Immune response Antigen presentation by MHC class II

Pathway network for the Immune response Antigen presentation by MHC class II SuperPath

Sources:

GeneGo (Thomson Reuters)
QIAGEN

Pathways in the Immune response Antigen presentation by MHC class II SuperPath

#	Name	Source	Genes
1	Immune response Antigen presentation by MHC class II	GeneGo (Thomson Reuters)	CD247 CD3D CD3E CD3G CD4 CD74 CTSL CTSS HLA-DMA HLA-DMB HLA-DOA HLA-DOB HLA-DPA1 HLA-DPB1 HLA-DPB2 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DQB3 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 IFI30 LGMN TRA TRAC TRAJ18 TRAV24 TRB TRBV11-1 TRBV11-2 TRBV11-3 TRBV17 (see all 36) (see less)
2	Immune response IL-22 signaling pathway	GeneGo (Thomson Reuters)	BCL2 BCL2L1 CD28 CD4 CD86 FOS HLA-DMA HLA-DMB HLA-DOA HLA-DOB HLA-DPA1 HLA-DPB1 HLA-DPB2 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DQB3 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 IL10RB IL12A IL12B IL12RB1 IL12RB2 IL2 IL22 IL22RA1 IL22RA2 IL2RA IL2RB IL2RG JAK1 JAK2 JAK3 JUN MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 MCL1 MYC SOCS3 STAT1 STAT3 STAT4 STAT5A STAT5B TRA TRAC TRAJ18 TRAV24 TRB TRBV11-1 TRBV11-2 TRBV11-3 TRBV17 TYK2 (see all 66) (see less)
3	G-protein signaling N-RAS regulation pathway	GeneGo (Thomson Reuters)	ARAF BRAF CD247 CD3D CD3E CD3G CD4 EGF EGFR GRB2 HLA-DMA HLA-DMB HLA-DOA HLA-DOB HLA-DPA1 HLA-DPB1 HLA-DPB2 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DQB3 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 ICMT ITPR1 ITPR2 ITPR3 LAT LCK NRAS PLCG1 RAF1 RALGDS RASGRF1 RASGRP1 RASGRP2 RGL1 RGL2 SHC1 SOS1 SOS2 TRA TRAC TRAJ18 TRAV24 TRB TRBV11-1 TRBV11-2 TRBV11-3 TRBV17 ZAP70 (see all 55) (see less)
4	IL-22 Pathway	QIAGEN	IL10RB IL22 IL22RA1 IL22RA2 JAK1 MAPK11 MAPK12 MAPK13 MAPK14 SOCS3 STAT1 STAT3 STAT5A STAT5B TYK2 (see all 15) (see less)

Gene overlap in member pathways for Immune response Antigen presentation by MHC class II SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CD4	CD4 Molecule	Protein Coding	3
2	HLA-DMA	Major Histocompatibility Complex, Class II, DM Alpha	Protein Coding	3
3	HLA-DMB	Major Histocompatibility Complex, Class II, DM Beta	Protein Coding	3
4	HLA-DOA	Major Histocompatibility Complex, Class II, DO Alpha	Protein Coding	3
5	HLA-DOB	Major Histocompatibility Complex, Class II, DO Beta	Protein Coding	3
6	HLA-DPA1	Major Histocompatibility Complex, Class II, DP Alpha 1	Protein Coding	3
7	HLA-DPB1	Major Histocompatibility Complex, Class II, DP Beta 1	Protein Coding	3
8	HLA-DPB2	Major Histocompatibility Complex, Class II, DP Beta 2 (Pseudogene)	Pseudogene	3
9	HLA-DQA1	Major Histocompatibility Complex, Class II, DQ Alpha 1	Protein Coding	3
10	HLA-DQA2	Major Histocompatibility Complex, Class II, DQ Alpha 2	Protein Coding	3
11	HLA-DQB1	Major Histocompatibility Complex, Class II, DQ Beta 1	Protein Coding	3
12	HLA-DQB2	Major Histocompatibility Complex, Class II, DQ Beta 2	Protein Coding	3
13	HLA-DQB3	Major Histocompatibility Complex, Class II, DQ Beta 3	Protein Coding	3
14	HLA-DRA	Major Histocompatibility Complex, Class II, DR Alpha	Protein Coding	3
15	HLA-DRB1	Major Histocompatibility Complex, Class II, DR Beta 1	Protein Coding	3
16	HLA-DRB3	Major Histocompatibility Complex, Class II, DR Beta 3	Protein Coding	3
17	HLA-DRB4	Major Histocompatibility Complex, Class II, DR Beta 4	Protein Coding	3
18	HLA-DRB5	Major Histocompatibility Complex, Class II, DR Beta 5	Protein Coding	3
19	TRA	T Cell Receptor Alpha Locus	Protein Coding	3
20	TRB	T Cell Receptor Beta Locus	Protein Coding	3
21	TRBV17	T Cell Receptor Beta Variable 17 (Non-Functional)	Protein Coding	3
22	TRBV11-3	T Cell Receptor Beta Variable 11-3	Protein Coding	3
23	TRBV11-2	T Cell Receptor Beta Variable 11-2	Protein Coding	3
24	TRBV11-1	T Cell Receptor Beta Variable 11-1	Protein Coding	3
25	TRAV24	T Cell Receptor Alpha Variable 24	Protein Coding	3
26	TRAJ18	T Cell Receptor Alpha Joining 18	Protein Coding	3
27	TRAC	T Cell Receptor Alpha Constant	Protein Coding	3
28	CD3D	CD3 Delta Subunit Of T-Cell Receptor Complex	Protein Coding	2
29	CD3E	CD3 Epsilon Subunit Of T-Cell Receptor Complex	Protein Coding	2
30	CD3G	CD3 Gamma Subunit Of T-Cell Receptor Complex	Protein Coding	2
31	CD247	CD247 Molecule	Protein Coding	2
32	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	2
33	IL10RB	Interleukin 10 Receptor Subunit Beta	Protein Coding	2
34	JAK1	Janus Kinase 1	Protein Coding	2
35	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	2
36	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	2
37	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	2
38	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	2
39	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	2
40	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	2
41	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	2
42	TYK2	Tyrosine Kinase 2	Protein Coding	2
43	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	2
44	IL22	Interleukin 22	Protein Coding	2
45	IL22RA1	Interleukin 22 Receptor Subunit Alpha 1	Protein Coding	2
46	IL22RA2	Interleukin 22 Receptor Subunit Alpha 2	Protein Coding	2
47	CD74	CD74 Molecule	Protein Coding	1
48	CTSL	Cathepsin L	Protein Coding	1
49	CTSS	Cathepsin S	Protein Coding	1
50	LGMN	Legumain	Protein Coding	1
51	IFI30	IFI30 Lysosomal Thiol Reductase	Protein Coding	1
52	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
53	BCL2L1	BCL2 Like 1	Protein Coding	1
54	CD28	CD28 Molecule	Protein Coding	1
55	CD86	CD86 Molecule	Protein Coding	1
56	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
57	IL2	Interleukin 2	Protein Coding	1
58	IL2RA	Interleukin 2 Receptor Subunit Alpha	Protein Coding	1
59	IL2RB	Interleukin 2 Receptor Subunit Beta	Protein Coding	1
60	IL2RG	Interleukin 2 Receptor Subunit Gamma	Protein Coding	1
61	IL12A	Interleukin 12A	Protein Coding	1
62	IL12B	Interleukin 12B	Protein Coding	1
63	IL12RB1	Interleukin 12 Receptor Subunit Beta 1	Protein Coding	1
64	IL12RB2	Interleukin 12 Receptor Subunit Beta 2	Protein Coding	1
65	JAK2	Janus Kinase 2	Protein Coding	1
66	JAK3	Janus Kinase 3	Protein Coding	1
67	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
68	MCL1	MCL1 Apoptosis Regulator, BCL2 Family Member	Protein Coding	1
69	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
70	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
71	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
72	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
73	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
74	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
75	STAT4	Signal Transducer And Activator Of Transcription 4	Protein Coding	1
76	ARAF	A-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
77	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
78	EGF	Epidermal Growth Factor	Protein Coding	1
79	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
80	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
81	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	1
82	ITPR2	Inositol 1,4,5-Trisphosphate Receptor Type 2	Protein Coding	1
83	ITPR3	Inositol 1,4,5-Trisphosphate Receptor Type 3	Protein Coding	1
84	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
85	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	1
86	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
87	RGL2	Ral Guanine Nucleotide Dissociation Stimulator Like 2	Protein Coding	1
88	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
89	RALGDS	Ral Guanine Nucleotide Dissociation Stimulator	Protein Coding	1
90	RASGRF1	Ras Protein Specific Guanine Nucleotide Releasing Factor 1	Protein Coding	1
91	SHC1	SHC Adaptor Protein 1	Protein Coding	1
92	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
93	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	1
94	ZAP70	Zeta Chain Of T Cell Receptor Associated Protein Kinase 70	Protein Coding	1
95	RASGRP1	RAS Guanyl Releasing Protein 1	Protein Coding	1
96	RASGRP2	RAS Guanyl Releasing Protein 2	Protein Coding	1
97	RGL1	Ral Guanine Nucleotide Dissociation Stimulator Like 1	Protein Coding	1
98	ICMT	Isoprenylcysteine Carboxyl Methyltransferase	Protein Coding	1
99	LAT	Linker For Activation Of T Cells	Protein Coding	1

Disorders associated with Immune response Antigen presentation by MHC class II SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Severe combined immunodeficiency	Enrichment	CD247, CD3D, CD3E, CD3G, LCK, ZAP70	8.46
2	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD247, CD3D, CD3E	7.77
3	Noonan syndrome 1	Enrichment	BRAF, NRAS, RAF1, SOS1, SOS2	7.54
4	Rasopathy	Enrichment	BRAF, NRAS, RAF1, SOS1, SOS2	7.25
5	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, JAK2, STAT3	6.96
6	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, NRAS, RAF1, SOS1	6.50
7	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, NRAS, RAF1	5.46
8	Oligoarticular juvenile idiopathic arthritis	Enrichment	IL2RA, IL2RB, STAT4	5.42
9	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	IL2RA, IL2RB, STAT4	5.42
10	Celiac disease 1	Enrichment	HLA-DQA1, HLA-DQB1	5.16
11	Bullous pemphigoid	Enrichment	HLA-DQB1, HLA-DRB1	5.16
12	Pediatric multiple sclerosis	Enrichment	HLA-DQB1, HLA-DRB1	5.16
13	Lung non-small cell carcinoma	Enrichment	BRAF, EGFR, NRAS	4.99
14	Pulmonic stenosis	Enrichment	BRAF, SOS1	4.79
15	Immunodeficiency 7	Enrichment	TRA, TRAC	4.69
16	Multiple sclerosis	Enrichment	HLA-DQB1, HLA-DRB1, ITPR1	4.65
17	Idiopathic achalasia	Enrichment	HLA-DQA1, HLA-DQB1	4.39
18	Langerhans cell histiocytosis	Enrichment	BRAF, NRAS	4.32
19	Narcolepsy 2	Enrichment	HLA-DQB1, HLA-DRB1	4.17
20	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2, MYC	4.16
21	Acute promyelocytic leukemia	Enrichment	STAT3, STAT5B	4.05
22	Noonan syndrome with multiple lentigines	Enrichment	BRAF, RAF1	4.02
23	Granulomatosis with polyangiitis	Enrichment	HLA-DPA1, HLA-DPB1	3.99
24	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC, TRA, TRB	3.74
25	Narcolepsy 1	Enrichment	HLA-DQB1, HLA-DRB1	3.72
26	Follicular lymphoma	Enrichment	BCL2, HLA-DRB1	3.64
27	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF, NRAS	3.48
28	Noonan syndrome 3	Enrichment	RAF1, SOS1	3.48
29	Pilomyxoid astrocytoma	Enrichment	BRAF, RAF1	3.48
30	Follicular thyroid carcinoma	Enrichment	BRAF, NRAS	3.48
31	Severe covid-19	Enrichment	HLA-DQB1, IL10RB, JAK3	3.44
32	Primary biliary cholangitis	Enrichment	IL12A, IL12RB1	3.09
33	Lip and oral cavity carcinoma	Enrichment	BRAF, EGFR	2.98
34	Immunodeficiency 35	Enrichment	TYK2	2.96
35	Dermatitis, atopic, 4	Enrichment	SOCS3	2.96
36	Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant	Enrichment	STAT5B	2.96
37	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.96
38	Immunodeficiency 31a	Enrichment	STAT1	2.96
39	Immunodeficiency 31b	Enrichment	STAT1	2.96
40	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.96
41	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.96
42	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.96
43	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.96
44	Lung cancer susceptibility 3	Enrichment	BRAF, EGFR	2.85
45	Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive	Enrichment	STAT5B	2.66
46	Immunodeficiency 31c	Enrichment	STAT1	2.66
47	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.66
48	Lymphomatoid papulosis	Enrichment	TYK2	2.66
49	Laron syndrome with immunodeficiency	Enrichment	STAT5B	2.66
50	Primary cutaneous anaplastic large cell lymphoma	Enrichment	TYK2	2.66
51	Arteriovenous malformations of the brain	Enrichment	BRAF, EGFR	2.58
52	Okt4 epitope deficiency	Enrichment	CD4	2.58
53	Immunodeficiency 18	Enrichment	CD3E	2.58
54	Pulmonary alveolar proteinosis, acquired	Enrichment	HLA-DRB1	2.58
55	Immunodeficiency 25	Enrichment	CD247	2.58
56	Graham little-piccardi-lassueur syndrome	Enrichment	HLA-DRA	2.58
57	Berylliosis	Enrichment	HLA-DPB1	2.58
58	Immunodeficiency 79	Enrichment	CD4	2.58
59	Immunodeficiency 19, severe combined	Enrichment	CD3D	2.58
60	Immunodeficiency 19	Enrichment	CD3D	2.58
61	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.48
62	Hyper ige syndrome	Enrichment	STAT3	2.48
63	Inflammatory bowel disease 25	Enrichment	IL10RB	2.48
64	Behcet syndrome	Enrichment	IL12A, STAT4	2.42
65	Anhidrosis, isolated, with normal sweat glands	Enrichment	ITPR2	2.39
66	Pallister-killian syndrome	Enrichment	ARAF	2.39
67	Noonan syndrome 5	Enrichment	RAF1	2.39
68	Hypomagnesemia 4, renal	Enrichment	EGF	2.39
69	Noonan syndrome 4	Enrichment	SOS1	2.39
70	Noonan syndrome 7	Enrichment	BRAF	2.39
71	Leopard syndrome 3	Enrichment	BRAF	2.39
72	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.39
73	Melanosis, neurocutaneous	Enrichment	NRAS	2.39
74	Noonan syndrome 9	Enrichment	SOS2	2.39
75	Bleeding disorder, platelet-type, 18	Enrichment	RASGRP2	2.39
76	Noonan syndrome 6	Enrichment	NRAS	2.39
77	Immunodeficiency 64 with lymphoproliferation	Enrichment	RASGRP1	2.39
78	Charcot-marie-tooth disease, demyelinating, type 1j	Enrichment	ITPR3	2.39
79	Immunodeficiency 48	Enrichment	ZAP70	2.39
80	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.39
81	Lymphangioma	Enrichment	BRAF	2.39
82	Phace association	Enrichment	BRAF	2.39
83	Leopard syndrome 2	Enrichment	RAF1	2.39
84	Autoimmune disease, multisystem, infantile-onset, 2	Enrichment	ZAP70	2.39
85	Immunodeficiency 22	Enrichment	LCK	2.39
86	Trigonitis	Enrichment	RAF1	2.39
87	Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathy	Enrichment	ITPR3	2.39
88	Immunodeficiency 64	Enrichment	RASGRP1	2.39
89	Ebv-induced lymphoproliferative disease due to rasgrp1 deficiency	Enrichment	RASGRP1	2.39
90	Syringocystadenoma papilliferum	Enrichment	BRAF	2.39
91	Ganglioglioma	Enrichment	BRAF	2.39
92	Nongerminomatous germ cell tumor	Enrichment	BRAF	2.39
93	Phace syndrome	Enrichment	BRAF	2.39
94	Classic hairy cell leukemia	Enrichment	BRAF	2.39
95	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	2.39
96	Neurocutaneous melanocytosis	Enrichment	NRAS	2.39
97	Zap70-related severe combined immunodeficiency	Enrichment	ZAP70	2.39
98	Hepatitis b	Enrichment	IL10RB	2.35
99	Type 1 diabetes mellitus 10	Enrichment	IL2RA	2.31
100	Immunodeficiency 30	Enrichment	IL12RB1	2.31
101	Noonan syndrome 13	Enrichment	MAPK1	2.31
102	Immunodeficiency 63 with lymphoproliferation and autoimmunity	Enrichment	IL2RB	2.31
103	Disabling pansclerotic morphea of childhood	Enrichment	STAT4	2.31
104	Systemic lupus erythematosus 11	Enrichment	STAT4	2.31
105	Immunodeficiency 29	Enrichment	IL12B	2.31
106	Immunodeficiency 123 with hpv-related verrucosis	Enrichment	CD28	2.31
107	T-b+ severe combined immunodeficiency due to jak3 deficiency	Enrichment	JAK3	2.31
108	Creutzfeldt-jakob disease	Enrichment	HLA-DQB1	2.28
109	Sarcoidosis 1	Enrichment	HLA-DRB1	2.28
110	Trypsinogen deficiency	Enrichment	TRB	2.28
111	Immunodeficiency 17	Enrichment	CD3G	2.28
112	Differentiated thyroid carcinoma	Enrichment	BRAF, NRAS	2.21
113	Inflammatory bowel disease 25, autosomal recessive	Enrichment	IL10RB	2.18
114	Chronic mucocutaneous candidiasis	Enrichment	STAT1	2.18
115	Il10-related early-onset inflammatory bowel disease	Enrichment	IL10RB	2.18
116	Lung cancer	Enrichment	BRAF, EGFR	2.13
117	Adult-onset myasthenia gravis	Enrichment	HLA-DQA1	2.10
118	Vogt-koyanagi-harada disease	Enrichment	HLA-DRB1	2.10
119	Spinocerebellar ataxia 29	Enrichment	ITPR1	2.09
120	Fibromatosis, gingival, 1	Enrichment	SOS1	2.09
121	Ras-associated autoimmune leukoproliferative disorder	Enrichment	NRAS	2.09
122	Immunodeficiency 52	Enrichment	LAT	2.09
123	Permanent neonatal diabetes mellitus	Enrichment	STAT3	2.05
124	Burkitt lymphoma	Enrichment	MYC	2.01
125	Immunodeficiency 41 with lymphoproliferation and autoimmunity	Enrichment	IL2RA	2.01
126	Thrombocythemia 3	Enrichment	JAK2	2.01
127	Intravascular large b-cell lymphoma	Enrichment	BCL2	2.01
128	Polycythemia	Enrichment	JAK2	2.01
129	Hypereosinophilic syndrome	Enrichment	JAK2	2.01
130	Temporal arteritis	Enrichment	HLA-DRB1	1.98
131	Systemic-onset juvenile idiopathic arthritis	Enrichment	HLA-DRB1	1.98
132	Ataxia-telangiectasia	Enrichment	BRAF	1.92
133	Gillespie syndrome	Enrichment	ITPR1	1.92
134	Nuchal bleb, familial	Enrichment	SOS1	1.92
135	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	1.92
136	Tethered spinal cord syndrome	Enrichment	BRAF	1.92
137	Large congenital melanocytic nevus	Enrichment	NRAS	1.92
138	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	1.92
139	Vitamin d-dependent rickets, type 2a	Enrichment	TRB	1.88
140	Diffuse cutaneous systemic sclerosis	Enrichment	HLA-DRB1	1.88
141	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	JAK3	1.84
142	Takayasu arteritis	Enrichment	IL12B	1.84
143	Polycythemia vera	Enrichment	JAK2	1.84
144	Mycosis fungoides	Enrichment	CD28	1.84
145	Severe combined immunodeficiency, x-linked	Enrichment	IL2RG	1.84
146	Combined immunodeficiency, x-linked	Enrichment	IL2RG	1.84
147	Saczary syndrome	Enrichment	CD28	1.84
148	Systemic lupus erythematosus	Enrichment	HLA-DRB1, STAT4	1.81
149	Limited scleroderma	Enrichment	HLA-DRB1	1.80
150	Schimmelpenning-feuerstein-mims syndrome	Enrichment	NRAS	1.79
151	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF	1.79
152	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	1.79
153	Spinocerebellar ataxia 15	Enrichment	ITPR1	1.79
154	Cardiofaciocutaneous syndrome	Enrichment	BRAF	1.79
155	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	NRAS	1.79
156	Craniopharyngioma	Enrichment	BRAF	1.79
157	Newborn respiratory distress syndrome	Enrichment	BRAF	1.79
158	Gingival fibromatosis	Enrichment	SOS1	1.79
159	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.79
160	Erythrocytosis, familial, 1	Enrichment	JAK2	1.71
161	Budd-chiari syndrome	Enrichment	JAK2	1.71
162	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.71
163	Congenital generalized lipodystrophy	Enrichment	FOS	1.71
164	Adenosine deaminase deficiency	Enrichment	JAK3	1.71
165	Pediatric systemic lupus erythematosus	Enrichment	STAT4	1.71
166	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.68
167	Multisystem inflammatory syndrome in children	Enrichment	IL22RA2	1.62
168	Cowden syndrome 1	Enrichment	EGFR	1.62
169	Wilms tumor 5	Enrichment	BRAF	1.62
170	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	1.62
171	Lung squamous cell carcinoma	Enrichment	EGFR	1.62
172	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	JAK3	1.62
173	Myeloproliferative neoplasm	Enrichment	JAK2	1.62
174	Histiocytoid hemangioma	Enrichment	FOS	1.62
175	Nevus, epidermal	Enrichment	NRAS	1.55
176	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.55
177	Leukemia, chronic myeloid	Enrichment	NRAS	1.55
178	Gallbladder cancer	Enrichment	BRAF	1.55
179	Lymphoma, non-hodgkin, familial	Enrichment	BRAF	1.50
180	Myelofibrosis	Enrichment	JAK2	1.47
181	Essential thrombocythemia	Enrichment	JAK2	1.47
182	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.44
183	Adult hepatocellular carcinoma	Enrichment	EGF	1.44
184	Primary hyperaldosteronism	Enrichment	BRAF	1.44
185	Ventricular septal defect	Enrichment	BRAF	1.44
186	Hereditary chronic pancreatitis	Enrichment	TRB	1.44
187	Lennox-gastaut syndrome	Enrichment	MAPK10	1.42
188	Melanoma	Enrichment	BRAF	1.40
189	Dilated cardiomyopathy	Enrichment	BRAF, RAF1	1.38
190	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.37
191	Combined immunodeficiency	Enrichment	ZAP70	1.36
192	Combined t cell and b cell immunodeficiency	Enrichment	ZAP70	1.36
193	Combined t and b cell immunodeficiency	Enrichment	ZAP70	1.36
194	Pancreatitis, hereditary	Enrichment	TRB	1.35
195	Juvenile myelomonocytic leukemia	Enrichment	NRAS	1.32
196	Congenital long qt syndrome	Enrichment	ITPR3	1.32
197	Omenn syndrome	Enrichment	IL2RG	1.32
198	Colorectal cancer	Enrichment	BRAF, NRAS	1.31
199	Aortic valve disease 1	Enrichment	SOS1	1.29
200	Protein-deficiency anemia	Enrichment	NRAS	1.29
201	Breast cancer	Enrichment	IL2, JUN	1.29
202	Ichthyosis	Enrichment	IL2RB	1.28
203	Specific learning disability	Enrichment	MAPK1	1.28
204	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.26
205	Wilms tumor 1	Enrichment	BRAF	1.23
206	Anterior segment dysgenesis	Enrichment	ITPR1	1.23
207	Nk-cell enteropathy	Enrichment	JAK3	1.21
208	Gliosarcoma	Enrichment	EGFR	1.20
209	Melanoma, cutaneous malignant 1	Enrichment	BRAF	1.18
210	Dandy-walker syndrome	Enrichment	BRAF	1.18
211	Giant cell glioblastoma	Enrichment	EGFR	1.18
212	Heart, malformation of	Enrichment	MAPK1	1.08
213	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.03
214	Bladder cancer	Enrichment	EGFR	0.95
215	Long qt syndrome 1	Enrichment	ITPR3	0.94
216	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.90
217	Left ventricular noncompaction	Enrichment	RAF1	0.88
218	Leukemia, acute myeloid	Enrichment	NRAS	0.82
219	Spastic ataxia	Enrichment	ITPR1	0.71
220	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.71
221	Myeloma, multiple	Enrichment	BRAF	0.69
222	Primary ovarian insufficiency	Enrichment	JAK2	0.60
223	Ovarian cancer	Enrichment	EGFR	0.47
224	Inherited cancer-predisposing syndrome	Enrichment	EGFR	0.38
225	Microcephaly	Enrichment	MAPK1	0.34

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Immune response Antigen presentation by MHC class II

Pathway Network for Immune response Antigen presentation by MHC class II

Pathway network for the Immune response Antigen presentation by MHC class II SuperPath

Member Pathways for Immune response Antigen presentation by MHC class II

Pathways in the Immune response Antigen presentation by MHC class II SuperPath

Gene overlap in member pathways for Immune response Antigen presentation by MHC class II SuperPath

Associated Genes for Immune response Antigen presentation by MHC class II

Associated Disorders for Immune response Antigen presentation by MHC class II

Disorders associated with Immune response Antigen presentation by MHC class II SuperPath

STRING Interaction Network for Immune response Antigen presentation by MHC class II

Sources for Immune response Antigen presentation by MHC class II