Immune response CD16 signaling in NK cells

No Pathway Network information available for Immune response CD16 signaling in NK cells

Pathways in the Immune response CD16 signaling in NK cells SuperPath

#	Name	Source	Genes
1	Immune response CD16 signaling in NK cells	GeneGo (Thomson Reuters)	ACTB ACTG1 ACTR2 ACTR3 ACTR3B ARF6 ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 ATF2 CALM1 CALM2 CALM3 CBL CD247 CDC42 CSF2 CYTH1 FASLG FCGR3A FOS FOSB FOSL1 FOSL2 GRB2 HLA-E HRAS IFNG IGH IGHG1 IGHG3 IGHV3-23 IGK IGKC IGKJ IGKV@ IGL IGLJ IGLV@ IL2 IL3 IL4 INPP5D ITPR1 ITPR2 ITPR3 JUN JUNB JUND KLRC1 KLRD1 LAT LCK MAP2K1 MAP2K2 MAPK1 MAPK3 NFATC2 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PIP5K1A PLA2G10 PLA2G12A PLA2G12B PLA2G1B PLA2G2A PLA2G2D PLA2G2E PLA2G2F PLA2G3 PLA2G4A PLA2G4C PLA2G5 PLA2G6 PLA2G7 PLCG1 PLCG2 PLD1 PNPLA8 PPP3CA PPP3CB PPP3CC PPP3R1 PPP3R2 PRDX6 PRKCQ PTPN6 RAC1 RAF1 SHC1 SOS1 SOS2 SYK TNF VAV1 WAS WIPF1 ZAP70 (see all 105) (see less)
2	Immune response Role of DAP12 receptors in NK cells	GeneGo (Thomson Reuters)	ACTB ACTG1 ACTR2 ACTR3 ACTR3B ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 CRKL FYN GRB2 HLA-B HLA-C HLA-E HLA-G HRAS KIR2DL1 KIR2DL2 KIR2DL3 KIR2DL4 KIR2DL5A KIR2DS1 KIR2DS2 KIR3DL1 KLRA1P KLRC1 KLRC2 KLRC3 KLRD1 LAT LCK MAP2K1 MAP2K2 MAPK1 MAPK3 NCR2 PAK1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PLCG2 PRKCQ PTPN11 PTPN6 RAC1 RAF1 SHC1 SOS1 SOS2 SYK TYROBP VAV2 VAV3 WAS WIPF1 ZAP70 (see all 63) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ACTB	Actin Beta	Protein Coding	2
2	ACTG1	Actin Gamma 1	Protein Coding	2
3	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	2
4	HLA-E	Major Histocompatibility Complex, Class I, E	Protein Coding	2
5	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	2
6	KLRC1	Killer Cell Lectin Like Receptor C1	Protein Coding	2
7	KLRD1	Killer Cell Lectin Like Receptor D1	Protein Coding	2
8	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	2
9	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	2
10	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	2
11	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	2
12	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	2
13	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	2
14	PLCG1	Phospholipase C Gamma 1	Protein Coding	2
15	PLCG2	Phospholipase C Gamma 2	Protein Coding	2
16	PRKCQ	Protein Kinase C Theta	Protein Coding	2
17	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	2
18	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
19	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	2
20	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	2
21	PTPN6	Protein Tyrosine Phosphatase Non-Receptor Type 6	Protein Coding	2
22	RAC1	Rac Family Small GTPase 1	Protein Coding	2
23	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	2
24	SHC1	SHC Adaptor Protein 1	Protein Coding	2
25	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	2
26	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	2
27	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	2
28	WAS	WASP Actin Nucleation Promoting Factor	Protein Coding	2
29	WIPF1	WAS/WASL Interacting Protein Family Member 1	Protein Coding	2
30	ZAP70	Zeta Chain Of T Cell Receptor Associated Protein Kinase 70	Protein Coding	2
31	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	2
32	ARPC5	Actin Related Protein 2/3 Complex Subunit 5	Protein Coding	2
33	ARPC4	Actin Related Protein 2/3 Complex Subunit 4	Protein Coding	2
34	ARPC3	Actin Related Protein 2/3 Complex Subunit 3	Protein Coding	2
35	ARPC1B	Actin Related Protein 2/3 Complex Subunit 1B	Protein Coding	2
36	ACTR3	Actin Related Protein 3	Protein Coding	2
37	ACTR2	Actin Related Protein 2	Protein Coding	2
38	ARPC2	Actin Related Protein 2/3 Complex Subunit 2	Protein Coding	2
39	ARPC1A	Actin Related Protein 2/3 Complex Subunit 1A	Protein Coding	2
40	LAT	Linker For Activation Of T Cells	Protein Coding	2
41	ACTR3B	Actin Related Protein 3B	Protein Coding	2
42	FASLG	Fas Ligand	Protein Coding	1
43	ARF6	ARF GTPase 6	Protein Coding	1
44	CALM1	Calmodulin 1	Protein Coding	1
45	CALM2	Calmodulin 2	Protein Coding	1
46	CALM3	Calmodulin 3	Protein Coding	1
47	CBL	Cbl Proto-Oncogene	Protein Coding	1
48	CD247	CD247 Molecule	Protein Coding	1
49	CDC42	Cell Division Cycle 42	Protein Coding	1
50	ATF2	Activating Transcription Factor 2	Protein Coding	1
51	CSF2	Colony Stimulating Factor 2	Protein Coding	1
52	FCGR3A	Fc Gamma Receptor IIIa	Protein Coding	1
53	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
54	FOSB	FosB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
55	FOSL2	FOS Like 2, AP-1 Transcription Factor Subunit	Protein Coding	1
56	IFNG	Interferon Gamma	Protein Coding	1
57	IGH	Immunoglobulin Heavy Locus	Protein Coding	1
58	IGHG1	Immunoglobulin Heavy Constant Gamma 1 (G1m Marker)	Protein Coding	1
59	IGHG3	Immunoglobulin Heavy Constant Gamma 3 (G3m Marker)	Protein Coding	1
60	IGKC	Immunoglobulin Kappa Constant	Protein Coding	1
61	IGKV@	Immunoglobulin Kappa Variable Cluster	Gene Cluster	1
62	IGL	Immunoglobulin Lambda Locus	Protein Coding	1
63	IGLV@	Immunoglobulin Lambda Variable Cluster	Gene Cluster	1
64	IL2	Interleukin 2	Protein Coding	1
65	IL3	Interleukin 3	Protein Coding	1
66	IL4	Interleukin 4	Protein Coding	1
67	INPP5D	Inositol Polyphosphate-5-Phosphatase D	Protein Coding	1
68	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	1
69	ITPR2	Inositol 1,4,5-Trisphosphate Receptor Type 2	Protein Coding	1
70	ITPR3	Inositol 1,4,5-Trisphosphate Receptor Type 3	Protein Coding	1
71	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
72	JUNB	JunB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
73	JUND	JunD Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
74	NFATC2	Nuclear Factor Of Activated T Cells 2	Protein Coding	1
75	PLA2G1B	Phospholipase A2 Group IB	Protein Coding	1
76	PLA2G2A	Phospholipase A2 Group IIA	Protein Coding	1
77	PLA2G4A	Phospholipase A2 Group IVA	Protein Coding	1
78	PLA2G5	Phospholipase A2 Group V	Protein Coding	1
79	PLD1	Phospholipase D1	Protein Coding	1
80	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	1
81	PPP3CB	Protein Phosphatase 3 Catalytic Subunit Beta	Protein Coding	1
82	PPP3CC	Protein Phosphatase 3 Catalytic Subunit Gamma	Protein Coding	1
83	PPP3R1	Protein Phosphatase 3 Regulatory Subunit B, Alpha	Protein Coding	1
84	PPP3R2	Protein Phosphatase 3 Regulatory Subunit B, Beta	Protein Coding	1
85	TNF	Tumor Necrosis Factor	Protein Coding	1
86	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	1
87	IGKJ	Immunoglobulin Kappa Joining Cluster	Genetic Locus	1
88	PLA2G7	Phospholipase A2 Group VII	Protein Coding	1
89	FOSL1	FOS Like 1, AP-1 Transcription Factor Subunit	Protein Coding	1
90	IGLJ	Immunoglobulin Lambda Joining Cluster	Genetic Locus	1
91	PIP5K1A	Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Alpha	Protein Coding	1
92	PLA2G6	Phospholipase A2 Group VI	Protein Coding	1
93	PLA2G10	Phospholipase A2 Group X	Protein Coding	1
94	PLA2G4C	Phospholipase A2 Group IVC	Protein Coding	1
95	CYTH1	Cytohesin 1	Protein Coding	1
96	PRDX6	Peroxiredoxin 6	Protein Coding	1
97	PLA2G2D	Phospholipase A2 Group IID	Protein Coding	1
98	IGHV3-23	Immunoglobulin Heavy Variable 3-23	Protein Coding	1
99	PLA2G2E	Phospholipase A2 Group IIE	Protein Coding	1
100	PLA2G3	Phospholipase A2 Group III	Protein Coding	1
101	PNPLA8	Patatin Like Domain 8, Phospholipase A2	Protein Coding	1
102	IGK	Immunoglobulin Kappa Locus	Protein Coding	1
103	PLA2G2F	Phospholipase A2 Group IIF	Protein Coding	1
104	PLA2G12A	Phospholipase A2 Group XIIA	Protein Coding	1
105	PLA2G12B	Phospholipase A2 Group XIIB	Protein Coding	1
106	CRKL	CRK Like Proto-Oncogene, Adaptor Protein	Protein Coding	1
107	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
108	HLA-B	Major Histocompatibility Complex, Class I, B	Protein Coding	1
109	HLA-C	Major Histocompatibility Complex, Class I, C	Protein Coding	1
110	HLA-G	Major Histocompatibility Complex, Class I, G	Protein Coding	1
111	KIR2DL1	Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 1	Protein Coding	1
112	KIR2DL2	Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 2	Protein Coding	1
113	KIR2DL3	Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 3	Protein Coding	1
114	KIR2DL4	Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 4	Protein Coding	1
115	KIR2DS1	Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Short Cytoplasmic Tail 1	Protein Coding	1
116	KIR3DL1	Killer Cell Immunoglobulin Like Receptor, Three Ig Domains And Long Cytoplasmic Tail 1	Protein Coding	1
117	KLRC2	Killer Cell Lectin Like Receptor C2	Protein Coding	1
118	KLRC3	Killer Cell Lectin Like Receptor C3	Protein Coding	1
119	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
120	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
121	TYROBP	Transmembrane Immune Signaling Adaptor TYROBP	Protein Coding	1
122	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	1
123	NCR2	Natural Cytotoxicity Triggering Receptor 2	Protein Coding	1
124	VAV3	Vav Guanine Nucleotide Exchange Factor 3	Protein Coding	1
125	KLRA1P	Killer Cell Lectin Like Receptor A1, Pseudogene	Pseudogene	1
126	KIR2DL5A	Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 5A	Protein Coding	1
127	KIR2DS2	Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Short Cytoplasmic Tail 2	Protein Coding	1

Disorders associated with Immune response CD16 signaling in NK cells SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rasopathy	Enrichment	HRAS, MAP2K1, MAP2K2, PTPN11, RAF1, SOS1, SOS2	10.98
2	Noonan syndrome 1	Enrichment	HRAS, MAP2K1, MAP2K2, PTPN11, RAF1, SOS1, SOS2	10.57
3	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, MAP2K1, MAP2K2, PTPN11, RAF1, SOS1	10.27
4	Noonan syndrome 3	Enrichment	HRAS, PTPN11, RAF1, SOS1	7.83
5	Arteriovenous malformation	Enrichment	HRAS, MAP2K1, PIK3CA	5.10
6	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1, PIK3CA	4.95
7	Lung non-small cell carcinoma	Enrichment	HRAS, MAP2K1, PIK3CA	4.81
8	Wiskott-aldrich syndrome	Enrichment	WAS, WIPF1	4.67
9	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	4.67
10	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	4.61
11	Immunoglobulin kappa light chain deficiency	Enrichment	IGK, IGKC	4.23
12	Immune system disease	Enrichment	CDC42, PIK3CD	4.23
13	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.20
14	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	4.20
15	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	4.20
16	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3, ITPR3	4.10
17	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1, MAP2K2	3.90
18	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, PIK3R2	3.90
19	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	CRKL, MAPK1	3.90
20	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1, MAP2K2	3.90
21	Noonan syndrome with multiple lentigines	Enrichment	PTPN11, RAF1	3.90
22	Recurrent infections associated with rare immunoglobulin isotypes deficiency	Enrichment	IGK, IGKC	3.75
23	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL, CDC42	3.45
24	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB, FOSB	3.45
25	Nevus, epidermal	Enrichment	HRAS, PIK3CA	3.36
26	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1, PIK3CA	3.36
27	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, RAF1	3.23
28	Histiocytoid hemangioma	Enrichment	FOS, FOSB	3.23
29	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	3.03
30	Combined immunodeficiency	Enrichment	ARPC1B, ZAP70	2.94
31	Combined t cell and b cell immunodeficiency	Enrichment	ARPC1B, ZAP70	2.94
32	Specific learning disability	Enrichment	MAPK1, PTPN11	2.94
33	Combined t and b cell immunodeficiency	Enrichment	ARPC1B, ZAP70	2.94
34	Lip and oral cavity carcinoma	Enrichment	HRAS, PIK3CA	2.87
35	Severe combined immunodeficiency	Enrichment	CD247, LCK, ZAP70	2.68
36	Microcephaly	Enrichment	ACTB, ACTG1, MAPK1, PTPN11	2.60
37	Breast cancer	Enrichment	IL2, JUN, PIK3CA, SHC1	2.57
38	Macrodactyly	Enrichment	PIK3CA	2.33
39	Spondyloarthropathy 1	Enrichment	HLA-B	2.33
40	Metachondromatosis	Enrichment	PTPN11	2.33
41	Baraitser-winter syndrome 1	Enrichment	ACTB	2.33
42	Thrombocytopenia 1	Enrichment	WAS	2.33
43	Noonan syndrome 5	Enrichment	RAF1	2.33
44	Noonan syndrome 4	Enrichment	SOS1	2.33
45	Psoriasis 1	Enrichment	HLA-C	2.33
46	Melorheostosis, isolated	Enrichment	MAP2K1	2.33
47	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.33
48	Leopard syndrome 1	Enrichment	PTPN11	2.33
49	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.33
50	Cowden syndrome 5	Enrichment	PIK3CA	2.33
51	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.33
52	Noonan syndrome 9	Enrichment	SOS2	2.33
53	Wiskott-aldrich syndrome 2	Enrichment	WIPF1	2.33
54	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.33
55	Noonan syndrome 13	Enrichment	MAPK1	2.33
56	Immunodeficiency 82 with systemic inflammation	Enrichment	SYK	2.33
57	Immunodeficiency 48	Enrichment	ZAP70	2.33
58	Short syndrome	Enrichment	PIK3R1	2.33
59	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.33
60	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.33
61	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.33
62	Immunodeficiency 71 with inflammatory disease and congenital thrombocytopenia	Enrichment	ARPC1B	2.33
63	Ankylosing spondylitis 1	Enrichment	HLA-B	2.33
64	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.33
65	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.33
66	Becker nevus syndrome	Enrichment	ACTB	2.33
67	Melorheostosis	Enrichment	MAP2K1	2.33
68	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.33
69	Leopard syndrome 2	Enrichment	RAF1	2.33
70	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.33
71	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.33
72	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.33
73	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.33
74	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.33
75	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.33
76	Autoimmune disease, multisystem, infantile-onset, 2	Enrichment	ZAP70	2.33
77	Reactive arthritis	Enrichment	HLA-B	2.33
78	Immunodeficiency 22	Enrichment	LCK	2.33
79	Was-related disorders	Enrichment	WAS	2.33
80	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.33
81	Trigonitis	Enrichment	RAF1	2.33
82	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.33
83	Baraitser-winter syndrome	Enrichment	ACTB	2.33
84	Hypospadias	Enrichment	PIK3CA	2.33
85	Colitis	Enrichment	SYK	2.33
86	Rare venous malformation	Enrichment	PIK3CA	2.33
87	Vegetative pyoderma gangrenosum	Enrichment	PTPN6	2.33
88	Bullous pyoderma gangrenosum	Enrichment	PTPN6	2.33
89	Diaphragmatic eventration	Enrichment	PIK3CA	2.33
90	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.33
91	Pustular pyoderma gangrenosum	Enrichment	PTPN6	2.33
92	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.33
93	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.33
94	Pulmonary arterial hypertension associated with connective tissue disease	Enrichment	HLA-B	2.33
95	Rare combined vascular malformation	Enrichment	PIK3CA	2.33
96	Cavernous lymphangioma	Enrichment	PIK3CA	2.33
97	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.33
98	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.33
99	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.33
100	Classic pyoderma gangrenosum	Enrichment	PTPN6	2.33
101	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.33
102	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.33
103	Macrodactyly of toe	Enrichment	PIK3CA	2.33
104	Zap70-related severe combined immunodeficiency	Enrichment	ZAP70	2.33
105	Malignant astrocytoma	Enrichment	PTPN11	2.33
106	Hydrops fetalis, nonimmune	Enrichment	HRAS, PTPN11	2.19
107	Rhabdomyosarcoma	Enrichment	CBL, HRAS	2.18
108	Anhidrosis, isolated, with normal sweat glands	Enrichment	ITPR2	2.11
109	Mitochondrial myopathy with lactic acidosis	Enrichment	PNPLA8	2.11
110	Osteopetrosis and infantile neuroaxonal dystrophy	Enrichment	PLA2G6	2.11
111	Cardiac valvular dysplasia 1	Enrichment	PLD1	2.11
112	Fleck retina, familial benign	Enrichment	PLA2G5	2.11
113	Immunodeficiency 20	Enrichment	FCGR3A	2.11
114	Immunodeficiency 69	Enrichment	IFNG	2.11
115	Neurodegeneration with brain iron accumulation 2a	Enrichment	PLA2G6	2.11
116	Charcot-marie-tooth disease, demyelinating, type 1j	Enrichment	ITPR3	2.11
117	Developmental and epileptic encephalopathy 91	Enrichment	PPP3CA	2.11
118	Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development	Enrichment	PPP3CA	2.11
119	Immunodeficiency 25	Enrichment	CD247	2.11
120	Parkinson disease 14, autosomal recessive	Enrichment	PLA2G6	2.11
121	Neurodegeneration with brain iron accumulation 2b	Enrichment	PLA2G6	2.11
122	Cytosolic phospholipase-a2 alpha deficiency associated bleeding disorder	Enrichment	PLA2G4A	2.11
123	Long qt syndrome 16	Enrichment	CALM3	2.11
124	Platelet-activating factor acetylhydrolase deficiency	Enrichment	PLA2G7	2.11
125	Gastrointestinal ulceration, recurrent, with dysfunctional platelets	Enrichment	PLA2G4A	2.11
126	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.11
127	Long qt syndrome 15	Enrichment	CALM2	2.11
128	Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathy	Enrichment	ITPR3	2.11
129	B-lymphoblastic leukemia/lymphoma with t(5;14)(q31.1;q32.3)	Enrichment	IGH	2.11
130	Nocarh syndrome	Enrichment	CDC42	2.11
131	Aplasia cutis-enamel dysplasia syndrome	Enrichment	FOSL2	2.11
132	Cryptogenic multifocal ulcerous stenosing enteritis	Enrichment	PLA2G4A	2.11
133	Familial benign flecked retina	Enrichment	PLA2G5	2.11
134	Bladder cancer	Enrichment	HRAS, PIK3CA	2.10
135	Non-immune hydrops fetalis	Enrichment	HRAS, PTPN11	2.04
136	Fibromatosis, gingival, 1	Enrichment	SOS1	2.03
137	Costello syndrome	Enrichment	HRAS	2.03
138	Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1	Enrichment	TYROBP	2.03
139	Neutropenia, severe congenital, x-linked	Enrichment	WAS	2.03
140	Severe cutaneous adverse reaction	Enrichment	HLA-B	2.03
141	Pulmonic stenosis	Enrichment	SOS1	2.03
142	Deafness, autosomal dominant 20	Enrichment	ACTG1	2.03
143	Keratosis, seborrheic	Enrichment	PIK3CA	2.03
144	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.03
145	Baraitser-winter syndrome 2	Enrichment	ACTG1	2.03
146	Noonan syndrome 8	Enrichment	PIK3CA	2.03
147	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.03
148	Developmental delay, language impairment, and ocular abnormalities	Enrichment	ARPC4	2.03
149	Werner syndrome	Enrichment	PTPN11	2.03
150	Stevens-johnson syndrome	Enrichment	HLA-B	2.03
151	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.03
152	Immunodeficiency 113 with autoimmunity and autoinflammation	Enrichment	ARPC5	2.03
153	Immunodeficiency 52	Enrichment	LAT	2.03
154	Arthritis	Enrichment	SYK	2.03
155	Immunodeficiency 133	Enrichment	ARPC5	2.03
156	Tafro syndrome	Enrichment	MAP2K2	2.03
157	Wooly hair nevus	Enrichment	HRAS	2.03
158	Takayasu arteritis	Enrichment	HLA-B	1.86
159	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.86
160	Nuchal bleb, familial	Enrichment	SOS1	1.86
161	Langerhans cell histiocytosis	Enrichment	MAP2K1	1.86
162	Neutrophilic dermatosis, acute febrile	Enrichment	PTPN6	1.86
163	Large congenital melanocytic nevus	Enrichment	HRAS	1.86
164	Spermatocytoma	Enrichment	HRAS	1.86
165	Tricuspid valve insufficiency	Enrichment	PTPN11	1.86
166	Keratoacanthoma	Enrichment	PIK3CA	1.86
167	Spinocerebellar ataxia 29	Enrichment	ITPR1	1.81
168	Ovarian germ cell cancer	Enrichment	CBL	1.81
169	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	1.81
170	Long qt syndrome 14	Enrichment	CALM1	1.81
171	Immunodeficiency 127	Enrichment	TNF	1.81
172	Intellectual developmental disorder, autosomal dominant 60, with seizures	Enrichment	PIP5K1A	1.81
173	Joint contractures, osteochondromas, and b-cell lymphoma	Enrichment	NFATC2	1.81
174	Malignant germ cell tumor of ovary	Enrichment	CBL	1.81
175	Infantile osteopetrosis with neuroaxonal dysplasia	Enrichment	PLA2G6	1.81
176	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	1.73
177	Temporal arteritis	Enrichment	HLA-B	1.73
178	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.73
179	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	1.73
180	Aminoacylase 1 deficiency	Enrichment	ACTB	1.73
181	Cerebrovascular disease	Enrichment	PIK3CA	1.73
182	Epidermolytic nevus	Enrichment	HRAS	1.73
183	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.73
184	Gingival fibromatosis	Enrichment	SOS1	1.73
185	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.73
186	Thrombocytopenia	Enrichment	PTPN11, WAS	1.68
187	Capillary malformations, congenital	Enrichment	PIK3CA	1.64
188	Lymphoma	Enrichment	PTPN11	1.64
189	Hemimegalencephaly	Enrichment	PIK3CA	1.64
190	Coloboma of choroid and retina	Enrichment	ACTG1	1.64
191	Gillespie syndrome	Enrichment	ITPR1	1.64
192	Tuberous sclerosis 1	Enrichment	IFNG	1.64
193	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	FASLG	1.64
194	Agammaglobulinemia 1, autosomal recessive	Enrichment	IGH	1.64
195	Late-onset retinal degeneration	Enrichment	PLA2G5	1.64
196	Psoriatic arthritis	Enrichment	TNF	1.64
197	Hepatitis c virus	Enrichment	IFNG	1.64
198	Tuberous sclerosis 2	Enrichment	IFNG	1.64
199	Agammaglobulinemia 1	Enrichment	IGH	1.64
200	Migraine without aura	Enrichment	TNF	1.64
201	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD247	1.64
202	Long qt syndrome	Enrichment	CALM1, CALM2	1.62
203	Lung cancer	Enrichment	FASLG, PIK3CA	1.60
204	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.56
205	Cowden syndrome 1	Enrichment	PIK3CA	1.56
206	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.56
207	Patent ductus arteriosus	Enrichment	PTPN11	1.56
208	Breast adenocarcinoma	Enrichment	PIK3CA	1.56
209	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.56
210	Colorectal cancer	Enrichment	PIK3CA, PIK3R1, PLA2G2A	1.52
211	Autoimmune lymphoproliferative syndrome	Enrichment	FASLG	1.51
212	Spinocerebellar ataxia 15	Enrichment	ITPR1	1.51
213	Congenital generalized lipodystrophy	Enrichment	FOS	1.51
214	Mantle cell lymphoma	Enrichment	IGH	1.51
215	Cerebral malaria	Enrichment	TNF	1.51
216	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	1.49
217	Gallbladder cancer	Enrichment	PIK3CA	1.49
218	Pilomyxoid astrocytoma	Enrichment	RAF1	1.49
219	Follicular thyroid carcinoma	Enrichment	HRAS	1.49
220	Overgrowth syndrome	Enrichment	PIK3R1	1.49
221	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	HLA-C	1.49
222	Systemic lupus erythematosus	Enrichment	IGHG1, TNF	1.44
223	Lymphoma, mucosa-associated lymphoid type	Enrichment	IGH	1.42
224	Follicular lymphoma	Enrichment	IGH	1.42
225	Myeloproliferative neoplasm	Enrichment	CBL	1.42
226	Vascular dementia	Enrichment	TNF	1.42
227	Aggressive systemic mastocytosis	Enrichment	CBL	1.42
228	Idiopathic aplastic anemia	Enrichment	IFNG	1.42
229	Inflammatory bowel disease 1	Enrichment	PRKCQ	1.39
230	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.39
231	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.39
232	Cowden syndrome	Enrichment	PIK3CA	1.39
233	Cat eye syndrome	Enrichment	ACTG1	1.34
234	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.34
235	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	1.34
236	Pectus excavatum	Enrichment	PTPN11	1.30
237	Immune deficiency disease	Enrichment	SYK	1.30
238	Asthma	Enrichment	HLA-G	1.30
239	Oligoarticular juvenile idiopathic arthritis	Enrichment	CD247	1.28
240	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	CD247	1.28
241	Epicanthus	Enrichment	PTPN11	1.26
242	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.26
243	Meningioma	Enrichment	PIK3CA	1.26
244	Congenital long qt syndrome	Enrichment	PTPN11	1.26
245	Aortic valve disease 1	Enrichment	SOS1	1.23
246	Nk-cell enteropathy	Enrichment	PIK3CB	1.23
247	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.22
248	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.20
249	Spastic ataxia	Enrichment	ITPR1, PLA2G6	1.20
250	Lynch syndrome	Enrichment	PIK3CA	1.17
251	Leukemia, chronic lymphocytic	Enrichment	IGHG1	1.13
252	Aplastic anemia	Enrichment	IFNG	1.13
253	Neurodegeneration with brain iron accumulation	Enrichment	PLA2G6	1.13
254	Familial colorectal cancer	Enrichment	PLA2G2A	1.13
255	Heart, malformation of	Enrichment	MAPK1	1.09
256	Human immunodeficiency virus type 1	Enrichment	HLA-C	1.09
257	Patent foramen ovale	Enrichment	PTPN11	1.09
258	Behcet syndrome	Enrichment	HLA-B	1.07
259	Autism spectrum disorder	Enrichment	MAP2K1, PTPN11	1.04
260	Endometrial cancer	Enrichment	PIK3CA	1.03
261	Lissencephaly	Enrichment	ACTG1	1.03
262	Alzheimer's disease	Enrichment	TNF	1.02
263	Hepatocellular carcinoma	Enrichment	PIK3CA	1.01
264	Multiple sclerosis	Enrichment	ITPR1	0.99
265	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	0.98
266	Scoliosis	Enrichment	PTPN11	0.98
267	Anterior segment dysgenesis	Enrichment	ITPR1	0.96
268	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	PLA2G6	0.93
269	Strabismus	Enrichment	PTPN11	0.93
270	Sudden infant death syndrome	Enrichment	CALM2	0.91
271	Prostate cancer	Enrichment	PIK3CA	0.90
272	Differentiated thyroid carcinoma	Enrichment	HRAS	0.90
273	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.85
274	Cakut	Enrichment	ACTG1	0.83
275	Left ventricular noncompaction	Enrichment	RAF1	0.82
276	Cardiomyopathy, dilated, 1a	Enrichment	NFATC2	0.82
277	Non-syndromic genetic deafness	Enrichment	ACTG1	0.81
278	Malaria	Enrichment	TNF	0.79
279	Nonsyndromic hearing loss	Enrichment	ACTG1	0.75
280	Gastric cancer	Enrichment	PIK3CA	0.74
281	Hypertrophic cardiomyopathy	Enrichment	PTPN11	0.74
282	Hereditary breast carcinoma	Enrichment	PIK3CA	0.73
283	Hypertelorism	Enrichment	PIK3CA	0.67
284	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1	0.67
285	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.66
286	Myeloma, multiple	Enrichment	PIK3R2	0.64
287	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.64
288	Rare genetic deafness	Enrichment	ACTG1	0.51
289	Dilated cardiomyopathy	Enrichment	RAF1	0.51
290	Autosomal dominant non-syndromic intellectual disability	Enrichment	PPP3CA	0.49
291	Undetermined early-onset epileptic encephalopathy	Enrichment	PPP3CA	0.45
292	Ovarian cancer	Enrichment	PIK3CA	0.42
293	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	0.34
294	Congenital nervous system abnormality	Enrichment	PLA2G6	0.25
295	Nervous system disease	Enrichment	PLA2G6	0.25

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Immune response CD16 signaling in NK cells

Pathway Network for Immune response CD16 signaling in NK cells

Member Pathways for Immune response CD16 signaling in NK cells

Pathways in the Immune response CD16 signaling in NK cells SuperPath

Associated Genes for Immune response CD16 signaling in NK cells

Associated Disorders for Immune response CD16 signaling in NK cells

Disorders associated with Immune response CD16 signaling in NK cells SuperPath

STRING Interaction Network for Immune response CD16 signaling in NK cells

Sources for Immune response CD16 signaling in NK cells