Initial triggering of complement

Pathway network for the Initial triggering of complement SuperPath

Sources:

Reactome
WikiPathways
Sino Biological
QIAGEN

Pathways in the Initial triggering of complement SuperPath

#	Name	Source	Genes
1	Initial triggering of complement	Reactome	C1QA C1QB C1QC C1R C1S C2 C3 C4A C4B C4B_2 CFB CFD CFP COLEC10 COLEC11 CRP FCN1 FCN2 FCN3 GZMM MASP1 MASP2 MBL2 (see all 23) (see less)
2	Complement activation	WikiPathways	C1QA C1QB C1QC C1R C1S C2 C3 C4A C4B C5 C6 C7 C8A C8B C8G C9 CD55 CFB CFD CFP MASP1 MASP2 (see all 22) (see less)
3	Complement Activation Pathways	Sino Biological	C1QA C1QB C1QC C1R C1S C2 C3 C5 C5AR1 C6 C7 C9 CD46 CD55 CD59 CFB CFD CFH CR2 MASP1 MBL2 (see all 21) (see less)
4	Creation of C4 and C2 activators	Reactome	C1QA C1QB C1QC C1R C1S COLEC10 COLEC11 CRP FCN1 FCN2 FCN3 MASP1 MASP2 MBL2 (see all 14) (see less)
5	Alternative Complement Pathway	QIAGEN	C3 C5 C6 C7 C8A C8B C8G C9 CFB CFD CFP (see all 11) (see less)
6	Lectin pathway of complement activation	Reactome	COLEC10 COLEC11 FCN1 FCN2 FCN3 MASP1 MASP2 MBL2 (see all 8) (see less)
7	Classical antibody-mediated complement activation	Reactome	C1QA C1QB C1QC C1R C1S CRP (see all 6) (see less)
8	Ficolins bind to repetitive carbohydrate structures on the target cell surface	Reactome	FCN1 FCN2 FCN3 MASP1 MASP2
9	Alternative complement activation	Reactome	C3 CFB CFD CFP GZMM

Gene overlap in member pathways for Initial triggering of complement SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MASP1	MBL Associated Serine Protease 1	Protein Coding	6
2	MASP2	MBL Associated Serine Protease 2	Protein Coding	5
3	CFD	Complement Factor D	Protein Coding	5
4	CFB	Complement Factor B	Protein Coding	5
5	C1QA	Complement C1q A Chain	Protein Coding	5
6	C1QB	Complement C1q B Chain	Protein Coding	5
7	C1QC	Complement C1q C Chain	Protein Coding	5
8	C1R	Complement C1r	Protein Coding	5
9	C1S	Complement C1s	Protein Coding	5
10	C3	Complement C3	Protein Coding	5
11	FCN1	Ficolin 1	Protein Coding	4
12	FCN2	Ficolin 2	Protein Coding	4
13	MBL2	Mannose Binding Lectin 2	Protein Coding	4
14	CFP	Complement Factor Properdin	Protein Coding	4
15	FCN3	Ficolin 3	Protein Coding	4
16	COLEC10	Collectin Subfamily Member 10	Protein Coding	3
17	CRP	C-Reactive Protein	Protein Coding	3
18	C2	Complement C2	Protein Coding	3
19	COLEC11	Collectin Subfamily Member 11	Protein Coding	3
20	C9	Complement C9	Protein Coding	3
21	C7	Complement C7	Protein Coding	3
22	C6	Complement C6	Protein Coding	3
23	C5	Complement C5	Protein Coding	3
24	GZMM	Granzyme M	Protein Coding	2
25	C4A	Complement C4A (Chido/Rodgers Blood Group)	Protein Coding	2
26	C4B	Complement C4B (Chido/Rodgers Blood Group)	Protein Coding	2
27	C8G	Complement C8 Gamma Chain	Protein Coding	2
28	C8B	Complement C8 Beta Chain	Protein Coding	2
29	C8A	Complement C8 Alpha Chain	Protein Coding	2
30	CD55	CD55 Molecule (Cromer Blood Group)	Protein Coding	2
31	C4B_2	Complement Component 4B (Chido/Rodgers Blood Group), Copy 2	Protein Coding	1
32	C5AR1	Complement C5a Receptor 1	Protein Coding	1
33	CD46	CD46 Molecule	Protein Coding	1
34	CD59	CD59 Molecule (CD59 Blood Group)	Protein Coding	1
35	CFH	Complement Factor H	Protein Coding	1
36	CR2	Complement C3d Receptor 2	Protein Coding	1

Disorders associated with Initial triggering of complement SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Immunodeficiency due to a classical component pathway complement deficiency	Enrichment	C1QA, C1QB, C1QC, C1R, C1S	10.96
2	Immunodeficiency due to a late component of complement deficiency	Enrichment	C5, C6, C7, C8A, C8B, C8G, C9	10.58
3	C1q deficiency 1	Enrichment	C1QA, C1QB, C1QC	10.25
4	Atypical hemolytic uremic syndrome with complement gene abnormality	Enrichment	C3, CD46, CFB, CFH	10.09
5	3mc syndrome	Enrichment	COLEC10, COLEC11, MASP1	8.56
6	Genetic atypical hemolytic-uremic syndrome	Enrichment	C3, CD46, CFH	8.50
7	Systemic lupus erythematosus 16	Enrichment	C1QA, C1R, C4A	7.43
8	Periodontal ehlers-danlos syndrome	Enrichment	C1R, C1S	6.79
9	Ehlers-danlos syndrome, periodontal type, 1	Enrichment	C1R, C1S	6.31
10	Ehlers-danlos syndrome, periodontal type, 2	Enrichment	C1R, C1S	6.31
11	Complement component 6 deficiency	Enrichment	C6, C8B	6.22
12	Atypical hemolytic-uremic syndrome	Enrichment	C3, CD46, CFH	5.84
13	Macular degeneration, age-related, 14	Enrichment	C2, CFB	5.64
14	Hellp syndrome	Enrichment	CD46, CFH	4.86
15	3mc syndrome 1	Enrichment	MASP1	3.43
16	Ficolin 3 deficiency	Enrichment	FCN3	3.43
17	Masp2 deficiency	Enrichment	MASP2	3.43
18	Rheumatic heart disease	Enrichment	FCN3	3.43
19	Immunodeficiency due to ficolin3 deficiency	Enrichment	FCN3	3.43
20	Immunodeficiency due to masp-2 deficiency	Enrichment	MASP2	3.43
21	Hemolytic uremic syndrome, atypical 4	Enrichment	CFB	3.43
22	Complement factor d deficiency	Enrichment	CFD	3.43
23	Hemolytic uremic syndrome, atypical 5	Enrichment	C3	3.43
24	Properdin deficiency, x-linked	Enrichment	CFP	3.43
25	Macular degeneration, age-related, 9	Enrichment	C3	3.43
26	Complement component 3 deficiency, autosomal recessive	Enrichment	C3	3.43
27	Complement factor b deficiency	Enrichment	CFB	3.43
28	Complement component 3 deficiency	Enrichment	C3	3.43
29	Membranoproliferative glomerulonephritis	Enrichment	C3	3.43
30	Primary membranoproliferative glomerulonephritis	Enrichment	C3	3.43
31	Recurrent neisseria infections due to factor d deficiency	Enrichment	CFD	3.43
32	C1q deficiency 3	Enrichment	C1QC	3.35
33	C1q deficiency 2	Enrichment	C1QB	3.35
34	Mannose-binding lectin deficiency	Enrichment	MBL2	3.23
35	Cyclic neutropenia	Enrichment	CFD	3.13
36	Complement component 5 deficiency	Enrichment	C5	3.09
37	Complement component 7 deficiency	Enrichment	C7	3.09
38	Complement component 8 deficiency, type i	Enrichment	C8A	3.09
39	Macular degeneration, age-related, 15	Enrichment	C9	3.09
40	Eculizumab, poor response to	Enrichment	C5	3.09
41	Complement component 9 deficiency	Enrichment	C9	3.09
42	Complement component 8 deficiency, type ii	Enrichment	C8B	3.09
43	Complement component c1s deficiency	Enrichment	C1S	3.05
44	Neutropenia, severe congenital, 1, autosomal dominant	Enrichment	CFD	2.96
45	3mc syndrome 2	Enrichment	COLEC11	2.93
46	Complement component 2 deficiency	Enrichment	C2	2.81
47	Basal laminar drusen	Enrichment	CFH	2.81
48	Macular degeneration, age-related, 4	Enrichment	CFH	2.81
49	Complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy	Enrichment	CD55	2.81
50	Blood group, cromer system	Enrichment	CD55	2.81
51	Complement factor h deficiency	Enrichment	CFH	2.81
52	Hemolytic uremic syndrome, atypical 2	Enrichment	CD46	2.81
53	Hemolytic anemia, cd59-mediated, with or without immune-mediated polyneuropathy	Enrichment	CD59	2.81
54	Protein-losing enteropathy	Enrichment	CD55	2.81
55	Genetic hemolytic uremic syndrome	Enrichment	CFH	2.81
56	Immunodeficiency with factor h anomaly	Enrichment	CFH	2.81
57	Lathosterolosis	Enrichment	C5	2.79
58	Complement component 4a deficiency	Enrichment	C4A	2.79
59	Blood group, chido/rodgers system	Enrichment	C4A	2.79
60	Complement component 4b deficiency	Enrichment	C4B	2.79
61	3mc syndrome 3	Enrichment	COLEC10	2.75
62	Systemic lupus erythematosus	Enrichment	C4A, C4B	2.75
63	Amyotrophic lateral sclerosis 10 with or without frontotemporal dementia	Enrichment	MASP2	2.73
64	Immunodeficiency, common variable, 2	Enrichment	CR2	2.51
65	Immunodeficiency, common variable, 7	Enrichment	CR2	2.51
66	Nephrotic syndrome, type 7	Enrichment	CFH	2.51
67	De novo thrombotic microangiopathy after kidney transplantation	Enrichment	CFH	2.51
68	Systemic lupus erythematosus 9	Enrichment	CR2	2.33
69	Familial drusen	Enrichment	CFH	2.33
70	Thrombotic microangiopathy	Enrichment	CD46	2.21
71	Hemolytic uremic syndrome, atypical 1	Enrichment	CFH	2.11
72	C3 glomerulopathy	Enrichment	CFH	2.11
73	Ehlers-danlos syndrome	Enrichment	C1R	2.08
74	Severe covid-19	Enrichment	FCN2	1.97
75	Cystic fibrosis	Enrichment	MBL2	1.73
76	Chronic kidney disease	Enrichment	CFH	1.70
77	Behcet syndrome	Enrichment	C4A	1.52
78	Hereditary retinal dystrophy	Enrichment	CFH	0.44
79	Fundus dystrophy	Enrichment	CFH	0.44

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Initial triggering of complement

Pathway Network for Initial triggering of complement

Pathway network for the Initial triggering of complement SuperPath

Member Pathways for Initial triggering of complement

Pathways in the Initial triggering of complement SuperPath

Gene overlap in member pathways for Initial triggering of complement SuperPath

Associated Genes for Initial triggering of complement

Associated Disorders for Initial triggering of complement

Disorders associated with Initial triggering of complement SuperPath

STRING Interaction Network for Initial triggering of complement

Sources for Initial triggering of complement