Incretin synthesis, secretion, and inactivation

Pathway network for the Incretin synthesis, secretion, and inactivation SuperPath

Sources:

Reactome

Pathways in the Incretin synthesis, secretion, and inactivation SuperPath

#	Name	Source	Genes
1	Incretin synthesis, secretion, and inactivation	Reactome	CDX2 CTNNB1 DPP4 FFAR1 FFAR4 GATA4 GCG GIP GNAT3 GNB1 GNB3 GNG13 GPR119 GRP ISL1 LEP PAX6 PCSK1 SEC11A SEC11C SPCS1 SPCS2 SPCS3 TCF7L2 (see all 24) (see less)
2	Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	Reactome	CDX2 CTNNB1 DPP4 FFAR1 FFAR4 GCG GNAT3 GNB1 GNB3 GNG13 GPR119 GRP LEP PAX6 PCSK1 SEC11A SEC11C SPCS1 SPCS2 SPCS3 TCF7L2 (see all 21) (see less)
3	Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	Reactome	DPP4 FFAR1 GATA4 GIP GPR119 ISL1 PAX6 PCSK1 SEC11A SEC11C SPCS1 SPCS2 SPCS3 (see all 13) (see less)

Gene overlap in member pathways for Incretin synthesis, secretion, and inactivation SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GPR119	G Protein-Coupled Receptor 119	Protein Coding	3
2	DPP4	Dipeptidyl Peptidase 4	Protein Coding	3
3	SEC11A	SEC11 Homolog A, Signal Peptidase Complex Subunit	Protein Coding	3
4	FFAR1	Free Fatty Acid Receptor 1	Protein Coding	3
5	SPCS1	Signal Peptidase Complex Subunit 1	Protein Coding	3
6	PAX6	Paired Box 6	Protein Coding	3
7	PCSK1	Proprotein Convertase Subtilisin/Kexin Type 1	Protein Coding	3
8	SPCS3	Signal Peptidase Complex Subunit 3	Protein Coding	3
9	SEC11C	SEC11 Homolog C, Signal Peptidase Complex Subunit	Protein Coding	3
10	SPCS2	Signal Peptidase Complex Subunit 2	Protein Coding	3
11	CDX2	Caudal Type Homeobox 2	Protein Coding	2
12	CTNNB1	Catenin Beta 1	Protein Coding	2
13	GATA4	GATA Binding Protein 4	Protein Coding	2
14	GCG	Glucagon	Protein Coding	2
15	GIP	Gastric Inhibitory Polypeptide	Protein Coding	2
16	GNB1	G Protein Subunit Beta 1	Protein Coding	2
17	GNB3	G Protein Subunit Beta 3	Protein Coding	2
18	GRP	Gastrin Releasing Peptide	Protein Coding	2
19	FFAR4	Free Fatty Acid Receptor 4	Protein Coding	2
20	GNAT3	G Protein Subunit Alpha Transducin 3	Protein Coding	2
21	ISL1	ISL LIM Homeobox 1	Protein Coding	2
22	LEP	Leptin	Protein Coding	2
23	GNG13	G Protein Subunit Gamma 13	Protein Coding	2
24	TCF7L2	Transcription Factor 7 Like 2	Protein Coding	2

Disorders associated with Incretin synthesis, secretion, and inactivation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Atrioventricular septal defect 4	Enrichment	GATA4	3.02
2	Atrial septal defect 2	Enrichment	GATA4	3.02
3	Testicular anomalies with or without congenital heart disease	Enrichment	GATA4	3.02
4	8p23.1 microdeletion syndrome	Enrichment	GATA4	3.02
5	Partial atrioventricular septal defect with ventricular hypoplasia	Enrichment	GATA4	3.02
6	Body mass index quantitative trait locus 10	Enrichment	FFAR4	2.81
7	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.81
8	Adenoid ameloblastoma	Enrichment	CTNNB1	2.81
9	Sirenomelia	Enrichment	CDX2	2.81
10	Anorectal malformation	Enrichment	CDX2	2.81
11	Microcystic stromal tumor	Enrichment	CTNNB1	2.81
12	Keratitis, hereditary	Enrichment	PAX6	2.72
13	Foveal hypoplasia 1	Enrichment	PAX6	2.72
14	Optic nerve hypoplasia, bilateral	Enrichment	PAX6	2.72
15	Bladder exstrophy	Enrichment	ISL1	2.72
16	46,xy sex reversal 3	Enrichment	GATA4	2.72
17	Gillespie syndrome	Enrichment	PAX6	2.54
18	Body mass index quantitative trait locus 12	Enrichment	PCSK1	2.54
19	Proprotein convertase 1/3 deficiency	Enrichment	PCSK1	2.54
20	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.51
21	Night blindness, congenital stationary, type 1h	Enrichment	GNB3	2.51
22	Retinal dystrophy, iris coloboma, and comedogenic acne syndrome	Enrichment	FFAR4	2.51
23	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	2.51
24	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.51
25	Progressive retinal dystrophy due to retinol transport defect	Enrichment	FFAR4	2.51
26	Teratoma	Enrichment	CTNNB1	2.51
27	Cerebral visual impairment	Enrichment	GNB1	2.51
28	Aniridia 1	Enrichment	PAX6	2.42
29	Eyelid coloboma	Enrichment	PAX6	2.42
30	Transposition of the great arteries	Enrichment	GATA4	2.42
31	Lens coloboma	Enrichment	PAX6	2.42
32	Desmoid disease, hereditary	Enrichment	CTNNB1	2.33
33	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	2.33
34	Anus, imperforate	Enrichment	CTNNB1	2.33
35	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	2.33
36	Desmoid tumor	Enrichment	CTNNB1	2.33
37	Ventricular septal defect 1	Enrichment	GATA4	2.32
38	Congenital heart defects, multiple types, 4	Enrichment	GATA4	2.32
39	Aniridia	Enrichment	PAX6	2.32
40	Coloboma of choroid and retina	Enrichment	PAX6	2.32
41	Coloboma of optic nerve	Enrichment	PAX6	2.24
42	Wilms tumor, aniridia, genitourinary anomalies, and impaired intellectual development syndrome	Enrichment	PAX6	2.24
43	Anterior segment dysgenesis 5	Enrichment	PAX6	2.24
44	Pilomatrixoma	Enrichment	CTNNB1	2.21
45	Leptin deficiency or dysfunction	Enrichment	LEP	2.21
46	Alazami syndrome	Enrichment	CTNNB1	2.21
47	Craniopharyngioma	Enrichment	CTNNB1	2.21
48	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	2.11
49	Weyers acrofacial dysostosis	Enrichment	CTNNB1	2.03
50	Adrenocortical carcinoma	Enrichment	CTNNB1	2.03
51	Cat eye syndrome	Enrichment	PAX6	2.02
52	Peters-plus syndrome	Enrichment	PAX6	2.02
53	Gallbladder cancer	Enrichment	CTNNB1	1.97
54	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.91
55	Hypothyroidism	Enrichment	GNB1	1.91
56	Microphthalmia/coloboma 12	Enrichment	PAX6	1.91
57	Aortic aneurysm, familial thoracic 1	Enrichment	GATA4	1.87
58	Heart disease	Enrichment	GATA4	1.87
59	46,xy partial gonadal dysgenesis	Enrichment	GATA4	1.87
60	Adult hepatocellular carcinoma	Enrichment	CTNNB1	1.86
61	Coloboma of macula	Enrichment	PAX6	1.85
62	Anterior segment dysgenesis	Enrichment	PAX6	1.85
63	Microcephaly	Enrichment	CTNNB1, GNB1	1.82
64	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.77
65	Myelodysplastic syndrome	Enrichment	GNB1	1.77
66	Heart, malformation of	Enrichment	GATA4	1.77
67	Patent foramen ovale	Enrichment	GATA4	1.77
68	Macs syndrome	Enrichment	PAX6	1.72
69	Microphthalmia	Enrichment	PAX6	1.68
70	Medulloblastoma	Enrichment	CTNNB1	1.67
71	Familial atrial fibrillation	Enrichment	GATA4	1.64
72	Tetralogy of fallot	Enrichment	GATA4	1.61
73	Hypertension, essential	Enrichment	GNB3	1.58
74	Cleft palate, isolated	Enrichment	GNB1	1.58
75	Polycystic liver disease	Enrichment	CTNNB1	1.58
76	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	1.58
77	Hepatoblastoma	Enrichment	CTNNB1	1.49
78	Hepatocellular carcinoma	Enrichment	CTNNB1	1.47
79	Congenital stationary night blindness	Enrichment	GNB3	1.46
80	Strabismus	Enrichment	GNB1	1.39
81	Bladder cancer	Enrichment	CTNNB1	1.36
82	Body mass index quantitative trait locus 11	Enrichment	PCSK1	1.33
83	Hypertelorism	Enrichment	PAX6	1.31
84	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	GATA4	1.28
85	Dystonia	Enrichment	GNB1	1.28
86	Cerebral palsy	Enrichment	GNB1	1.23
87	Type 2 diabetes mellitus	Enrichment	TCF7L2	1.20
88	Autosomal dominant non-syndromic intellectual disability	Enrichment	GNB1	1.13
89	Autism	Enrichment	TCF7L2	0.98
90	Colorectal cancer	Enrichment	CTNNB1	0.90
91	Ovarian cancer	Enrichment	CTNNB1	0.84
92	Congenital nervous system abnormality	Enrichment	CTNNB1	0.82
93	Nervous system disease	Enrichment	CTNNB1	0.82
94	Autism spectrum disorder	Enrichment	GNB1	0.81
95	Complex neurodevelopmental disorder	Enrichment	TCF7L2	0.76

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Incretin synthesis, secretion, and inactivation

Pathway Network for Incretin synthesis, secretion, and inactivation

Pathway network for the Incretin synthesis, secretion, and inactivation SuperPath

Member Pathways for Incretin synthesis, secretion, and inactivation

Pathways in the Incretin synthesis, secretion, and inactivation SuperPath

Gene overlap in member pathways for Incretin synthesis, secretion, and inactivation SuperPath

Associated Genes for Incretin synthesis, secretion, and inactivation

Associated Disorders for Incretin synthesis, secretion, and inactivation

Disorders associated with Incretin synthesis, secretion, and inactivation SuperPath

STRING Interaction Network for Incretin synthesis, secretion, and inactivation

Sources for Incretin synthesis, secretion, and inactivation