Inhibition of Ribosome Biogenesis by p14(ARF)

No Pathway Network information available for Inhibition of Ribosome Biogenesis by p14(ARF)

Pathways in the Inhibition of Ribosome Biogenesis by p14(ARF) SuperPath

#	Name	Source	Genes
1	Inhibition of Ribosome Biogenesis by p14(ARF)	QIAGEN	ABL1 CDKN2A E2F1 MDM2 MYC PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 POLR1A POLR1B POLR1C POLR1D RAC1 RB1 TBX2 TP53 TWIST1 UBB UBC UBD (see all 22) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	1
2	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	1
3	E2F1	E2F Transcription Factor 1	Protein Coding	1
4	MDM2	MDM2 Proto-Oncogene	Protein Coding	1
5	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
6	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	1
7	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
8	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
9	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	1
10	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	1
11	POLR1A	RNA Polymerase I Subunit A	Protein Coding	1
12	POLR1B	RNA Polymerase I Subunit B	Protein Coding	1
13	POLR1C	RNA Polymerase I And III Subunit C	Protein Coding	1
14	RAC1	Rac Family Small GTPase 1	Protein Coding	1
15	RB1	RB Transcriptional Corepressor 1	Protein Coding	1
16	POLR1D	RNA Polymerase I And III Subunit D	Protein Coding	1
17	TBX2	T-Box Transcription Factor 2	Protein Coding	1
18	TP53	Tumor Protein P53	Protein Coding	1
19	TWIST1	Twist Family BHLH Transcription Factor 1	Protein Coding	1
20	UBB	Ubiquitin B	Protein Coding	1
21	UBC	Ubiquitin C	Protein Coding	1
22	UBD	Ubiquitin Like Modifier D	Protein Coding	1

Disorders associated with Inhibition of Ribosome Biogenesis by p14(ARF) SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Lip and oral cavity carcinoma	Enrichment	ABL1, CDKN2A, RB1, TP53	8.59
2	Li-fraumeni syndrome	Enrichment	CDKN2A, MDM2, TP53	7.13
3	Treacher collins syndrome 1	Enrichment	POLR1B, POLR1C, POLR1D	6.89
4	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	ABL1, CDKN2A, TP53	6.89
5	Precursor t-cell acute lymphoblastic leukemia	Enrichment	ABL1, CDKN2A, MYC	5.19
6	Osteogenic sarcoma	Enrichment	RB1, TP53	5.12
7	Squamous cell carcinoma	Enrichment	RB1, TP53	5.12
8	Bone osteosarcoma	Enrichment	RB1, TP53	5.12
9	Bladder cancer	Enrichment	CDKN2A, RB1, TP53	4.88
10	Small cell cancer of the lung	Enrichment	RB1, TP53	4.82
11	Adrenocortical carcinoma	Enrichment	CDKN2A, TP53	4.43
12	Lung cancer susceptibility 3	Enrichment	RB1, TP53	3.65
13	Ovarian cancer	Enrichment	CDKN2A, RB1, TP53	3.25
14	Pancreatic cancer	Enrichment	CDKN2A, TP53	3.13
15	Inherited cancer-predisposing syndrome	Enrichment	CDKN2A, RB1, TP53	2.92
16	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.79
17	Accelerated tumor formation	Enrichment	MDM2	2.79
18	Leukodystrophy, hypomyelinating, 27	Enrichment	POLR1A	2.79
19	Lessel-kubisch syndrome	Enrichment	MDM2	2.79
20	Short syndrome	Enrichment	PIK3R1	2.79
21	Treacher collins syndrome 4	Enrichment	POLR1B	2.79
22	Bone marrow failure syndrome 5	Enrichment	TP53	2.79
23	Papilloma of choroid plexus	Enrichment	TP53	2.79
24	Basal cell carcinoma 7	Enrichment	TP53	2.79
25	Anaplastic thyroid carcinoma	Enrichment	TP53	2.79
26	Treacher collins syndrome 2	Enrichment	POLR1D	2.79
27	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.79
28	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.79
29	Ductal carcinoma in situ	Enrichment	TP53	2.79
30	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.79
31	Trilateral retinoblastoma	Enrichment	RB1	2.79
32	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.79
33	Cdkn2a cancer predisposition	Enrichment	CDKN2A	2.79
34	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.79
35	Choroid plexus cancer	Enrichment	TP53	2.79
36	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.79
37	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.79
38	Lung oat cell carcinoma	Enrichment	RB1	2.79
39	Gastric cancer	Enrichment	CDKN2A, TP53	2.66
40	Melanoma-astrocytoma syndrome	Enrichment	CDKN2A	2.49
41	Burkitt lymphoma	Enrichment	MYC	2.49
42	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.49
43	Robinow-sorauf syndrome	Enrichment	TWIST1	2.49
44	Treacher collins syndrome 3	Enrichment	POLR1C	2.49
45	Cervical cancer	Enrichment	TP53	2.49
46	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	2.49
47	Melanoma, cutaneous malignant 2	Enrichment	CDKN2A	2.49
48	Chromosome 13q14 deletion syndrome	Enrichment	RB1	2.49
49	Lymphoma, hodgkin, classic	Enrichment	TP53	2.49
50	Leukoencephalopathy, progressive, with ovarian failure	Enrichment	POLR1C	2.49
51	Sweeney-cox syndrome	Enrichment	TWIST1	2.49
52	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.49
53	Congenital heart defects and skeletal malformations syndrome	Enrichment	ABL1	2.49
54	Vertebral anomalies and variable endocrine and t-cell dysfunction	Enrichment	TBX2	2.49
55	Melanoma-pancreatic cancer syndrome	Enrichment	CDKN2A	2.49
56	Leukodystrophy, hypomyelinating, 11	Enrichment	POLR1C	2.49
57	Congenital fibrosarcoma	Enrichment	TP53	2.49
58	Li-fraumeni syndrome 1	Enrichment	TP53	2.49
59	Sarcoma	Enrichment	TP53	2.49
60	Cervix carcinoma	Enrichment	TP53	2.49
61	Hodgkin's lymphoma	Enrichment	TP53	2.49
62	Acrofacial dysostosis, cincinnati type	Enrichment	POLR1A	2.49
63	Familial retinoblastoma	Enrichment	RB1	2.49
64	Non-syndromic sagittal craniosynostosis	Enrichment	TWIST1	2.49
65	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.49
66	Submucosal cleft palate	Enrichment	UBB	2.49
67	Cleft hard palate	Enrichment	UBB	2.49
68	Myeloma, multiple	Enrichment	PIK3R2, TP53	2.44
69	Craniosynostosis 1	Enrichment	TWIST1	2.31
70	Retinoblastoma	Enrichment	RB1	2.31
71	Uvula, bifid	Enrichment	UBB	2.31
72	Burn-mckeown syndrome	Enrichment	POLR1A	2.31
73	Cleft soft palate	Enrichment	UBB	2.31
74	Nasopharyngeal carcinoma	Enrichment	TP53	2.31
75	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3R1	2.31
76	Woolly hair, autosomal recessive 3	Enrichment	RB1	2.31
77	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.31
78	Hypotrichosis 8	Enrichment	RB1	2.31
79	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	2.31
80	Dedifferentiated liposarcoma	Enrichment	MDM2	2.31
81	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.31
82	Anaplastic astrocytoma	Enrichment	TP53	2.31
83	Immunodeficiency 14	Enrichment	PIK3R1	2.31
84	T-cell acute lymphoblastic leukemia	Enrichment	ABL1	2.31
85	Adenocarcinoma	Enrichment	TP53	2.31
86	Well-differentiated liposarcoma	Enrichment	MDM2	2.31
87	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	2.19
88	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3R2	2.19
89	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	2.19
90	Saethre-chotzen syndrome	Enrichment	TWIST1	2.19
91	Lynch syndrome 4	Enrichment	RB1	2.19
92	Lung sarcomatoid carcinoma	Enrichment	TP53	2.19
93	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	ABL1	2.19
94	Embryonal rhabdomyosarcoma	Enrichment	TP53	2.19
95	Non-syndromic bicoronal craniosynostosis	Enrichment	TWIST1	2.19
96	Rhabdomyosarcoma 2	Enrichment	TP53	2.09
97	Leukodystrophy, hypomyelinating, 7, with or without oligodontia and/or hypogonadotropic hypogonadism	Enrichment	POLR1C	2.09
98	Lymphoma	Enrichment	TP53	2.09
99	Acute megakaryocytic leukemia	Enrichment	TP53	2.09
100	Colorectal cancer	Enrichment	PIK3R1, TP53	2.06
101	Breast adenocarcinoma	Enrichment	TP53	2.01
102	Lung squamous cell carcinoma	Enrichment	CDKN2A	2.01
103	Esophageal cancer	Enrichment	TP53	1.95
104	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.95
105	Leukemia, chronic myeloid	Enrichment	ABL1	1.95
106	Essential thrombocythemia	Enrichment	TP53	1.95
107	Gallbladder cancer	Enrichment	TP53	1.95
108	Overgrowth syndrome	Enrichment	PIK3R1	1.95
109	Moyamoya angiopathy	Enrichment	ABL1	1.95
110	Glioma susceptibility 1	Enrichment	TP53	1.89
111	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.89
112	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.84
113	Adult hepatocellular carcinoma	Enrichment	TP53	1.84
114	Primary hyperaldosteronism	Enrichment	TP53	1.84
115	Leukemia, chronic lymphocytic	Enrichment	TP53	1.79
116	Melanoma	Enrichment	CDKN2A	1.79
117	Familial colorectal cancer	Enrichment	TP53	1.79
118	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.79
119	Leukemia, acute lymphoblastic	Enrichment	CDKN2A	1.75
120	Myelodysplastic syndrome	Enrichment	TP53	1.75
121	Heart disease	Enrichment	ABL1	1.65
122	Rhabdomyosarcoma	Enrichment	TP53	1.59
123	Gliosarcoma	Enrichment	TP53	1.59
124	Melanoma, cutaneous malignant 1	Enrichment	CDKN2A	1.56
125	Giant cell glioblastoma	Enrichment	TP53	1.56
126	Diffuse large b-cell lymphoma	Enrichment	TP53	1.52
127	Hepatoblastoma	Enrichment	TP53	1.47
128	Hepatocellular carcinoma	Enrichment	TP53	1.45
129	Diamond-blackfan anemia 1	Enrichment	TP53	1.44
130	Prostate cancer	Enrichment	TP53	1.34
131	Diamond-blackfan anemia	Enrichment	TP53	1.25
132	Leukemia, acute myeloid	Enrichment	TP53	1.20
133	Hereditary breast carcinoma	Enrichment	TP53	1.16
134	Hereditary breast ovarian cancer syndrome	Enrichment	TP53	1.07
135	Breast cancer	Enrichment	TP53	0.94
136	Microcephaly	Enrichment	ABL1	0.74

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Inhibition of Ribosome Biogenesis by p14(ARF)

Pathway Network for Inhibition of Ribosome Biogenesis by p14(ARF)

Member Pathways for Inhibition of Ribosome Biogenesis by p14(ARF)

Pathways in the Inhibition of Ribosome Biogenesis by p14(ARF) SuperPath

Associated Genes for Inhibition of Ribosome Biogenesis by p14(ARF)

Associated Disorders for Inhibition of Ribosome Biogenesis by p14(ARF)

Disorders associated with Inhibition of Ribosome Biogenesis by p14(ARF) SuperPath

STRING Interaction Network for Inhibition of Ribosome Biogenesis by p14(ARF)

Sources for Inhibition of Ribosome Biogenesis by p14(ARF)