IL8- and CXCR2-mediated signaling events

No Pathway Network information available for IL8- and CXCR2-mediated signaling events

Pathways in the IL8- and CXCR2-mediated signaling events SuperPath

#	Name	Source	Genes
1	IL8- and CXCR2-mediated signaling events	PubChem	AKT1 CBL CXCL8 CXCR2 DNM1 DOCK2 ELMO1 GNA14 GNA15 GNAI2 GNB1 GNG2 HCK MTG1 PDPK1 PIK3CG PIK3R6 PLCB2 PLCB3 PLD2 PPP2CA PPP2R1A RAB11A RAB5A RAB7A RAC2 VASP (see all 27) (see less)
2	IL8- and CXCR1-mediated signaling events	PubChem	AKT1 CBL CXCL8 CXCR1 DNM1 GNA14 GNA15 GNAI2 GNB1 GNG2 GRK2 HCK MTG1 PDPK1 PIK3CG PIK3R6 PLCB2 PLCB3 PLD1 PRKCE RAB5A (see all 21) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MTG1	Mitochondrial Ribosome Associated GTPase 1	Protein Coding	2
2	GNA14	G Protein Subunit Alpha 14	Protein Coding	2
3	GNAI2	G Protein Subunit Alpha I2	Protein Coding	2
4	GNA15	G Protein Subunit Alpha 15	Protein Coding	2
5	HCK	HCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	2
6	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	2
7	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	2
8	PIK3R6	Phosphoinositide-3-Kinase Regulatory Subunit 6	Protein Coding	2
9	PLCB3	Phospholipase C Beta 3	Protein Coding	2
10	RAB5A	RAB5A, Member RAS Oncogene Family	Protein Coding	2
11	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	2
12	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	2
13	DNM1	Dynamin 1	Protein Coding	2
14	CBL	Cbl Proto-Oncogene	Protein Coding	2
15	GNB1	G Protein Subunit Beta 1	Protein Coding	2
16	GNG2	G Protein Subunit Gamma 2	Protein Coding	2
17	PLCB2	Phospholipase C Beta 2	Protein Coding	2
18	PLD2	Phospholipase D2	Protein Coding	1
19	ELMO1	Engulfment And Cell Motility 1	Protein Coding	1
20	DOCK2	Dedicator Of Cytokinesis 2	Protein Coding	1
21	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	1
22	CXCR2	C-X-C Motif Chemokine Receptor 2	Protein Coding	1
23	VASP	Vasodilator Stimulated Phosphoprotein	Protein Coding	1
24	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	1
25	RAB7A	RAB7A, Member RAS Oncogene Family	Protein Coding	1
26	RAB11A	RAB11A, Member RAS Oncogene Family	Protein Coding	1
27	RAC2	Rac Family Small GTPase 2	Protein Coding	1
28	PLD1	Phospholipase D1	Protein Coding	1
29	GRK2	G Protein-Coupled Receptor Kinase 2	Protein Coding	1
30	CXCR1	C-X-C Motif Chemokine Receptor 1	Protein Coding	1
31	PRKCE	Protein Kinase C Epsilon	Protein Coding	1

Disorders associated with IL8- and CXCR2-mediated signaling events SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Proteus syndrome	Enrichment	AKT1	2.81
2	Cardiac valvular dysplasia 1	Enrichment	PLD1	2.81
3	Ventricular tachycardia, familial	Enrichment	GNAI2	2.81
4	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	2.81
5	Cowden syndrome 6	Enrichment	AKT1	2.81
6	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.81
7	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.81
8	Autoinflammation with pulmonary and cutaneous vasculitis	Enrichment	HCK	2.81
9	Kaposiform hemangioendothelioma	Enrichment	GNA14	2.81
10	Immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis	Enrichment	RAC2	2.70
11	Charcot-marie-tooth disease, axonal, type 2b	Enrichment	RAB7A	2.70
12	Charcot-marie-tooth disease type 2b	Enrichment	RAB7A	2.70
13	Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia	Enrichment	RAC2	2.70
14	Houge-janssens syndrome 2	Enrichment	PPP2R1A	2.70
15	Immunodeficiency 40	Enrichment	DOCK2	2.70
16	Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia	Enrichment	RAC2	2.70
17	Whim syndrome 2	Enrichment	CXCR2	2.70
18	Infantile lad-like disease due to rac2 deficiency	Enrichment	RAC2	2.70
19	Reticular dysgenesis-like severe combined immunodeficiency	Enrichment	RAC2	2.70
20	Autosomal recessive severe congenital neutropenia due to cxcr2 deficiency	Enrichment	CXCR2	2.70
21	Ppp2r1a-related neurodevelopmental disorder	Enrichment	PPP2R1A	2.70
22	Rac2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndrome	Enrichment	RAC2	2.70
23	Pituitary adenoma 4, acth-secreting	Enrichment	GNAI2	2.51
24	Ovarian germ cell cancer	Enrichment	CBL	2.51
25	Angioma, tufted	Enrichment	GNA14	2.51
26	Hypopituitarism	Enrichment	GNAI2	2.51
27	Malignant germ cell tumor of ovary	Enrichment	CBL	2.51
28	Cerebral visual impairment	Enrichment	GNB1	2.51
29	Houge-janssens syndrome 3	Enrichment	PPP2CA	2.40
30	Autosomal dominant non-syndromic intellectual disability	Enrichment	GNB1, RAB11A	2.36
31	Developmental and epileptic encephalopathy 31b	Enrichment	DNM1	2.33
32	Anastomosing haemangioma	Enrichment	GNA14	2.33
33	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL	2.21
34	Developmental and epileptic encephalopathy 31a	Enrichment	DNM1	2.11
35	Myeloproliferative neoplasm	Enrichment	CBL	2.11
36	Aggressive systemic mastocytosis	Enrichment	CBL	2.11
37	Breast adenocarcinoma	Enrichment	AKT1	2.03
38	Lennox-gastaut syndrome	Enrichment	DNM1	1.91
39	Hypothyroidism	Enrichment	GNB1	1.91
40	Cowden syndrome	Enrichment	AKT1	1.86
41	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.77
42	Myelodysplastic syndrome	Enrichment	GNB1	1.77
43	Juvenile myelomonocytic leukemia	Enrichment	CBL	1.73
44	Meningioma	Enrichment	AKT1	1.73
45	Stereotypic movement disorder	Enrichment	DNM1	1.70
46	Noonan syndrome and noonan-related syndrome	Enrichment	CBL	1.64
47	Rhabdomyosarcoma	Enrichment	CBL	1.61
48	Cleft palate, isolated	Enrichment	GNB1	1.58
49	Human immunodeficiency virus type 1	Enrichment	CXCR1	1.56
50	Isolated congenital microcephaly	Enrichment	RAB11A	1.50
51	Noonan syndrome 1	Enrichment	CBL	1.46
52	Jeune thoracic dystrophy	Enrichment	GRK2	1.42
53	Rasopathy	Enrichment	CBL	1.40
54	Strabismus	Enrichment	GNB1	1.39
55	Asphyxiating thoracic dystrophy	Enrichment	GRK2	1.37
56	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	GRK2	1.30
57	Dystonia	Enrichment	GNB1	1.28
58	Cerebral palsy	Enrichment	GNB1	1.23
59	West syndrome	Enrichment	DNM1	1.18
60	Hereditary breast carcinoma	Enrichment	AKT1	1.18
61	Undetermined early-onset epileptic encephalopathy	Enrichment	DNM1	1.08
62	Breast cancer	Enrichment	AKT1	0.96
63	Colorectal cancer	Enrichment	AKT1	0.90
64	Ovarian cancer	Enrichment	AKT1	0.84
65	Autism spectrum disorder	Enrichment	GNB1	0.81
66	Microcephaly	Enrichment	GNB1	0.76
67	Complex neurodevelopmental disorder	Enrichment	PPP2CA	0.66

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

IL8- and CXCR2-mediated signaling events

Pathway Network for IL8- and CXCR2-mediated signaling events

Member Pathways for IL8- and CXCR2-mediated signaling events

Pathways in the IL8- and CXCR2-mediated signaling events SuperPath

Associated Genes for IL8- and CXCR2-mediated signaling events

Associated Disorders for IL8- and CXCR2-mediated signaling events

Disorders associated with IL8- and CXCR2-mediated signaling events SuperPath

STRING Interaction Network for IL8- and CXCR2-mediated signaling events

Sources for IL8- and CXCR2-mediated signaling events