Imatinib and chronic myeloid leukemia

No Pathway Network information available for Imatinib and chronic myeloid leukemia

Pathways in the Imatinib and chronic myeloid leukemia SuperPath

#	Name	Source	Genes
1	Imatinib and chronic myeloid leukemia	WikiPathways	ABCB1 ABCG2 ABL1 BCR CDKN1B CSF1R FLT1 FOXO3 GAB2 GADD45A KIT LYL1 MYC NOP2 PDGFRA PDGFRB PIM1 PIM2 SKP2 SPRED2 (see all 20) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GAB2	GRB2 Associated Binding Protein 2	Protein Coding	1
2	ABCG2	ATP Binding Cassette Subfamily G Member 2 (JR Blood Group)	Protein Coding	1
3	SKP2	S-Phase Kinase Associated Protein 2	Protein Coding	1
4	BCR	BCR Activator Of RhoGEF And GTPase	Protein Coding	1
5	PIM1	Pim-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
6	ABCB1	ATP Binding Cassette Subfamily B Member 1	Protein Coding	1
7	PDGFRB	Platelet Derived Growth Factor Receptor Beta	Protein Coding	1
8	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	1
9	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
10	LYL1	LYL1 Basic Helix-Loop-Helix Family Member	Protein Coding	1
11	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	1
12	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	1
13	FLT1	Fms Related Receptor Tyrosine Kinase 1	Protein Coding	1
14	FOXO3	Forkhead Box O3	Protein Coding	1
15	SPRED2	Sprouty Related EVH1 Domain Containing 2	Protein Coding	1
16	GADD45A	Growth Arrest And DNA Damage Inducible Alpha	Protein Coding	1
17	CSF1R	Colony Stimulating Factor 1 Receptor	Protein Coding	1
18	PIM2	Pim-2 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
19	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1
20	NOP2	NOP2 Nucleolar Protein	Protein Coding	1

Disorders associated with Imatinib and chronic myeloid leukemia SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Precursor t-cell acute lymphoblastic leukemia	Enrichment	ABL1, BCR, MYC	5.32
2	Primary hypereosinophilic syndrome	Enrichment	PDGFRA, PDGFRB	4.69
3	Gastrointestinal stromal tumor	Enrichment	KIT, PDGFRA	4.36
4	Leukemia, chronic myeloid	Enrichment	ABL1, BCR	4.36
5	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	ABL1, BCR	4.36
6	Lip and oral cavity carcinoma	Enrichment	ABL1, KIT	3.87
7	Ovarian cancer	Enrichment	CDKN1B, KIT, PDGFRA	3.38
8	Inherited cancer-predisposing syndrome	Enrichment	CDKN1B, KIT, PDGFRA	3.04
9	Premature aging syndrome, penttinen type	Enrichment	PDGFRB	2.83
10	Hypereosinophilic syndrome, idiopathic	Enrichment	PDGFRA	2.83
11	Mastocytosis, cutaneous	Enrichment	KIT	2.83
12	Colchicine resistance	Enrichment	ABCB1	2.83
13	Uric acid concentration, serum, quantitative trait locus 1	Enrichment	ABCG2	2.83
14	Myofibromatosis, infantile, 1	Enrichment	PDGFRB	2.83
15	Gist-plus syndrome	Enrichment	PDGFRA	2.83
16	Encephalopathy, acute transient	Enrichment	ABCB1	2.83
17	Myeloid and lymphoid neoplasms associated with pdgfra rearrangement	Enrichment	PDGFRA	2.83
18	Noonan syndrome 14	Enrichment	SPRED2	2.83
19	Inflammatory bowel disease 13	Enrichment	ABCB1	2.83
20	Neuroendocrine tumor	Enrichment	CDKN1B	2.83
21	Basal ganglia calcification, idiopathic, 4	Enrichment	PDGFRB	2.83
22	Myeloid and lymphoid neoplasms associated with pdgfrb rearrangement	Enrichment	PDGFRB	2.83
23	Kosaki overgrowth syndrome	Enrichment	PDGFRB	2.83
24	Blood group, junior system	Enrichment	ABCG2	2.83
25	Brain abnormalities, neurodegeneration, and dysosteosclerosis	Enrichment	CSF1R	2.83
26	Ocular pterygium-digital keloid dysplasia syndrome	Enrichment	PDGFRB	2.83
27	Chronic mast cell leukemia	Enrichment	KIT	2.83
28	Csf1r-related disorder	Enrichment	CSF1R	2.83
29	Isolated bone marrow mastocytosis	Enrichment	KIT	2.83
30	Smoldering systemic mastocytosis	Enrichment	KIT	2.83
31	Mastocytosis	Enrichment	KIT	2.83
32	Early-onset calcifying leukoencephalopathy-skeletal dysplasia	Enrichment	CSF1R	2.83
33	Cutaneous mastocytoma	Enrichment	KIT	2.83
34	Typical urticaria pigmentosa	Enrichment	KIT	2.83
35	Nodular urticaria pigmentosa	Enrichment	KIT	2.83
36	Pseudoxanthomatous diffuse cutaneous mastocytosis	Enrichment	KIT	2.83
37	Telangiectasia macularis eruptiva perstans	Enrichment	KIT	2.83
38	Acute mast cell leukemia	Enrichment	KIT	2.83
39	Plaque-form urticaria pigmentosa	Enrichment	KIT	2.83
40	Bullous diffuse cutaneous mastocytosis	Enrichment	KIT	2.83
41	Testis seminoma	Enrichment	KIT	2.83
42	Burkitt lymphoma	Enrichment	MYC	2.53
43	Myeloproliferative disorder, chronic, with eosinophilia	Enrichment	PDGFRB	2.53
44	Piebald trait	Enrichment	KIT	2.53
45	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	2.53
46	Congenital heart defects and skeletal malformations syndrome	Enrichment	ABL1	2.53
47	Infantile myofibromatosis	Enrichment	PDGFRB	2.53
48	Chronic eosinophilic leukemia	Enrichment	PDGFRA	2.53
49	B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormality	Enrichment	PDGFRA	2.53
50	B-lymphoblastic leukemia/lymphoma with t	Enrichment	KIT	2.53
51	Leukoencephalopathy, hereditary diffuse, with spheroids 1	Enrichment	CSF1R	2.35
52	Chromosome 8p11 myeloproliferative syndrome	Enrichment	BCR	2.35
53	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	2.35
54	Testicular germ cell cancer	Enrichment	KIT	2.35
55	T-cell acute lymphoblastic leukemia	Enrichment	ABL1	2.35
56	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	BCR	2.23
57	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	ABL1	2.23
58	Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	Enrichment	KIT	2.23
59	Primary hyperparathyroidism	Enrichment	CDKN1B	2.23
60	Systemic mastocytosis with associated hematologic neoplasm	Enrichment	KIT	2.23
61	Pre-eclampsia	Enrichment	FLT1	2.13
62	Acute myeloid leukemia with maturation	Enrichment	KIT	2.13
63	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	KIT	2.13
64	Testicular germ cell tumor	Enrichment	KIT	2.05
65	Multiple endocrine neoplasia, type i	Enrichment	CDKN1B	1.99
66	Moyamoya angiopathy	Enrichment	ABL1	1.99
67	Basal ganglia calcification, idiopathic, 1	Enrichment	PDGFRB	1.93
68	Frontotemporal dementia 1	Enrichment	CSF1R	1.79
69	Epilepsy, idiopathic generalized	Enrichment	ABCB1	1.79
70	Alzheimer's disease	Enrichment	CSF1R	1.72
71	Heart disease	Enrichment	ABL1	1.69
72	Cleft lip/palate	Enrichment	PDGFRA	1.69
73	Hydrocephalus	Enrichment	PDGFRB	1.66
74	Alzheimer disease, familial, 1	Enrichment	CSF1R	1.61
75	Dandy-walker syndrome	Enrichment	PDGFRB	1.61
76	Noonan syndrome 1	Enrichment	SPRED2	1.48
77	Cerebral palsy	Enrichment	PDGFRB	1.25
78	Leukemia, acute myeloid	Enrichment	KIT	1.24
79	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	CSF1R	1.09
80	Microcephaly	Enrichment	ABL1	0.78

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Imatinib and chronic myeloid leukemia

Pathway Network for Imatinib and chronic myeloid leukemia

Member Pathways for Imatinib and chronic myeloid leukemia

Pathways in the Imatinib and chronic myeloid leukemia SuperPath

Associated Genes for Imatinib and chronic myeloid leukemia

Associated Disorders for Imatinib and chronic myeloid leukemia

Disorders associated with Imatinib and chronic myeloid leukemia SuperPath

STRING Interaction Network for Imatinib and chronic myeloid leukemia

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