Imatinib-resistant KIT mutants

Sources:

#	Name	Source	Genes
1	Imatinib-resistant KIT mutants	Reactome	KIT
2	Signaling by juxtamembrane domain KIT mutants	Reactome	KIT
3	Signaling by kinase domain mutants of KIT	Reactome	KIT
4	Signaling by extracellular domain mutants of KIT	Reactome	KIT
5	Sunitinib-resistant KIT mutants	Reactome	KIT
6	Nilotinib-resistant KIT mutants	Reactome	KIT
7	Drug resistance of KIT mutants	Reactome	KIT
8	Dasatinib-resistant KIT mutants	Reactome	KIT
9	Sorafenib-resistant KIT mutants	Reactome	KIT
10	Regorafenib-resistant KIT mutants	Reactome	KIT
11	Masitinib-resistant KIT mutants	Reactome	KIT
12	KIT mutants bind TKIs	Reactome	KIT

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	12

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Mastocytosis, cutaneous	Enrichment	KIT	4.13
2	Chronic mast cell leukemia	Enrichment	KIT	4.13
3	Isolated bone marrow mastocytosis	Enrichment	KIT	4.13
4	Smoldering systemic mastocytosis	Enrichment	KIT	4.13
5	Mastocytosis	Enrichment	KIT	4.13
6	Cutaneous mastocytoma	Enrichment	KIT	4.13
7	Typical urticaria pigmentosa	Enrichment	KIT	4.13
8	Nodular urticaria pigmentosa	Enrichment	KIT	4.13
9	Pseudoxanthomatous diffuse cutaneous mastocytosis	Enrichment	KIT	4.13
10	Telangiectasia macularis eruptiva perstans	Enrichment	KIT	4.13
11	Acute mast cell leukemia	Enrichment	KIT	4.13
12	Plaque-form urticaria pigmentosa	Enrichment	KIT	4.13
13	Bullous diffuse cutaneous mastocytosis	Enrichment	KIT	4.13
14	Testis seminoma	Enrichment	KIT	4.13
15	Piebald trait	Enrichment	KIT	3.83
16	B-lymphoblastic leukemia/lymphoma with t	Enrichment	KIT	3.83
17	Testicular germ cell cancer	Enrichment	KIT	3.66
18	Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	Enrichment	KIT	3.53
19	Systemic mastocytosis with associated hematologic neoplasm	Enrichment	KIT	3.53
20	Acute myeloid leukemia with maturation	Enrichment	KIT	3.43
21	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	KIT	3.43
22	Testicular germ cell tumor	Enrichment	KIT	3.35
23	Gastrointestinal stromal tumor	Enrichment	KIT	3.29
24	Lip and oral cavity carcinoma	Enrichment	KIT	3.05
25	Leukemia, acute myeloid	Enrichment	KIT	2.53
26	Ovarian cancer	Enrichment	KIT	2.13
27	Inherited cancer-predisposing syndrome	Enrichment	KIT	2.01

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Imatinib-resistant KIT mutants