Immune response_IL-12 signaling pathway

No Pathway Network information available for Immune response_IL-12 signaling pathway

Pathways in the Immune response_IL-12 signaling pathway SuperPath

#	Name	Source	Genes
1	Immune response_IL-12 signaling pathway	GeneGo (Thomson Reuters)	GCNT1 IFNG IL12A IL12B IL12RB1 IL12RB2 IL18R1 IL2RA IRF1 IRF4 JAK2 JUN PDLIM2 PIAS2 PRF1 SELP SOCS3 STAT3 STAT4 STAT5A STAT5B TYK2 UBA52 UBB UBC (see all 25) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GCNT1	Glucosaminyl (N-Acetyl) Transferase 1	Protein Coding	1
2	IFNG	Interferon Gamma	Protein Coding	1
3	IL2RA	Interleukin 2 Receptor Subunit Alpha	Protein Coding	1
4	IL12A	Interleukin 12A	Protein Coding	1
5	IL12B	Interleukin 12B	Protein Coding	1
6	IL12RB1	Interleukin 12 Receptor Subunit Beta 1	Protein Coding	1
7	IL12RB2	Interleukin 12 Receptor Subunit Beta 2	Protein Coding	1
8	IRF1	Interferon Regulatory Factor 1	Protein Coding	1
9	IRF4	Interferon Regulatory Factor 4	Protein Coding	1
10	JAK2	Janus Kinase 2	Protein Coding	1
11	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
12	PRF1	Perforin 1	Protein Coding	1
13	SELP	Selectin P	Protein Coding	1
14	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
15	STAT4	Signal Transducer And Activator Of Transcription 4	Protein Coding	1
16	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	1
17	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	1
18	TYK2	Tyrosine Kinase 2	Protein Coding	1
19	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	1
20	UBB	Ubiquitin B	Protein Coding	1
21	UBC	Ubiquitin C	Protein Coding	1
22	IL18R1	Interleukin 18 Receptor 1	Protein Coding	1
23	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	1
24	PIAS2	Protein Inhibitor Of Activated STAT 2	Protein Coding	1
25	PDLIM2	PDZ And LIM Domain 2	Protein Coding	1

Disorders associated with Immune response_IL-12 signaling pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK2, STAT3	5.01
2	Idiopathic aplastic anemia	Enrichment	IFNG, PRF1	4.49
3	Oligoarticular juvenile idiopathic arthritis	Enrichment	IL2RA, STAT4	4.17
4	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	IL2RA, STAT4	4.17
5	Primary biliary cholangitis	Enrichment	IL12A, IL12RB1	3.93
6	Aplastic anemia	Enrichment	IFNG, PRF1	3.84
7	Acute promyelocytic leukemia	Enrichment	STAT3, STAT5B	3.60
8	Behcet syndrome	Enrichment	IL12A, STAT4	3.26
9	Type 1 diabetes mellitus 10	Enrichment	IL2RA	2.73
10	Hemophagocytic lymphohistiocytosis, familial, 2	Enrichment	PRF1	2.73
11	Immunodeficiency 35	Enrichment	TYK2	2.73
12	Skin/hair/eye pigmentation, variation in, 8	Enrichment	IRF4	2.73
13	Immunodeficiency 30	Enrichment	IL12RB1	2.73
14	Dermatitis, atopic, 4	Enrichment	SOCS3	2.73
15	Immunodeficiency 69	Enrichment	IFNG	2.73
16	Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant	Enrichment	STAT5B	2.73
17	Immunodeficiency 131	Enrichment	IRF4	2.73
18	Disabling pansclerotic morphea of childhood	Enrichment	STAT4	2.73
19	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.73
20	Systemic lupus erythematosus 11	Enrichment	STAT4	2.73
21	Immunodeficiency 29	Enrichment	IL12B	2.73
22	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.73
23	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.73
24	Whipple disease	Enrichment	IRF4	2.73
25	Fatal post-viral neurodegenerative disorder	Enrichment	PRF1	2.73
26	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.73
27	Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive	Enrichment	STAT5B	2.43
28	Immunodeficiency 41 with lymphoproliferation and autoimmunity	Enrichment	IL2RA	2.43
29	Thrombocythemia 3	Enrichment	JAK2	2.43
30	Polycythemia	Enrichment	JAK2	2.43
31	Lymphomatoid papulosis	Enrichment	TYK2	2.43
32	Hypereosinophilic syndrome	Enrichment	JAK2	2.43
33	Immunodeficiency 117	Enrichment	IRF1	2.43
34	Laron syndrome with immunodeficiency	Enrichment	STAT5B	2.43
35	Primary cutaneous anaplastic large cell lymphoma	Enrichment	TYK2	2.43
36	Submucosal cleft palate	Enrichment	UBB	2.43
37	Cleft hard palate	Enrichment	UBB	2.43
38	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.26
39	Takayasu arteritis	Enrichment	IL12B	2.26
40	Polycythemia vera	Enrichment	JAK2	2.26
41	Tuberous sclerosis 1	Enrichment	IFNG	2.26
42	Uvula, bifid	Enrichment	UBB	2.26
43	Cleft soft palate	Enrichment	UBB	2.26
44	Hepatitis c virus	Enrichment	IFNG	2.26
45	Tuberous sclerosis 2	Enrichment	IFNG	2.26
46	Hyper ige syndrome	Enrichment	STAT3	2.26
47	Erythrocytosis, familial, 1	Enrichment	JAK2	2.13
48	Budd-chiari syndrome	Enrichment	JAK2	2.13
49	Pediatric systemic lupus erythematosus	Enrichment	STAT4	2.13
50	Hemophagocytic lymphohistiocytosis, familial, 1	Enrichment	PRF1	2.04
51	Myeloproliferative neoplasm	Enrichment	JAK2	2.04
52	Myelofibrosis	Enrichment	JAK2	1.89
53	Essential thrombocythemia	Enrichment	JAK2	1.89
54	Lymphoma, non-hodgkin, familial	Enrichment	PRF1	1.83
55	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.83
56	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.78
57	Lung non-small cell carcinoma	Enrichment	IRF1	1.70
58	Human immunodeficiency virus type 1	Enrichment	IFNG	1.49
59	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.46
60	Autoinflammatory disease	Enrichment	PRF1	1.36
61	Lung cancer	Enrichment	IRF1	1.24
62	Systemic lupus erythematosus	Enrichment	STAT4	1.16
63	Leukemia, acute myeloid	Enrichment	JAK2	1.15
64	Gastric cancer	Enrichment	IRF1	1.12
65	Primary ovarian insufficiency	Enrichment	JAK2	0.99
66	Breast cancer	Enrichment	JUN	0.89

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Immune response_IL-12 signaling pathway

Pathway Network for Immune response_IL-12 signaling pathway

Member Pathways for Immune response_IL-12 signaling pathway

Pathways in the Immune response_IL-12 signaling pathway SuperPath

Associated Genes for Immune response_IL-12 signaling pathway

Associated Disorders for Immune response_IL-12 signaling pathway

Disorders associated with Immune response_IL-12 signaling pathway SuperPath

STRING Interaction Network for Immune response_IL-12 signaling pathway

Sources for Immune response_IL-12 signaling pathway