Insertion of tail-anchored proteins into the endoplasmic reticulum membrane

No Pathway Network information available for Insertion of tail-anchored proteins into the endoplasmic reticulum membrane

Pathways in the Insertion of tail-anchored proteins into the endoplasmic reticulum membrane SuperPath

#	Name	Source	Genes
1	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Reactome	ALDH3A2 APP BAG6 CAMLG CYB5A EMD GET1 GET3 GET4 HMOX1 OTOF PRNP SEC61B SEC61G SERP1 SGTA STX1A STX5 UBE2J2 UBL4A VAMP2 VAPA (see all 22) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SEC61B	SEC61 Translocon Subunit Beta	Protein Coding	1
2	UBE2J2	Ubiquitin Conjugating Enzyme E2 J2	Protein Coding	1
3	CYB5A	Cytochrome B5 Type A	Protein Coding	1
4	EMD	Emerin	Protein Coding	1
5	ALDH3A2	Aldehyde Dehydrogenase 3 Family Member A2	Protein Coding	1
6	SEC61G	SEC61 Translocon Subunit Gamma	Protein Coding	1
7	SERP1	Stress Associated Endoplasmic Reticulum Protein 1	Protein Coding	1
8	HMOX1	Heme Oxygenase 1	Protein Coding	1
9	APP	Amyloid Beta Precursor Protein	Protein Coding	1
10	GET3	Guided Entry Of Tail-Anchored Proteins Factor 3, ATPase	Protein Coding	1
11	GET4	Guided Entry Of Tail-Anchored Proteins Factor 4	Protein Coding	1
12	PRNP	Prion Protein (Kanno Blood Group)	Protein Coding	1
13	SGTA	Small Glutamine Rich Tetratricopeptide Repeat Co-Chaperone Alpha	Protein Coding	1
14	STX1A	Syntaxin 1A	Protein Coding	1
15	STX5	Syntaxin 5	Protein Coding	1
16	VAMP2	Vesicle Associated Membrane Protein 2	Protein Coding	1
17	GET1	Guided Entry Of Tail-Anchored Proteins Factor 1	Protein Coding	1
18	BAG6	BAG Cochaperone 6	Protein Coding	1
19	CAMLG	Calcium Modulating Ligand	Protein Coding	1
20	UBL4A	Ubiquitin Like 4A	Protein Coding	1
21	VAPA	VAMP Associated Protein A	Protein Coding	1
22	OTOF	Otoferlin	Protein Coding	1

Disorders associated with Insertion of tail-anchored proteins into the endoplasmic reticulum membrane SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Cystic fibrosis	Enrichment	HMOX1, STX1A	2.92
2	Fatal familial insomnia	Enrichment	PRNP	2.79
3	Gerstmann-straussler disease	Enrichment	PRNP	2.79
4	Kuru	Enrichment	PRNP	2.79
5	Cardiomyopathy, dilated, 2h	Enrichment	GET3	2.79
6	Congenital disorder of glycosylation, type iiz	Enrichment	CAMLG	2.79
7	Spongiform encephalopathy with neuropsychiatric features	Enrichment	PRNP	2.79
8	Huntington disease-like 1	Enrichment	PRNP	2.79
9	Arthrogryposis and ectodermal dysplasia	Enrichment	OTOF	2.79
10	Cerebral amyloid angiopathy, app-related	Enrichment	APP	2.79
11	Congenital disorder of glycosylation, type iiaa	Enrichment	STX5	2.79
12	Familial alzheimer-like prion disease	Enrichment	PRNP	2.79
13	Neurodevelopmental disorder with hypotonia and autistic features with or without hyperkinetic movements	Enrichment	VAMP2	2.79
14	Heme oxygenase 1 deficiency	Enrichment	HMOX1	2.79
15	Prion disease	Enrichment	PRNP	2.79
16	Congenital disorder of glycosylation, type iiy	Enrichment	GET4	2.79
17	Prp systemic amyloidosis	Enrichment	PRNP	2.79
18	Inherited human prion disease	Enrichment	PRNP	2.79
19	Inherited creutzfeldt-jakob disease	Enrichment	PRNP	2.79
20	Cerebral amyloid angiopathy, cst3-related	Enrichment	APP	2.49
21	Methemoglobinemia and ambiguous genitalia	Enrichment	CYB5A	2.49
22	Myopathy, x-linked, with postural muscle atrophy	Enrichment	EMD	2.49
23	Creutzfeldt-jakob disease	Enrichment	PRNP	2.49
24	Sjogren-larsson syndrome	Enrichment	ALDH3A2	2.49
25	Hereditary methemoglobinemia	Enrichment	CYB5A	2.49
26	X-linked emery-dreifuss muscular dystrophy	Enrichment	EMD	2.49
27	Adrenal hyperplasia, congenital, due to 17-alpha-hydroxylase deficiency	Enrichment	CYB5A	2.31
28	Deafness, autosomal recessive 3	Enrichment	OTOF	2.31
29	Emery-dreifuss muscular dystrophy 1, x-linked	Enrichment	EMD	2.19
30	Frontotemporal dementia 2	Enrichment	PRNP	2.19
31	Emery-dreifuss muscular dystrophy	Enrichment	EMD	2.19
32	Deafness, autosomal recessive 9	Enrichment	OTOF	2.09
33	Otof-related hearing loss	Enrichment	OTOF	2.09
34	Alzheimer's disease 1	Enrichment	APP	1.95
35	Early-onset autosomal dominant alzheimer disease	Enrichment	APP	1.95
36	Pulmonary disease, chronic obstructive	Enrichment	HMOX1	1.68
37	Alzheimer's disease	Enrichment	APP	1.68
38	Alzheimer disease, familial, 1	Enrichment	APP	1.56
39	Neuromuscular disease	Enrichment	EMD	1.54
40	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	EMD	1.52
41	Williams-beuren syndrome	Enrichment	STX1A	1.50
42	Ear malformation	Enrichment	OTOF	1.42
43	Auditory neuropathy	Enrichment	OTOF	1.38
44	Non-syndromic genetic deafness	Enrichment	OTOF	1.25
45	Cerebral palsy	Enrichment	ALDH3A2	1.21
46	Myopathy	Enrichment	EMD	1.20
47	Nonsyndromic hearing loss	Enrichment	OTOF	1.18
48	Familial isolated dilated cardiomyopathy	Enrichment	GET3	1.08
49	Deafness, autosomal recessive	Enrichment	OTOF	1.01
50	Autosomal recessive nonsyndromic deafness	Enrichment	OTOF	1.00
51	Autism	Enrichment	STX1A	0.96
52	Rare genetic deafness	Enrichment	OTOF	0.92
53	Dilated cardiomyopathy	Enrichment	EMD	0.91
54	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	OTOF	0.87

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Insertion of tail-anchored proteins into the endoplasmic reticulum membrane

Pathway Network for Insertion of tail-anchored proteins into the endoplasmic reticulum membrane

Member Pathways for Insertion of tail-anchored proteins into the endoplasmic reticulum membrane

Pathways in the Insertion of tail-anchored proteins into the endoplasmic reticulum membrane SuperPath

Associated Genes for Insertion of tail-anchored proteins into the endoplasmic reticulum membrane

Associated Disorders for Insertion of tail-anchored proteins into the endoplasmic reticulum membrane

Disorders associated with Insertion of tail-anchored proteins into the endoplasmic reticulum membrane SuperPath

STRING Interaction Network for Insertion of tail-anchored proteins into the endoplasmic reticulum membrane

Sources for Insertion of tail-anchored proteins into the endoplasmic reticulum membrane