Insulin Pathway

No Pathway Network information available for Insulin Pathway

Pathways in the Insulin Pathway SuperPath

#	Name	Source	Genes
1	Insulin Pathway	PubChem	AKT1 AKT2 CAV1 CBL CRK DOK1 EIF4EBP1 EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6 EXOC7 EXOC8 F2RL2 FOXO3 GRB10 GRB14 GRB2 HRAS INS INSR IRS1 NCK1 NCK2 PARD6A PDPK1 PIK3CA PIK3R1 PTPN1 PTPN11 PTPRA RAPGEF1 RASA1 RHOQ RPS6KB1 SCNN1A SGK1 SH2B2 SHC1 SORBS1 SOS1 TRIP10 (see all 44) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	F2RL2	Coagulation Factor II Thrombin Receptor Like 2	Protein Coding	1
2	SORBS1	Sorbin And SH3 Domain Containing 1	Protein Coding	1
3	EIF4EBP1	Eukaryotic Translation Initiation Factor 4E Binding Protein 1	Protein Coding	1
4	DOK1	Docking Protein 1	Protein Coding	1
5	SGK1	Serum/Glucocorticoid Regulated Kinase 1	Protein Coding	1
6	PARD6A	Par-6 Family Cell Polarity Regulator Alpha	Protein Coding	1
7	SH2B2	SH2B Adaptor Protein 2	Protein Coding	1
8	GRB10	Growth Factor Receptor Bound Protein 10	Protein Coding	1
9	RAPGEF1	Rap Guanine Nucleotide Exchange Factor 1	Protein Coding	1
10	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
11	GRB14	Growth Factor Receptor Bound Protein 14	Protein Coding	1
12	CAV1	Caveolin 1	Protein Coding	1
13	PTPN1	Protein Tyrosine Phosphatase Non-Receptor Type 1	Protein Coding	1
14	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
15	FOXO3	Forkhead Box O3	Protein Coding	1
16	RASA1	RAS P21 Protein Activator 1	Protein Coding	1
17	NCK2	NCK Adaptor Protein 2	Protein Coding	1
18	NCK1	NCK Adaptor Protein 1	Protein Coding	1
19	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
20	PTPRA	Protein Tyrosine Phosphatase Receptor Type A	Protein Coding	1
21	EXOC2	Exocyst Complex Component 2	Protein Coding	1
22	EXOC4	Exocyst Complex Component 4	Protein Coding	1
23	EXOC5	Exocyst Complex Component 5	Protein Coding	1
24	EXOC7	Exocyst Complex Component 7	Protein Coding	1
25	EXOC1	Exocyst Complex Component 1	Protein Coding	1
26	EXOC6	Exocyst Complex Component 6	Protein Coding	1
27	EXOC8	Exocyst Complex Component 8	Protein Coding	1
28	EXOC3	Exocyst Complex Component 3	Protein Coding	1
29	RHOQ	Ras Homolog Family Member Q	Protein Coding	1
30	TRIP10	Thyroid Hormone Receptor Interactor 10	Protein Coding	1
31	CBL	Cbl Proto-Oncogene	Protein Coding	1
32	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
33	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	1
34	SCNN1A	Sodium Channel Epithelial 1 Subunit Alpha	Protein Coding	1
35	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	1
36	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
37	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
38	INS	Insulin	Protein Coding	1
39	IRS1	Insulin Receptor Substrate 1	Protein Coding	1
40	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
41	INSR	Insulin Receptor	Protein Coding	1
42	SHC1	SHC Adaptor Protein 1	Protein Coding	1
43	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
44	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1

Disorders associated with Insulin Pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome and noonan-related syndrome	Enrichment	CBL, HRAS, PTPN11, SOS1	6.89
2	Noonan syndrome 1	Enrichment	CBL, HRAS, PTPN11, SOS1	6.09
3	Noonan syndrome 3	Enrichment	HRAS, PTPN11, SOS1	5.96
4	Rasopathy	Enrichment	CBL, HRAS, PTPN11, SOS1	5.86
5	Arteriovenous malformation	Enrichment	HRAS, PIK3CA, RASA1	5.58
6	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, PIK3CA, RASA1	5.42
7	Type 2 diabetes mellitus	Enrichment	AKT2, INSR, IRS1, PTPN1	5.01
8	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.51
9	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL, PTPN11	4.21
10	Capillary malformations, congenital	Enrichment	PIK3CA, RASA1	3.99
11	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA, RASA1	3.82
12	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	3.82
13	Nevus, epidermal	Enrichment	HRAS, PIK3CA	3.67
14	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA, RASA1	3.67
15	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.44
16	Lung non-small cell carcinoma	Enrichment	HRAS, PIK3CA	3.26
17	Juvenile myelomonocytic leukemia	Enrichment	CBL, PTPN11	3.18
18	Meningioma	Enrichment	AKT1, PIK3CA	3.18
19	Lip and oral cavity carcinoma	Enrichment	HRAS, PIK3CA	3.18
20	Rhabdomyosarcoma	Enrichment	CBL, HRAS	2.92
21	Breast cancer	Enrichment	AKT1, PIK3CA, SHC1	2.74
22	Colorectal cancer	Enrichment	AKT1, PIK3CA, PIK3R1	2.55
23	Hydrops fetalis, nonimmune	Enrichment	HRAS, PTPN11	2.50
24	Macrodactyly	Enrichment	PIK3CA	2.49
25	Proteus syndrome	Enrichment	AKT1	2.49
26	Metachondromatosis	Enrichment	PTPN11	2.49
27	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	2.49
28	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.49
29	Donohue syndrome	Enrichment	INSR	2.49
30	Hyperinsulinemic hypoglycemia, familial, 5	Enrichment	INSR	2.49
31	Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities	Enrichment	INSR	2.49
32	Diabetes mellitus, insulin-resistant, with acanthosis nigricans	Enrichment	INSR	2.49
33	Noonan syndrome 4	Enrichment	SOS1	2.49
34	Lipodystrophy, congenital generalized, type 3	Enrichment	CAV1	2.49
35	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.49
36	Bronchiectasis with or without elevated sweat chloride 2	Enrichment	SCNN1A	2.49
37	Leopard syndrome 1	Enrichment	PTPN11	2.49
38	Cowden syndrome 5	Enrichment	PIK3CA	2.49
39	Pulmonary hypertension, primary, 3	Enrichment	CAV1	2.49
40	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.49
41	Short syndrome	Enrichment	PIK3R1	2.49
42	Liddle syndrome 3	Enrichment	SCNN1A	2.49
43	Lipodystrophy, familial partial, type 7	Enrichment	CAV1	2.49
44	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.49
45	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.49
46	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.49
47	Cowden syndrome 6	Enrichment	AKT1	2.49
48	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.49
49	Neurodevelopmental disorder with seizures and brain atrophy	Enrichment	EXOC7	2.49
50	Neurodevelopmental disorder with microcephaly, seizures, and brain atrophy	Enrichment	EXOC8	2.49
51	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.49
52	Hypospadias	Enrichment	PIK3CA	2.49
53	Rare venous malformation	Enrichment	PIK3CA	2.49
54	Gorham's disease	Enrichment	RASA1	2.49
55	Diaphragmatic eventration	Enrichment	PIK3CA	2.49
56	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.49
57	Rare combined vascular malformation	Enrichment	PIK3CA	2.49
58	Cavernous lymphangioma	Enrichment	PIK3CA	2.49
59	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.49
60	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.49
61	Silver-russell syndrome due to maternal uniparental disomy of chromosome 7	Enrichment	GRB10	2.49
62	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.49
63	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.49
64	Macrodactyly of toe	Enrichment	PIK3CA	2.49
65	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.49
66	Malignant astrocytoma	Enrichment	PTPN11	2.49
67	Bladder cancer	Enrichment	HRAS, PIK3CA	2.40
68	Non-immune hydrops fetalis	Enrichment	HRAS, PTPN11	2.35
69	Fibromatosis, gingival, 1	Enrichment	SOS1	2.19
70	Costello syndrome	Enrichment	HRAS	2.19
71	Ovarian germ cell cancer	Enrichment	CBL	2.19
72	Pulmonic stenosis	Enrichment	SOS1	2.19
73	Hyperinsulinemic hypoglycemia, familial, 4	Enrichment	INSR	2.19
74	Keratosis, seborrheic	Enrichment	PIK3CA	2.19
75	Maturity-onset diabetes of the young, type 10	Enrichment	INS	2.19
76	Noonan syndrome 8	Enrichment	PIK3CA	2.19
77	Myopia 28, autosomal recessive	Enrichment	DOK1	2.19
78	Hyperproinsulinemia	Enrichment	INS	2.19
79	Dystonia 30	Enrichment	PTPRA	2.19
80	Werner syndrome	Enrichment	PTPN11	2.19
81	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.19
82	Diabetes mellitus, permanent neonatal, 4	Enrichment	INS	2.19
83	Neurodevelopmental disorder with dysmorphic facies and cerebellar hypoplasia	Enrichment	EXOC2	2.19
84	Malignant germ cell tumor of ovary	Enrichment	CBL	2.19
85	Pseudohypoaldosteronism	Enrichment	SCNN1A	2.19
86	Wooly hair nevus	Enrichment	HRAS	2.19
87	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA	2.05
88	Type 1 diabetes mellitus 2	Enrichment	INS	2.01
89	Liddle syndrome 1	Enrichment	SCNN1A	2.01
90	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.01
91	Nuchal bleb, familial	Enrichment	SOS1	2.01
92	Pseudohypoaldosteronism, type ib1, autosomal recessive	Enrichment	SCNN1A	2.01
93	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.01
94	Large congenital melanocytic nevus	Enrichment	HRAS	2.01
95	Wieacker-wolff syndrome	Enrichment	RASA1	2.01
96	Immunodeficiency 14	Enrichment	PIK3R1	2.01
97	Spermatocytoma	Enrichment	HRAS	2.01
98	Tricuspid valve insufficiency	Enrichment	PTPN11	2.01
99	Keratoacanthoma	Enrichment	PIK3CA	2.01
100	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	1.89
101	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	1.89
102	Neonatal diabetes mellitus	Enrichment	INS	1.89
103	Cerebrovascular disease	Enrichment	PIK3CA	1.89
104	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	1.89
105	Epidermolytic nevus	Enrichment	HRAS	1.89
106	Idiopathic bronchiectasis	Enrichment	SCNN1A	1.89
107	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.89
108	Gingival fibromatosis	Enrichment	SOS1	1.89
109	Lymphoma	Enrichment	PTPN11	1.79
110	Myeloproliferative neoplasm	Enrichment	CBL	1.79
111	Hemimegalencephaly	Enrichment	PIK3CA	1.79
112	Aggressive systemic mastocytosis	Enrichment	CBL	1.79
113	Diffuse cutaneous systemic sclerosis	Enrichment	CAV1	1.79
114	Cowden syndrome 1	Enrichment	PIK3CA	1.71
115	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	1.71
116	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.71
117	Type 1 diabetes mellitus	Enrichment	INS	1.71
118	Hemangioma, capillary infantile	Enrichment	RASA1	1.71
119	Basal cell carcinoma 1	Enrichment	RASA1	1.71
120	Patent ductus arteriosus	Enrichment	PTPN11	1.71
121	Limited scleroderma	Enrichment	CAV1	1.71
122	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.71
123	46,xy disorder of sex development	Enrichment	INSR	1.71
124	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	1.65
125	Gallbladder cancer	Enrichment	PIK3CA	1.65
126	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	1.65
127	Follicular thyroid carcinoma	Enrichment	HRAS	1.65
128	Overgrowth syndrome	Enrichment	PIK3R1	1.65
129	Melanocytic nevus syndrome, congenital	Enrichment	HRAS	1.59
130	Permanent neonatal diabetes mellitus	Enrichment	INS	1.59
131	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.54
132	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.50
133	Pectus excavatum	Enrichment	PTPN11	1.45
134	Diabetes mellitus	Enrichment	INS	1.45
135	Heritable pulmonary arterial hypertension	Enrichment	CAV1	1.45
136	Specific learning disability	Enrichment	PTPN11	1.45
137	Epicanthus	Enrichment	PTPN11	1.42
138	Congenital long qt syndrome	Enrichment	PTPN11	1.42
139	Aortic valve disease 1	Enrichment	SOS1	1.38
140	Ovarian cancer	Enrichment	AKT1, PIK3CA	1.37
141	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.35
142	Lynch syndrome	Enrichment	PIK3CA	1.32
143	Patent foramen ovale	Enrichment	PTPN11	1.25
144	Maturity-onset diabetes of the young	Enrichment	INS	1.20
145	Endometrial cancer	Enrichment	PIK3CA	1.18
146	Hepatocellular carcinoma	Enrichment	PIK3CA	1.16
147	Scoliosis	Enrichment	PTPN11	1.12
148	Brugada syndrome	Enrichment	SCNN1A	1.09
149	Strabismus	Enrichment	PTPN11	1.08
150	Prostate cancer	Enrichment	PIK3CA	1.05
151	Meckel syndrome, type 1	Enrichment	EXOC4	1.05
152	Differentiated thyroid carcinoma	Enrichment	HRAS	1.05
153	Long qt syndrome 1	Enrichment	PTPN11	1.03
154	Lung cancer	Enrichment	PIK3CA	1.01
155	Gastric cancer	Enrichment	PIK3CA	0.88
156	Hypertrophic cardiomyopathy	Enrichment	PTPN11	0.88
157	Thrombocytopenia	Enrichment	PTPN11	0.84
158	Hypertelorism	Enrichment	PIK3CA	0.81
159	Myeloma, multiple	Enrichment	SGK1	0.78
160	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.78
161	Autism spectrum disorder	Enrichment	PTPN11	0.52
162	Microcephaly	Enrichment	PTPN11	0.48
163	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	0.46

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Insulin Pathway

Pathway Network for Insulin Pathway

Member Pathways for Insulin Pathway

Pathways in the Insulin Pathway SuperPath

Associated Genes for Insulin Pathway

Associated Disorders for Insulin Pathway

Disorders associated with Insulin Pathway SuperPath

STRING Interaction Network for Insulin Pathway

Sources for Insulin Pathway