Inflammatory response pathway

No Pathway Network information available for Inflammatory response pathway

Pathways in the Inflammatory response pathway SuperPath

#	Name	Source	Genes
1	Inflammatory response pathway	WikiPathways	CD28 CD40 CD40LG CD80 CD86 COL1A1 COL1A2 COL3A1 FN1 IFNG IGHA1 IGHA2 IGHM IL2 IL2RA IL2RB IL2RG IL4 IL4R IL5 IL5RA LAMA5 LAMB1 LAMB2 LAMC1 LAMC2 LCK THBS1 THBS3 TNFRSF1A TNFRSF1B VTN ZAP70 (see all 33) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CD40LG	CD40 Ligand	Protein Coding	1
2	CD40	CD40 Molecule	Protein Coding	1
3	CD86	CD86 Molecule	Protein Coding	1
4	CD80	CD80 Molecule	Protein Coding	1
5	CD28	CD28 Molecule	Protein Coding	1
6	ZAP70	Zeta Chain Of T Cell Receptor Associated Protein Kinase 70	Protein Coding	1
7	VTN	Vitronectin	Protein Coding	1
8	TNFRSF1B	TNF Receptor Superfamily Member 1B	Protein Coding	1
9	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	1
10	THBS1	Thrombospondin 1	Protein Coding	1
11	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
12	LAMC2	Laminin Subunit Gamma 2	Protein Coding	1
13	LAMC1	Laminin Subunit Gamma 1	Protein Coding	1
14	LAMB2	Laminin Subunit Beta 2	Protein Coding	1
15	LAMB1	Laminin Subunit Beta 1	Protein Coding	1
16	IL5RA	Interleukin 5 Receptor Subunit Alpha	Protein Coding	1
17	IL5	Interleukin 5	Protein Coding	1
18	IL4R	Interleukin 4 Receptor	Protein Coding	1
19	IL4	Interleukin 4	Protein Coding	1
20	IL2RG	Interleukin 2 Receptor Subunit Gamma	Protein Coding	1
21	IL2RB	Interleukin 2 Receptor Subunit Beta	Protein Coding	1
22	IL2RA	Interleukin 2 Receptor Subunit Alpha	Protein Coding	1
23	IL2	Interleukin 2	Protein Coding	1
24	IGHM	Immunoglobulin Heavy Constant Mu	Protein Coding	1
25	IFNG	Interferon Gamma	Protein Coding	1
26	FN1	Fibronectin 1	Protein Coding	1
27	COL3A1	Collagen Type III Alpha 1 Chain	Protein Coding	1
28	COL1A2	Collagen Type I Alpha 2 Chain	Protein Coding	1
29	COL1A1	Collagen Type I Alpha 1 Chain	Protein Coding	1
30	THBS3	Thrombospondin 3	Protein Coding	1
31	LAMA5	Laminin Subunit Alpha 5	Protein Coding	1
32	IGHA2	Immunoglobulin Heavy Constant Alpha 2 (A2m Marker)	Protein Coding	1
33	IGHA1	Immunoglobulin Heavy Constant Alpha 1	Protein Coding	1

Disorders associated with Inflammatory response pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Multiple sclerosis	Enrichment	LAMA5, LAMB1, TNFRSF1A	5.33
2	Ehlers-danlos syndrome, arthrochalasia type, 2	Enrichment	COL1A1, COL1A2	5.24
3	Ehlers-danlos/osteogenesis imperfecta syndrome	Enrichment	COL1A1, COL1A2	5.24
4	Ehlers-danlos syndrome	Enrichment	COL1A1, COL1A2, COL3A1	4.91
5	Mycosis fungoides	Enrichment	CD28, TNFRSF1B	4.76
6	High bone mass osteogenesis imperfecta	Enrichment	COL1A1, COL1A2	4.76
7	Saczary syndrome	Enrichment	CD28, TNFRSF1B	4.76
8	Ehlers-danlos syndrome, arthrochalasia type, 1	Enrichment	COL1A1, COL1A2	4.46
9	Osteogenesis imperfecta with normal sclerae, dominant form	Enrichment	COL1A1, COL1A2	4.46
10	Ehlers-danlos syndrome, classic type, 1	Enrichment	COL1A1, COL1A2	4.07
11	Osteogenesis imperfecta, type i	Enrichment	COL1A1, COL1A2	4.07
12	Classic ehlers-danlos syndrome	Enrichment	COL1A1, COL1A2	4.07
13	Osteogenesis imperfecta, type ii	Enrichment	COL1A1, COL1A2	3.92
14	Oligoarticular juvenile idiopathic arthritis	Enrichment	IL2RA, IL2RB	3.92
15	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	IL2RA, IL2RB	3.92
16	Nephrotic syndrome	Enrichment	FN1, LAMA5, LAMB2	3.82
17	Primary bone dysplasia	Enrichment	COL1A1, COL1A2	3.59
18	Combined immunodeficiency	Enrichment	IL2RG, ZAP70	3.51
19	Osteochondrodysplasia	Enrichment	COL1A1, COL1A2	3.51
20	Combined t cell and b cell immunodeficiency	Enrichment	IL2RG, ZAP70	3.51
21	Combined t and b cell immunodeficiency	Enrichment	IL2RG, ZAP70	3.51
22	Osteogenesis imperfecta, type iv	Enrichment	COL1A1, COL1A2	3.36
23	Osteoporosis	Enrichment	COL1A1, COL1A2	3.29
24	Osteogenesis imperfecta, type iii	Enrichment	COL1A1, COL1A2	3.23
25	Brittle bone disorder	Enrichment	COL1A1, COL1A2	2.85
26	Periodic fever, familial, autosomal dominant	Enrichment	TNFRSF1A	2.61
27	Ehlers-danlos syndrome, cardiac valvular type	Enrichment	COL1A2	2.61
28	Type 1 diabetes mellitus 10	Enrichment	IL2RA	2.61
29	Lissencephaly 5	Enrichment	LAMB1	2.61
30	Acrogeria, gottron type	Enrichment	COL3A1	2.61
31	Immunodeficiency 69	Enrichment	IFNG	2.61
32	Nephrotic syndrome, type 26	Enrichment	LAMA5	2.61
33	Immunodeficiency with hyper-igm, type 1	Enrichment	CD40LG	2.61
34	Immunodeficiency 63 with lymphoproliferation and autoimmunity	Enrichment	IL2RB	2.61
35	Immunodeficiency 48	Enrichment	ZAP70	2.61
36	Combined osteogenesis imperfecta and ehlers-danlos syndrome 2	Enrichment	COL1A2	2.61
37	Immunodeficiency with hyper-igm, type 3	Enrichment	CD40	2.61
38	Multiple sclerosis 5	Enrichment	TNFRSF1A	2.61
39	Immunodeficiency 123 with hpv-related verrucosis	Enrichment	CD28	2.61
40	Autoimmune disease, multisystem, infantile-onset, 2	Enrichment	ZAP70	2.61
41	Immunodeficiency 22	Enrichment	LCK	2.61
42	Tnf receptor-associated periodic fever syndrome	Enrichment	TNFRSF1A	2.61
43	Bent bone dysplasia syndrome 2	Enrichment	LAMA5	2.61
44	Asphyxia neonatorum	Enrichment	COL1A1	2.61
45	Cd40 ligand deficiency	Enrichment	CD40LG	2.61
46	Abdominal aortic aneurysm	Enrichment	COL3A1	2.61
47	Lama5-related multisystemic syndrome	Enrichment	LAMA5	2.61
48	Zap70-related severe combined immunodeficiency	Enrichment	ZAP70	2.61
49	Severe combined immunodeficiency	Enrichment	LCK, ZAP70	2.54
50	Ehlers-danlos syndrome, vascular type	Enrichment	COL3A1	2.31
51	Epiphyseal dysplasia, multiple, 1	Enrichment	COL1A1	2.31
52	Ehlers-danlos syndrome, hypermobility type	Enrichment	COL3A1	2.31
53	Spondyloepimetaphyseal dysplasia, strudwick type	Enrichment	FN1	2.31
54	Spondylometaphyseal dysplasia, corner fracture type	Enrichment	FN1	2.31
55	Bruck syndrome 1	Enrichment	COL1A2	2.31
56	Myasthenic syndrome, congenital, 5	Enrichment	LAMB2	2.31
57	Dermatofibrosarcoma protuberans	Enrichment	COL1A1	2.31
58	Immunodeficiency 41 with lymphoproliferation and autoimmunity	Enrichment	IL2RA	2.31
59	Lissencephaly 1	Enrichment	LAMB1	2.31
60	Pierson syndrome	Enrichment	LAMB2	2.31
61	Combined osteogenesis imperfecta and ehlers-danlos syndrome 1	Enrichment	COL1A1	2.31
62	Epidermolysis bullosa, junctional 3b, severe	Enrichment	LAMC2	2.31
63	Epidermolysis bullosa, junctional 3a, intermediate	Enrichment	LAMC2	2.31
64	Polymicrogyria with or without vascular-type ehlers-danlos syndrome	Enrichment	COL3A1	2.31
65	Nephrotic syndrome, type 5, with or without ocular abnormalities	Enrichment	LAMB2	2.31
66	Aortic dissection	Enrichment	COL3A1	2.31
67	Stickler syndrome, type ii	Enrichment	COL1A1	2.31
68	Intermittent hydrarthrosis	Enrichment	TNFRSF1A	2.31
69	Dentinogenesis imperfecta	Enrichment	COL1A2	2.31
70	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	COL1A1, COL3A1	2.29
71	Tuberous sclerosis 1	Enrichment	IFNG	2.14
72	Severe combined immunodeficiency, x-linked	Enrichment	IL2RG	2.14
73	Agammaglobulinemia 1, autosomal recessive	Enrichment	IGHM	2.14
74	Glomerulopathy with fibronectin deposits 2	Enrichment	FN1	2.14
75	Combined immunodeficiency, x-linked	Enrichment	IL2RG	2.14
76	Hepatitis c virus	Enrichment	IFNG	2.14
77	Caffey disease	Enrichment	COL1A1	2.14
78	Tuberous sclerosis 2	Enrichment	IFNG	2.14
79	Agammaglobulinemia 1	Enrichment	IGHM	2.14
80	Phenylketonuria	Enrichment	COL1A1	2.01
81	Idiopathic aplastic anemia	Enrichment	IFNG	1.92
82	Familial cerebral saccular aneurysm	Enrichment	COL3A1	1.92
83	Epidermolysis bullosa, junctional 1a, intermediate	Enrichment	LAMC2	1.84
84	Epidermolysis bullosa, junctional 1b, severe	Enrichment	LAMC2	1.84
85	Junctional epidermolysis bullosa non-herlitz type	Enrichment	LAMC2	1.84
86	Keratoconus	Enrichment	COL1A1	1.84
87	Common variable immunodeficiency	Enrichment	CD40LG	1.77
88	Spastic paraplegia 4, autosomal dominant	Enrichment	COL3A1	1.71
89	Charge syndrome	Enrichment	TNFRSF1A	1.66
90	Junctional epidermolysis bullosa	Enrichment	LAMC2	1.66
91	Familial thoracic aortic aneurysm and dissection	Enrichment	COL3A1	1.66
92	Omenn syndrome	Enrichment	IL2RG	1.62
93	Aplastic anemia	Enrichment	IFNG	1.62
94	Autosomal non-syndromic agammaglobulinemia	Enrichment	IGHM	1.62
95	Ichthyosis	Enrichment	IL2RB	1.58
96	Presynaptic congenital myasthenic syndromes	Enrichment	LAMA5	1.58
97	Aortic aneurysm, familial thoracic 1	Enrichment	COL3A1	1.47
98	Kidney disease	Enrichment	LAMB2	1.44
99	Human immunodeficiency virus type 1	Enrichment	IFNG	1.37
100	Behcet syndrome	Enrichment	TNFRSF1A	1.34
101	Skin disease	Enrichment	LAMC2	1.28
102	Autoinflammatory disease	Enrichment	TNFRSF1A	1.25
103	Genetic steroid-resistant nephrotic syndrome	Enrichment	LAMA5	1.10
104	Hypertelorism	Enrichment	COL1A1	0.92
105	Primary ovarian insufficiency	Enrichment	THBS1	0.87
106	Breast cancer	Enrichment	IL2	0.78

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Inflammatory response pathway

Pathway Network for Inflammatory response pathway

Member Pathways for Inflammatory response pathway

Pathways in the Inflammatory response pathway SuperPath

Associated Genes for Inflammatory response pathway

Associated Disorders for Inflammatory response pathway

Disorders associated with Inflammatory response pathway SuperPath

STRING Interaction Network for Inflammatory response pathway

Sources for Inflammatory response pathway