Inflammasomes

Pathway network for the Inflammasomes SuperPath

Sources:

Reactome

Pathways in the Inflammasomes SuperPath

#	Name	Source	Genes
1	Inflammasomes	Reactome	AIM2 APP BCL2 BCL2L1 CASP1 HMOX1 HSP90AB1 MEFV NFKB1 NFKB2 NLRC4 NLRP1 NLRP3 P2RX7 PANX1 PSTPIP1 PYCARD RELA SUGT1 TXN TXNIP (see all 21) (see less)
2	Cell recruitment (pro-inflammatory response)	Reactome	APP C3 C3AR1 CASP1 CTSG ENTPD1 ENTPD5 GSDMD HMOX1 HSP90AB1 IL18 IL1A IL1B MEFV NFKB1 NFKB2 NLRP3 NT5E P2RX4 P2RX7 PSTPIP1 PYCARD RELA SUGT1 TXN TXNIP (see all 26) (see less)
3	Purinergic signaling in leishmaniasis infection	Reactome	APP C3 C3AR1 CASP1 CTSG ENTPD1 ENTPD5 GSDMD HMOX1 HSP90AB1 IL18 IL1A IL1B MEFV NFKB1 NFKB2 NLRP3 NT5E P2RX4 P2RX7 PSTPIP1 PYCARD RELA SUGT1 TXN TXNIP (see all 26) (see less)
4	The NLRP3 inflammasome	Reactome	APP CASP1 HMOX1 HSP90AB1 MEFV NFKB1 NFKB2 NLRP3 P2RX7 PANX1 PSTPIP1 PYCARD RELA SUGT1 TXN TXNIP (see all 16) (see less)
5	Interleukin-1 processing	Reactome	CASP1 CTSG GSDMD IL18 IL1A IL1B NFKB1 NFKB2 RELA (see all 9) (see less)
6	The NLRP1 inflammasome	Reactome	BCL2 BCL2L1 NLRP1
7	The AIM2 inflammasome	Reactome	AIM2 CASP1 PYCARD

Gene overlap in member pathways for Inflammasomes SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CASP1	Caspase 1	Protein Coding	6
2	PYCARD	PYD And CARD Domain Containing	Protein Coding	5
3	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	5
4	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	5
5	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	5
6	TXNIP	Thioredoxin Interacting Protein	Protein Coding	4
7	SUGT1	SGT1 Assembly Cochaperone Of MIS12 Kinetochore Complex	Protein Coding	4
8	NLRP3	NLR Family Pyrin Domain Containing 3	Protein Coding	4
9	HMOX1	Heme Oxygenase 1	Protein Coding	4
10	HSP90AB1	Heat Shock Protein 90 Alpha Family Class B Member 1	Protein Coding	4
11	APP	Amyloid Beta Precursor Protein	Protein Coding	4
12	MEFV	MEFV Innate Immunity Regulator, Pyrin	Protein Coding	4
13	P2RX7	Purinergic Receptor P2X 7	Protein Coding	4
14	TXN	Thioredoxin	Protein Coding	4
15	PSTPIP1	Proline-Serine-Threonine Phosphatase Interacting Protein 1	Protein Coding	4
16	CTSG	Cathepsin G	Protein Coding	3
17	IL1A	Interleukin 1 Alpha	Protein Coding	3
18	IL1B	Interleukin 1 Beta	Protein Coding	3
19	IL18	Interleukin 18	Protein Coding	3
20	GSDMD	Gasdermin D	Protein Coding	3
21	NLRP1	NLR Family Pyrin Domain Containing 1	Protein Coding	2
22	PANX1	Pannexin 1	Protein Coding	2
23	BCL2	BCL2 Apoptosis Regulator	Protein Coding	2
24	BCL2L1	BCL2 Like 1	Protein Coding	2
25	AIM2	Absent In Melanoma 2	Protein Coding	2
26	NT5E	5''-Nucleotidase Ecto	Protein Coding	2
27	P2RX4	Purinergic Receptor P2X 4	Protein Coding	2
28	C3	Complement C3	Protein Coding	2
29	C3AR1	Complement C3a Receptor 1	Protein Coding	2
30	ENTPD1	Ectonucleoside Triphosphate Diphosphohydrolase 1	Protein Coding	2
31	ENTPD5	Ectonucleoside Triphosphate Diphosphohydrolase 5 (Inactive)	Protein Coding	2
32	NLRC4	NLR Family CARD Domain Containing 4	Protein Coding	1

Disorders associated with Inflammasomes SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Cutaneous leishmaniasis	Direct
2	Autoinflammatory disease	Enrichment	MEFV, NLRC4, NLRP3	5.20
3	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	5.09
4	Behcet syndrome	Enrichment	MEFV, PSTPIP1	3.66
5	Vitiligo-associated multiple autoimmune disease susceptibility 1	Enrichment	NLRP1	3.66
6	Respiratory papillomatosis, juvenile recurrent, congenital	Enrichment	NLRP1	3.66
7	Palmoplantar carcinoma, multiple self-healing	Enrichment	NLRP1	3.66
8	Autoinflammation with arthritis and dyskeratosis	Enrichment	NLRP1	3.66
9	Intravascular large b-cell lymphoma	Enrichment	BCL2	3.35
10	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2	3.18
11	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	3.18
12	Follicular lymphoma	Enrichment	BCL2	2.96
13	Cinca syndrome	Enrichment	NLRP3	2.93
14	Keratoendotheliitis fugax hereditaria	Enrichment	NLRP3	2.93
15	Pyogenic sterile arthritis, pyoderma gangrenosum, and acne	Enrichment	PSTPIP1	2.93
16	Familial cold autoinflammatory syndrome 1	Enrichment	NLRP3	2.93
17	Muckle-wells syndrome	Enrichment	NLRP3	2.93
18	Autoinflammatory syndrome with cytopenia, hyperzincemia, and hypercalprotectinemia	Enrichment	PSTPIP1	2.93
19	Deafness, autosomal dominant 34, with or without inflammation	Enrichment	NLRP3	2.93
20	Cerebral amyloid angiopathy, app-related	Enrichment	APP	2.93
21	Heme oxygenase 1 deficiency	Enrichment	HMOX1	2.93
22	Cryopyrin associated periodic syndrome	Enrichment	NLRP3	2.93
23	Familial amyloid nephropathy with urticaria and deafness	Enrichment	NLRP3	2.93
24	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.88
25	Immunodeficiency, common variable, 10	Enrichment	NFKB2	2.88
26	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.88
27	Rela fusion-positive ependymoma	Enrichment	RELA	2.88
28	Common variable immunodeficiency 12	Enrichment	NFKB1	2.88
29	Familial cold autoinflammatory syndrome 4	Enrichment	NLRC4	2.81
30	Autoinflammation with infantile enterocolitis	Enrichment	NLRC4	2.81
31	Periodic fever-infantile enterocolitis-autoinflammatory syndrome	Enrichment	NLRC4	2.81
32	Cerebral amyloid angiopathy, cst3-related	Enrichment	APP	2.63
33	Familial mediterranean fever, autosomal dominant	Enrichment	MEFV	2.63
34	Familial mediterranean fever	Enrichment	MEFV	2.63
35	Oocyte/zygote/embryo maturation arrest 7	Enrichment	PANX1	2.63
36	Pericardial effusion	Enrichment	NLRP3	2.63
37	Intermittent hydrarthrosis	Enrichment	MEFV	2.63
38	Immunodeficiency, common variable, 1	Enrichment	NFKB2	2.58
39	Neutrophilic dermatosis, acute febrile	Enrichment	MEFV	2.45
40	Female infertility due to oocyte meiotic arrest	Enrichment	PANX1	2.23
41	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	2.18
42	Alzheimer's disease 1	Enrichment	APP	2.08
43	Early-onset autosomal dominant alzheimer disease	Enrichment	APP	2.08
44	Leukemia, chronic lymphocytic	Enrichment	P2RX7	1.93
45	Pulmonary disease, chronic obstructive	Enrichment	HMOX1	1.82
46	Alzheimer's disease	Enrichment	APP	1.82
47	Neuronal ceroid lipofuscinosis	Enrichment	MEFV	1.76
48	Kidney disease	Enrichment	MEFV	1.76
49	Alzheimer disease, familial, 1	Enrichment	APP	1.70
50	Arteriovenous malformations of the brain	Enrichment	NLRP3	1.65
51	Gastric cancer	Enrichment	IL1B	1.55
52	Cystic fibrosis	Enrichment	HMOX1	1.43

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Inflammasomes

Pathway network for the Inflammasomes SuperPath

Member Pathways for Inflammasomes

Pathways in the Inflammasomes SuperPath

Gene overlap in member pathways for Inflammasomes SuperPath

Associated Genes for Inflammasomes

Associated Disorders for Inflammasomes

Disorders associated with Inflammasomes SuperPath

STRING Interaction Network for Inflammasomes

Sources for Inflammasomes