Insulin receptor recycling

Pathway network for the Insulin receptor recycling SuperPath

Sources:
  • Reactome
  • PubChem

Pathways in the Insulin receptor recycling SuperPath

#NameSourceGenes
1Insulin receptor recyclingReactome
2Iron uptake and transportReactome
3ROS and RNS production in phagocytesReactome
4Transferrin endocytosis and recyclingReactome
5ATP biosynthesisPubChem
6Events associated with phagocytolytic activity of PMN cellsReactome
7melatonin degradation IIIPubChem

Gene overlap in member pathways for Insulin receptor recycling SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

Disorders associated with Insulin receptor recycling SuperPath

according to GeneCards Suite gene sharing
#DisorderTypeGenesScore
1Chronic granulomatous diseaseEnrichmentCYBA, CYBB, NCF1, NCF2, NCF410.49
2Autosomal recessive cutis laxa type ii classic typeEnrichmentATP6V0A2, ATP6V1A, ATP6V1E18.01
3Myeloperoxidase deficiencyEnrichmentLPO, MPO7.19
4Renal tubular acidosis, distal, 1EnrichmentATP6V0A4, ATP6V1B1, ATP6V1C26.71
5Distal renal tubular acidosisEnrichmentATP6V0A4, ATP6V1B1, ATP6V1C26.71
6Alzheimer's disease 1EnrichmentLPO, MPO6.64
7Alzheimer disease, familial, 1EnrichmentLPO, MPO5.83
8Deafness, onychodystrophy, osteodystrophy, impaired intellectual development, and seizures syndromeEnrichmentATP6V1B2, ATP6V1C15.59
9Renal tubular acidosis, distal, 3, with or without sensorineural hearing lossEnrichmentATP6V0A4, ATP6V1B14.85
10Granulomatous disease, chronic, autosomal recessive, 2EnrichmentNCF1, NCF24.69
11Digenic hemochromatosisEnrichmentHFE, TFR24.52
12Granulomatous disease, chronic, x-linkedEnrichmentCYBB, NCF14.39
13Autosomal recessive distal renal tubular acidosisEnrichmentATP6V0A4, ATP6V1B14.15
14Hemochromatosis, type 1EnrichmentHFE, TFR23.85
15Cutis laxaEnrichmentATP6V0A2, ATP6V1E13.51
16Deafness, congenital, with onychodystrophy, autosomal dominantEnrichmentATP6V1B23.02
17Cutis laxa, autosomal recessive, type iidEnrichmentATP6V1A3.02
18Zimmermann-laband syndrome 2EnrichmentATP6V1B23.02
19Cutis laxa, autosomal recessive, type iicEnrichmentATP6V1E13.02
20Developmental and epileptic encephalopathy 104EnrichmentATP6V0A13.02
21Neurodevelopmental disorder with epilepsy and brain atrophyEnrichmentATP6V0A13.02
22Epilepsy, early-onset, 3, with or without developmental delayEnrichmentATP6V0C3.02
23Autosomal dominant deafness - onychodystrophy syndromeEnrichmentATP6V1B23.02
24Alzheimer's diseaseEnrichmentMPO3.02
25Developmental and epileptic encephalopathy 93EnrichmentATP6V1A2.72
26Childhood-onset epilepsy syndromeEnrichmentATP6V0C2.72
27Donohue syndromeEnrichmentINSR2.66
28Hyperinsulinemic hypoglycemia, familial, 5EnrichmentINSR2.66
29Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalitiesEnrichmentINSR2.66
30Diabetes mellitus, insulin-resistant, with acanthosis nigricansEnrichmentINSR2.66
31Breasts and/or nipples, aplasia or hypoplasia of, 1EnrichmentPTPRF2.66
32Ceroid lipofuscinosis, neuronal, 10EnrichmentCTSD2.66
33Breasts and/or nipples, aplasia or hypoplasia of, 2EnrichmentPTPRF2.66
34AtransferrinemiaEnrichmentTF2.64
35Immunodeficiency 46EnrichmentTFRC2.64
36Pyloric stenosis, infantile hypertrophic, 1EnrichmentNOS12.58
37Granulomatous disease, chronic, autosomal recessive, 4EnrichmentCYBA2.58
38Buruli ulcerEnrichmentSLC11A12.58
39Immunodeficiency 34EnrichmentCYBB2.58
40Immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosisEnrichmentRAC22.58
41Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemiaEnrichmentRAC22.58
42Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopeniaEnrichmentRAC22.58
43Infantile lad-like disease due to rac2 deficiencyEnrichmentRAC22.58
44Reticular dysgenesis-like severe combined immunodeficiencyEnrichmentRAC22.58
45Rac2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndromeEnrichmentRAC22.58
46Zimmermann-laband syndrome 1EnrichmentATP6V1B22.54
47Type 2 diabetes mellitusEnrichmentINSR, PTPN12.41
48Retinopathy-sensory neuropathy syndromeEnrichmentFLVCR12.37
49AceruloplasminemiaEnrichmentCP2.37
50Neurodegeneration with brain iron accumulation 3EnrichmentFTL2.37
51Uric acid concentration, serum, quantitative trait locus 1EnrichmentABCG22.37
52Anemia, hypochromic microcytic, with iron overload 1EnrichmentSLC11A22.37
53Hereditary sensory neuropathyEnrichmentFLVCR12.37
54Hemochromatosis, type 4EnrichmentSLC40A12.37
55L-ferritin deficiencyEnrichmentFTL2.37
56Neurodevelopmental disorder with microcephaly, absent speech, and hypotoniaEnrichmentFLVCR12.37
57Blood group, junior systemEnrichmentABCG22.37
58Heme oxygenase 1 deficiencyEnrichmentHMOX12.37
59Neurodegeneration, early-onset, with choreoathetoid movements and microcytic anemiaEnrichmentIREB22.37
60Genetic hyperferritinemia without iron overloadEnrichmentFTL2.37
61Renal tubular acidosis, distal, 2, with progressive sensorineural hearing lossEnrichmentATP6V1B12.35
62Hyperinsulinemic hypoglycemia, familial, 4EnrichmentINSR2.35
63Maturity-onset diabetes of the young, type 10EnrichmentINS2.35
64Wrinkly skin syndromeEnrichmentATP6V0A22.35
65HyperproinsulinemiaEnrichmentINS2.35
66Osteopetrosis, autosomal recessive 1EnrichmentTCIRG12.35
67Renal tubular acidosisEnrichmentATP6V1B12.35
68Diabetes mellitus, permanent neonatal, 4EnrichmentINS2.35
69Porphyria cutanea tarda, type iEnrichmentHFE2.34
70Anemia, hypochromic microcytic, with iron overload 2EnrichmentSTEAP32.34
71Mucolipidosis ivEnrichmentMCOLN12.34
72Corneal dystrophy, lisch epithelialEnrichmentMCOLN12.34
73Hemochromatosis type 2EnrichmentHFE2.34
74Granulomatous disease, chronic, autosomal recessive, 1EnrichmentNCF12.28
75Granulomatous disease, chronic, autosomal recessive, 3EnrichmentNCF42.28
76Type 1 diabetes mellitus 2EnrichmentINS2.18
77ChoreoacanthocytosisEnrichmentTCIRG12.18
78Cutis laxa, autosomal recessive, type iiaEnrichmentATP6V0A22.18
79Neutropenia, severe congenital, 1, autosomal dominantEnrichmentTCIRG12.18
80DysosteosclerosisEnrichmentTCIRG12.18
81Osteopetrosis, autosomal recessive 6EnrichmentTCIRG12.18
82Atp6v0a2-related cutis laxaEnrichmentATP6V0A22.18
83Hemochromatosis, type 3EnrichmentTFR22.16
84Microvascular complications of diabetes 7EnrichmentHFE2.16
85Transferrin serum level quantitative trait locus 2EnrichmentHFE2.16
86MucolipidosisEnrichmentMCOLN12.16
87Periventricular leukomalaciaEnrichmentMCOLN12.16
88Familial porphyria cutanea tardaEnrichmentHFE2.16
89Autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasiaEnrichmentCYBA2.10
90Autoimmune polyendocrine syndrome type 1EnrichmentCYBA2.10
91Cystic fibrosisEnrichmentHFE, HMOX12.09
92VitreoretinochoroidopathyEnrichmentFTH12.07
93Retinitis pigmentosa 50EnrichmentFTH12.07
94Hermansky-pudlak syndrome 3EnrichmentCP2.07
95Hyperferritinemia with or without cataractEnrichmentFTL2.07
96Hemochromatosis, type 5EnrichmentFTH12.07
97Neurodegeneration with brain iron accumulation 9EnrichmentFTH12.07
98Submucosal cleft palateEnrichmentUBB2.07
99Cleft hard palateEnrichmentUBB2.07
100Neonatal diabetes mellitusEnrichmentINS2.05
101Autosomal recessive osteopetrosisEnrichmentTCIRG12.05
102Porphyria cutanea tardaEnrichmentHFE2.04
103TuberculosisEnrichmentSLC11A11.98
104Idiopathic achalasiaEnrichmentNOS11.98
105Congenital disorder of glycosylation, type ilEnrichmentATP6V0A21.96
106OsteopetrosisEnrichmentTCIRG11.96
107Alg9-congenital disorder of glycosylationEnrichmentATP6V0A21.96
108Autosomal dominant severe congenital neutropeniaEnrichmentTCIRG11.96
109Variegate porphyriaEnrichmentHFE1.94
110Uvula, bifidEnrichmentUBB1.89
111Cleft soft palateEnrichmentUBB1.89
112Folate malabsorption, hereditaryEnrichmentSLC46A11.89
113Type 1 diabetes mellitusEnrichmentINS1.88
11446,xy disorder of sex developmentEnrichmentINSR1.88
115Alzheimer disease 2EnrichmentNOS31.88
116Pre-eclampsiaEnrichmentNOS31.88
117Pain disorderEnrichmentHFE1.87
118Bestrophinopathy, autosomal recessiveEnrichmentFTH11.77
119Immunodeficiency 47EnrichmentATP6AP11.76
120Severe congenital neutropeniaEnrichmentTCIRG11.76
121Permanent neonatal diabetes mellitusEnrichmentINS1.76
122Macular dystrophy, vitelliform, 2EnrichmentFTH11.67
123NephrocalcinosisEnrichmentATP6V1B11.66
124NephrolithiasisEnrichmentATP6V1B11.66
125Cardiomyopathy, familial hypertrophic, 4EnrichmentNCF11.63
126Diabetes mellitusEnrichmentINS1.62
127Congenital nervous system abnormalityEnrichmentHFE, MCOLN11.61
128Nervous system diseaseEnrichmentHFE, MCOLN11.61
129RasopathyEnrichmentATP6V1E11.61
130Combined immunodeficiencyEnrichmentTFRC1.60
131Combined t cell and b cell immunodeficiencyEnrichmentTFRC1.60
132Combined t and b cell immunodeficiencyEnrichmentTFRC1.60
133Stroke, ischemicEnrichmentNOS31.58
134Polydactyly, postaxial, type a1EnrichmentATP6V1B11.49
135Neuronal ceroid lipofuscinosisEnrichmentCTSD1.49
136Neurodegeneration with brain iron accumulationEnrichmentCP1.38
137Maturity-onset diabetes of the youngEnrichmentINS1.36
138Hypertension, essentialEnrichmentNOS31.35
139Williams-beuren syndromeEnrichmentNCF11.29
140Undetermined early-onset epileptic encephalopathyEnrichmentATP6V1A1.28
141Pulmonary disease, chronic obstructiveEnrichmentHMOX11.27
142MalariaEnrichmentNOS21.23
143Hermansky-pudlak syndromeEnrichmentCP1.21
144Hermansky-pudlak syndrome 1EnrichmentCP1.18
145AutismEnrichmentATP6V0A11.17
146Peripheral nervous system diseaseEnrichmentHFE1.15
147NeuropathyEnrichmentHFE1.15
148Non-syndromic x-linked intellectual disabilityEnrichmentATP6AP11.12
149Sensorineural hearing lossEnrichmentATP6V0A41.00
150Jeune thoracic dystrophyEnrichmentFLVCR10.99
151MicrocephalyEnrichmentATP6V0A10.95
152Complex neurodevelopmental disorderEnrichmentATP6V0A10.95
153Asphyxiating thoracic dystrophyEnrichmentFLVCR10.95
154Stargardt disease 1EnrichmentFLVCR10.92
155Short-rib thoracic dysplasia 1 with or without polydactylyEnrichmentFLVCR10.88
156Primary ovarian insufficiencyEnrichmentNOS30.84
157Rare genetic deafnessEnrichmentATP6V1B10.79
158Inherited cancer-predisposing syndromeEnrichmentHFE0.58
159Hereditary retinal dystrophyEnrichmentFLVCR1, FTH10.45
160Fundus dystrophyEnrichmentFLVCR1, FTH10.45
161Retinitis pigmentosaEnrichmentFLVCR10.22

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