IL3-mediated signaling events

Pathway network for the IL3-mediated signaling events SuperPath

Sources:

PubChem

Pathways in the IL3-mediated signaling events SuperPath

#	Name	Source	Genes
1	IL3-mediated signaling events	PubChem	BCL2L1 CEBPB CISH CNKSR1 CSF2RB GAB2 GRB2 HDAC1 ID1 IL3 IL3RA JAK2 OSM PIK3CA PIK3R1 PIM1 PRKACA PRKACB PTPN11 SHC1 SRP9 STAT5A STAT5B YWHAG YWHAZ (see all 25) (see less)
2	GMCSF-mediated signaling events	PubChem	CCL2 CISH CSF2 CSF2RA CSF2RB FOS GAB2 GRB2 IKBKB IRF8 JAK2 LYN MAP2K1 MAPK3 OSM PIK3CA PIK3R1 PIM1 PRKACA PRKACB PTPN11 RAF1 SHC1 SOS1 STAT1 STAT2 STAT3 STAT5A STAT5B SYK YWHAZ (see all 31) (see less)
3	IL5-mediated signaling events	PubChem	CISH CSF2RB GRB2 IL5 IL5RA JAK2 LYN PIK3CA PIK3R1 PIM1 PTPN11 SDCBP STAT5A STAT5B (see all 14) (see less)

Gene overlap in member pathways for IL3-mediated signaling events SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CISH	Cytokine Inducible SH2 Containing Protein	Protein Coding	3
2	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	3
3	PIM1	Pim-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	3
4	CSF2RB	Colony Stimulating Factor 2 Receptor Subunit Beta	Protein Coding	3
5	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	3
6	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	3
7	JAK2	Janus Kinase 2	Protein Coding	3
8	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	3
9	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	3
10	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	3
11	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	2
12	OSM	Oncostatin M	Protein Coding	2
13	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	2
14	YWHAZ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta	Protein Coding	2
15	GAB2	GRB2 Associated Binding Protein 2	Protein Coding	2
16	SHC1	SHC Adaptor Protein 1	Protein Coding	2
17	LYN	LYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	2
18	CNKSR1	Connector Enhancer Of Kinase Suppressor Of Ras 1	Protein Coding	1
19	IL3RA	Interleukin 3 Receptor Subunit Alpha	Protein Coding	1
20	IL3	Interleukin 3	Protein Coding	1
21	SRP9	Signal Recognition Particle 9	Protein Coding	1
22	ID1	Inhibitor Of DNA Binding 1	Protein Coding	1
23	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	1
24	YWHAG	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma	Protein Coding	1
25	BCL2L1	BCL2 Like 1	Protein Coding	1
26	HDAC1	Histone Deacetylase 1	Protein Coding	1
27	IRF8	Interferon Regulatory Factor 8	Protein Coding	1
28	STAT2	Signal Transducer And Activator Of Transcription 2	Protein Coding	1
29	CSF2	Colony Stimulating Factor 2	Protein Coding	1
30	CSF2RA	Colony Stimulating Factor 2 Receptor Subunit Alpha	Protein Coding	1
31	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	1
32	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
33	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
34	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	1
35	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
36	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
37	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
38	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
39	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
40	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
41	IL5RA	Interleukin 5 Receptor Subunit Alpha	Protein Coding	1
42	IL5	Interleukin 5	Protein Coding	1
43	SDCBP	Syndecan Binding Protein	Protein Coding	1

Disorders associated with IL3-mediated signaling events SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome and noonan-related syndrome	Enrichment	MAP2K1, PTPN11, RAF1, SOS1	7.52
2	Noonan syndrome 1	Enrichment	MAP2K1, PTPN11, RAF1, SOS1	6.72
3	Rasopathy	Enrichment	MAP2K1, PTPN11, RAF1, SOS1	6.49
4	Noonan syndrome 3	Enrichment	PTPN11, RAF1, SOS1	6.42
5	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	5.53
6	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK2, STAT3	4.82
7	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11, YWHAZ	4.71
8	Noonan syndrome with multiple lentigines	Enrichment	PTPN11, RAF1	4.52
9	Hereditary pulmonary alveolar proteinosis	Enrichment	CSF2RA, CSF2RB	4.30
10	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1, PIK3CA	3.98
11	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	3.93
12	Specific learning disability	Enrichment	PTPN11, YWHAG	3.75
13	Arteriovenous malformation	Enrichment	MAP2K1, PIK3CA	3.74
14	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1, PIK3CA	3.65
15	Lung non-small cell carcinoma	Enrichment	MAP2K1, PIK3CA	3.56
16	Acute promyelocytic leukemia	Enrichment	STAT3, STAT5B	3.41
17	Macrodactyly	Enrichment	PIK3CA	2.99
18	Metachondromatosis	Enrichment	PTPN11	2.99
19	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.99
20	Leopard syndrome 1	Enrichment	PTPN11	2.99
21	Cowden syndrome 5	Enrichment	PIK3CA	2.99
22	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.99
23	Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant	Enrichment	STAT5B	2.99
24	Short syndrome	Enrichment	PIK3R1	2.99
25	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.99
26	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.99
27	Surfactant metabolism dysfunction, pulmonary, 5	Enrichment	CSF2RB	2.99
28	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.99
29	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.99
30	Autoinflammatory disease, systemic, with vasculitis	Enrichment	LYN	2.99
31	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.99
32	Hypospadias	Enrichment	PIK3CA	2.99
33	Rare venous malformation	Enrichment	PIK3CA	2.99
34	Diaphragmatic eventration	Enrichment	PIK3CA	2.99
35	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.99
36	Rare combined vascular malformation	Enrichment	PIK3CA	2.99
37	Cavernous lymphangioma	Enrichment	PIK3CA	2.99
38	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.99
39	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.99
40	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.99
41	Macrodactyly of toe	Enrichment	PIK3CA	2.99
42	Malignant astrocytoma	Enrichment	PTPN11	2.99
43	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	2.73
44	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.73
45	Developmental and epileptic encephalopathy 56	Enrichment	YWHAG	2.73
46	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.73
47	Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive	Enrichment	STAT5B	2.69
48	Keratosis, seborrheic	Enrichment	PIK3CA	2.69
49	Noonan syndrome 8	Enrichment	PIK3CA	2.69
50	Thrombocythemia 3	Enrichment	JAK2	2.69
51	Werner syndrome	Enrichment	PTPN11	2.69
52	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.69
53	Polycythemia	Enrichment	JAK2	2.69
54	Hypereosinophilic syndrome	Enrichment	JAK2	2.69
55	Laron syndrome with immunodeficiency	Enrichment	STAT5B	2.69
56	Surfactant metabolism dysfunction, pulmonary, 4	Enrichment	CSF2RA	2.64
57	Noonan syndrome 5	Enrichment	RAF1	2.64
58	Noonan syndrome 4	Enrichment	SOS1	2.64
59	Melorheostosis, isolated	Enrichment	MAP2K1	2.64
60	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.64
61	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.64
62	Immunodeficiency 32a	Enrichment	IRF8	2.64
63	Immunodeficiency 15b	Enrichment	IKBKB	2.64
64	Pseudo-torch syndrome 3	Enrichment	STAT2	2.64
65	Immunodeficiency 82 with systemic inflammation	Enrichment	SYK	2.64
66	Immunodeficiency 15a	Enrichment	IKBKB	2.64
67	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.64
68	Melorheostosis	Enrichment	MAP2K1	2.64
69	Leopard syndrome 2	Enrichment	RAF1	2.64
70	Immunodeficiency 31a	Enrichment	STAT1	2.64
71	Immunodeficiency 31b	Enrichment	STAT1	2.64
72	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.64
73	Trigonitis	Enrichment	RAF1	2.64
74	Colitis	Enrichment	SYK	2.64
75	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.64
76	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.64
77	Polycythemia vera	Enrichment	JAK2	2.51
78	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.51
79	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.51
80	Bacteremia 2	Enrichment	CISH	2.51
81	Immunodeficiency 14	Enrichment	PIK3R1	2.51
82	Tricuspid valve insufficiency	Enrichment	PTPN11	2.51
83	Keratoacanthoma	Enrichment	PIK3CA	2.51
84	Colorectal cancer	Enrichment	PIK3CA, PIK3R1	2.45
85	Fibrolamellar carcinoma	Enrichment	PRKACA	2.43
86	Erythrocytosis, familial, 1	Enrichment	JAK2	2.38
87	Budd-chiari syndrome	Enrichment	JAK2	2.38
88	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.38
89	Cerebrovascular disease	Enrichment	PIK3CA	2.38
90	Tuberculosis	Enrichment	CISH	2.38
91	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.38
92	Fibromatosis, gingival, 1	Enrichment	SOS1	2.34
93	Immunodeficiency 32b	Enrichment	IRF8	2.34
94	Pulmonic stenosis	Enrichment	SOS1	2.34
95	Immunodeficiency 31c	Enrichment	STAT1	2.34
96	Arthritis	Enrichment	SYK	2.34
97	Capillary malformations, congenital	Enrichment	PIK3CA	2.29
98	Lymphoma	Enrichment	PTPN11	2.29
99	Myeloproliferative neoplasm	Enrichment	JAK2	2.29
100	Hemimegalencephaly	Enrichment	PIK3CA	2.29
101	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	2.21
102	Cowden syndrome 1	Enrichment	PIK3CA	2.21
103	Hemihyperplasia, isolated	Enrichment	PIK3CA	2.21
104	Patent ductus arteriosus	Enrichment	PTPN11	2.21
105	Breast adenocarcinoma	Enrichment	PIK3CA	2.21
106	Lung squamous cell carcinoma	Enrichment	PIK3CA	2.21
107	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.16
108	Nuchal bleb, familial	Enrichment	SOS1	2.16
109	Langerhans cell histiocytosis	Enrichment	MAP2K1	2.16
110	Hyper ige syndrome	Enrichment	STAT3	2.16
111	Immunodeficiency 44	Enrichment	STAT2	2.16
112	Nevus, epidermal	Enrichment	PIK3CA	2.14
113	Myelofibrosis	Enrichment	JAK2	2.14
114	Essential thrombocythemia	Enrichment	JAK2	2.14
115	Gallbladder cancer	Enrichment	PIK3CA	2.14
116	Overgrowth syndrome	Enrichment	PIK3R1	2.14
117	Breast cancer	Enrichment	PIK3CA, SHC1	2.08
118	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1	2.04
119	Congenital generalized lipodystrophy	Enrichment	FOS	2.04
120	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1	2.04
121	Gingival fibromatosis	Enrichment	SOS1	2.04
122	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	2.03
123	Adult hepatocellular carcinoma	Enrichment	PIK3CA	2.03
124	Cowden syndrome	Enrichment	PIK3CA	2.03
125	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.99
126	Pectus excavatum	Enrichment	PTPN11	1.95
127	Histiocytoid hemangioma	Enrichment	FOS	1.94
128	Epicanthus	Enrichment	PTPN11	1.91
129	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.91
130	Meningioma	Enrichment	PIK3CA	1.91
131	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.91
132	Congenital long qt syndrome	Enrichment	PTPN11	1.91
133	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.87
134	Lynch syndrome	Enrichment	PIK3CA	1.81
135	Pilomyxoid astrocytoma	Enrichment	RAF1	1.80
136	Melanocytic nevus syndrome, congenital	Enrichment	RAF1	1.74
137	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.74
138	Patent foramen ovale	Enrichment	PTPN11	1.73
139	Microcephaly	Enrichment	PTPN11, YWHAG	1.67
140	Endometrial cancer	Enrichment	PIK3CA	1.67
141	Hepatocellular carcinoma	Enrichment	PIK3CA	1.65
142	Malaria	Enrichment	CISH	1.63
143	Scoliosis	Enrichment	PTPN11	1.61
144	Immune deficiency disease	Enrichment	SYK	1.60
145	Autism spectrum disorder	Enrichment	MAP2K1, PTPN11	1.59
146	Hydrops fetalis, nonimmune	Enrichment	PTPN11	1.58
147	Strabismus	Enrichment	PTPN11	1.56
148	Aortic valve disease 1	Enrichment	SOS1	1.53
149	Bladder cancer	Enrichment	PIK3CA	1.53
150	Prostate cancer	Enrichment	PIK3CA	1.53
151	Long qt syndrome 1	Enrichment	PTPN11	1.52
152	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.50
153	Non-immune hydrops fetalis	Enrichment	PTPN11	1.50
154	Lung cancer	Enrichment	PIK3CA	1.49
155	Human immunodeficiency virus type 1	Enrichment	CCL2	1.39
156	Leukemia, acute myeloid	Enrichment	JAK2	1.39
157	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.37
158	Esophageal atresia/tracheoesophageal fistula	Enrichment	IRF8	1.37
159	Gastric cancer	Enrichment	PIK3CA	1.36
160	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.36
161	Hereditary breast carcinoma	Enrichment	PIK3CA	1.35
162	Thrombocytopenia	Enrichment	PTPN11	1.31
163	Hypertelorism	Enrichment	PIK3CA	1.28
164	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.27
165	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	1.25
166	Primary ovarian insufficiency	Enrichment	JAK2	1.23
167	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.14
168	Severe combined immunodeficiency	Enrichment	IKBKB	1.14
169	Left ventricular noncompaction	Enrichment	RAF1	1.11
170	Autosomal dominant non-syndromic intellectual disability	Enrichment	YWHAZ	1.05
171	Undetermined early-onset epileptic encephalopathy	Enrichment	YWHAG	1.01
172	Ovarian cancer	Enrichment	PIK3CA	1.00
173	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.94
174	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	0.89
175	Dilated cardiomyopathy	Enrichment	RAF1	0.78

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

IL3-mediated signaling events

Pathway Network for IL3-mediated signaling events

Pathway network for the IL3-mediated signaling events SuperPath

Member Pathways for IL3-mediated signaling events

Pathways in the IL3-mediated signaling events SuperPath

Gene overlap in member pathways for IL3-mediated signaling events SuperPath

Associated Genes for IL3-mediated signaling events

Associated Disorders for IL3-mediated signaling events

Disorders associated with IL3-mediated signaling events SuperPath

STRING Interaction Network for IL3-mediated signaling events

Sources for IL3-mediated signaling events