IL 10 signaling pathway

No Pathway Network information available for IL 10 signaling pathway

Pathways in the IL 10 signaling pathway SuperPath

#	Name	Source	Genes
1	IL 10 signaling pathway	Sino Biological	CD14 CD40LG CD70 EDA IKBKB IKBKE IL10 IL10RA IL10RB IL1A IL1B IL6 IL6R IL6ST IRAK1 IRAK4 JAK1 JAK2 JAK3 LTA LTB MAP3K7 MAPK11 MAPK12 MAPK13 MAPK14 MYD88 NFKB1 NFKBIA NFKBIB PIK3C2A PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R4 PIK3R6 REL RELA RELB SOCS1 SOCS2 SOCS3 SOCS4 SOCS5 SOCS6 STAT3 TLR4 TNF TNFSF10 TNFSF11 TNFSF13 TNFSF13B TNFSF14 TNFSF15 TNFSF4 TNFSF8 TNFSF9 TRAF6 TYK2 (see all 62) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CD14	CD14 Molecule	Protein Coding	1
2	CD40LG	CD40 Ligand	Protein Coding	1
3	CD70	CD70 Molecule	Protein Coding	1
4	EDA	Ectodysplasin A	Protein Coding	1
5	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
6	IKBKE	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon	Protein Coding	1
7	IL10	Interleukin 10	Protein Coding	1
8	IL10RA	Interleukin 10 Receptor Subunit Alpha	Protein Coding	1
9	IL10RB	Interleukin 10 Receptor Subunit Beta	Protein Coding	1
10	IL1A	Interleukin 1 Alpha	Protein Coding	1
11	IL1B	Interleukin 1 Beta	Protein Coding	1
12	IL6	Interleukin 6	Protein Coding	1
13	IL6R	Interleukin 6 Receptor	Protein Coding	1
14	IL6ST	Interleukin 6 Cytokine Family Signal Transducer	Protein Coding	1
15	IRAK1	Interleukin 1 Receptor Associated Kinase 1	Protein Coding	1
16	IRAK4	Interleukin 1 Receptor Associated Kinase 4	Protein Coding	1
17	JAK1	Janus Kinase 1	Protein Coding	1
18	JAK2	Janus Kinase 2	Protein Coding	1
19	JAK3	Janus Kinase 3	Protein Coding	1
20	LTA	Lymphotoxin Alpha	Protein Coding	1
21	LTB	Lymphotoxin Beta	Protein Coding	1
22	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	1
23	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	1
24	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	1
25	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	1
26	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
27	MYD88	MYD88 Innate Immune Signal Transduction Adaptor	Protein Coding	1
28	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
29	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
30	NFKBIB	NFKB Inhibitor Beta	Protein Coding	1
31	PIK3C2A	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha	Protein Coding	1
32	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
33	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
34	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	1
35	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	1
36	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
37	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
38	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	1
39	PIK3R6	Phosphoinositide-3-Kinase Regulatory Subunit 6	Protein Coding	1
40	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	1
41	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
42	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	1
43	SOCS1	Suppressor Of Cytokine Signaling 1	Protein Coding	1
44	SOCS2	Suppressor Of Cytokine Signaling 2	Protein Coding	1
45	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	1
46	SOCS4	Suppressor Of Cytokine Signaling 4	Protein Coding	1
47	SOCS5	Suppressor Of Cytokine Signaling 5	Protein Coding	1
48	SOCS6	Suppressor Of Cytokine Signaling 6	Protein Coding	1
49	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
50	TLR4	Toll Like Receptor 4	Protein Coding	1
51	TNF	Tumor Necrosis Factor	Protein Coding	1
52	TNFSF10	TNF Superfamily Member 10	Protein Coding	1
53	TNFSF11	TNF Superfamily Member 11	Protein Coding	1
54	TNFSF13	TNF Superfamily Member 13	Protein Coding	1
55	TNFSF13B	TNF Superfamily Member 13b	Protein Coding	1
56	TNFSF14	TNF Superfamily Member 14	Protein Coding	1
57	TNFSF15	TNF Superfamily Member 15	Protein Coding	1
58	TNFSF4	TNF Superfamily Member 4	Protein Coding	1
59	TNFSF8	TNF Superfamily Member 8	Protein Coding	1
60	TNFSF9	TNF Superfamily Member 9	Protein Coding	1
61	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	1
62	TYK2	Tyrosine Kinase 2	Protein Coding	1

Disorders associated with IL 10 signaling pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, JAK2, STAT3	7.04
2	Systemic lupus erythematosus	Enrichment	IL10, IRAK1, SOCS1, TNF, TNFSF4	6.06
3	Il10-related early-onset inflammatory bowel disease	Enrichment	IL10, IL10RA, IL10RB	5.74
4	Transient predisposition to invasive pyogenic bacterial infection	Enrichment	IRAK4, MYD88	4.69
5	Psoriatic arthritis	Enrichment	LTA, TNF	4.21
6	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.21
7	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	4.21
8	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	4.21
9	Diffuse large b-cell lymphoma	Enrichment	MYD88, SOCS1, STAT3	4.08
10	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, PIK3R2	3.91
11	Common variable immunodeficiency	Enrichment	CD40LG, NFKB1	3.37
12	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	3.04
13	Nk-cell enteropathy	Enrichment	JAK3, PIK3CB	2.81
14	Behcet syndrome	Enrichment	IL10, TLR4	2.48
15	Myocardial infarction	Enrichment	LTA, TNFSF4	2.35
16	Macrodactyly	Enrichment	PIK3CA	2.34
17	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.34
18	Immunodeficiency 35	Enrichment	TYK2	2.34
19	Immunodeficiency 68	Enrichment	MYD88	2.34
20	Leprosy 4	Enrichment	LTA	2.34
21	Macroglobulinemia, waldenstrom 1	Enrichment	MYD88	2.34
22	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.34
23	Dermatitis, atopic, 4	Enrichment	SOCS3	2.34
24	Cowden syndrome 5	Enrichment	PIK3CA	2.34
25	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.34
26	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.34
27	Immunodeficiency 15b	Enrichment	IKBKB	2.34
28	Stuve-wiedemann syndrome 2	Enrichment	IL6ST	2.34
29	Hyper-ige syndrome 4a, autosomal dominant, with recurrent infections	Enrichment	IL6ST	2.34
30	Immunodeficiency 15a	Enrichment	IKBKB	2.34
31	Immunodeficiency 92	Enrichment	REL	2.34
32	Lymphoproliferative syndrome 3	Enrichment	CD70	2.34
33	Immunodeficiency with hyper-igm, type 1	Enrichment	CD40LG	2.34
34	Short syndrome	Enrichment	PIK3R1	2.34
35	Graft-versus-host disease	Enrichment	IL10	2.34
36	Oculoskeletodental syndrome	Enrichment	PIK3C2A	2.34
37	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.34
38	Tooth agenesis, selective, x-linked, 1	Enrichment	EDA	2.34
39	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.34
40	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.34
41	Immunodeficiency 67	Enrichment	IRAK4	2.34
42	Interleukin 6, serum level of, quantitative trait locus	Enrichment	IL6R	2.34
43	Soluble interleukin-6 receptor, serum level of, quantitative trait locus	Enrichment	IL6R	2.34
44	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.34
45	Hyper-ige syndrome 5, autosomal recessive, with recurrent infections	Enrichment	IL6R	2.34
46	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.34
47	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.34
48	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.34
49	Macular degeneration, age-related, 10	Enrichment	TLR4	2.34
50	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.34
51	Hyper-ige syndrome 4b, autosomal recessive, with recurrent infections	Enrichment	IL6ST	2.34
52	Immunodeficiency 94 with autoinflammation and dysmorphic facies	Enrichment	IL6ST	2.34
53	Immunodeficiency 53	Enrichment	RELB	2.34
54	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.34
55	T-b+ severe combined immunodeficiency due to jak3 deficiency	Enrichment	JAK3	2.34
56	Hypospadias	Enrichment	PIK3CA	2.34
57	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.34
58	Rare venous malformation	Enrichment	PIK3CA	2.34
59	Cd40 ligand deficiency	Enrichment	CD40LG	2.34
60	Diaphragmatic eventration	Enrichment	PIK3CA	2.34
61	Waldenstram macroglobulinemia	Enrichment	MYD88	2.34
62	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.34
63	Rare combined vascular malformation	Enrichment	PIK3CA	2.34
64	Cavernous lymphangioma	Enrichment	PIK3CA	2.34
65	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.34
66	Oculocerebrodental syndrome	Enrichment	PIK3C2A	2.34
67	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.34
68	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.34
69	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.34
70	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.34
71	Macrodactyly of toe	Enrichment	PIK3CA	2.34
72	Severe covid-19	Enrichment	IL10RB, JAK3	2.11
73	Immunodeficiency 33	Enrichment	IRAK4	2.04
74	Inflammatory bowel disease 28, autosomal recessive	Enrichment	IL10RA	2.04
75	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.04
76	Keratosis, seborrheic	Enrichment	PIK3CA	2.04
77	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.04
78	Noonan syndrome 8	Enrichment	PIK3CA	2.04
79	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.04
80	Thrombocythemia 3	Enrichment	JAK2	2.04
81	Osteopetrosis, autosomal recessive 2	Enrichment	TNFSF11	2.04
82	Ectodermal dysplasia 1, hypohidrotic, x-linked	Enrichment	EDA	2.04
83	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.04
84	Immunodeficiency 127	Enrichment	TNF	2.04
85	Rela fusion-positive ependymoma	Enrichment	RELA	2.04
86	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.04
87	Inflammatory bowel disease 28	Enrichment	IL10RA	2.04
88	Congenital dyserythropoietic anemia	Enrichment	IRAK4	2.04
89	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.04
90	Ectodermal dysplasia and immune deficiency	Enrichment	NFKBIA	2.04
91	Immune system disease	Enrichment	PIK3CD	2.04
92	Polycythemia	Enrichment	JAK2	2.04
93	Lymphomatoid papulosis	Enrichment	TYK2	2.04
94	Hypereosinophilic syndrome	Enrichment	JAK2	2.04
95	Common variable immunodeficiency 12	Enrichment	NFKB1	2.04
96	Primary cutaneous anaplastic large cell lymphoma	Enrichment	TYK2	2.04
97	Severe combined immunodeficiency	Enrichment	IKBKB, JAK3	2.00
98	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	JAK3	1.86
99	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	1.86
100	Immune thrombocytopenia	Enrichment	SOCS1	1.86
101	Polycythemia vera	Enrichment	JAK2	1.86
102	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.86
103	Tooth agenesis, selective, 2	Enrichment	EDA	1.86
104	Stuve-wiedemann syndrome 1	Enrichment	IL6ST	1.86
105	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.86
106	Autoinflammatory syndrome, familial, with or without immunodeficiency	Enrichment	SOCS1	1.86
107	Hyper ige syndrome	Enrichment	STAT3	1.86
108	Inflammatory bowel disease 25	Enrichment	IL10RB	1.86
109	Frontometaphyseal dysplasia	Enrichment	MAP3K7	1.86
110	Migraine without aura	Enrichment	TNF	1.86
111	Stüve-wiedemann syndrome	Enrichment	IL6ST	1.86
112	Keratoacanthoma	Enrichment	PIK3CA	1.86
113	Gastric cancer	Enrichment	IL1B, PIK3CA	1.78
114	Kaposi sarcoma	Enrichment	IL6	1.74
115	Erythrocytosis, familial, 1	Enrichment	JAK2	1.74
116	Ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive	Enrichment	EDA	1.74
117	Anemia, autoimmune hemolytic	Enrichment	SOCS1	1.74
118	Budd-chiari syndrome	Enrichment	JAK2	1.74
119	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	1.74
120	Ectodermal dysplasia	Enrichment	EDA	1.74
121	Hepatitis b	Enrichment	IL10RB	1.74
122	Cerebrovascular disease	Enrichment	PIK3CA	1.74
123	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.74
124	Adenosine deaminase deficiency	Enrichment	JAK3	1.74
125	Autosomal recessive osteopetrosis	Enrichment	TNFSF11	1.74
126	Cerebral malaria	Enrichment	TNF	1.74
127	Pediatric systemic lupus erythematosus	Enrichment	IRAK1	1.74
128	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	1.74
129	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	1.64
130	Capillary malformations, congenital	Enrichment	PIK3CA	1.64
131	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	JAK3	1.64
132	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.64
133	Myeloproliferative neoplasm	Enrichment	JAK2	1.64
134	Vascular dementia	Enrichment	TNF	1.64
135	Hemimegalencephaly	Enrichment	PIK3CA	1.64
136	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.57
137	Cowden syndrome 1	Enrichment	PIK3CA	1.57
138	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.57
139	Type 1 diabetes mellitus	Enrichment	IL6	1.57
140	Inflammatory bowel disease 25, autosomal recessive	Enrichment	IL10RB	1.57
141	Breast adenocarcinoma	Enrichment	PIK3CA	1.57
142	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.57
143	Nevus, epidermal	Enrichment	PIK3CA	1.50
144	Myelofibrosis	Enrichment	JAK2	1.50
145	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.50
146	Essential thrombocythemia	Enrichment	JAK2	1.50
147	Gallbladder cancer	Enrichment	PIK3CA	1.50
148	Overgrowth syndrome	Enrichment	PIK3R1	1.50
149	Narcolepsy 1	Enrichment	TNFSF4	1.44
150	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.44
151	Tooth agenesis, selective, 1	Enrichment	EDA	1.39
152	Rheumatoid arthritis	Enrichment	IL10	1.39
153	Inflammatory bowel disease 1	Enrichment	IL6	1.39
154	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.39
155	Arteriovenous malformation	Enrichment	PIK3CA	1.39
156	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.39
157	Primary biliary cholangitis	Enrichment	TNFSF15	1.39
158	Cowden syndrome	Enrichment	PIK3CA	1.39
159	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.35
160	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.35
161	Asthma	Enrichment	TNF	1.31
162	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.31
163	Meningioma	Enrichment	PIK3CA	1.27
164	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.27
165	Acute promyelocytic leukemia	Enrichment	STAT3	1.24
166	Alzheimer's disease	Enrichment	TNF	1.24
167	Colorectal cancer	Enrichment	PIK3CA, PIK3R1	1.22
168	Lynch syndrome	Enrichment	PIK3CA	1.18
169	Gliosarcoma	Enrichment	NFKBIA	1.15
170	Giant cell glioblastoma	Enrichment	NFKBIA	1.13
171	Human immunodeficiency virus type 1	Enrichment	IL10	1.10
172	Arteriovenous malformations of the brain	Enrichment	IL6	1.08
173	Endometrial cancer	Enrichment	PIK3CA	1.04
174	Hepatocellular carcinoma	Enrichment	PIK3CA	1.02
175	Tooth agenesis	Enrichment	EDA	1.02
176	Malaria	Enrichment	TNF	1.00
177	Bladder cancer	Enrichment	PIK3CA	0.90
178	Prostate cancer	Enrichment	PIK3CA	0.90
179	Lung cancer	Enrichment	PIK3CA	0.86
180	Leukemia, acute myeloid	Enrichment	JAK2	0.78
181	Type 2 diabetes mellitus	Enrichment	IL6	0.76
182	Hereditary breast carcinoma	Enrichment	PIK3CA	0.74
183	Hypertelorism	Enrichment	PIK3CA	0.67
184	Myeloma, multiple	Enrichment	PIK3R2	0.64
185	Primary ovarian insufficiency	Enrichment	JAK2	0.62
186	Breast cancer	Enrichment	PIK3CA	0.54
187	Ovarian cancer	Enrichment	PIK3CA	0.43

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

IL 10 signaling pathway

Pathway Network for IL 10 signaling pathway

Member Pathways for IL 10 signaling pathway

Pathways in the IL 10 signaling pathway SuperPath

Associated Genes for IL 10 signaling pathway

Associated Disorders for IL 10 signaling pathway

Disorders associated with IL 10 signaling pathway SuperPath

STRING Interaction Network for IL 10 signaling pathway

Sources for IL 10 signaling pathway