	Janus Kinase 1	Protein Coding	4
9	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	3
10	BCL2	BCL2 Apoptosis Regulator	Protein Coding	3
11	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	3
12	GAB2	GRB2 Associated Binding Protein 2	Protein Coding	3
13	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	3
14	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	3
15	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	3
16	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	3
17	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	3
18	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	3
19	BCL2L1	BCL2 Like 1	Protein Coding	2
20	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	2
21	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	2
22	PRF1	Perforin 1	Protein Coding	1
23	LTA	Lymphotoxin Alpha	Protein Coding	1
24	IL4	Interleukin 4	Protein Coding	1
25	ELF1	E74 Like ETS Transcription Factor 1	Protein Coding	1
26	FOXP3	Forkhead Box P3~Name Same As:- HGNC:13781	Protein Coding	1
27	CCND2	Cyclin D2	Protein Coding	1
28	CDK6	Cyclin Dependent Kinase 6	Protein Coding	1
29	CCNA2	Cyclin A2	Protein Coding	1
30	FASLG	Fas Ligand	Protein Coding	1
31	SP1	Sp1 Transcription Factor	Protein Coding	1
32	CCND3	Cyclin D3	Protein Coding	1
33	IKZF3	IKAROS Family Zinc Finger 3	Protein Coding	1
34	CISH	Cytokine Inducible SH2 Containing Protein	Protein Coding	1
35	SOCS2	Suppressor Of Cytokine Signaling 2	Protein Coding	1
36	IFNG	Interferon Gamma	Protein Coding	1
37	STAM	Signal Transducing Adaptor Molecule	Protein Coding	1
38	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
39	PRKCE	Protein Kinase C Epsilon	Protein Coding	1
40	SOCS1	Suppressor Of Cytokine Signaling 1	Protein Coding	1
41	MAPKAPK2	MAPK Activated Protein Kinase 2	Protein Coding	1
42	CDK2	Cyclin Dependent Kinase 2	Protein Coding	1
43	DOK2	Docking Protein 2	Protein Coding	1
44	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
45	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
46	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
47	RASA1	RAS P21 Protein Activator 1	Protein Coding	1
48	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
49	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
50	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
51	RHOA	Ras Homolog Family Member A	Protein Coding	1
52	PRKCB	Protein Kinase C Beta	Protein Coding	1
53	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	1
54	IRS1	Insulin Receptor Substrate 1	Protein Coding	1
55	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
56	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
57	SMPD1	Sphingomyelin Phosphodiesterase 1	Protein Coding	1
58	UGCG	UDP-Glucose Ceramide Glucosyltransferase	Protein Coding	1
59	NFATC2	Nuclear Factor Of Activated T Cells 2	Protein Coding	1
60	EIF3A	Eukaryotic Translation Initiation Factor 3 Subunit A	Protein Coding	1
61	TERT	Telomerase Reverse Transcriptase	Protein Coding	1
62	E2F1	E2F Transcription Factor 1	Protein Coding	1
63	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
64	SGMS1	Sphingomyelin Synthase 1	Protein Coding	1
65	MYB	MYB Proto-Oncogene, Transcription Factor	Protein Coding	1
66	PRKCZ	Protein Kinase C Zeta	Protein Coding	1
67	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
68	FOXO3	Forkhead Box O3	Protein Coding	1
69	RPS6	Ribosomal Protein S6	Protein Coding	1
70	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	1
71	RAC1	Rac Family Small GTPase 1	Protein Coding	1
72	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	1
73	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
74	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1

Disorders associated with IL2 signaling events mediated by STAT5 SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome and noonan-related syndrome	Enrichment	MAP2K1, PTPN11, RAF1, SOS1	6.89
2	Noonan syndrome 1	Enrichment	MAP2K1, PTPN11, RAF1, SOS1	6.09
3	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1, PIK3CA, RASA1	5.96
4	Noonan syndrome 3	Enrichment	PTPN11, RAF1, SOS1	5.96
5	Rasopathy	Enrichment	MAP2K1, PTPN11, RAF1, SOS1	5.86
6	Arteriovenous malformation	Enrichment	MAP2K1, PIK3CA, RASA1	5.58
7	Meningioma	Enrichment	AKT1, PIK3CA, TERT	5.47
8	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1, PIK3CA, RASA1	5.42
9	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.85
10	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2, MYC	4.85
11	Oligoarticular juvenile idiopathic arthritis	Enrichment	IL2RA, IL2RB	4.82
12	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	IL2RA, IL2RB	4.82
13	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, STAT3	4.51
14	Breast cancer	Enrichment	AKT1, IL2, PIK3CA, SHC1	4.40
15	Noonan syndrome with multiple lentigines	Enrichment	PTPN11, RAF1	4.21
16	Hemimegalencephaly	Enrichment	MTOR, PIK3CA	4.19
17	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	4.02
18	Capillary malformations, congenital	Enrichment	PIK3CA, RASA1	3.99
19	Overgrowth syndrome	Enrichment	MTOR, PIK3R1	3.87
20	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA, RASA1	3.82
21	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	3.82
22	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.64
23	Severe combined immunodeficiency	Enrichment	JAK3, LCK	3.43
24	Lung non-small cell carcinoma	Enrichment	MAP2K1, PIK3CA	3.26
25	Acute promyelocytic leukemia	Enrichment	STAT3, STAT5B	3.11
26	Type 1 diabetes mellitus 10	Enrichment	IL2RA	3.05
27	Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant	Enrichment	STAT5B	3.05
28	Immunodeficiency 82 with systemic inflammation	Enrichment	SYK	3.05
29	Immunodeficiency 63 with lymphoproliferation and autoimmunity	Enrichment	IL2RB	3.05
30	Immunodeficiency 22	Enrichment	LCK	3.05
31	T-b+ severe combined immunodeficiency due to jak3 deficiency	Enrichment	JAK3	3.05
32	Colitis	Enrichment	SYK	3.05
33	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	3.05
34	Colorectal cancer	Enrichment	AKT1, PIK3CA, PIK3R1	2.84
35	Hepatocellular carcinoma	Enrichment	PIK3CA, TERT	2.84
36	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYB, MYC	2.80
37	Diffuse large b-cell lymphoma	Enrichment	SOCS1, STAT3	2.77
38	Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive	Enrichment	STAT5B	2.75
39	Immunodeficiency 41 with lymphoproliferation and autoimmunity	Enrichment	IL2RA	2.75
40	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.75
41	Arthritis	Enrichment	SYK	2.75
42	Laron syndrome with immunodeficiency	Enrichment	STAT5B	2.75
43	Macrodactyly	Enrichment	PIK3CA	2.66
44	Metachondromatosis	Enrichment	PTPN11	2.66
45	Hemophagocytic lymphohistiocytosis, familial, 2	Enrichment	PRF1	2.66
46	Immunodysregulation, polyendocrinopathy, and enteropathy, x-linked	Enrichment	FOXP3	2.66
47	Noonan syndrome 4	Enrichment	SOS1	2.66
48	Leprosy 4	Enrichment	LTA	2.66
49	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.66
50	Leopard syndrome 1	Enrichment	PTPN11	2.66
51	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3	Enrichment	CCND2	2.66
52	Cowden syndrome 5	Enrichment	PIK3CA	2.66
53	Microcephaly 12, primary, autosomal recessive	Enrichment	CDK6	2.66
54	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.66
55	Short syndrome	Enrichment	PIK3R1	2.66
56	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.66
57	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.66
58	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.66
59	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.66
60	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.66
61	Hypospadias	Enrichment	PIK3CA	2.66
62	Rare venous malformation	Enrichment	PIK3CA	2.66
63	Diaphragmatic eventration	Enrichment	PIK3CA	2.66
64	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.66
65	Rare combined vascular malformation	Enrichment	PIK3CA	2.66
66	Cavernous lymphangioma	Enrichment	PIK3CA	2.66
67	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.66
68	Fatal post-viral neurodegenerative disorder	Enrichment	PRF1	2.66
69	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.66
70	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.66
71	Macrodactyly of toe	Enrichment	PIK3CA	2.66
72	Malignant astrocytoma	Enrichment	PTPN11	2.66
73	Lung cancer	Enrichment	FASLG, PIK3CA	2.65
74	Bladder cancer	Enrichment	PIK3CA, TERT	2.60
75	Proteus syndrome	Enrichment	AKT1	2.59
76	Cowden syndrome 6	Enrichment	AKT1	2.59
77	Acid sphingomyelinase deficiency	Enrichment	SMPD1	2.59
78	Autosomal recessive dyskeratosis congenita 4	Enrichment	TERT	2.59
79	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.59
80	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	JAK3	2.58
81	Severe combined immunodeficiency, x-linked	Enrichment	IL2RG	2.58
82	Combined immunodeficiency, x-linked	Enrichment	IL2RG	2.58
83	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	2.49
84	Noonan syndrome 5	Enrichment	RAF1	2.49
85	Melorheostosis, isolated	Enrichment	MAP2K1	2.49
86	Dermatitis, atopic, 4	Enrichment	SOCS3	2.49
87	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.49
88	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.49
89	Immunodeficiency 69	Enrichment	IFNG	2.49
90	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.49
91	Melorheostosis	Enrichment	MAP2K1	2.49
92	Leopard syndrome 2	Enrichment	RAF1	2.49
93	Immunodeficiency 31a	Enrichment	STAT1	2.49
94	Immunodeficiency 31b	Enrichment	STAT1	2.49
95	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.49
96	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.49
97	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.49
98	Trigonitis	Enrichment	RAF1	2.49
99	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.49
100	Gorham's disease	Enrichment	RASA1	2.49
101	Combined immunodeficiency-lymphopenia-cancer predisposing syndrome due to aiolos deficiency	Enrichment	IKZF3	2.49
102	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.49
103	Adenosine deaminase deficiency	Enrichment	JAK3	2.45
104	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	JAK3	2.35
105	Burkitt lymphoma	Enrichment	MYC	2.35
106	Fibromatosis, gingival, 1	Enrichment	SOS1	2.35
107	Multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly	Enrichment	FOXP3	2.35
108	Pulmonic stenosis	Enrichment	SOS1	2.35
109	Keratosis, seborrheic	Enrichment	PIK3CA	2.35
110	Noonan syndrome 8	Enrichment	PIK3CA	2.35
111	Werner syndrome	Enrichment	PTPN11	2.35
112	Intravascular large b-cell lymphoma	Enrichment	BCL2	2.35
113	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.35
114	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 1	Enrichment	TERT	2.29
115	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.29
116	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.29
117	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.29
118	Cebalid syndrome	Enrichment	MTOR	2.29
119	Rela fusion-positive ependymoma	Enrichment	RELA	2.29
120	Acute basophilic leukemia	Enrichment	MYB	2.29
121	Angiocentric glioma	Enrichment	MYB	2.29
122	Melanoma, cutaneous malignant 9	Enrichment	TERT	2.29
123	Smith-kingsmore syndrome	Enrichment	MTOR	2.29
124	Idiopathic interstitial pneumonia	Enrichment	TERT	2.29
125	Joint contractures, osteochondromas, and b-cell lymphoma	Enrichment	NFATC2	2.29
126	Common variable immunodeficiency 12	Enrichment	NFKB1	2.29
127	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA	2.24
128	Immunodeficiency 31c	Enrichment	STAT1	2.19
129	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.18
130	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	FASLG	2.18
131	Nuchal bleb, familial	Enrichment	SOS1	2.18
132	Psoriatic arthritis	Enrichment	LTA	2.18
133	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.18
134	Immunodeficiency 14	Enrichment	PIK3R1	2.18
135	Tricuspid valve insufficiency	Enrichment	PTPN11	2.18
136	Keratoacanthoma	Enrichment	PIK3CA	2.18
137	Niemann-pick disease, type a	Enrichment	SMPD1	2.11
138	Niemann-pick disease, type b	Enrichment	SMPD1	2.11
139	Ceroid lipofuscinosis, neuronal, 6a	Enrichment	SMPD1	2.11
140	Interstitial lung disease	Enrichment	TERT	2.11
141	Macrocytic anemia	Enrichment	TERT	2.11
142	Adenoid cystic carcinoma	Enrichment	MYB	2.11
143	Omenn syndrome	Enrichment	IL2RG	2.05
144	Autoimmune lymphoproliferative syndrome	Enrichment	FASLG	2.05
145	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.05
146	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	CCND2	2.05
147	Cerebrovascular disease	Enrichment	PIK3CA	2.05
148	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	2.05
149	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.05
150	Gingival fibromatosis	Enrichment	SOS1	2.05
151	Immune deficiency disease	Enrichment	SYK	2.01
152	Combined immunodeficiency	Enrichment	IL2RG	2.01
153	Ichthyosis	Enrichment	IL2RB	2.01
154	Combined t cell and b cell immunodeficiency	Enrichment	IL2RG	2.01
155	Combined t and b cell immunodeficiency	Enrichment	IL2RG	2.01
156	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.01
157	Immune thrombocytopenia	Enrichment	SOCS1	2.01
158	Tuberous sclerosis 1	Enrichment	IFNG	2.01
159	Langerhans cell histiocytosis	Enrichment	MAP2K1	2.01
160	Hepatitis c virus	Enrichment	IFNG	2.01
161	Tuberous sclerosis 2	Enrichment	IFNG	2.01
162	Autoinflammatory syndrome, familial, with or without immunodeficiency	Enrichment	SOCS1	2.01
163	Immunodeficiency 84	Enrichment	IKZF3	2.01
164	Bacteremia 2	Enrichment	CISH	2.01
165	Hyper ige syndrome	Enrichment	STAT3	2.01
166	Wieacker-wolff syndrome	Enrichment	RASA1	2.01
167	Focal cortical dysplasia, type ii	Enrichment	MTOR	1.99
168	Lung sarcomatoid carcinoma	Enrichment	TERT	1.99
169	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	1.99
170	Hemophagocytic lymphohistiocytosis, familial, 1	Enrichment	PRF1	1.96
171	Follicular lymphoma	Enrichment	BCL2	1.96
172	Lymphoma	Enrichment	PTPN11	1.96
173	Idiopathic aplastic anemia	Enrichment	PRF1	1.96
174	Nk-cell enteropathy	Enrichment	JAK3	1.94
175	Niemann-pick disease, type c1	Enrichment	SMPD1	1.89
176	Niemann-pick disease	Enrichment	SMPD1	1.89
177	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1	1.89
178	Anemia, autoimmune hemolytic	Enrichment	SOCS1	1.89
179	Congenital generalized lipodystrophy	Enrichment	FOS	1.89
180	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1	1.89
181	Tuberculosis	Enrichment	CISH	1.89
182	Cowden syndrome 1	Enrichment	PIK3CA	1.88
183	Type 1 diabetes mellitus	Enrichment	FOXP3	1.88
184	Patent ductus arteriosus	Enrichment	PTPN11	1.88
185	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.88
186	Nevus, epidermal	Enrichment	PIK3CA	1.81
187	Gallbladder cancer	Enrichment	PIK3CA	1.81
188	Dyskeratosis congenita, autosomal dominant 1	Enrichment	TERT	1.81
189	Pulmonary fibrosis	Enrichment	TERT	1.81
190	Adrenocortical carcinoma	Enrichment	TERT	1.81
191	Hoyeraal-hreidarsson syndrome	Enrichment	TERT	1.81
192	Kidney clear cell sarcoma	Enrichment	TERT	1.81
193	Histiocytoid hemangioma	Enrichment	FOS	1.79
194	Lymphoma, non-hodgkin, familial	Enrichment	PRF1	1.76
195	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.75
196	Dyskeratosis congenita, autosomal dominant 2	Enrichment	TERT	1.75
197	Common variable immunodeficiency	Enrichment	NFKB1	1.75
198	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	1.71
199	Hemangioma, capillary infantile	Enrichment	RASA1	1.71
200	Basal cell carcinoma 1	Enrichment	RASA1	1.71
201	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.71
202	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.70
203	Hydrops fetalis	Enrichment	FOXP3	1.70
204	Aplastic anemia	Enrichment	PRF1	1.66
205	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.66
206	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	1.65
207	Pilomyxoid astrocytoma	Enrichment	RAF1	1.65
208	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.64
209	Pectus excavatum	Enrichment	PTPN11	1.62
210	Specific learning disability	Enrichment	PTPN11	1.62
211	Severe covid-19	Enrichment	JAK3	1.60
212	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.59
213	Melanocytic nevus syndrome, congenital	Enrichment	RAF1	1.59
214	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.59
215	Epicanthus	Enrichment	PTPN11	1.58
216	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.58
217	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.58
218	Congenital long qt syndrome	Enrichment	PTPN11	1.58
219	Ovarian cancer	Enrichment	AKT1, PIK3CA	1.56
220	Aortic valve disease 1	Enrichment	SOS1	1.55
221	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.52
222	Leukemia, chronic lymphocytic	Enrichment	IKZF3	1.50
223	Lynch syndrome	Enrichment	PIK3CA	1.49
224	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	1.48
225	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.42
226	Rare genetic intellectual disability	Enrichment	MTOR	1.42
227	Patent foramen ovale	Enrichment	PTPN11	1.41
228	Melanoma, cutaneous malignant 1	Enrichment	TERT	1.37
229	Interstitial lung disease 2	Enrichment	TERT	1.37
230	Endometrial cancer	Enrichment	PIK3CA	1.34
231	Centronuclear myopathy	Enrichment	FOXP3	1.34
232	Myocardial infarction	Enrichment	LTA	1.32
233	Dyskeratosis congenita	Enrichment	TERT	1.32
234	Autism spectrum disorder	Enrichment	MAP2K1, PTPN11	1.31
235	Autoinflammatory disease	Enrichment	PRF1	1.29
236	Scoliosis	Enrichment	PTPN11	1.29
237	Cardiomyopathy, dilated, 1a	Enrichment	NFATC2	1.28
238	Hepatoblastoma	Enrichment	TERT	1.28
239	Hydrops fetalis, nonimmune	Enrichment	PTPN11	1.25
240	Human immunodeficiency virus type 1	Enrichment	IFNG	1.25
241	Strabismus	Enrichment	PTPN11	1.24
242	Prostate cancer	Enrichment	PIK3CA	1.21
243	Long qt syndrome 1	Enrichment	PTPN11	1.19
244	Non-immune hydrops fetalis	Enrichment	PTPN11	1.18
245	Primary autosomal recessive microcephaly	Enrichment	CDK6	1.16
246	Malaria	Enrichment	CISH	1.14
247	Differentiated thyroid carcinoma	Enrichment	TERT	1.14
248	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.12
249	Gastric cancer	Enrichment	PIK3CA	1.04
250	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.04
251	Leukemia, acute myeloid	Enrichment	TERT	1.01
252	Thrombocytopenia	Enrichment	PTPN11	1.00
253	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.99
254	Left ventricular noncompaction	Enrichment	RAF1	0.97
255	Hypertelorism	Enrichment	PIK3CA	0.96
256	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.93
257	Systemic lupus erythematosus	Enrichment	SOCS1	0.92
258	Type 2 diabetes mellitus	Enrichment	IRS1	0.89
259	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.80
260	Dilated cardiomyopathy	Enrichment	RAF1	0.64
261	Microcephaly	Enrichment	PTPN11	0.62
262	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	0.59

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

IL2 signaling events mediated by STAT5

Pathway Network for IL2 signaling events mediated by STAT5

Pathway network for the IL2 signaling events mediated by STAT5 SuperPath

Member Pathways for IL2 signaling events mediated by STAT5

Pathways in the IL2 signaling events mediated by STAT5 SuperPath

Gene overlap in member pathways for IL2 signaling events mediated by STAT5 SuperPath

Associated Genes for IL2 signaling events mediated by STAT5

Associated Disorders for IL2 signaling events mediated by STAT5

Disorders associated with IL2 signaling events mediated by STAT5 SuperPath

STRING Interaction Network for IL2 signaling events mediated by STAT5

Sources for IL2 signaling events mediated by STAT5