Immune response_Role of integrins in NK cells cytotoxicity

No Pathway Network information available for Immune response_Role of integrins in NK cells cytotoxicity

Pathways in the Immune response_Role of integrins in NK cells cytotoxicity SuperPath

#	Name	Source	Genes
1	Immune response_Role of integrins in NK cells cytotoxicity	GeneGo (Thomson Reuters)	ATF2 CXCL8 FASLG FN1 FOS GRB2 HLA-E HRAS ICAM1 ICAM2 ICAM3 IFNG ITGA4 ITGAL ITGAM ITGB1 ITGB2 KLRC1 KLRD1 LYN MAP2K1 MAP2K2 MAP2K3 MAP3K1 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 PAK1 PRKCE PTK2B PTPN11 PTPN6 PXN RAC1 RACK1 RAF1 SHC1 SOS1 SOS2 VAV1 VCAM1 (see all 44) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	FASLG	Fas Ligand	Protein Coding	1
2	ATF2	Activating Transcription Factor 2	Protein Coding	1
3	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
4	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	1
5	FN1	Fibronectin 1	Protein Coding	1
6	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
7	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
8	HLA-E	Major Histocompatibility Complex, Class I, E	Protein Coding	1
9	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
10	ICAM1	Intercellular Adhesion Molecule 1	Protein Coding	1
11	ICAM2	Intercellular Adhesion Molecule 2	Protein Coding	1
12	ICAM3	Intercellular Adhesion Molecule 3	Protein Coding	1
13	IFNG	Interferon Gamma	Protein Coding	1
14	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	1
15	ITGA4	Integrin Subunit Alpha 4	Protein Coding	1
16	ITGAL	Integrin Subunit Alpha L	Protein Coding	1
17	ITGAM	Integrin Subunit Alpha M	Protein Coding	1
18	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
19	ITGB2	Integrin Subunit Beta 2	Protein Coding	1
20	KLRC1	Killer Cell Lectin Like Receptor C1	Protein Coding	1
21	KLRD1	Killer Cell Lectin Like Receptor D1	Protein Coding	1
22	LYN	LYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
23	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	1
24	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
25	PRKCE	Protein Kinase C Epsilon	Protein Coding	1
26	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
27	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
28	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	1
29	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	1
30	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
31	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	1
32	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
33	PTPN6	Protein Tyrosine Phosphatase Non-Receptor Type 6	Protein Coding	1
34	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
35	PXN	Paxillin	Protein Coding	1
36	RAC1	Rac Family Small GTPase 1	Protein Coding	1
37	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
38	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	1
39	SHC1	SHC Adaptor Protein 1	Protein Coding	1
40	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
41	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	1
42	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	1
43	VCAM1	Vascular Cell Adhesion Molecule 1	Protein Coding	1
44	RACK1	Receptor For Activated C Kinase 1	Protein Coding	1

Disorders associated with Immune response_Role of integrins in NK cells cytotoxicity SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rasopathy	Enrichment	HRAS, MAP2K1, MAP2K2, PTPN11, RAF1, SOS1, SOS2	16.00
2	Noonan syndrome 1	Enrichment	HRAS, MAP2K1, MAP2K2, PTPN11, RAF1, SOS1, SOS2	11.62
3	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, MAP2K1, MAP2K2, PTPN11, RAF1, SOS1	11.11
4	Noonan syndrome 3	Enrichment	HRAS, PTPN11, RAF1, SOS1	8.47
5	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1, MAP2K2	4.21
6	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1, MAP2K2	4.21
7	Noonan syndrome with multiple lentigines	Enrichment	PTPN11, RAF1	4.21
8	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, RAF1	3.55
9	Arteriovenous malformation	Enrichment	HRAS, MAP2K1	3.44
10	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1	3.34
11	Lung non-small cell carcinoma	Enrichment	HRAS, MAP2K1	3.26
12	Specific learning disability	Enrichment	MAPK1, PTPN11	3.26
13	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1, SOS1	3.04
14	Hydrops fetalis, nonimmune	Enrichment	HRAS, PTPN11	2.50
15	Metachondromatosis	Enrichment	PTPN11	2.49
16	Systemic lupus erythematosus 6	Enrichment	ITGAM	2.49
17	Noonan syndrome 5	Enrichment	RAF1	2.49
18	Noonan syndrome 4	Enrichment	SOS1	2.49
19	Melorheostosis, isolated	Enrichment	MAP2K1	2.49
20	Leopard syndrome 1	Enrichment	PTPN11	2.49
21	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.49
22	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.49
23	Noonan syndrome 9	Enrichment	SOS2	2.49
24	46,xy sex reversal 6	Enrichment	MAP3K1	2.49
25	Immunodeficiency 69	Enrichment	IFNG	2.49
26	Noonan syndrome 13	Enrichment	MAPK1	2.49
27	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.49
28	Melorheostosis	Enrichment	MAP2K1	2.49
29	Leopard syndrome 2	Enrichment	RAF1	2.49
30	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.49
31	Autoinflammatory disease, systemic, with vasculitis	Enrichment	LYN	2.49
32	Trigonitis	Enrichment	RAF1	2.49
33	Vegetative pyoderma gangrenosum	Enrichment	PTPN6	2.49
34	Bullous pyoderma gangrenosum	Enrichment	PTPN6	2.49
35	Pustular pyoderma gangrenosum	Enrichment	PTPN6	2.49
36	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.49
37	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.49
38	Classic pyoderma gangrenosum	Enrichment	PTPN6	2.49
39	Malignant astrocytoma	Enrichment	PTPN11	2.49
40	Non-immune hydrops fetalis	Enrichment	HRAS, PTPN11	2.35
41	Leukocyte adhesion deficiency, type i	Enrichment	ITGB2	2.19
42	Fibromatosis, gingival, 1	Enrichment	SOS1	2.19
43	Spondyloepimetaphyseal dysplasia, strudwick type	Enrichment	FN1	2.19
44	Costello syndrome	Enrichment	HRAS	2.19
45	Spondylometaphyseal dysplasia, corner fracture type	Enrichment	FN1	2.19
46	Pulmonic stenosis	Enrichment	SOS1	2.19
47	Leukocyte adhesion deficiency, type iii	Enrichment	ITGB2	2.19
48	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.19
49	Werner syndrome	Enrichment	PTPN11	2.19
50	Tafro syndrome	Enrichment	MAP2K2	2.19
51	Wooly hair nevus	Enrichment	HRAS	2.19
52	Tuberous sclerosis 1	Enrichment	IFNG	2.01
53	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	FASLG	2.01
54	Glomerulopathy with fibronectin deposits 2	Enrichment	FN1	2.01
55	Nuchal bleb, familial	Enrichment	SOS1	2.01
56	Langerhans cell histiocytosis	Enrichment	MAP2K1	2.01
57	Hepatitis c virus	Enrichment	IFNG	2.01
58	Neutrophilic dermatosis, acute febrile	Enrichment	PTPN6	2.01
59	Tuberous sclerosis 2	Enrichment	IFNG	2.01
60	Large congenital melanocytic nevus	Enrichment	HRAS	2.01
61	Spermatocytoma	Enrichment	HRAS	2.01
62	Tricuspid valve insufficiency	Enrichment	PTPN11	2.01
63	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	1.89
64	Autoimmune lymphoproliferative syndrome	Enrichment	FASLG	1.89
65	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.89
66	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.89
67	Retinitis pigmentosa 26	Enrichment	ITGA4	1.89
68	Congenital generalized lipodystrophy	Enrichment	FOS	1.89
69	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.89
70	Epidermolytic nevus	Enrichment	HRAS	1.89
71	Cerebral malaria	Enrichment	ICAM1	1.89
72	Gingival fibromatosis	Enrichment	SOS1	1.89
73	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.89
74	Lymphoma	Enrichment	PTPN11	1.79
75	Histiocytoid hemangioma	Enrichment	FOS	1.79
76	Idiopathic aplastic anemia	Enrichment	IFNG	1.79
77	Patent ductus arteriosus	Enrichment	PTPN11	1.71
78	Nevus, epidermal	Enrichment	HRAS	1.65
79	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	1.65
80	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1	1.65
81	Pilomyxoid astrocytoma	Enrichment	RAF1	1.65
82	Follicular thyroid carcinoma	Enrichment	HRAS	1.65
83	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.54
84	Aplastic anemia	Enrichment	IFNG	1.50
85	Pectus excavatum	Enrichment	PTPN11	1.45
86	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.45
87	Epicanthus	Enrichment	PTPN11	1.42
88	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.42
89	Lip and oral cavity carcinoma	Enrichment	HRAS	1.42
90	Congenital long qt syndrome	Enrichment	PTPN11	1.42
91	Aortic valve disease 1	Enrichment	SOS1	1.38
92	Neural tube defects	Enrichment	ITGB1	1.38
93	Isolated macular dystrophy	Enrichment	ITGA4	1.35
94	Autism spectrum disorder	Enrichment	MAP2K1, PTPN11	1.31
95	Rhabdomyosarcoma	Enrichment	HRAS	1.30
96	Heart, malformation of	Enrichment	MAPK1	1.25
97	Human immunodeficiency virus type 1	Enrichment	IFNG	1.25
98	Patent foramen ovale	Enrichment	PTPN11	1.25
99	Microcephaly	Enrichment	MAPK1, PTPN11	1.22
100	Malaria	Enrichment	ICAM1	1.14
101	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.12
102	Scoliosis	Enrichment	PTPN11	1.12
103	Strabismus	Enrichment	PTPN11	1.08
104	Bladder cancer	Enrichment	HRAS	1.05
105	Differentiated thyroid carcinoma	Enrichment	HRAS	1.05
106	Long qt syndrome 1	Enrichment	PTPN11	1.03
107	Lung cancer	Enrichment	FASLG	1.01
108	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.99
109	Left ventricular noncompaction	Enrichment	RAF1	0.97
110	Systemic lupus erythematosus	Enrichment	ITGAM	0.92
111	Nephrotic syndrome	Enrichment	FN1	0.88
112	Hypertrophic cardiomyopathy	Enrichment	PTPN11	0.88
113	Thrombocytopenia	Enrichment	PTPN11	0.84
114	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.80
115	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.78
116	Cone-rod dystrophy 2	Enrichment	ITGA4	0.70
117	Breast cancer	Enrichment	SHC1	0.66
118	Dilated cardiomyopathy	Enrichment	RAF1	0.64
119	Ovarian cancer	Enrichment	MAP3K1	0.55
120	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	0.46
121	Hereditary retinal dystrophy	Enrichment	ITGA4	0.21
122	Fundus dystrophy	Enrichment	ITGA4	0.21

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Immune response_Role of integrins in NK cells cytotoxicity

Pathway Network for Immune response_Role of integrins in NK cells cytotoxicity

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Pathways in the Immune response_Role of integrins in NK cells cytotoxicity SuperPath

Associated Genes for Immune response_Role of integrins in NK cells cytotoxicity

Associated Disorders for Immune response_Role of integrins in NK cells cytotoxicity

Disorders associated with Immune response_Role of integrins in NK cells cytotoxicity SuperPath

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