IL4-mediated signaling events

No Pathway Network information available for IL4-mediated signaling events

Pathways in the IL4-mediated signaling events SuperPath

#	Name	Source	Genes
1	IL4-mediated signaling events	PubChem	AICDA AKT1 ALOX15 ARG1 BCL2L1 BCL6 CBL CCL11 CCL17 CCL26 CD40LG CD74 CEBPB COL1A1 COL1A2 DOK2 EGR2 ETS1 FCER2 FES GRB2 GTF3A HMGA1 IL10 IL13RA1 IL13RA2 IL2RG IL4 IL4R IL5 IRF4 IRS1 IRS2 ITGB3 JAK1 JAK2 JAK3 LTA MAPK14 MTOR OPRM1 PARP14 PIGR PIK3CA PIK3R1 PTPN6 RETNLB RPS6KB1 SELP SHC1 SOCS1 SOCS3 SOCS5 SP1 SPI1 STAT5A STAT5B STAT6 TFF3 THY1 (see all 60) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CCL26	C-C Motif Chemokine Ligand 26	Protein Coding	1
2	SOCS5	Suppressor Of Cytokine Signaling 5	Protein Coding	1
3	RETNLB	Resistin Like Beta	Protein Coding	1
4	CCL17	C-C Motif Chemokine Ligand 17	Protein Coding	1
5	PARP14	Poly(ADP-Ribose) Polymerase Family Member 14	Protein Coding	1
6	SELP	Selectin P	Protein Coding	1
7	CCL11	C-C Motif Chemokine Ligand 11	Protein Coding	1
8	THY1	Thy-1 Cell Surface Antigen	Protein Coding	1
9	PIGR	Polymeric Immunoglobulin Receptor	Protein Coding	1
10	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	1
11	AICDA	Activation Induced Cytidine Deaminase	Protein Coding	1
12	IRF4	Interferon Regulatory Factor 4	Protein Coding	1
13	LTA	Lymphotoxin Alpha	Protein Coding	1
14	IL10	Interleukin 10	Protein Coding	1
15	IL13RA2	Interleukin 13 Receptor Subunit Alpha 2	Protein Coding	1
16	IL13RA1	Interleukin 13 Receptor Subunit Alpha 1	Protein Coding	1
17	IL4R	Interleukin 4 Receptor	Protein Coding	1
18	IL4	Interleukin 4	Protein Coding	1
19	IL5	Interleukin 5	Protein Coding	1
20	IL2RG	Interleukin 2 Receptor Subunit Gamma	Protein Coding	1
21	JAK3	Janus Kinase 3	Protein Coding	1
22	STAT6	Signal Transducer And Activator Of Transcription 6	Protein Coding	1
23	CD40LG	CD40 Ligand	Protein Coding	1
24	GTF3A	General Transcription Factor IIIA	Protein Coding	1
25	SPI1	Spi-1 Proto-Oncogene	Protein Coding	1
26	COL1A1	Collagen Type I Alpha 1 Chain	Protein Coding	1
27	BCL6	BCL6 Transcription Repressor	Protein Coding	1
28	HMGA1	High Mobility Group AT-Hook 1	Protein Coding	1
29	ETS1	ETS Proto-Oncogene 1, Transcription Factor	Protein Coding	1
30	TFF3	Trefoil Factor 3	Protein Coding	1
31	FCER2	Fc Epsilon Receptor II	Protein Coding	1
32	OPRM1	Opioid Receptor Mu 1	Protein Coding	1
33	COL1A2	Collagen Type I Alpha 2 Chain	Protein Coding	1
34	SOCS1	Suppressor Of Cytokine Signaling 1	Protein Coding	1
35	ARG1	Arginase 1	Protein Coding	1
36	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
37	ALOX15	Arachidonate 15-Lipoxygenase	Protein Coding	1
38	DOK2	Docking Protein 2	Protein Coding	1
39	CD74	CD74 Molecule	Protein Coding	1
40	PTPN6	Protein Tyrosine Phosphatase Non-Receptor Type 6	Protein Coding	1
41	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
42	SP1	Sp1 Transcription Factor	Protein Coding	1
43	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	1
44	EGR2	Early Growth Response 2	Protein Coding	1
45	FES	FES Proto-Oncogene, Tyrosine Kinase	Protein Coding	1
46	CBL	Cbl Proto-Oncogene	Protein Coding	1
47	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
48	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	1
49	JAK2	Janus Kinase 2	Protein Coding	1
50	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	1
51	ITGB3	Integrin Subunit Beta 3	Protein Coding	1
52	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	1
53	BCL2L1	BCL2 Like 1	Protein Coding	1
54	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
55	IRS2	Insulin Receptor Substrate 2	Protein Coding	1
56	IRS1	Insulin Receptor Substrate 1	Protein Coding	1
57	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
58	SHC1	SHC Adaptor Protein 1	Protein Coding	1
59	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
60	JAK1	Janus Kinase 1	Protein Coding	1

Disorders associated with IL4-mediated signaling events SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Ehlers-danlos syndrome, arthrochalasia type, 2	Enrichment	COL1A1, COL1A2	4.72
2	Ehlers-danlos/osteogenesis imperfecta syndrome	Enrichment	COL1A1, COL1A2	4.72
3	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.24
4	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, JAK2	4.24
5	High bone mass osteogenesis imperfecta	Enrichment	COL1A1, COL1A2	4.24
6	Ehlers-danlos syndrome, arthrochalasia type, 1	Enrichment	COL1A1, COL1A2	3.94
7	Osteogenesis imperfecta with normal sclerae, dominant form	Enrichment	COL1A1, COL1A2	3.94
8	Myeloproliferative neoplasm	Enrichment	CBL, JAK2	3.72
9	Hemimegalencephaly	Enrichment	MTOR, PIK3CA	3.72
10	Ehlers-danlos syndrome, classic type, 1	Enrichment	COL1A1, COL1A2	3.54
11	Osteogenesis imperfecta, type i	Enrichment	COL1A1, COL1A2	3.54
12	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	3.54
13	Classic ehlers-danlos syndrome	Enrichment	COL1A1, COL1A2	3.54
14	Osteogenesis imperfecta, type ii	Enrichment	COL1A1, COL1A2	3.40
15	Overgrowth syndrome	Enrichment	MTOR, PIK3R1	3.40
16	Systemic lupus erythematosus	Enrichment	ETS1, IL10, SOCS1	3.17
17	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.17
18	Type 2 diabetes mellitus	Enrichment	HMGA1, IRS1, IRS2	3.08
19	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1, SPI1	3.07
20	Primary bone dysplasia	Enrichment	COL1A1, COL1A2	3.07
21	Osteochondrodysplasia	Enrichment	COL1A1, COL1A2	2.99
22	Meningioma	Enrichment	AKT1, PIK3CA	2.91
23	Osteogenesis imperfecta, type iv	Enrichment	COL1A1, COL1A2	2.84
24	Osteoporosis	Enrichment	COL1A1, COL1A2	2.77
25	Osteogenesis imperfecta, type iii	Enrichment	COL1A1, COL1A2	2.71
26	Human immunodeficiency virus type 1	Enrichment	CCL11, IL10	2.55
27	Ehlers-danlos syndrome	Enrichment	COL1A1, COL1A2	2.50
28	Myocardial infarction	Enrichment	ITGB3, LTA	2.38
29	Macrodactyly	Enrichment	PIK3CA	2.35
30	Proteus syndrome	Enrichment	AKT1	2.35
31	Ehlers-danlos syndrome, cardiac valvular type	Enrichment	COL1A2	2.35
32	Leprosy 4	Enrichment	LTA	2.35
33	Charcot-marie-tooth disease, demyelinating, type 1d	Enrichment	EGR2	2.35
34	Skin/hair/eye pigmentation, variation in, 8	Enrichment	IRF4	2.35
35	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.35
36	Dermatitis, atopic, 4	Enrichment	SOCS3	2.35
37	Cowden syndrome 5	Enrichment	PIK3CA	2.35
38	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.35
39	Agammaglobulinemia 10, autosomal dominant	Enrichment	SPI1	2.35
40	Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant	Enrichment	STAT5B	2.35
41	Hyper-ige syndrome 6, autosomal dominant, with recurrent infections	Enrichment	STAT6	2.35
42	Immunodeficiency with hyper-igm, type 1	Enrichment	CD40LG	2.35
43	Immunodeficiency 131	Enrichment	IRF4	2.35
44	Short syndrome	Enrichment	PIK3R1	2.35
45	Combined osteogenesis imperfecta and ehlers-danlos syndrome 2	Enrichment	COL1A2	2.35
46	Graft-versus-host disease	Enrichment	IL10	2.35
47	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.35
48	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.35
49	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.35
50	Cowden syndrome 6	Enrichment	AKT1	2.35
51	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.35
52	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.35
53	Asphyxia neonatorum	Enrichment	COL1A1	2.35
54	T-b+ severe combined immunodeficiency due to jak3 deficiency	Enrichment	JAK3	2.35
55	Hypospadias	Enrichment	PIK3CA	2.35
56	Charcot-marie-tooth disease type 1d	Enrichment	EGR2	2.35
57	Agammaglobulinemia	Enrichment	SPI1	2.35
58	Rare venous malformation	Enrichment	PIK3CA	2.35
59	Vegetative pyoderma gangrenosum	Enrichment	PTPN6	2.35
60	Bullous pyoderma gangrenosum	Enrichment	PTPN6	2.35
61	Cd40 ligand deficiency	Enrichment	CD40LG	2.35
62	Diaphragmatic eventration	Enrichment	PIK3CA	2.35
63	Pustular pyoderma gangrenosum	Enrichment	PTPN6	2.35
64	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.35
65	Rare combined vascular malformation	Enrichment	PIK3CA	2.35
66	Cavernous lymphangioma	Enrichment	PIK3CA	2.35
67	Whipple disease	Enrichment	IRF4	2.35
68	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.35
69	Classic pyoderma gangrenosum	Enrichment	PTPN6	2.35
70	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.35
71	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.35
72	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.35
73	Macrodactyly of toe	Enrichment	PIK3CA	2.35
74	Breast cancer	Enrichment	AKT1, PIK3CA, SHC1	2.35
75	Brittle bone disorder	Enrichment	COL1A1, COL1A2	2.34
76	Colorectal cancer	Enrichment	AKT1, PIK3CA, PIK3R1	2.17
77	Epiphyseal dysplasia, multiple, 1	Enrichment	COL1A1	2.05
78	Hemangiopericytoma, malignant	Enrichment	STAT6	2.05
79	Bruck syndrome 1	Enrichment	COL1A2	2.05
80	Argininemia	Enrichment	ARG1	2.05
81	Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive	Enrichment	STAT5B	2.05
82	Ovarian germ cell cancer	Enrichment	CBL	2.05
83	Dermatofibrosarcoma protuberans	Enrichment	COL1A1	2.05
84	Immunodeficiency with hyper-igm, type 2	Enrichment	AICDA	2.05
85	Keratosis, seborrheic	Enrichment	PIK3CA	2.05
86	Neuropathy, congenital hypomyelinating, 1, autosomal recessive	Enrichment	EGR2	2.05
87	Noonan syndrome 8	Enrichment	PIK3CA	2.05
88	Thrombocythemia 3	Enrichment	JAK2	2.05
89	Combined osteogenesis imperfecta and ehlers-danlos syndrome 1	Enrichment	COL1A1	2.05
90	Cebalid syndrome	Enrichment	MTOR	2.05
91	Intravascular large b-cell lymphoma	Enrichment	BCL6	2.05
92	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.05
93	Stickler syndrome, type ii	Enrichment	COL1A1	2.05
94	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.05
95	Smith-kingsmore syndrome	Enrichment	MTOR	2.05
96	Polycythemia	Enrichment	JAK2	2.05
97	Hypereosinophilic syndrome	Enrichment	JAK2	2.05
98	Malignant germ cell tumor of ovary	Enrichment	CBL	2.05
99	Dentinogenesis imperfecta	Enrichment	COL1A2	2.05
100	Primary mediastinal large b-cell lymphoma	Enrichment	BCL6	2.05
101	Laron syndrome with immunodeficiency	Enrichment	STAT5B	2.05
102	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	JAK3	1.88
103	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3	1.88
104	Jacobsen syndrome	Enrichment	ETS1	1.88
105	Bleeding disorder, platelet-type, 16	Enrichment	ITGB3	1.88
106	Immune thrombocytopenia	Enrichment	SOCS1	1.88
107	Polycythemia vera	Enrichment	JAK2	1.88
108	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.88
109	Severe combined immunodeficiency, x-linked	Enrichment	IL2RG	1.88
110	Combined immunodeficiency, x-linked	Enrichment	IL2RG	1.88
111	Psoriatic arthritis	Enrichment	LTA	1.88
112	Caffey disease	Enrichment	COL1A1	1.88
113	Neutrophilic dermatosis, acute febrile	Enrichment	PTPN6	1.88
114	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.88
115	Autoinflammatory syndrome, familial, with or without immunodeficiency	Enrichment	SOCS1	1.88
116	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL6	1.88
117	Immunodeficiency 14	Enrichment	PIK3R1	1.88
118	Charcot-marie-tooth disease type 1	Enrichment	EGR2	1.88
119	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	1.88
120	Keratoacanthoma	Enrichment	PIK3CA	1.88
121	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA	1.79
122	Erythrocytosis, familial, 1	Enrichment	JAK2	1.76
123	Anemia, autoimmune hemolytic	Enrichment	SOCS1	1.76
124	Phenylketonuria	Enrichment	COL1A1	1.76
125	Budd-chiari syndrome	Enrichment	JAK2	1.76
126	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	1.76
127	Focal cortical dysplasia, type ii	Enrichment	MTOR	1.76
128	Cerebrovascular disease	Enrichment	PIK3CA	1.76
129	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL	1.76
130	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.76
131	Adenosine deaminase deficiency	Enrichment	JAK3	1.76
132	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	1.76
133	Hypertrophic neuropathy of dejerine-sottas	Enrichment	EGR2	1.66
134	Capillary malformations, congenital	Enrichment	PIK3CA	1.66
135	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	JAK3	1.66
136	Glanzmann thrombasthenia 2	Enrichment	ITGB3	1.66
137	Follicular lymphoma	Enrichment	BCL6	1.66
138	Aggressive systemic mastocytosis	Enrichment	CBL	1.66
139	Hypertelorism	Enrichment	COL1A1, PIK3CA	1.65
140	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.58
141	Cowden syndrome 1	Enrichment	PIK3CA	1.58
142	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.58
143	Keratoconus	Enrichment	COL1A1	1.58
144	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGB3	1.58
145	Il10-related early-onset inflammatory bowel disease	Enrichment	IL10	1.58
146	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.58
147	Nevus, epidermal	Enrichment	PIK3CA	1.51
148	Myelofibrosis	Enrichment	JAK2	1.51
149	Glanzmann thrombasthenia 1	Enrichment	ITGB3	1.51
150	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.51
151	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.51
152	Essential thrombocythemia	Enrichment	JAK2	1.51
153	Gallbladder cancer	Enrichment	PIK3CA	1.51
154	Common variable immunodeficiency	Enrichment	CD40LG	1.51
155	Rheumatoid arthritis	Enrichment	IL10	1.41
156	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.41
157	Arteriovenous malformation	Enrichment	PIK3CA	1.41
158	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.41
159	Omenn syndrome	Enrichment	IL2RG	1.36
160	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.36
161	Autosomal dominant macrothrombocytopenia	Enrichment	ITGB3	1.36
162	Asthma	Enrichment	CCL11	1.32
163	Combined immunodeficiency	Enrichment	IL2RG	1.32
164	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.32
165	Combined t cell and b cell immunodeficiency	Enrichment	IL2RG	1.32
166	Combined t and b cell immunodeficiency	Enrichment	IL2RG	1.32
167	Juvenile myelomonocytic leukemia	Enrichment	CBL	1.29
168	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.29
169	Acute promyelocytic leukemia	Enrichment	STAT5B	1.25
170	Nk-cell enteropathy	Enrichment	JAK3	1.25
171	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.19
172	Lynch syndrome	Enrichment	PIK3CA	1.19
173	Rare genetic intellectual disability	Enrichment	MTOR	1.19
174	Noonan syndrome and noonan-related syndrome	Enrichment	CBL	1.19
175	Rhabdomyosarcoma	Enrichment	CBL	1.16
176	Ovarian cancer	Enrichment	AKT1, PIK3CA	1.13
177	Charcot-marie-tooth disease type 4	Enrichment	EGR2	1.11
178	Behcet syndrome	Enrichment	IL10	1.09
179	Diffuse large b-cell lymphoma	Enrichment	SOCS1	1.09
180	Endometrial cancer	Enrichment	PIK3CA	1.05
181	Hepatocellular carcinoma	Enrichment	PIK3CA	1.03
182	Noonan syndrome 1	Enrichment	CBL	1.01
183	Rasopathy	Enrichment	CBL	0.96
184	Bladder cancer	Enrichment	PIK3CA	0.92
185	Prostate cancer	Enrichment	PIK3CA	0.92
186	Severe covid-19	Enrichment	JAK3	0.92
187	Lung cancer	Enrichment	PIK3CA	0.88
188	Severe combined immunodeficiency	Enrichment	JAK3	0.87
189	Leukemia, acute myeloid	Enrichment	JAK2	0.79
190	Gastric cancer	Enrichment	PIK3CA	0.76
191	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	COL1A1	0.75
192	Thrombocytopenia	Enrichment	ITGB3	0.72
193	Primary ovarian insufficiency	Enrichment	JAK2	0.64

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

IL4-mediated signaling events

Pathway Network for IL4-mediated signaling events

Member Pathways for IL4-mediated signaling events

Pathways in the IL4-mediated signaling events SuperPath

Associated Genes for IL4-mediated signaling events

Associated Disorders for IL4-mediated signaling events

Disorders associated with IL4-mediated signaling events SuperPath

STRING Interaction Network for IL4-mediated signaling events

Sources for IL4-mediated signaling events