Immune response IL-2 activation and signaling pathway

Pathway network for the Immune response IL-2 activation and signaling pathway SuperPath

Sources:

GeneGo (Thomson Reuters)
WikiPathways

Pathways in the Immune response IL-2 activation and signaling pathway SuperPath

#	Name	Source	Genes
1	Immune response IL-2 activation and signaling pathway	GeneGo (Thomson Reuters)	AKT1 AKT2 AKT3 ATF2 CHUK CISH EGR1 ELF1 ELK1 FOS FOSB FOSL1 FOSL2 GAB2 GRB2 HMGA1 HRAS IKBKB IL2 IL2RA IL2RB IL2RG JAK1 JAK3 JUN JUNB JUND LCK MAP2K1 MAP2K2 MAPK1 MAPK3 MYC NFATC2 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE PDPK1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PPP3CA PPP3CB PPP3CC PTPN11 PTPN6 RAF1 REL RELA RELB SHC1 SIRPA SMAD3 SMAD4 SOCS3 SOS1 SOS2 STAT5A STAT5B SYK TOB1 (see all 65) (see less)
2	Immune response IL-3 activation and signaling pathway	GeneGo (Thomson Reuters)	ATF2 CISH CSF2RB EGR1 ELF1 ELK1 FOS FOSB FOSL1 FOSL2 GRB2 HRAS ID1 IL3 IL3RA INPP5D JAK2 JUN JUNB JUND MAP2K1 MAP2K2 MAPK1 MAPK3 NFATC2 OSM PIM1 POU2F1 PPP3CA PPP3CB PPP3CC PTPN11 PTPN6 RAF1 SHC1 SOCS1 SOCS3 SOS1 SOS2 STAT5A STAT5B (see all 41) (see less)
3	IL-2 signaling pathway	WikiPathways	HRAS IL2RA

Gene overlap in member pathways for Immune response IL-2 activation and signaling pathway SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	3
2	CISH	Cytokine Inducible SH2 Containing Protein	Protein Coding	2
3	ATF2	Activating Transcription Factor 2	Protein Coding	2
4	EGR1	Early Growth Response 1	Protein Coding	2
5	ELF1	E74 Like ETS Transcription Factor 1	Protein Coding	2
6	ELK1	ETS Transcription Factor ELK1	Protein Coding	2
7	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
8	FOSB	FosB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
9	FOSL2	FOS Like 2, AP-1 Transcription Factor Subunit	Protein Coding	2
10	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	2
11	IL2RA	Interleukin 2 Receptor Subunit Alpha	Protein Coding	2
12	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
13	JUNB	JunB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
14	JUND	JunD Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
15	NFATC2	Nuclear Factor Of Activated T Cells 2	Protein Coding	2
16	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	2
17	PPP3CB	Protein Phosphatase 3 Catalytic Subunit Beta	Protein Coding	2
18	PPP3CC	Protein Phosphatase 3 Catalytic Subunit Gamma	Protein Coding	2
19	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	2
20	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
21	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	2
22	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	2
23	PTPN6	Protein Tyrosine Phosphatase Non-Receptor Type 6	Protein Coding	2
24	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	2
25	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	2
26	SHC1	SHC Adaptor Protein 1	Protein Coding	2
27	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	2
28	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	2
29	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	2
30	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	2
31	FOSL1	FOS Like 1, AP-1 Transcription Factor Subunit	Protein Coding	2
32	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	2
33	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
34	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
35	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
36	HMGA1	High Mobility Group AT-Hook 1	Protein Coding	1
37	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
38	IL2	Interleukin 2	Protein Coding	1
39	IL2RB	Interleukin 2 Receptor Subunit Beta	Protein Coding	1
40	IL2RG	Interleukin 2 Receptor Subunit Gamma	Protein Coding	1
41	JAK1	Janus Kinase 1	Protein Coding	1
42	JAK3	Janus Kinase 3	Protein Coding	1
43	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
44	SMAD3	SMAD Family Member 3	Protein Coding	1
45	SMAD4	SMAD Family Member 4	Protein Coding	1
46	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
47	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
48	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	1
49	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
50	NFKBIB	NFKB Inhibitor Beta	Protein Coding	1
51	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	1
52	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
53	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
54	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
55	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	1
56	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
57	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
58	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	1
59	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
60	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	1
61	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	1
62	GAB2	GRB2 Associated Binding Protein 2	Protein Coding	1
63	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
64	TOB1	Transducer Of ERBB2, 1	Protein Coding	1
65	SIRPA	Signal Regulatory Protein Alpha	Protein Coding	1
66	CSF2RB	Colony Stimulating Factor 2 Receptor Subunit Beta	Protein Coding	1
67	ID1	Inhibitor Of DNA Binding 1	Protein Coding	1
68	IL3	Interleukin 3	Protein Coding	1
69	IL3RA	Interleukin 3 Receptor Subunit Alpha	Protein Coding	1
70	INPP5D	Inositol Polyphosphate-5-Phosphatase D	Protein Coding	1
71	JAK2	Janus Kinase 2	Protein Coding	1
72	OSM	Oncostatin M	Protein Coding	1
73	PIM1	Pim-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
74	POU2F1	POU Class 2 Homeobox 1	Protein Coding	1
75	SOCS1	Suppressor Of Cytokine Signaling 1	Protein Coding	1

Disorders associated with Immune response IL-2 activation and signaling pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rasopathy	Enrichment	HRAS, MAP2K1, MAP2K2, PTPN11, RAF1, SOS1, SOS2	16.00
2	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, MAP2K1, MAP2K2, PTPN11, RAF1, SOS1	11.34
3	Noonan syndrome 1	Enrichment	HRAS, MAP2K1, MAP2K2, PTPN11, RAF1, SOS1, SOS2	11.12
4	Noonan syndrome 3	Enrichment	HRAS, PTPN11, RAF1, SOS1	8.60
5	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA, PIK3R2	6.38
6	Arteriovenous malformation	Enrichment	HRAS, MAP2K1, PIK3CA	5.06
7	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1, PIK3CA	4.91
8	Lung non-small cell carcinoma	Enrichment	HRAS, MAP2K1, PIK3CA	4.77
9	Breast cancer	Enrichment	AKT1, IL2, JUN, PIK3CA, SHC1	4.54
10	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1, MAP2K2	4.27
11	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1, MAP2K2	4.27
12	Noonan syndrome with multiple lentigines	Enrichment	PTPN11, RAF1	4.27
13	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.17
14	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	4.17
15	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	4.17
16	Histiocytoid hemangioma	Enrichment	FOS, FOSB	4.05
17	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	3.87
18	Type 1 diabetes mellitus 10	Enrichment	IL2RA	3.83
19	Phakomatosis pigmentokeratotica	Enrichment	HRAS	3.83
20	Hemimegalencephaly	Enrichment	AKT3, PIK3CA	3.65
21	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, RAF1	3.61
22	Costello syndrome	Enrichment	HRAS	3.53
23	Immunodeficiency 41 with lymphoproliferation and autoimmunity	Enrichment	IL2RA	3.53
24	Wooly hair nevus	Enrichment	HRAS	3.53
25	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	3.48
26	Large congenital melanocytic nevus	Enrichment	HRAS	3.35
27	Spermatocytoma	Enrichment	HRAS	3.35
28	Nevus, epidermal	Enrichment	HRAS, PIK3CA	3.33
29	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1, PIK3CA	3.33
30	Gallbladder cancer	Enrichment	PIK3CA, SMAD4	3.33
31	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	3.33
32	Oligoarticular juvenile idiopathic arthritis	Enrichment	IL2RA, IL2RB	3.33
33	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	IL2RA, IL2RB	3.33
34	Specific learning disability	Enrichment	MAPK1, PTPN11	3.32
35	Severe combined immunodeficiency	Enrichment	IKBKB, JAK3, LCK	3.29
36	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	3.23
37	Epidermolytic nevus	Enrichment	HRAS	3.23
38	Colorectal cancer	Enrichment	AKT1, PIK3CA, PIK3R1, SMAD4	3.10
39	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.10
40	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	3.00
41	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	2.99
42	Follicular thyroid carcinoma	Enrichment	HRAS	2.99
43	Meningioma	Enrichment	AKT1, PIK3CA	2.84
44	Lip and oral cavity carcinoma	Enrichment	HRAS, PIK3CA	2.84
45	Nk-cell enteropathy	Enrichment	JAK3, PIK3CB	2.77
46	Rhabdomyosarcoma	Enrichment	HRAS	2.63
47	Hydrops fetalis, nonimmune	Enrichment	HRAS, PTPN11	2.56
48	Metachondromatosis	Enrichment	PTPN11	2.52
49	Noonan syndrome 5	Enrichment	RAF1	2.52
50	Noonan syndrome 4	Enrichment	SOS1	2.52
51	Melorheostosis, isolated	Enrichment	MAP2K1	2.52
52	Dermatitis, atopic, 4	Enrichment	SOCS3	2.52
53	Leopard syndrome 1	Enrichment	PTPN11	2.52
54	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.52
55	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.52
56	Noonan syndrome 9	Enrichment	SOS2	2.52
57	Noonan syndrome 13	Enrichment	MAPK1	2.52
58	Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant	Enrichment	STAT5B	2.52
59	Developmental and epileptic encephalopathy 91	Enrichment	PPP3CA	2.52
60	Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development	Enrichment	PPP3CA	2.52
61	Melorheostosis	Enrichment	MAP2K1	2.52
62	Leopard syndrome 2	Enrichment	RAF1	2.52
63	Surfactant metabolism dysfunction, pulmonary, 5	Enrichment	CSF2RB	2.52
64	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.52
65	Trigonitis	Enrichment	RAF1	2.52
66	Vegetative pyoderma gangrenosum	Enrichment	PTPN6	2.52
67	Bullous pyoderma gangrenosum	Enrichment	PTPN6	2.52
68	Pustular pyoderma gangrenosum	Enrichment	PTPN6	2.52
69	Aplasia cutis-enamel dysplasia syndrome	Enrichment	FOSL2	2.52
70	Classic pyoderma gangrenosum	Enrichment	PTPN6	2.52
71	Malignant astrocytoma	Enrichment	PTPN11	2.52
72	Non-immune hydrops fetalis	Enrichment	HRAS, PTPN11	2.41
73	Bladder cancer	Enrichment	HRAS	2.37
74	Differentiated thyroid carcinoma	Enrichment	HRAS	2.37
75	Macrodactyly	Enrichment	PIK3CA	2.32
76	Proteus syndrome	Enrichment	AKT1	2.32
77	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.32
78	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.32
79	Cowden syndrome 5	Enrichment	PIK3CA	2.32
80	Fetal encasement syndrome	Enrichment	CHUK	2.32
81	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.32
82	Immunodeficiency 15b	Enrichment	IKBKB	2.32
83	Immunodeficiency 82 with systemic inflammation	Enrichment	SYK	2.32
84	Immunodeficiency 15a	Enrichment	IKBKB	2.32
85	Immunodeficiency 92	Enrichment	REL	2.32
86	Immunodeficiency 63 with lymphoproliferation and autoimmunity	Enrichment	IL2RB	2.32
87	Short syndrome	Enrichment	PIK3R1	2.32
88	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.32
89	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.32
90	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.32
91	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.32
92	Cowden syndrome 6	Enrichment	AKT1	2.32
93	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.32
94	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.32
95	Immunodeficiency 22	Enrichment	LCK	2.32
96	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.32
97	Immunodeficiency 53	Enrichment	RELB	2.32
98	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.32
99	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.32
100	T-b+ severe combined immunodeficiency due to jak3 deficiency	Enrichment	JAK3	2.32
101	Heritable thoracic aortic disease	Enrichment	SMAD4	2.32
102	Hypospadias	Enrichment	PIK3CA	2.32
103	Capillary hemangioma	Enrichment	AKT3	2.32
104	Colitis	Enrichment	SYK	2.32
105	Rare venous malformation	Enrichment	PIK3CA	2.32
106	Diaphragmatic eventration	Enrichment	PIK3CA	2.32
107	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.32
108	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.32
109	Rare combined vascular malformation	Enrichment	PIK3CA	2.32
110	Cavernous lymphangioma	Enrichment	PIK3CA	2.32
111	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.32
112	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.32
113	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.32
114	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.32
115	Macrodactyly of toe	Enrichment	PIK3CA	2.32
116	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.32
117	Fibromatosis, gingival, 1	Enrichment	SOS1	2.22
118	Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive	Enrichment	STAT5B	2.22
119	Pulmonic stenosis	Enrichment	SOS1	2.22
120	Thrombocythemia 3	Enrichment	JAK2	2.22
121	Werner syndrome	Enrichment	PTPN11	2.22
122	Polycythemia	Enrichment	JAK2	2.22
123	Joint contractures, osteochondromas, and b-cell lymphoma	Enrichment	NFATC2	2.22
124	Hypereosinophilic syndrome	Enrichment	JAK2	2.22
125	Tafro syndrome	Enrichment	MAP2K2	2.22
126	Laron syndrome with immunodeficiency	Enrichment	STAT5B	2.22
127	Immune thrombocytopenia	Enrichment	SOCS1	2.04
128	Polycythemia vera	Enrichment	JAK2	2.04
129	Nuchal bleb, familial	Enrichment	SOS1	2.04
130	Langerhans cell histiocytosis	Enrichment	MAP2K1	2.04
131	Neutrophilic dermatosis, acute febrile	Enrichment	PTPN6	2.04
132	Autoinflammatory syndrome, familial, with or without immunodeficiency	Enrichment	SOCS1	2.04
133	Bacteremia 2	Enrichment	CISH	2.04
134	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK2	2.04
135	Tricuspid valve insufficiency	Enrichment	PTPN11	2.04
136	Burkitt lymphoma	Enrichment	MYC	2.02
137	Myhre syndrome	Enrichment	SMAD4	2.02
138	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.02
139	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	2.02
140	Keratosis, seborrheic	Enrichment	PIK3CA	2.02
141	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.02
142	Noonan syndrome 8	Enrichment	PIK3CA	2.02
143	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.02
144	Immunodeficiency, common variable, 10	Enrichment	NFKB2	2.02
145	Loeys-dietz syndrome 3	Enrichment	SMAD3	2.02
146	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.02
147	Rela fusion-positive ependymoma	Enrichment	RELA	2.02
148	Senior-loken syndrome 7	Enrichment	AKT3	2.02
149	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.02
150	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.02
151	Ectodermal dysplasia and immune deficiency	Enrichment	NFKBIA	2.02
152	Immune system disease	Enrichment	PIK3CD	2.02
153	Bardet-biedl syndrome 16	Enrichment	AKT3	2.02
154	Arthritis	Enrichment	SYK	2.02
155	Common variable immunodeficiency 12	Enrichment	NFKB1	2.02
156	Erythrocytosis, familial, 1	Enrichment	JAK2	1.92
157	Anemia, autoimmune hemolytic	Enrichment	SOCS1	1.92
158	Budd-chiari syndrome	Enrichment	JAK2	1.92
159	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.92
160	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.92
161	Congenital generalized lipodystrophy	Enrichment	FOS	1.92
162	Tuberculosis	Enrichment	CISH	1.92
163	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.92
164	Gingival fibromatosis	Enrichment	SOS1	1.92
165	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.92
166	Pseudomyogenic hemangioendothelioma	Enrichment	FOSB	1.92
167	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	JAK3	1.84
168	Juvenile polyposis syndrome	Enrichment	SMAD4	1.84
169	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.84
170	Severe combined immunodeficiency, x-linked	Enrichment	IL2RG	1.84
171	Combined immunodeficiency, x-linked	Enrichment	IL2RG	1.84
172	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.84
173	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	1.84
174	Keratoacanthoma	Enrichment	PIK3CA	1.84
175	Lymphoma	Enrichment	PTPN11	1.82
176	Myeloproliferative neoplasm	Enrichment	JAK2	1.82
177	Hereditary pulmonary alveolar proteinosis	Enrichment	CSF2RB	1.82
178	Type 2 diabetes mellitus	Enrichment	AKT2, HMGA1	1.76
179	Gastric cancer	Enrichment	PIK3CA, SMAD4	1.74
180	Patent ductus arteriosus	Enrichment	PTPN11	1.74
181	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD3, SMAD4	1.73
182	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA	1.73
183	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.72
184	Cerebrovascular disease	Enrichment	PIK3CA	1.72
185	Aortic aneurysm	Enrichment	SMAD3	1.72
186	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.72
187	Adenosine deaminase deficiency	Enrichment	JAK3	1.72
188	Myelofibrosis	Enrichment	JAK2	1.68
189	Essential thrombocythemia	Enrichment	JAK2	1.68
190	Pilomyxoid astrocytoma	Enrichment	RAF1	1.68
191	Thrombocytopenia	Enrichment	PTPN11, SMAD4	1.65
192	Capillary malformations, congenital	Enrichment	PIK3CA	1.62
193	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	JAK3	1.62
194	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	1.62
195	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.57
196	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.55
197	Cowden syndrome 1	Enrichment	PIK3CA	1.55
198	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.55
199	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.55
200	Pectus excavatum	Enrichment	PTPN11	1.48
201	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	1.48
202	Megacolon	Enrichment	AKT3	1.48
203	Overgrowth syndrome	Enrichment	PIK3R1	1.48
204	Epicanthus	Enrichment	PTPN11	1.45
205	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.45
206	Congenital long qt syndrome	Enrichment	PTPN11	1.45
207	Aortic valve disease 1	Enrichment	SOS1	1.41
208	Acute promyelocytic leukemia	Enrichment	STAT5B	1.41
209	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.38
210	Loeys-dietz syndrome	Enrichment	SMAD3	1.37
211	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.37
212	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.37
213	Autism spectrum disorder	Enrichment	MAP2K1, PTPN11	1.37
214	Omenn syndrome	Enrichment	IL2RG	1.33
215	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.33
216	Polymicrogyria	Enrichment	AKT3	1.33
217	Immune deficiency disease	Enrichment	SYK	1.29
218	Combined immunodeficiency	Enrichment	IL2RG	1.29
219	Ichthyosis	Enrichment	IL2RB	1.29
220	Combined t cell and b cell immunodeficiency	Enrichment	IL2RG	1.29
221	Combined t and b cell immunodeficiency	Enrichment	IL2RG	1.29
222	Heart, malformation of	Enrichment	MAPK1	1.28
223	Patent foramen ovale	Enrichment	PTPN11	1.28
224	Microcephaly	Enrichment	MAPK1, PTPN11	1.27
225	Diffuse large b-cell lymphoma	Enrichment	SOCS1	1.25
226	Cardiomyopathy, dilated, 1a	Enrichment	NFATC2	1.21
227	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	1.19
228	Malaria	Enrichment	CISH	1.17
229	Lynch syndrome	Enrichment	PIK3CA	1.16
230	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.15
231	Scoliosis	Enrichment	PTPN11	1.15
232	Gliosarcoma	Enrichment	NFKBIA	1.13
233	Giant cell glioblastoma	Enrichment	NFKBIA	1.11
234	Strabismus	Enrichment	PTPN11	1.10
235	Ovarian cancer	Enrichment	AKT1, PIK3CA	1.07
236	Long qt syndrome 1	Enrichment	PTPN11	1.06
237	Ehlers-danlos syndrome	Enrichment	SMAD3	1.06
238	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.02
239	Endometrial cancer	Enrichment	PIK3CA	1.02
240	Hepatocellular carcinoma	Enrichment	PIK3CA	1.00
241	Left ventricular noncompaction	Enrichment	RAF1	1.00
242	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	0.98
243	Systemic lupus erythematosus	Enrichment	SOCS1	0.95
244	Pancreatic cancer	Enrichment	SMAD4	0.95
245	Leukemia, acute myeloid	Enrichment	JAK2	0.94
246	Hypertrophic cardiomyopathy	Enrichment	PTPN11	0.91
247	Prostate cancer	Enrichment	PIK3CA	0.89
248	Severe covid-19	Enrichment	JAK3	0.89
249	Inherited cancer-predisposing syndrome	Enrichment	PTPN11, SMAD4	0.88
250	Autosomal dominant non-syndromic intellectual disability	Enrichment	PPP3CA	0.85
251	Lung cancer	Enrichment	PIK3CA	0.85
252	Connective tissue disease	Enrichment	SMAD3	0.85
253	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.83
254	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.81
255	Undetermined early-onset epileptic encephalopathy	Enrichment	PPP3CA	0.81
256	Primary ovarian insufficiency	Enrichment	JAK2	0.79
257	Dilated cardiomyopathy	Enrichment	RAF1	0.67
258	Hypertelorism	Enrichment	PIK3CA	0.65
259	Myeloma, multiple	Enrichment	PIK3R2	0.63

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Immune response IL-2 activation and signaling pathway

Pathway Network for Immune response IL-2 activation and signaling pathway

Pathway network for the Immune response IL-2 activation and signaling pathway SuperPath

Member Pathways for Immune response IL-2 activation and signaling pathway

Pathways in the Immune response IL-2 activation and signaling pathway SuperPath

Gene overlap in member pathways for Immune response IL-2 activation and signaling pathway SuperPath

Associated Genes for Immune response IL-2 activation and signaling pathway

Associated Disorders for Immune response IL-2 activation and signaling pathway

Disorders associated with Immune response IL-2 activation and signaling pathway SuperPath

STRING Interaction Network for Immune response IL-2 activation and signaling pathway

Sources for Immune response IL-2 activation and signaling pathway