Immune response Lectin induced complement pathway

Pathway network for the Immune response Lectin induced complement pathway SuperPath

Sources:

GeneGo (Thomson Reuters)
Reactome

Pathways in the Immune response Lectin induced complement pathway SuperPath

#	Name	Source	Genes
1	Immune response Lectin induced complement pathway	GeneGo (Thomson Reuters)	C2 C3 C3AR1 C4A C4B C4BPA C4BPB C5 C5AR1 C6 C7 C8A C8B C8G C9 CD46 CD55 CD59 CD93 CFI CLU CR1 CR2 FCN2 FCN3 ITGAM ITGAX ITGB2 MASP1 MASP2 MBL2 SERPING1 (see all 32) (see less)
2	Immune response Classical complement pathway	GeneGo (Thomson Reuters)	C1QA C1QB C1QC C1R C1S C2 C3 C3AR1 C4A C4B C4BPA C4BPB C5 C5AR1 C6 C7 C8A C8B C8G C9 CD46 CD55 CD59 CD93 CFI CLU CR1 CR2 CRP IGH IGHG1 IGHM IGHV3-23 IGK IGKC IGKJ IGKV@ IGL IGLJ IGLV@ ITGAM ITGAX ITGB2 SERPING1 (see all 44) (see less)
3	Immune response Alternative complement pathway	GeneGo (Thomson Reuters)	C3 C3AR1 C5 C5AR1 C6 C7 C8A C8B C8G C9 CD46 CD55 CD59 CFB CFD CFH CFI CFP CLU CR1 CR2 ITGAM ITGAX ITGB2 (see all 24) (see less)
4	Terminal pathway of complement	Reactome	C5 C6 C7 C8A C8B C8G C9 CLU (see all 8) (see less)

Gene overlap in member pathways for Immune response Lectin induced complement pathway SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	C5	Complement C5	Protein Coding	4
2	C6	Complement C6	Protein Coding	4
3	C7	Complement C7	Protein Coding	4
4	C8A	Complement C8 Alpha Chain	Protein Coding	4
5	C8B	Complement C8 Beta Chain	Protein Coding	4
6	C8G	Complement C8 Gamma Chain	Protein Coding	4
7	C9	Complement C9	Protein Coding	4
8	CLU	Clusterin	Protein Coding	4
9	C3	Complement C3	Protein Coding	3
10	C3AR1	Complement C3a Receptor 1	Protein Coding	3
11	C5AR1	Complement C5a Receptor 1	Protein Coding	3
12	CD59	CD59 Molecule (CD59 Blood Group)	Protein Coding	3
13	CR1	Complement C3b/C4b Receptor 1 (Knops Blood Group)	Protein Coding	3
14	CR2	Complement C3d Receptor 2	Protein Coding	3
15	CD55	CD55 Molecule (Cromer Blood Group)	Protein Coding	3
16	CFI	Complement Factor I	Protein Coding	3
17	ITGAM	Integrin Subunit Alpha M	Protein Coding	3
18	ITGAX	Integrin Subunit Alpha X	Protein Coding	3
19	ITGB2	Integrin Subunit Beta 2	Protein Coding	3
20	CD46	CD46 Molecule	Protein Coding	3
21	SERPING1	Serpin Family G Member 1	Protein Coding	2
22	C2	Complement C2	Protein Coding	2
23	C4A	Complement C4A (Chido/Rodgers Blood Group)	Protein Coding	2
24	C4B	Complement C4B (Chido/Rodgers Blood Group)	Protein Coding	2
25	C4BPA	Complement Component 4 Binding Protein Alpha	Protein Coding	2
26	C4BPB	Complement Component 4 Binding Protein Beta	Protein Coding	2
27	CD93	CD93 Molecule	Protein Coding	2
28	FCN2	Ficolin 2	Protein Coding	1
29	MBL2	Mannose Binding Lectin 2	Protein Coding	1
30	MASP1	MBL Associated Serine Protease 1	Protein Coding	1
31	FCN3	Ficolin 3	Protein Coding	1
32	MASP2	MBL Associated Serine Protease 2	Protein Coding	1
33	C1QA	Complement C1q A Chain	Protein Coding	1
34	C1QB	Complement C1q B Chain	Protein Coding	1
35	C1QC	Complement C1q C Chain	Protein Coding	1
36	C1R	Complement C1r	Protein Coding	1
37	C1S	Complement C1s	Protein Coding	1
38	CRP	C-Reactive Protein	Protein Coding	1
39	IGH	Immunoglobulin Heavy Locus	Protein Coding	1
40	IGHG1	Immunoglobulin Heavy Constant Gamma 1 (G1m Marker)	Protein Coding	1
41	IGHM	Immunoglobulin Heavy Constant Mu	Protein Coding	1
42	IGKC	Immunoglobulin Kappa Constant	Protein Coding	1
43	IGKV@	Immunoglobulin Kappa Variable Cluster	Gene Cluster	1
44	IGL	Immunoglobulin Lambda Locus	Protein Coding	1
45	IGLV@	Immunoglobulin Lambda Variable Cluster	Gene Cluster	1
46	IGKJ	Immunoglobulin Kappa Joining Cluster	Genetic Locus	1
47	IGLJ	Immunoglobulin Lambda Joining Cluster	Genetic Locus	1
48	IGHV3-23	Immunoglobulin Heavy Variable 3-23	Protein Coding	1
49	IGK	Immunoglobulin Kappa Locus	Protein Coding	1
50	CFB	Complement Factor B	Protein Coding	1
51	CFD	Complement Factor D	Protein Coding	1
52	CFH	Complement Factor H	Protein Coding	1
53	CFP	Complement Factor Properdin	Protein Coding	1

Disorders associated with Immune response Lectin induced complement pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Immunodeficiency due to a classical component pathway complement deficiency	Enrichment	C1QA, C1QB, C1QC, C1R, C1S, C2, C4A, C4B	11.22
2	Immunodeficiency due to a late component of complement deficiency	Enrichment	C5, C6, C7, C8A, C8B, C8G, C9	10.58
3	Atypical hemolytic uremic syndrome with complement gene abnormality	Enrichment	C3, CD46, CFB, CFH, CFI	10.40
4	Genetic atypical hemolytic-uremic syndrome	Enrichment	C3, CD46, CFH	8.31
5	Atypical hemolytic-uremic syndrome	Enrichment	C3, CD46, CFH, CFI	7.99
6	Hellp syndrome	Enrichment	CD46, CFH, CFI	7.71
7	C1q deficiency 1	Enrichment	C1QA, C1QB, C1QC	7.50
8	Systemic lupus erythematosus	Enrichment	C4A, C4B, CR2, IGHG1, ITGAM	6.82
9	Complement component 6 deficiency	Enrichment	C6, C8B	6.52
10	Systemic lupus erythematosus 16	Enrichment	C1QA, C1R, C4A	6.50
11	De novo thrombotic microangiopathy after kidney transplantation	Enrichment	CFH, CFI	5.52
12	Familial drusen	Enrichment	CFH, CFI	5.05
13	Immunoglobulin kappa light chain deficiency	Enrichment	IGK, IGKC	4.99
14	Periodontal ehlers-danlos syndrome	Enrichment	C1R, C1S	4.99
15	Hemolytic uremic syndrome, atypical 1	Enrichment	C3AR1, CFH	4.52
16	Ehlers-danlos syndrome, periodontal type, 1	Enrichment	C1R, C1S	4.51
17	Agammaglobulinemia 1, autosomal recessive	Enrichment	IGH, IGHM	4.51
18	Agammaglobulinemia 1	Enrichment	IGH, IGHM	4.51
19	Ehlers-danlos syndrome, periodontal type, 2	Enrichment	C1R, C1S	4.51
20	Recurrent infections associated with rare immunoglobulin isotypes deficiency	Enrichment	IGK, IGKC	4.51
21	Complement component 5 deficiency	Enrichment	C5	3.23
22	Complement component 7 deficiency	Enrichment	C7	3.23
23	Complement component 8 deficiency, type i	Enrichment	C8A	3.23
24	Macular degeneration, age-related, 15	Enrichment	C9	3.23
25	Eculizumab, poor response to	Enrichment	C5	3.23
26	Complement component 9 deficiency	Enrichment	C9	3.23
27	Complement component 8 deficiency, type ii	Enrichment	C8B	3.23
28	Lathosterolosis	Enrichment	C5	2.93
29	Systemic lupus erythematosus 6	Enrichment	ITGAM	2.75
30	Basal laminar drusen	Enrichment	CFH	2.75
31	Hemolytic uremic syndrome, atypical 4	Enrichment	CFB	2.75
32	Complement factor d deficiency	Enrichment	CFD	2.75
33	Macular degeneration, age-related, 4	Enrichment	CFH	2.75
34	Hemolytic uremic syndrome, atypical 5	Enrichment	C3	2.75
35	Complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy	Enrichment	CD55	2.75
36	Blood group, cromer system	Enrichment	CD55	2.75
37	Hemolytic uremic syndrome, atypical 3	Enrichment	CFI	2.75
38	Macular degeneration, age-related, 13	Enrichment	CFI	2.75
39	Properdin deficiency, x-linked	Enrichment	CFP	2.75
40	Complement factor h deficiency	Enrichment	CFH	2.75
41	Complement factor i deficiency	Enrichment	CFI	2.75
42	Hemolytic uremic syndrome, atypical 2	Enrichment	CD46	2.75
43	Hemolytic anemia, cd59-mediated, with or without immune-mediated polyneuropathy	Enrichment	CD59	2.75
44	Macular degeneration, age-related, 9	Enrichment	C3	2.75
45	Complement component 3 deficiency, autosomal recessive	Enrichment	C3	2.75
46	Complement factor b deficiency	Enrichment	CFB	2.75
47	Complement component 3 deficiency	Enrichment	C3	2.75
48	Membranoproliferative glomerulonephritis	Enrichment	C3	2.75
49	Primary membranoproliferative glomerulonephritis	Enrichment	C3	2.75
50	Protein-losing enteropathy	Enrichment	CD55	2.75
51	Genetic hemolytic uremic syndrome	Enrichment	CFH	2.75
52	Recurrent neisseria infections due to factor d deficiency	Enrichment	CFD	2.75
53	Immunodeficiency with factor h anomaly	Enrichment	CFH	2.75
54	Complement component 4, partial deficiency of	Enrichment	SERPING1	2.63
55	3mc syndrome 1	Enrichment	MASP1	2.63
56	Complement component 2 deficiency	Enrichment	C2	2.63
57	Ficolin 3 deficiency	Enrichment	FCN3	2.63
58	Complement component 4a deficiency	Enrichment	C4A	2.63
59	Blood group, chido/rodgers system	Enrichment	C4A	2.63
60	Complement component 4b deficiency	Enrichment	C4B	2.63
61	Masp2 deficiency	Enrichment	MASP2	2.63
62	Mannose-binding lectin deficiency	Enrichment	MBL2	2.63
63	C1 inhibitor deficiency	Enrichment	SERPING1	2.63
64	Rheumatic heart disease	Enrichment	FCN3	2.63
65	Immunodeficiency due to ficolin3 deficiency	Enrichment	FCN3	2.63
66	Hereditary angioedema with c1inh deficiency	Enrichment	SERPING1	2.63
67	Immunodeficiency due to masp-2 deficiency	Enrichment	MASP2	2.63
68	C1q deficiency 3	Enrichment	C1QC	2.49
69	C1q deficiency 2	Enrichment	C1QB	2.49
70	B-lymphoblastic leukemia/lymphoma with t(5;14)(q31.1;q32.3)	Enrichment	IGH	2.49
71	Leukocyte adhesion deficiency, type i	Enrichment	ITGB2	2.45
72	Cyclic neutropenia	Enrichment	CFD	2.45
73	Immunodeficiency, common variable, 2	Enrichment	CR2	2.45
74	Leukocyte adhesion deficiency, type iii	Enrichment	ITGB2	2.45
75	Macular degeneration, age-related, 14	Enrichment	CFB	2.45
76	Immunodeficiency, common variable, 7	Enrichment	CR2	2.45
77	Nephrotic syndrome, type 7	Enrichment	CFH	2.45
78	Angioedema	Enrichment	SERPING1	2.33
79	Neutropenia, severe congenital, 1, autosomal dominant	Enrichment	CFD	2.28
80	Systemic lupus erythematosus 9	Enrichment	CR2	2.28
81	Complement component c1s deficiency	Enrichment	C1S	2.19
82	Afibrinogenemia, congenital	Enrichment	CFI	2.15
83	Thrombotic microangiopathy	Enrichment	CD46	2.15
84	Angioedema, hereditary, 1	Enrichment	SERPING1	2.15
85	C3 glomerulopathy	Enrichment	CFH	2.05
86	Amyotrophic lateral sclerosis 10 with or without frontotemporal dementia	Enrichment	MASP2	1.93
87	Mantle cell lymphoma	Enrichment	IGH	1.89
88	3mc syndrome	Enrichment	MASP1	1.85
89	Lymphoma, mucosa-associated lymphoid type	Enrichment	IGH	1.79
90	Follicular lymphoma	Enrichment	IGH	1.79
91	Chronic kidney disease	Enrichment	CFH	1.64
92	Leukemia, chronic lymphocytic	Enrichment	IGHG1	1.50
93	Autosomal non-syndromic agammaglobulinemia	Enrichment	IGHM	1.50
94	Malaria	Enrichment	CR1	1.40
95	Behcet syndrome	Enrichment	C4A	1.36
96	Ehlers-danlos syndrome	Enrichment	C1R	1.22
97	Severe covid-19	Enrichment	FCN2	1.18
98	Cystic fibrosis	Enrichment	MBL2	1.14
99	Hereditary retinal dystrophy	Enrichment	CFH	0.39
100	Fundus dystrophy	Enrichment	CFH	0.39

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Immune response Lectin induced complement pathway

Pathway Network for Immune response Lectin induced complement pathway

Pathway network for the Immune response Lectin induced complement pathway SuperPath

Member Pathways for Immune response Lectin induced complement pathway

Pathways in the Immune response Lectin induced complement pathway SuperPath

Gene overlap in member pathways for Immune response Lectin induced complement pathway SuperPath

Associated Genes for Immune response Lectin induced complement pathway

Associated Disorders for Immune response Lectin induced complement pathway

Disorders associated with Immune response Lectin induced complement pathway SuperPath

STRING Interaction Network for Immune response Lectin induced complement pathway

Sources for Immune response Lectin induced complement pathway