Immune response Fc epsilon RI pathway

Pathway network for the Immune response Fc epsilon RI pathway SuperPath

Sources:

GeneGo (Thomson Reuters)
PubChem

Pathways in the Immune response Fc epsilon RI pathway SuperPath

#	Name	Source	Genes
1	Immune response Fc epsilon RI pathway	GeneGo (Thomson Reuters)	AKT1 AKT2 AKT3 ATF2 BLNK BTK CALM1 CALM2 CALM3 CHUK ELK1 FCER1A FCER1G FER GAB2 GRB2 HRAS IGH IGHE IGHV3-23 IGK IGKC IGKJ IGKV@ IGL IGLJ IGLV@ IKBKB IKBKG ITPR1 ITPR2 ITPR3 JUN LAT LCP2 LYN MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 MS4A2 NFATC4 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE PAK2 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLA2G4A PLA2G4C PLCG1 PLCG2 PPP3CA PPP3CB PPP3CC PRKCQ RAC1 RAF1 REL RELA RELB SOS1 SOS2 SYK VAV1 (see all 83) (see less)
2	Immune response BCR pathway	GeneGo (Thomson Reuters)	AKT1 AKT2 AKT3 BAD BCL2L1 BCL6 BLNK BTK CALM1 CALM2 CALM3 CD19 CD22 CD79A CD79B CD81 CDC42 CR2 EGR1 ELK1 FCGR2B GRB2 GSK3B HRAS IGH IGHM IGHV3-23 IGK IGKC IGKJ IGKV@ IGL IGLJ IGLV@ INPP5D ITPR1 ITPR2 ITPR3 LYN MAPK1 MAPK3 NFATC2 NFKB1 NFKB2 PDPK1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PLCG2 PPP3CA PPP3CB PPP3CC PRKCB PTEN PTPN6 PTPRC RAC1 REL RELA RELB RPS6KB1 SHC1 SOS1 SOS2 SYK VAV1 VAV2 (see all 71) (see less)
3	Fc-epsilon receptor I signaling in mast cells	PubChem	AKT1 BTK CBL CBLB CHUK DOK1 DUSP1 FCER1A FCER1G FCGR2B FER FOS FYN GAB2 GAD1 GRB2 HCLS1 HRAS IKBKB IKBKG ITK JUN LAT LAT2 LCP2 LYN MAP2K1 MAP2K2 MAP2K4 MAP2K7 MAP3K1 MAPK1 MAPK3 MAPK8 MS4A2 NFATC2 NFKB1 PAK2 PIK3CA PIK3R1 PLA2G1B PLA2G4A PLCG1 PLD2 PLPP1 PRKCB PRRT2 PTK2 PTPN11 PTPN13 PXN RAF1 RASA1 RELA S1PR1 SHC1 SOS1 SPHK1 SYK VAV1 WIPF1 (see all 61) (see less)

Gene overlap in member pathways for Immune response Fc epsilon RI pathway SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	3
2	BTK	Bruton Tyrosine Kinase	Protein Coding	3
3	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	3
4	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	3
5	LYN	LYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	3
6	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	3
7	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	3
8	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	3
9	PLCG1	Phospholipase C Gamma 1	Protein Coding	3
10	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	3
11	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	3
12	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	3
13	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	3
14	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	3
15	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	3
16	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	2
17	CALM1	Calmodulin 1	Protein Coding	2
18	CALM2	Calmodulin 2	Protein Coding	2
19	CALM3	Calmodulin 3	Protein Coding	2
20	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	2
21	ELK1	ETS Transcription Factor ELK1	Protein Coding	2
22	FCER1A	Fc Epsilon Receptor Ia	Protein Coding	2
23	MS4A2	Membrane Spanning 4-Domains A2	Protein Coding	2
24	FCER1G	Fc Epsilon Receptor Ig	Protein Coding	2
25	FER	FER Tyrosine Kinase	Protein Coding	2
26	IGH	Immunoglobulin Heavy Locus	Protein Coding	2
27	IGKC	Immunoglobulin Kappa Constant	Protein Coding	2
28	IGKV@	Immunoglobulin Kappa Variable Cluster	Gene Cluster	2
29	IGL	Immunoglobulin Lambda Locus	Protein Coding	2
30	IGLV@	Immunoglobulin Lambda Variable Cluster	Gene Cluster	2
31	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	2
32	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	2
33	ITPR2	Inositol 1,4,5-Trisphosphate Receptor Type 2	Protein Coding	2
34	ITPR3	Inositol 1,4,5-Trisphosphate Receptor Type 3	Protein Coding	2
35	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
36	LCP2	Lymphocyte Cytosolic Protein 2	Protein Coding	2
37	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	2
38	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	2
39	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	2
40	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	2
41	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	2
42	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	2
43	PLA2G4A	Phospholipase A2 Group IVA	Protein Coding	2
44	PLCG2	Phospholipase C Gamma 2	Protein Coding	2
45	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	2
46	PPP3CB	Protein Phosphatase 3 Catalytic Subunit Beta	Protein Coding	2
47	PPP3CC	Protein Phosphatase 3 Catalytic Subunit Gamma	Protein Coding	2
48	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	2
49	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	2
50	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	2
51	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	2
52	RAC1	Rac Family Small GTPase 1	Protein Coding	2
53	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	2
54	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	2
55	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	2
56	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	2
57	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	2
58	IGKJ	Immunoglobulin Kappa Joining Cluster	Genetic Locus	2
59	IGLJ	Immunoglobulin Lambda Joining Cluster	Genetic Locus	2
60	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	2
61	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	2
62	GAB2	GRB2 Associated Binding Protein 2	Protein Coding	2
63	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	2
64	LAT	Linker For Activation Of T Cells	Protein Coding	2
65	IGHV3-23	Immunoglobulin Heavy Variable 3-23	Protein Coding	2
66	BLNK	B Cell Linker	Protein Coding	2
67	IGK	Immunoglobulin Kappa Locus	Protein Coding	2
68	FCGR2B	Fc Gamma Receptor IIb	Protein Coding	2
69	NFATC2	Nuclear Factor Of Activated T Cells 2	Protein Coding	2
70	PRKCB	Protein Kinase C Beta	Protein Coding	2
71	SHC1	SHC Adaptor Protein 1	Protein Coding	2
72	ATF2	Activating Transcription Factor 2	Protein Coding	1
73	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
74	IGHE	Immunoglobulin Heavy Constant Epsilon	Protein Coding	1
75	NFATC4	Nuclear Factor Of Activated T Cells 4	Protein Coding	1
76	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
77	NFKBIB	NFKB Inhibitor Beta	Protein Coding	1
78	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	1
79	PRKCQ	Protein Kinase C Theta	Protein Coding	1
80	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	1
81	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
82	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
83	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	1
84	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
85	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	1
86	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	1
87	PLA2G4C	Phospholipase A2 Group IVC	Protein Coding	1
88	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	1
89	BCL2L1	BCL2 Like 1	Protein Coding	1
90	BCL6	BCL6 Transcription Repressor	Protein Coding	1
91	CD19	CD19 Molecule	Protein Coding	1
92	CD22	CD22 Molecule	Protein Coding	1
93	CD79A	CD79a Molecule	Protein Coding	1
94	CD79B	CD79b Molecule	Protein Coding	1
95	CD81	CD81 Molecule	Protein Coding	1
96	CDC42	Cell Division Cycle 42	Protein Coding	1
97	CR2	Complement C3d Receptor 2	Protein Coding	1
98	EGR1	Early Growth Response 1	Protein Coding	1
99	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
100	IGHM	Immunoglobulin Heavy Constant Mu	Protein Coding	1
101	INPP5D	Inositol Polyphosphate-5-Phosphatase D	Protein Coding	1
102	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
103	PTEN	Phosphatase And Tensin Homolog	Protein Coding	1
104	PTPN6	Protein Tyrosine Phosphatase Non-Receptor Type 6	Protein Coding	1
105	PTPRC	Protein Tyrosine Phosphatase Receptor Type C	Protein Coding	1
106	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	1
107	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	1
108	WIPF1	WAS/WASL Interacting Protein Family Member 1	Protein Coding	1
109	PRRT2	Proline Rich Transmembrane Protein 2	Protein Coding	1
110	HCLS1	Hematopoietic Cell-Specific Lyn Substrate 1	Protein Coding	1
111	CBLB	Cbl Proto-Oncogene B	Protein Coding	1
112	DUSP1	Dual Specificity Phosphatase 1	Protein Coding	1
113	PLD2	Phospholipase D2	Protein Coding	1
114	PLPP1	Phospholipid Phosphatase 1	Protein Coding	1
115	LAT2	Linker For Activation Of T Cells Family Member 2	Protein Coding	1
116	ITK	IL2 Inducible T Cell Kinase	Protein Coding	1
117	GAD1	Glutamate Decarboxylase 1	Protein Coding	1
118	DOK1	Docking Protein 1	Protein Coding	1
119	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
120	S1PR1	Sphingosine-1-Phosphate Receptor 1	Protein Coding	1
121	SPHK1	Sphingosine Kinase 1	Protein Coding	1
122	PTPN13	Protein Tyrosine Phosphatase Non-Receptor Type 13	Protein Coding	1
123	PLA2G1B	Phospholipase A2 Group IB	Protein Coding	1
124	PXN	Paxillin	Protein Coding	1
125	RASA1	RAS P21 Protein Activator 1	Protein Coding	1
126	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
127	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
128	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
129	CBL	Cbl Proto-Oncogene	Protein Coding	1

Disorders associated with Immune response Fc epsilon RI pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rasopathy	Enrichment	CBL, HRAS, MAP2K1, MAP2K2, PTPN11, RAF1, SOS1	16.00
2	Autosomal non-syndromic agammaglobulinemia	Enrichment	BLNK, CD79A, CD79B, IGHM, PIK3CD, PIK3R1	11.87
3	Noonan syndrome and noonan-related syndrome	Enrichment	CBL, HRAS, MAP2K1, MAP2K2, PTPN11, RAF1, SOS1	11.63
4	Noonan syndrome 1	Enrichment	CBL, HRAS, MAP2K1, MAP2K2, PTPN11, RAF1, SOS1	10.60
5	Noonan syndrome 3	Enrichment	HRAS, PTPN11, RAF1, SOS1	7.89
6	Arteriovenous malformation	Enrichment	HRAS, MAP2K1, PIK3CA, RASA1	7.34
7	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1, PIK3CA, RASA1	7.12
8	Agammaglobulinemia 1, autosomal recessive	Enrichment	BTK, IGH, IGHM	6.86
9	Agammaglobulinemia 1	Enrichment	BTK, IGH, IGHM	6.86
10	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA, PIK3R2	6.26
11	Hemimegalencephaly	Enrichment	AKT3, PIK3CA, PTEN	5.87
12	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1, PIK3CA, RASA1	5.52
13	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	5.12
14	Cowden syndrome	Enrichment	AKT1, PIK3CA, PTEN	4.95
15	Lung non-small cell carcinoma	Enrichment	HRAS, MAP2K1, PIK3CA	4.86
16	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3, ITPR3	4.77
17	Immunoglobulin kappa light chain deficiency	Enrichment	IGK, IGKC	4.57
18	Immune system disease	Enrichment	CDC42, PIK3CD	4.57
19	Common variable immunodeficiency phenotype due to cd19/cd81 deficiency	Enrichment	CD19, CD81	4.57
20	Meningioma	Enrichment	AKT1, PIK3CA, PTEN	4.53
21	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	4.43
22	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.23
23	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	4.09
24	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	4.09
25	Recurrent infections associated with rare immunoglobulin isotypes deficiency	Enrichment	IGK, IGKC	4.09
26	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1, MAP2K2	3.93
27	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1, MAP2K2	3.93
28	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL, PTPN11	3.93
29	Noonan syndrome with multiple lentigines	Enrichment	PTPN11, RAF1	3.93
30	Diffuse large b-cell lymphoma	Enrichment	BTK, CD79B, PTEN	3.90
31	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	3.79
32	Capillary malformations, congenital	Enrichment	PIK3CA, RASA1	3.71
33	Follicular lymphoma	Enrichment	BCL6, IGH	3.57
34	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA, RASA1	3.53
35	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	3.53
36	Breast cancer	Enrichment	AKT1, JUN, PIK3CA, SHC1	3.45
37	Cowden syndrome 1	Enrichment	PIK3CA, PTEN	3.40
38	Nevus, epidermal	Enrichment	HRAS, PIK3CA	3.39
39	Bladder cancer	Enrichment	HRAS, PIK3CA, PTEN	3.34
40	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, RAF1	3.26
41	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, PTEN	3.25
42	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	3.25
43	Follicular thyroid carcinoma	Enrichment	HRAS, PTEN	3.25
44	Specific learning disability	Enrichment	MAPK1, PTPN11	2.97
45	Juvenile myelomonocytic leukemia	Enrichment	CBL, PTPN11	2.89
46	Lip and oral cavity carcinoma	Enrichment	HRAS, PIK3CA	2.89
47	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA, PTEN	2.81
48	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1, SOS1	2.76
49	Rhabdomyosarcoma	Enrichment	CBL, HRAS	2.64
50	Macrodactyly	Enrichment	PIK3CA	2.35
51	Proteus syndrome	Enrichment	AKT1	2.35
52	Metachondromatosis	Enrichment	PTPN11	2.35
53	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	2.35
54	Incontinentia pigmenti	Enrichment	IKBKG	2.35
55	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.35
56	Noonan syndrome 5	Enrichment	RAF1	2.35
57	Noonan syndrome 4	Enrichment	SOS1	2.35
58	Melorheostosis, isolated	Enrichment	MAP2K1	2.35
59	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.35
60	Leopard syndrome 1	Enrichment	PTPN11	2.35
61	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.35
62	Cowden syndrome 5	Enrichment	PIK3CA	2.35
63	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.35
64	Fetal encasement syndrome	Enrichment	CHUK	2.35
65	Wiskott-aldrich syndrome 2	Enrichment	WIPF1	2.35
66	46,xy sex reversal 6	Enrichment	MAP3K1	2.35
67	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.35
68	Immunodeficiency 15b	Enrichment	IKBKB	2.35
69	Noonan syndrome 13	Enrichment	MAPK1	2.35
70	Immunodeficiency 81	Enrichment	LCP2	2.35
71	Immunodeficiency 82 with systemic inflammation	Enrichment	SYK	2.35
72	Immunodeficiency 15a	Enrichment	IKBKB	2.35
73	Knobloch syndrome 2	Enrichment	PAK2	2.35
74	Short syndrome	Enrichment	PIK3R1	2.35
75	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.35
76	Developmental and epileptic encephalopathy 89	Enrichment	GAD1	2.35
77	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.35
78	Isolated growth hormone deficiency type iii	Enrichment	BTK	2.35
79	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.35
80	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.35
81	Lymphoproliferative syndrome 1	Enrichment	ITK	2.35
82	Melorheostosis	Enrichment	MAP2K1	2.35
83	Leopard syndrome 2	Enrichment	RAF1	2.35
84	Cytosolic phospholipase-a2 alpha deficiency associated bleeding disorder	Enrichment	PLA2G4A	2.35
85	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.35
86	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.35
87	Cowden syndrome 6	Enrichment	AKT1	2.35
88	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.35
89	Gastrointestinal ulceration, recurrent, with dysfunctional platelets	Enrichment	PLA2G4A	2.35
90	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.35
91	Autoinflammatory disease, systemic, with vasculitis	Enrichment	LYN	2.35
92	Trigonitis	Enrichment	RAF1	2.35
93	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.35
94	Hypospadias	Enrichment	PIK3CA	2.35
95	Colitis	Enrichment	SYK	2.35
96	Rare venous malformation	Enrichment	PIK3CA	2.35
97	Gorham's disease	Enrichment	RASA1	2.35
98	Diaphragmatic eventration	Enrichment	PIK3CA	2.35
99	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.35
100	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.35
101	Rare combined vascular malformation	Enrichment	PIK3CA	2.35
102	Cavernous lymphangioma	Enrichment	PIK3CA	2.35
103	Cryptogenic multifocal ulcerous stenosing enteritis	Enrichment	PLA2G4A	2.35
104	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.35
105	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.35
106	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.35
107	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.35
108	Macrodactyly of toe	Enrichment	PIK3CA	2.35
109	Malignant astrocytoma	Enrichment	PTPN11	2.35
110	Malaria	Enrichment	FCGR2B, IKBKG	2.32
111	Anhidrosis, isolated, with normal sweat glands	Enrichment	ITPR2	2.28
112	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.28
113	Vacterl association with hydrocephalus	Enrichment	PTEN	2.28
114	Noonan syndrome 9	Enrichment	SOS2	2.28
115	Immunodeficiency, common variable, 6	Enrichment	CD81	2.28
116	Agammaglobulinemia 3, autosomal recessive	Enrichment	CD79A	2.28
117	Immunodeficiency 92	Enrichment	REL	2.28
118	Charcot-marie-tooth disease, demyelinating, type 1j	Enrichment	ITPR3	2.28
119	Developmental and epileptic encephalopathy 91	Enrichment	PPP3CA	2.28
120	Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development	Enrichment	PPP3CA	2.28
121	Papillary tumor of the pineal region	Enrichment	PTEN	2.28
122	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.28
123	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.28
124	Long qt syndrome 16	Enrichment	CALM3	2.28
125	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.28
126	Immunodeficiency, common variable, 3	Enrichment	CD19	2.28
127	Immunodeficiency 105, severe combined	Enrichment	PTPRC	2.28
128	Glioma susceptibility 2	Enrichment	PTEN	2.28
129	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.28
130	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.28
131	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.28
132	Immunodeficiency 53	Enrichment	RELB	2.28
133	Cd45 deficiency	Enrichment	PTPRC	2.28
134	Long qt syndrome 15	Enrichment	CALM2	2.28
135	Capillary hemangioma	Enrichment	AKT3	2.28
136	Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathy	Enrichment	ITPR3	2.28
137	Vegetative pyoderma gangrenosum	Enrichment	PTPN6	2.28
138	B-lymphoblastic leukemia/lymphoma with t(5;14)(q31.1;q32.3)	Enrichment	IGH	2.28
139	Bullous pyoderma gangrenosum	Enrichment	PTPN6	2.28
140	Agammaglobulinemia 3	Enrichment	CD79A	2.28
141	Pustular pyoderma gangrenosum	Enrichment	PTPN6	2.28
142	Nocarh syndrome	Enrichment	CDC42	2.28
143	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	2.28
144	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.28
145	Classic pyoderma gangrenosum	Enrichment	PTPN6	2.28
146	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.28
147	Endometrial cancer	Enrichment	PIK3CA, PTEN	2.27
148	Hydrops fetalis, nonimmune	Enrichment	HRAS, PTPN11	2.22
149	Colorectal cancer	Enrichment	AKT1, PIK3CA, PIK3R1	2.15
150	Non-immune hydrops fetalis	Enrichment	HRAS, PTPN11	2.07
151	Fibromatosis, gingival, 1	Enrichment	SOS1	2.05
152	Costello syndrome	Enrichment	HRAS	2.05
153	Ovarian germ cell cancer	Enrichment	CBL	2.05
154	Wiskott-aldrich syndrome	Enrichment	WIPF1	2.05
155	Immunodeficiency 33	Enrichment	IKBKG	2.05
156	Pulmonic stenosis	Enrichment	SOS1	2.05
157	Isolated growth hormone deficiency, type iii, with agammaglobulinemia	Enrichment	BTK	2.05
158	Seizures, benign familial infantile, 2	Enrichment	PRRT2	2.05
159	Keratosis, seborrheic	Enrichment	PIK3CA	2.05
160	Noonan syndrome 8	Enrichment	PIK3CA	2.05
161	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.05
162	Myopia 28, autosomal recessive	Enrichment	DOK1	2.05
163	Agammaglobulinemia, x-linked	Enrichment	BTK	2.05
164	Werner syndrome	Enrichment	PTPN11	2.05
165	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.05
166	Autoimmune disease, multisystem, infantile-onset, 3	Enrichment	CBLB	2.05
167	Rela fusion-positive ependymoma	Enrichment	RELA	2.05
168	Lymphoproliferative syndrome	Enrichment	ITK	2.05
169	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.05
170	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.05
171	Immunodeficiency 52	Enrichment	LAT	2.05
172	Joint contractures, osteochondromas, and b-cell lymphoma	Enrichment	NFATC2	2.05
173	Arthritis	Enrichment	SYK	2.05
174	Malignant germ cell tumor of ovary	Enrichment	CBL	2.05
175	Common variable immunodeficiency 12	Enrichment	NFKB1	2.05
176	Prrt2-related disorder	Enrichment	PRRT2	2.05
177	Tafro syndrome	Enrichment	MAP2K2	2.05
178	Wooly hair nevus	Enrichment	HRAS	2.05
179	Prostate cancer	Enrichment	PIK3CA, PTEN	2.00
180	Spinocerebellar ataxia 29	Enrichment	ITPR1	1.98
181	Immunodeficiency, common variable, 2	Enrichment	CR2	1.98
182	Agammaglobulinemia 4, autosomal recessive	Enrichment	BLNK	1.98
183	Agammaglobulinemia 6, autosomal recessive	Enrichment	CD79B	1.98
184	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	1.98
185	Roifman-chitayat syndrome	Enrichment	PIK3CD	1.98
186	Immunodeficiency, common variable, 10	Enrichment	NFKB2	1.98
187	Long qt syndrome 14	Enrichment	CALM1	1.98
188	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.98
189	Intravascular large b-cell lymphoma	Enrichment	BCL6	1.98
190	Immunodeficiency, common variable, 7	Enrichment	CR2	1.98
191	Senior-loken syndrome 7	Enrichment	AKT3	1.98
192	Agammaglobulinemia 4	Enrichment	BLNK	1.98
193	Agammaglobulinemia 6	Enrichment	CD79B	1.98
194	Immunodeficiency 104, severe combined	Enrichment	PTPRC	1.98
195	Bardet-biedl syndrome 16	Enrichment	AKT3	1.98
196	Vacterl with hydrocephalus	Enrichment	PTEN	1.98
197	Primary mediastinal large b-cell lymphoma	Enrichment	BCL6	1.98
198	Juvenile polyposis of infancy	Enrichment	PTEN	1.98
199	Ovarian cancer	Enrichment	AKT1, MAP3K1, PIK3CA	1.98
200	Long qt syndrome	Enrichment	CALM1, CALM2	1.94
201	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	1.91
202	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.87
203	Nuchal bleb, familial	Enrichment	SOS1	1.87
204	Langerhans cell histiocytosis	Enrichment	MAP2K1	1.87
205	Glut1 deficiency syndrome 2	Enrichment	PRRT2	1.87
206	Large congenital melanocytic nevus	Enrichment	HRAS	1.87
207	Wieacker-wolff syndrome	Enrichment	RASA1	1.87
208	Spermatocytoma	Enrichment	HRAS	1.87
209	Tricuspid valve insufficiency	Enrichment	PTPN11	1.87
210	Keratoacanthoma	Enrichment	PIK3CA	1.87
211	Gillespie syndrome	Enrichment	ITPR1	1.81
212	Systemic lupus erythematosus 9	Enrichment	CR2	1.81
213	Neutrophilic dermatosis, acute febrile	Enrichment	PTPN6	1.81
214	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL6	1.81
215	Laryngeal squamous cell carcinoma	Enrichment	PTEN	1.81
216	Systemic lupus erythematosus	Enrichment	CR2, FCGR2B	1.75
217	Paroxysmal nonkinesigenic dyskinesia 1	Enrichment	PRRT2	1.75
218	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	1.75
219	Episodic kinesigenic dyskinesia 1	Enrichment	PRRT2	1.75
220	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.75
221	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.75
222	Congenital generalized lipodystrophy	Enrichment	FOS	1.75
223	Neurodevelopmental disorder with progressive spasticity and brain white matter abnormalities	Enrichment	GAD1	1.75
224	Cerebrovascular disease	Enrichment	PIK3CA	1.75
225	Spastic quadriplegic cerebral palsy	Enrichment	GAD1	1.75
226	Epidermolytic nevus	Enrichment	HRAS	1.75
227	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.75
228	Familial paroxysmal nonkinesigenic dyskinesia	Enrichment	PRRT2	1.75
229	Knobloch syndrome	Enrichment	PAK2	1.75
230	Familial or sporadic hemiplegic migraine	Enrichment	PRRT2	1.75
231	Gingival fibromatosis	Enrichment	SOS1	1.75
232	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.74
233	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.68
234	Spinocerebellar ataxia 15	Enrichment	ITPR1	1.68
235	Mantle cell lymphoma	Enrichment	IGH	1.68
236	Glioma	Enrichment	PTEN	1.68
237	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.68
238	Gastric cancer	Enrichment	PIK3CA, PTEN	1.67
239	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.65
240	Convulsions, familial infantile, with paroxysmal choreoathetosis	Enrichment	PRRT2	1.65
241	Knobloch syndrome 1	Enrichment	PAK2	1.65
242	Lymphoma	Enrichment	PTPN11	1.65
243	Myeloproliferative neoplasm	Enrichment	CBL	1.65
244	Histiocytoid hemangioma	Enrichment	FOS	1.65
245	Self-limited infantile epilepsy	Enrichment	PRRT2	1.65
246	Aggressive systemic mastocytosis	Enrichment	CBL	1.65
247	Lymphoma, mucosa-associated lymphoid type	Enrichment	IGH	1.59
248	Macrocephaly/autism syndrome	Enrichment	PTEN	1.59
249	Hemangioma	Enrichment	PTEN	1.59
250	Acute megakaryocytic leukemia	Enrichment	PTEN	1.59
251	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	1.57
252	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.57
253	Hemangioma, capillary infantile	Enrichment	RASA1	1.57
254	Basal cell carcinoma 1	Enrichment	RASA1	1.57
255	Patent ductus arteriosus	Enrichment	PTPN11	1.57
256	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.57
257	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.51
258	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	1.51
259	Gallbladder cancer	Enrichment	PIK3CA	1.51
260	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	1.51
261	Pilomyxoid astrocytoma	Enrichment	RAF1	1.51
262	Overgrowth syndrome	Enrichment	PIK3R1	1.51
263	Squamous cell carcinoma, head and neck	Enrichment	PTEN	1.44
264	Megacolon	Enrichment	AKT3	1.44
265	Coronary heart disease 5	Enrichment	IKBKG	1.40
266	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.40
267	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.39
268	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.36
269	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.34
270	Lennox-gastaut syndrome	Enrichment	MAPK10	1.32
271	Pectus excavatum	Enrichment	PTPN11	1.32
272	Immune deficiency disease	Enrichment	SYK	1.32
273	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.32
274	Polymicrogyria	Enrichment	AKT3	1.29
275	Melanoma	Enrichment	PTEN	1.29
276	Epicanthus	Enrichment	PTPN11	1.28
277	Congenital long qt syndrome	Enrichment	PTPN11	1.28
278	Inflammatory bowel disease 1	Enrichment	PRKCQ	1.27
279	Meningioma, familial	Enrichment	PTEN	1.25
280	Uterine corpus cancer	Enrichment	PTEN	1.25
281	Aortic valve disease 1	Enrichment	SOS1	1.24
282	Generalized epilepsy with febrile seizures plus	Enrichment	PRRT2	1.21
283	Lynch syndrome	Enrichment	PIK3CA	1.18
284	Nk-cell enteropathy	Enrichment	PIK3CB	1.18
285	Multiple sclerosis	Enrichment	ITPR1	1.15
286	Anterior segment dysgenesis	Enrichment	ITPR1	1.12
287	Heart, malformation of	Enrichment	MAPK1	1.11
288	Patent foramen ovale	Enrichment	PTPN11	1.11
289	Sudden infant death syndrome	Enrichment	CALM2	1.07
290	Autism spectrum disorder	Enrichment	MAP2K1, PTPN11	1.06
291	Cardiomyopathy, dilated, 1a	Enrichment	NFATC2	1.04
292	Gliosarcoma	Enrichment	NFKBIA	1.03
293	Hepatocellular carcinoma	Enrichment	PIK3CA	1.02
294	Giant cell glioblastoma	Enrichment	NFKBIA	1.00
295	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	0.99
296	Scoliosis	Enrichment	PTPN11	0.99
297	Microcephaly	Enrichment	MAPK1, PTPN11	0.98
298	Strabismus	Enrichment	PTPN11	0.94
299	Differentiated thyroid carcinoma	Enrichment	HRAS	0.91
300	Lung cancer	Enrichment	PIK3CA	0.87
301	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.86
302	Severe combined immunodeficiency	Enrichment	IKBKB	0.86
303	Left ventricular noncompaction	Enrichment	RAF1	0.84
304	Hypertrophic cardiomyopathy	Enrichment	PTPN11	0.75
305	Thrombocytopenia	Enrichment	PTPN11	0.71
306	Type 2 diabetes mellitus	Enrichment	AKT2	0.70
307	Hypertelorism	Enrichment	PIK3CA	0.68
308	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.67
309	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.65
310	Autosomal dominant non-syndromic intellectual disability	Enrichment	PPP3CA	0.64
311	Spastic ataxia	Enrichment	ITPR1	0.61
312	Hereditary breast ovarian cancer syndrome	Enrichment	PTEN	0.60
313	Myeloma, multiple	Enrichment	PIK3R2	0.59
314	Undetermined early-onset epileptic encephalopathy	Enrichment	PPP3CA	0.59
315	Dilated cardiomyopathy	Enrichment	RAF1	0.52
316	Congenital nervous system abnormality	Enrichment	PTEN	0.37
317	Nervous system disease	Enrichment	PTEN	0.37
318	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	0.35

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Immune response Fc epsilon RI pathway

Pathway Network for Immune response Fc epsilon RI pathway

Pathway network for the Immune response Fc epsilon RI pathway SuperPath

Member Pathways for Immune response Fc epsilon RI pathway

Pathways in the Immune response Fc epsilon RI pathway SuperPath

Gene overlap in member pathways for Immune response Fc epsilon RI pathway SuperPath

Associated Genes for Immune response Fc epsilon RI pathway

Associated Disorders for Immune response Fc epsilon RI pathway

Disorders associated with Immune response Fc epsilon RI pathway SuperPath

STRING Interaction Network for Immune response Fc epsilon RI pathway

Sources for Immune response Fc epsilon RI pathway