IL6-mediated signaling events

No Pathway Network information available for IL6-mediated signaling events

Pathways in the IL6-mediated signaling events SuperPath

#	Name	Source	Genes
1	IL6-mediated signaling events	PubChem	A1BG A2M AKT1 BCL2L1 CEBPB CEBPD CRP FGG FOS FOXO1 GRB2 HCK HSP90B1 IL6 IL6R IL6ST IRF1 JAK1 JAK2 JUN JUNB LBP LMO4 MAP2K4 MAP2K6 MAPK14 MCL1 MITF MYC PIAS1 PIAS3 PIK3CA PIK3R1 PRKCD PTPN11 PTPRE RAC1 SOCS3 SOS1 STAT1 STAT3 TIMP1 TNFSF11 TYK2 VAV1 (see all 45) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	A1BG	Alpha-1-B Glycoprotein	Protein Coding	1
2	CRP	C-Reactive Protein	Protein Coding	1
3	PTPRE	Protein Tyrosine Phosphatase Receptor Type E	Protein Coding	1
4	LMO4	LIM Domain Only 4	Protein Coding	1
5	MCL1	MCL1 Apoptosis Regulator, BCL2 Family Member	Protein Coding	1
6	TNFSF11	TNF Superfamily Member 11	Protein Coding	1
7	IL6ST	Interleukin 6 Cytokine Family Signal Transducer	Protein Coding	1
8	IL6R	Interleukin 6 Receptor	Protein Coding	1
9	LBP	Lipopolysaccharide Binding Protein	Protein Coding	1
10	HCK	HCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
11	HSP90B1	Heat Shock Protein 90 Beta Family Member 1	Protein Coding	1
12	PIAS3	Protein Inhibitor Of Activated STAT 3	Protein Coding	1
13	MITF	Melanocyte Inducing Transcription Factor	Protein Coding	1
14	IL6	Interleukin 6	Protein Coding	1
15	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1
16	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
17	JUNB	JunB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
18	PRKCD	Protein Kinase C Delta	Protein Coding	1
19	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
20	IRF1	Interferon Regulatory Factor 1	Protein Coding	1
21	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	1
22	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
23	FGG	Fibrinogen Gamma Chain	Protein Coding	1
24	TIMP1	TIMP Metallopeptidase Inhibitor 1	Protein Coding	1
25	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
26	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
27	CEBPD	CCAAT Enhancer Binding Protein Delta	Protein Coding	1
28	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	1
29	FOXO1	Forkhead Box O1	Protein Coding	1
30	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	1
31	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
32	RAC1	Rac Family Small GTPase 1	Protein Coding	1
33	A2M	Alpha-2-Macroglobulin	Protein Coding	1
34	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
35	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
36	JAK2	Janus Kinase 2	Protein Coding	1
37	PIAS1	Protein Inhibitor Of Activated STAT 1	Protein Coding	1
38	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	1
39	TYK2	Tyrosine Kinase 2	Protein Coding	1
40	BCL2L1	BCL2 Like 1	Protein Coding	1
41	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
42	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
43	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
44	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
45	JAK1	Janus Kinase 1	Protein Coding	1

Disorders associated with IL6-mediated signaling events SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, JAK2, STAT3	7.47
2	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.49
3	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	3.80
4	Noonan syndrome 3	Enrichment	PTPN11, SOS1	3.65
5	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.42
6	Lung non-small cell carcinoma	Enrichment	IRF1, PIK3CA	3.24
7	Meningioma	Enrichment	AKT1, PIK3CA	3.16
8	Noonan syndrome and noonan-related syndrome	Enrichment	PTPN11, SOS1	2.96
9	Diffuse large b-cell lymphoma	Enrichment	FOXO1, STAT3	2.75
10	Breast cancer	Enrichment	AKT1, JUN, PIK3CA	2.71
11	Noonan syndrome 1	Enrichment	PTPN11, SOS1	2.58
12	Colorectal cancer	Enrichment	AKT1, PIK3CA, PIK3R1	2.53
13	Macrodactyly	Enrichment	PIK3CA	2.48
14	Proteus syndrome	Enrichment	AKT1	2.48
15	Metachondromatosis	Enrichment	PTPN11	2.48
16	Immunodeficiency 35	Enrichment	TYK2	2.48
17	Noonan syndrome 4	Enrichment	SOS1	2.48
18	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.48
19	Dermatitis, atopic, 4	Enrichment	SOCS3	2.48
20	Heterochromia iridis	Enrichment	MITF	2.48
21	Leopard syndrome 1	Enrichment	PTPN11	2.48
22	Tietz albinism-deafness syndrome	Enrichment	MITF	2.48
23	Cowden syndrome 5	Enrichment	PIK3CA	2.48
24	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.48
25	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.48
26	Stuve-wiedemann syndrome 2	Enrichment	IL6ST	2.48
27	Hyper-ige syndrome 4a, autosomal dominant, with recurrent infections	Enrichment	IL6ST	2.48
28	Short syndrome	Enrichment	PIK3R1	2.48
29	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.48
30	Coloboma, osteopetrosis, microphthalmia, macrocephaly, albinism, and deafness	Enrichment	MITF	2.48
31	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.48
32	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.48
33	Interleukin 6, serum level of, quantitative trait locus	Enrichment	IL6R	2.48
34	Immunodeficiency 31a	Enrichment	STAT1	2.48
35	Soluble interleukin-6 receptor, serum level of, quantitative trait locus	Enrichment	IL6R	2.48
36	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.48
37	Cowden syndrome 6	Enrichment	AKT1	2.48
38	Hyper-ige syndrome 5, autosomal recessive, with recurrent infections	Enrichment	IL6R	2.48
39	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.48
40	Immunodeficiency 31b	Enrichment	STAT1	2.48
41	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.48
42	Hyper-ige syndrome 4b, autosomal recessive, with recurrent infections	Enrichment	IL6ST	2.48
43	Immunodeficiency 94 with autoinflammation and dysmorphic facies	Enrichment	IL6ST	2.48
44	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.48
45	Autoinflammation with pulmonary and cutaneous vasculitis	Enrichment	HCK	2.48
46	Congenital fibrinogen deficiency	Enrichment	FGG	2.48
47	Hypospadias	Enrichment	PIK3CA	2.48
48	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.48
49	Rare venous malformation	Enrichment	PIK3CA	2.48
50	Diaphragmatic eventration	Enrichment	PIK3CA	2.48
51	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.48
52	Rare combined vascular malformation	Enrichment	PIK3CA	2.48
53	Cavernous lymphangioma	Enrichment	PIK3CA	2.48
54	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.48
55	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.48
56	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.48
57	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.48
58	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.48
59	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.48
60	Macrodactyly of toe	Enrichment	PIK3CA	2.48
61	Malignant astrocytoma	Enrichment	PTPN11	2.48
62	Rasopathy	Enrichment	PTPN11, SOS1	2.48
63	Lung cancer	Enrichment	IRF1, PIK3CA	2.30
64	Burkitt lymphoma	Enrichment	MYC	2.18
65	Fibromatosis, gingival, 1	Enrichment	SOS1	2.18
66	Pulmonic stenosis	Enrichment	SOS1	2.18
67	Keratosis, seborrheic	Enrichment	PIK3CA	2.18
68	Noonan syndrome 8	Enrichment	PIK3CA	2.18
69	Thrombocythemia 3	Enrichment	JAK2	2.18
70	Osteopetrosis, autosomal recessive 2	Enrichment	TNFSF11	2.18
71	Immunodeficiency 31c	Enrichment	STAT1	2.18
72	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.18
73	Werner syndrome	Enrichment	PTPN11	2.18
74	Melanoma, cutaneous malignant 8	Enrichment	MITF	2.18
75	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.18
76	Papillary renal cell carcinoma	Enrichment	MITF	2.18
77	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.18
78	Polycythemia	Enrichment	JAK2	2.18
79	Lymphomatoid papulosis	Enrichment	TYK2	2.18
80	Hypereosinophilic syndrome	Enrichment	JAK2	2.18
81	Immunodeficiency 117	Enrichment	IRF1	2.18
82	Primary cutaneous anaplastic large cell lymphoma	Enrichment	TYK2	2.18
83	Gastric cancer	Enrichment	IRF1, PIK3CA	2.05
84	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA	2.03
85	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.00
86	Waardenburg syndrome, type 2a	Enrichment	MITF	2.00
87	Polycythemia vera	Enrichment	JAK2	2.00
88	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.00
89	Stuve-wiedemann syndrome 1	Enrichment	IL6ST	2.00
90	Nuchal bleb, familial	Enrichment	SOS1	2.00
91	Dysfibrinogenemia, congenital	Enrichment	FGG	2.00
92	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.00
93	Hyper ige syndrome	Enrichment	STAT3	2.00
94	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	2.00
95	Immunodeficiency 14	Enrichment	PIK3R1	2.00
96	Familial dysfibrinogenemia	Enrichment	FGG	2.00
97	Tricuspid valve insufficiency	Enrichment	PTPN11	2.00
98	Familial hypofibrinogenemia	Enrichment	FGG	2.00
99	Stüve-wiedemann syndrome	Enrichment	IL6ST	2.00
100	Keratoacanthoma	Enrichment	PIK3CA	2.00
101	Thrombocytopenia	Enrichment	FGG, PTPN11	1.96
102	Kaposi sarcoma	Enrichment	IL6	1.88
103	Erythrocytosis, familial, 1	Enrichment	JAK2	1.88
104	Afibrinogenemia, congenital	Enrichment	FGG	1.88
105	Budd-chiari syndrome	Enrichment	JAK2	1.88
106	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	1.88
107	Congenital generalized lipodystrophy	Enrichment	FOS	1.88
108	Cerebrovascular disease	Enrichment	PIK3CA	1.88
109	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.88
110	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	1.88
111	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.88
112	Autosomal recessive osteopetrosis	Enrichment	TNFSF11	1.88
113	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	1.88
114	Clear cell papillary renal cell carcinoma	Enrichment	MITF	1.88
115	Gingival fibromatosis	Enrichment	SOS1	1.88
116	Capillary malformations, congenital	Enrichment	PIK3CA	1.78
117	Rhabdomyosarcoma 2	Enrichment	FOXO1	1.78
118	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.78
119	Lymphoma	Enrichment	PTPN11	1.78
120	Myeloproliferative neoplasm	Enrichment	JAK2	1.78
121	Histiocytoid hemangioma	Enrichment	FOS	1.78
122	Hemimegalencephaly	Enrichment	PIK3CA	1.78
123	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.70
124	Cowden syndrome 1	Enrichment	PIK3CA	1.70
125	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.70
126	Type 1 diabetes mellitus	Enrichment	IL6	1.70
127	Waardenburg syndrome, type 4a	Enrichment	MITF	1.70
128	Patent ductus arteriosus	Enrichment	PTPN11	1.70
129	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.70
130	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.70
131	Waardenburg syndrome	Enrichment	MITF	1.70
132	Nevus, epidermal	Enrichment	PIK3CA	1.64
133	Waardenburg syndrome, type 1	Enrichment	MITF	1.64
134	Myelofibrosis	Enrichment	JAK2	1.64
135	Waardenburg syndrome, type 2e	Enrichment	MITF	1.64
136	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.64
137	Essential thrombocythemia	Enrichment	JAK2	1.64
138	Gallbladder cancer	Enrichment	PIK3CA	1.64
139	Overgrowth syndrome	Enrichment	PIK3R1	1.64
140	Spastic paraplegia 4, autosomal dominant	Enrichment	FGG	1.58
141	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.58
142	Inflammatory bowel disease 1	Enrichment	IL6	1.53
143	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.53
144	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.53
145	Arteriovenous malformation	Enrichment	PIK3CA	1.53
146	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.53
147	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.49
148	Melanoma	Enrichment	MITF	1.49
149	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.49
150	Pectus excavatum	Enrichment	PTPN11	1.44
151	Specific learning disability	Enrichment	PTPN11	1.44
152	Epicanthus	Enrichment	PTPN11	1.41
153	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.41
154	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.41
155	Congenital long qt syndrome	Enrichment	PTPN11	1.41
156	Aortic valve disease 1	Enrichment	SOS1	1.37
157	Acute promyelocytic leukemia	Enrichment	STAT3	1.37
158	Ovarian cancer	Enrichment	AKT1, PIK3CA	1.35
159	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.34
160	Lynch syndrome	Enrichment	PIK3CA	1.31
161	Melanoma, cutaneous malignant 1	Enrichment	MITF	1.26
162	Patent foramen ovale	Enrichment	PTPN11	1.24
163	Arteriovenous malformations of the brain	Enrichment	IL6	1.21
164	Endometrial cancer	Enrichment	PIK3CA	1.17
165	Hepatocellular carcinoma	Enrichment	PIK3CA	1.15
166	Inherited cancer-predisposing syndrome	Enrichment	MITF, PTPN11	1.15
167	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	1.13
168	Ear malformation	Enrichment	MITF	1.12
169	Scoliosis	Enrichment	PTPN11	1.12
170	Hydrops fetalis, nonimmune	Enrichment	PTPN11	1.08
171	Strabismus	Enrichment	PTPN11	1.07
172	Bladder cancer	Enrichment	PIK3CA	1.04
173	Prostate cancer	Enrichment	PIK3CA	1.04
174	Long qt syndrome 1	Enrichment	PTPN11	1.02
175	Non-immune hydrops fetalis	Enrichment	PTPN11	1.01
176	Nephronophthisis	Enrichment	PIAS1	0.98
177	Non-syndromic genetic deafness	Enrichment	MITF	0.95
178	Leukemia, acute myeloid	Enrichment	JAK2	0.90
179	Type 2 diabetes mellitus	Enrichment	IL6	0.88
180	Nonsyndromic hearing loss	Enrichment	MITF	0.88
181	Hypertrophic cardiomyopathy	Enrichment	PTPN11	0.88
182	Hypertelorism	Enrichment	PIK3CA	0.80
183	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	MITF	0.80
184	Hereditary breast ovarian cancer syndrome	Enrichment	MITF	0.78
185	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.77
186	Primary ovarian insufficiency	Enrichment	JAK2	0.75
187	Rare genetic deafness	Enrichment	MITF	0.64
188	Autism spectrum disorder	Enrichment	PTPN11	0.52
189	Microcephaly	Enrichment	PTPN11	0.47

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

IL6-mediated signaling events

Pathway Network for IL6-mediated signaling events

Member Pathways for IL6-mediated signaling events

Pathways in the IL6-mediated signaling events SuperPath

Associated Genes for IL6-mediated signaling events

Associated Disorders for IL6-mediated signaling events

Disorders associated with IL6-mediated signaling events SuperPath

STRING Interaction Network for IL6-mediated signaling events

Sources for IL6-mediated signaling events