Immune response_IL-6 signaling pathway

No Pathway Network information available for Immune response_IL-6 signaling pathway

Pathways in the Immune response_IL-6 signaling pathway SuperPath

#	Name	Source	Genes
1	Immune response_IL-6 signaling pathway	GeneGo (Thomson Reuters)	ADAM10 ADAM17 CEBPB CEBPD CREB1 ELK1 FOS GRB2 HRAS IL6 IL6R IL6ST JAK1 JUN JUND MAP2K1 MAP2K2 MAPK1 MAPK3 NFKB1 NFKB2 NR3C1 PTPN11 RAF1 REL RELA RELB SHC1 SOCS3 SOS1 SOS2 SRF STAT3 (see all 33) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ADAM10	ADAM Metallopeptidase Domain 10	Protein Coding	1
2	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	1
3	CEBPD	CCAAT Enhancer Binding Protein Delta	Protein Coding	1
4	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
5	ELK1	ETS Transcription Factor ELK1	Protein Coding	1
6	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
7	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
8	NR3C1	Nuclear Receptor Subfamily 3 Group C Member 1	Protein Coding	1
9	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
10	IL6	Interleukin 6	Protein Coding	1
11	IL6R	Interleukin 6 Receptor	Protein Coding	1
12	IL6ST	Interleukin 6 Cytokine Family Signal Transducer	Protein Coding	1
13	JAK1	Janus Kinase 1	Protein Coding	1
14	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
15	JUND	JunD Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
16	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
17	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	1
18	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
19	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
20	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
21	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	1
22	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
23	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
24	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	1
25	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
26	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	1
27	SHC1	SHC Adaptor Protein 1	Protein Coding	1
28	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
29	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	1
30	SRF	Serum Response Factor	Protein Coding	1
31	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
32	ADAM17	ADAM Metallopeptidase Domain 17	Protein Coding	1
33	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	1

Disorders associated with Immune response_IL-6 signaling pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rasopathy	Enrichment	HRAS, MAP2K1, MAP2K2, PTPN11, RAF1, SOS1, SOS2	16.00
2	Noonan syndrome 1	Enrichment	HRAS, MAP2K1, MAP2K2, PTPN11, RAF1, SOS1, SOS2	10.82
3	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, MAP2K1, MAP2K2, PTPN11, RAF1, SOS1	10.54
4	Noonan syndrome 3	Enrichment	HRAS, PTPN11, RAF1, SOS1	8.98
5	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, STAT3	4.76
6	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1, MAP2K2	4.46
7	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1, MAP2K2	4.46
8	Noonan syndrome with multiple lentigines	Enrichment	PTPN11, RAF1	4.46
9	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	3.92
10	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, RAF1	3.80
11	Arteriovenous malformation	Enrichment	HRAS, MAP2K1	3.69
12	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1	3.59
13	Lung non-small cell carcinoma	Enrichment	HRAS, MAP2K1	3.51
14	Specific learning disability	Enrichment	MAPK1, PTPN11	3.51
15	Hydrops fetalis, nonimmune	Enrichment	HRAS, PTPN11	2.75
16	Metachondromatosis	Enrichment	PTPN11	2.61
17	Noonan syndrome 5	Enrichment	RAF1	2.61
18	Noonan syndrome 4	Enrichment	SOS1	2.61
19	Melorheostosis, isolated	Enrichment	MAP2K1	2.61
20	Dermatitis, atopic, 4	Enrichment	SOCS3	2.61
21	Leopard syndrome 1	Enrichment	PTPN11	2.61
22	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.61
23	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.61
24	Noonan syndrome 9	Enrichment	SOS2	2.61
25	Glucocorticoid resistance, generalized	Enrichment	NR3C1	2.61
26	Stuve-wiedemann syndrome 2	Enrichment	IL6ST	2.61
27	Noonan syndrome 13	Enrichment	MAPK1	2.61
28	Hyper-ige syndrome 4a, autosomal dominant, with recurrent infections	Enrichment	IL6ST	2.61
29	Immunodeficiency 92	Enrichment	REL	2.61
30	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.61
31	Alzheimer disease 18	Enrichment	ADAM10	2.61
32	Melorheostosis	Enrichment	MAP2K1	2.61
33	Leopard syndrome 2	Enrichment	RAF1	2.61
34	Interleukin 6, serum level of, quantitative trait locus	Enrichment	IL6R	2.61
35	Soluble interleukin-6 receptor, serum level of, quantitative trait locus	Enrichment	IL6R	2.61
36	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.61
37	Hyper-ige syndrome 5, autosomal recessive, with recurrent infections	Enrichment	IL6R	2.61
38	Reticulate acropigmentation of kitamura	Enrichment	ADAM10	2.61
39	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.61
40	Hyper-ige syndrome 4b, autosomal recessive, with recurrent infections	Enrichment	IL6ST	2.61
41	Immunodeficiency 94 with autoinflammation and dysmorphic facies	Enrichment	IL6ST	2.61
42	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.61
43	Immunodeficiency 53	Enrichment	RELB	2.61
44	Trigonitis	Enrichment	RAF1	2.61
45	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.61
46	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.61
47	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.61
48	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.61
49	Malignant astrocytoma	Enrichment	PTPN11	2.61
50	Non-immune hydrops fetalis	Enrichment	HRAS, PTPN11	2.59
51	Fibromatosis, gingival, 1	Enrichment	SOS1	2.31
52	Costello syndrome	Enrichment	HRAS	2.31
53	Galactosemia ii	Enrichment	NR3C1	2.31
54	Pulmonic stenosis	Enrichment	SOS1	2.31
55	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.31
56	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.31
57	Immunodeficiency, common variable, 10	Enrichment	NFKB2	2.31
58	Werner syndrome	Enrichment	PTPN11	2.31
59	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.31
60	Rela fusion-positive ependymoma	Enrichment	RELA	2.31
61	Inflammatory skin and bowel disease, neonatal, 1	Enrichment	ADAM17	2.31
62	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.31
63	Common variable immunodeficiency 12	Enrichment	NFKB1	2.31
64	Tafro syndrome	Enrichment	MAP2K2	2.31
65	Wooly hair nevus	Enrichment	HRAS	2.31
66	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.14
67	Stuve-wiedemann syndrome 1	Enrichment	IL6ST	2.14
68	Nuchal bleb, familial	Enrichment	SOS1	2.14
69	Langerhans cell histiocytosis	Enrichment	MAP2K1	2.14
70	Large congenital melanocytic nevus	Enrichment	HRAS	2.14
71	Hyper ige syndrome	Enrichment	STAT3	2.14
72	Spermatocytoma	Enrichment	HRAS	2.14
73	Neonatal inflammatory skin and bowel disease	Enrichment	ADAM17	2.14
74	Melanoma of soft tissue	Enrichment	CREB1	2.14
75	Tricuspid valve insufficiency	Enrichment	PTPN11	2.14
76	Stüve-wiedemann syndrome	Enrichment	IL6ST	2.14
77	Kaposi sarcoma	Enrichment	IL6	2.01
78	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	2.01
79	Dowling-degos disease 1	Enrichment	ADAM10	2.01
80	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	2.01
81	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.01
82	Immunodeficiency, common variable, 1	Enrichment	NFKB2	2.01
83	Congenital generalized lipodystrophy	Enrichment	FOS	2.01
84	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	2.01
85	Epidermolytic nevus	Enrichment	HRAS	2.01
86	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	2.01
87	Gingival fibromatosis	Enrichment	SOS1	2.01
88	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	2.01
89	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.92
90	Lymphoma	Enrichment	PTPN11	1.92
91	Histiocytoid hemangioma	Enrichment	FOS	1.92
92	Breast cancer	Enrichment	JUN, SHC1	1.85
93	Type 1 diabetes mellitus	Enrichment	IL6	1.84
94	Patent ductus arteriosus	Enrichment	PTPN11	1.84
95	Nevus, epidermal	Enrichment	HRAS	1.77
96	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	1.77
97	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1	1.77
98	Pilomyxoid astrocytoma	Enrichment	RAF1	1.77
99	Follicular thyroid carcinoma	Enrichment	HRAS	1.77
100	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.71
101	Inflammatory bowel disease 1	Enrichment	IL6	1.66
102	Primary hyperaldosteronism	Enrichment	NR3C1	1.66
103	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.62
104	Pectus excavatum	Enrichment	PTPN11	1.58
105	Autism spectrum disorder	Enrichment	MAP2K1, PTPN11	1.54
106	Epicanthus	Enrichment	PTPN11	1.54
107	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.54
108	Lip and oral cavity carcinoma	Enrichment	HRAS	1.54
109	Congenital long qt syndrome	Enrichment	PTPN11	1.54
110	Aortic valve disease 1	Enrichment	SOS1	1.51
111	Acute promyelocytic leukemia	Enrichment	STAT3	1.51
112	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.47
113	Microcephaly	Enrichment	MAPK1, PTPN11	1.45
114	Rhabdomyosarcoma	Enrichment	HRAS	1.42
115	Heart, malformation of	Enrichment	MAPK1	1.37
116	Patent foramen ovale	Enrichment	PTPN11	1.37
117	Arteriovenous malformations of the brain	Enrichment	IL6	1.34
118	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.34
119	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.25
120	Scoliosis	Enrichment	PTPN11	1.25
121	Strabismus	Enrichment	PTPN11	1.20
122	Bladder cancer	Enrichment	HRAS	1.17
123	Differentiated thyroid carcinoma	Enrichment	HRAS	1.17
124	Long qt syndrome 1	Enrichment	PTPN11	1.15
125	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.11
126	Left ventricular noncompaction	Enrichment	RAF1	1.09
127	Type 2 diabetes mellitus	Enrichment	IL6	1.01
128	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.00
129	Thrombocytopenia	Enrichment	PTPN11	0.96
130	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.92
131	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.89
132	Dilated cardiomyopathy	Enrichment	RAF1	0.75
133	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	0.56

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Immune response_IL-6 signaling pathway

Pathway Network for Immune response_IL-6 signaling pathway

Member Pathways for Immune response_IL-6 signaling pathway

Pathways in the Immune response_IL-6 signaling pathway SuperPath

Associated Genes for Immune response_IL-6 signaling pathway

Associated Disorders for Immune response_IL-6 signaling pathway

Disorders associated with Immune response_IL-6 signaling pathway SuperPath

STRING Interaction Network for Immune response_IL-6 signaling pathway

Sources for Immune response_IL-6 signaling pathway