Inactivation of CDC42 and RAC1

No Pathway Network information available for Inactivation of CDC42 and RAC1

#	Name	Source	Genes
1	Inactivation of CDC42 and RAC1	Reactome	ARHGAP39 CDC42 RAC1 ROBO1 SLIT2 SRGAP1 SRGAP2 SRGAP3 (see all 8) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SRGAP2	SLIT-ROBO Rho GTPase Activating Protein 2	Protein Coding	1
2	SRGAP1	SLIT-ROBO Rho GTPase Activating Protein 1	Protein Coding	1
3	RAC1	Rac Family Small GTPase 1	Protein Coding	1
4	ROBO1	Roundabout Guidance Receptor 1	Protein Coding	1
5	ARHGAP39	Rho GTPase Activating Protein 39	Protein Coding	1
6	SLIT2	Slit Guidance Ligand 2	Protein Coding	1
7	SRGAP3	SLIT-ROBO Rho GTPase Activating Protein 3	Protein Coding	1
8	CDC42	Cell Division Cycle 42	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Cakut	Enrichment	ROBO1, SLIT2, SRGAP1	6.10
2	Nystagmus 8, congenital, autosomal recessive	Enrichment	ROBO1	3.23
3	Takenouchi-kosaki syndrome	Enrichment	CDC42	3.23
4	Autosomal recessive congenital nystagmus	Enrichment	ROBO1	3.23
5	Pituitary hormone deficiency, combined or isolated, 8	Enrichment	ROBO1	3.23
6	Neurooculorenal syndrome	Enrichment	ROBO1	3.23
7	Nocarh syndrome	Enrichment	CDC42	3.23
8	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	3.23
9	Congenital nystagmus	Enrichment	ROBO1	3.23
10	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.93
11	Immune system disease	Enrichment	CDC42	2.93
12	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	2.63
13	Thyroid cancer, nonmedullary, 2	Enrichment	SRGAP1	2.38
14	Pilomyxoid astrocytoma	Enrichment	SRGAP3	2.38
15	Follicular thyroid carcinoma	Enrichment	SRGAP1	2.38
16	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	2.28
17	Renal agenesis, bilateral	Enrichment	ROBO1	2.28
18	Pituitary stalk interruption syndrome	Enrichment	ROBO1	2.08
19	Tetralogy of fallot	Enrichment	ROBO1	1.82

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Inactivation of CDC42 and RAC1