Insulin receptor signalling cascade

Pathway network for the Insulin receptor signalling cascade SuperPath

Sources:

Reactome
WikiPathways

Pathways in the Insulin receptor signalling cascade SuperPath

#	Name	Source	Genes
1	Insulin receptor signalling cascade	Reactome	AKT2 FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FLT3 FLT3LG FRS2 GAB1 GAB2 GRB10 GRB2 HRAS INS INSR IRS1 IRS2 KL KLB KRAS MAPK1 MAPK3 NRAS PDE3B PDPK1 PIK3C3 PIK3CA PIK3CB PIK3R1 PIK3R2 PIK3R4 PTPN11 SHC1 SOS1 THEM4 TLR9 TRIB3 (see all 54) (see less)
2	Signaling by Insulin receptor	Reactome	AKT2 ATP6AP1 ATP6V0A1 ATP6V0A2 ATP6V0A4 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E1 ATP6V0E2 ATP6V1A ATP6V1B1 ATP6V1B2 ATP6V1C1 ATP6V1C2 ATP6V1D ATP6V1E1 ATP6V1E2 ATP6V1F ATP6V1G1 ATP6V1G2 ATP6V1G3 ATP6V1H CTSD FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FLT3 FLT3LG FRS2 GAB1 GAB2 GRB10 GRB2 HRAS IDE INS INSR IRS1 IRS2 KL KLB KRAS MAPK1 MAPK3 NRAS PDE3B PDPK1 PIK3C3 PIK3CA PIK3CB PIK3R1 PIK3R2 PIK3R4 PTPN1 PTPN11 PTPRF SHC1 SOS1 TCIRG1 THEM4 TLR9 TRIB3 (see all 82) (see less)
3	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	Reactome	AKT2 CILP FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FLT3 FLT3LG FRS2 GAB1 GAB2 GRB2 HRAS IGF1 IGF1R IGF2 IRS1 IRS2 IRS4 KL KLB KRAS NRAS PDE3B PDPK1 PIK3C3 PIK3CA PIK3CB PIK3R1 PIK3R2 PIK3R4 PTPN11 SHC1 SOS1 THEM4 TLR9 TRIB3 (see all 54) (see less)
4	IGF1R signaling cascade	Reactome	AKT2 FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FLT3 FLT3LG FRS2 GAB1 GAB2 GRB2 HRAS IGF1 IGF1R IGF2 IRS1 IRS2 IRS4 KL KLB KRAS NRAS PDE3B PDPK1 PIK3C3 PIK3CA PIK3CB PIK3R1 PIK3R2 PIK3R4 PTPN11 SHC1 SOS1 THEM4 TLR9 TRIB3 (see all 53) (see less)
5	IRS-related events triggered by IGF1R	Reactome	AKT2 FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FLT3 FLT3LG FRS2 GAB1 GAB2 GRB2 HRAS IGF1 IGF1R IGF2 IRS1 IRS2 IRS4 KL KLB KRAS NRAS PDE3B PDPK1 PIK3C3 PIK3CA PIK3CB PIK3R1 PIK3R2 PIK3R4 PTPN11 SOS1 THEM4 TLR9 TRIB3 (see all 52) (see less)
6	IRS-mediated signalling	Reactome	AKT2 FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FLT3 FLT3LG FRS2 GAB1 GAB2 GRB2 HRAS IRS1 IRS2 KL KLB KRAS NRAS PDE3B PDPK1 PIK3C3 PIK3CA PIK3CB PIK3R1 PIK3R2 PIK3R4 PTPN11 SOS1 THEM4 TLR9 TRIB3 (see all 48) (see less)
7	PI3K Cascade	Reactome	AKT2 FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FLT3 FLT3LG FRS2 GAB1 GAB2 GRB2 IRS1 IRS2 KL KLB PDE3B PDPK1 PIK3C3 PIK3CA PIK3CB PIK3R1 PIK3R2 PIK3R4 PTPN11 THEM4 TLR9 TRIB3 (see all 44) (see less)
8	Signal attenuation	Reactome	GRB10 GRB2 INS INSR IRS1 IRS2 MAPK1 MAPK3 SHC1 SOS1 (see all 10) (see less)
9	SHC-related events triggered by IGF1R	Reactome	GRB2 HRAS IGF1 IGF1R IGF2 KRAS NRAS SHC1 SOS1 (see all 9) (see less)
10	SOS-mediated signalling	Reactome	GRB2 HRAS IRS1 IRS2 KRAS NRAS SOS1 (see all 7) (see less)
11	IRS activation	Reactome	GRB10 INS INSR IRS1 IRS2
12	Glucose homeostasis	WikiPathways	INS

Gene overlap in member pathways for Insulin receptor signalling cascade SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	10
2	IRS1	Insulin Receptor Substrate 1	Protein Coding	10
3	IRS2	Insulin Receptor Substrate 2	Protein Coding	10
4	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	9
5	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	8
6	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	8
7	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	8
8	FRS2	Fibroblast Growth Factor Receptor Substrate 2	Protein Coding	7
9	THEM4	Thioesterase Superfamily Member 4	Protein Coding	7
10	KLB	Klotho Beta	Protein Coding	7
11	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	7
12	FGF1	Fibroblast Growth Factor 1	Protein Coding	7
13	FGF2	Fibroblast Growth Factor 2	Protein Coding	7
14	FGF3	Fibroblast Growth Factor 3	Protein Coding	7
15	FGF4	Fibroblast Growth Factor 4	Protein Coding	7
16	FGF5	Fibroblast Growth Factor 5	Protein Coding	7
17	FGF6	Fibroblast Growth Factor 6	Protein Coding	7
18	FGF7	Fibroblast Growth Factor 7	Protein Coding	7
19	FGF8	Fibroblast Growth Factor 8	Protein Coding	7
20	FGF9	Fibroblast Growth Factor 9	Protein Coding	7
21	FGF10	Fibroblast Growth Factor 10	Protein Coding	7
22	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	7
23	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	7
24	FGFR2	Fibroblast Growth Factor Receptor 2	Protein Coding	7
25	FGFR4	Fibroblast Growth Factor Receptor 4	Protein Coding	7
26	FLT3	Fms Related Receptor Tyrosine Kinase 3	Protein Coding	7
27	FLT3LG	Fms Related Receptor Tyrosine Kinase 3 Ligand	Protein Coding	7
28	GAB1	GRB2 Associated Binding Protein 1	Protein Coding	7
29	FGF20	Fibroblast Growth Factor 20	Protein Coding	7
30	FGF22	Fibroblast Growth Factor 22	Protein Coding	7
31	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	7
32	PDE3B	Phosphodiesterase 3B	Protein Coding	7
33	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	7
34	PIK3C3	Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3	Protein Coding	7
35	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	7
36	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	7
37	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	7
38	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	7
39	TLR9	Toll Like Receptor 9	Protein Coding	7
40	TRIB3	Tribbles Pseudokinase 3	Protein Coding	7
41	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	7
42	FGF23	Fibroblast Growth Factor 23	Protein Coding	7
43	FGF18	Fibroblast Growth Factor 18	Protein Coding	7
44	FGF17	Fibroblast Growth Factor 17	Protein Coding	7
45	FGF16	Fibroblast Growth Factor 16	Protein Coding	7
46	KL	Klotho	Protein Coding	7
47	GAB2	GRB2 Associated Binding Protein 2	Protein Coding	7
48	FGF19	Fibroblast Growth Factor 19	Protein Coding	7
49	SHC1	SHC Adaptor Protein 1	Protein Coding	6
50	INS	Insulin	Protein Coding	5
51	GRB10	Growth Factor Receptor Bound Protein 10	Protein Coding	4
52	INSR	Insulin Receptor	Protein Coding	4
53	IGF1	Insulin Like Growth Factor 1	Protein Coding	4
54	IGF1R	Insulin Like Growth Factor 1 Receptor	Protein Coding	4
55	IGF2	Insulin Like Growth Factor 2	Protein Coding	4
56	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	3
57	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	3
58	IRS4	Insulin Receptor Substrate 4	Protein Coding	3
59	TCIRG1	T Cell Immune Regulator 1, ATPase H+ Transporting V0 Subunit A3	Protein Coding	1
60	ATP6V1G3	ATPase H+ Transporting V1 Subunit G3	Protein Coding	1
61	CTSD	Cathepsin D	Protein Coding	1
62	ATP6V0E2	ATPase H+ Transporting V0 Subunit E2	Protein Coding	1
63	ATP6V0A2	ATPase H+ Transporting V0 Subunit A2	Protein Coding	1
64	ATP6V0D2	ATPase H+ Transporting V0 Subunit D2	Protein Coding	1
65	ATP6V1C2	ATPase H+ Transporting V1 Subunit C2	Protein Coding	1
66	IDE	Insulin Degrading Enzyme	Protein Coding	1
67	ATP6V0A4	ATPase H+ Transporting V0 Subunit A4	Protein Coding	1
68	ATP6V1D	ATPase H+ Transporting V1 Subunit D	Protein Coding	1
69	ATP6V1H	ATPase H+ Transporting V1 Subunit H	Protein Coding	1
70	ATP6V1A	ATPase H+ Transporting V1 Subunit A	Protein Coding	1
71	ATP6V1B1	ATPase H+ Transporting V1 Subunit B1	Protein Coding	1
72	ATP6V1B2	ATPase H+ Transporting V1 Subunit B2	Protein Coding	1
73	ATP6V0C	ATPase H+ Transporting V0 Subunit C	Protein Coding	1
74	ATP6V1C1	ATPase H+ Transporting V1 Subunit C1	Protein Coding	1
75	ATP6V1E1	ATPase H+ Transporting V1 Subunit E1	Protein Coding	1
76	ATP6V0B	ATPase H+ Transporting V0 Subunit B	Protein Coding	1
77	ATP6V1G2	ATPase H+ Transporting V1 Subunit G2	Protein Coding	1
78	ATP6V0A1	ATPase H+ Transporting V0 Subunit A1	Protein Coding	1
79	ATP6AP1	ATPase H+ Transporting Accessory Protein 1	Protein Coding	1
80	PTPN1	Protein Tyrosine Phosphatase Non-Receptor Type 1	Protein Coding	1
81	PTPRF	Protein Tyrosine Phosphatase Receptor Type F	Protein Coding	1
82	ATP6V0E1	ATPase H+ Transporting V0 Subunit E1	Protein Coding	1
83	ATP6V1E2	ATPase H+ Transporting V1 Subunit E2	Protein Coding	1
84	ATP6V0D1	ATPase H+ Transporting V0 Subunit D1	Protein Coding	1
85	ATP6V1F	ATPase H+ Transporting V1 Subunit F	Protein Coding	1
86	ATP6V1G1	ATPase H+ Transporting V1 Subunit G1	Protein Coding	1
87	CILP	Cartilage Intermediate Layer Protein	Protein Coding	1

Disorders associated with Insulin receptor signalling cascade SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Nevus, epidermal	Enrichment	FGFR3, HRAS, KRAS, NRAS, PIK3CA	10.57
2	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, NRAS, SOS1	10.29
3	Noonan syndrome 1	Enrichment	HRAS, KRAS, NRAS, SOS1	9.60
4	Rasopathy	Enrichment	HRAS, KRAS, NRAS, SOS1	9.43
5	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	9.43
6	Noonan syndrome 3	Enrichment	HRAS, KRAS, SOS1	8.53
7	Lung non-small cell carcinoma	Enrichment	HRAS, KRAS, NRAS	7.86
8	Lacrimoauriculodentodigital syndrome 1	Enrichment	FGF10, FGFR2, FGFR3	7.50
9	Autosomal recessive cutis laxa type ii classic type	Enrichment	ATP6V0A2, ATP6V1A, ATP6V1E1	6.67
10	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	6.64
11	Type 2 diabetes mellitus	Enrichment	INSR, IRS1, IRS2	6.56
12	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	6.51
13	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	6.16
14	Lung squamous cell carcinoma	Enrichment	FGFR3, KRAS, PIK3CA	6.08
15	Colorectal cancer	Enrichment	FGFR2, FGFR3, IGF2, NRAS, PIK3CA, PIK3R1	6.03
16	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	5.86
17	Bladder cancer	Enrichment	FGFR3, HRAS, KRAS, PIK3CA	5.51
18	Insulin-like growth factor i	Enrichment	IGF1, IGF1R	5.41
19	Renal tubular acidosis, distal, 1	Enrichment	ATP6V0A4, ATP6V1B1, ATP6V1C2	5.38
20	Distal renal tubular acidosis	Enrichment	ATP6V0A4, ATP6V1B1, ATP6V1C2	5.38
21	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	5.32
22	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	5.32
23	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	5.32
24	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS	5.20
25	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS, PTPN11	5.05
26	Keratosis, seborrheic	Enrichment	FGFR3, PIK3CA	4.99
27	Pfeiffer syndrome	Enrichment	FGFR1, FGFR2	4.99
28	Jackson-weiss syndrome	Enrichment	FGFR1, FGFR2	4.99
29	Rosette-forming glioneuronal tumor	Enrichment	FGFR1, PIK3CA	4.99
30	Encephalocraniocutaneous lipomatosis	Enrichment	FGFR1, KRAS	4.91
31	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	FGF17, FGF8, FGFR1	4.60
32	Crouzon syndrome	Enrichment	FGFR2, FGFR3	4.51
33	Tumoral calcinosis, hyperphosphatemic, familial, 1	Enrichment	FGF23, KL	4.51
34	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.51
35	Spermatocytoma	Enrichment	FGFR3, HRAS	4.44
36	Myeloma, multiple	Enrichment	FGFR3, FLT3, KRAS, PIK3R2	4.35
37	Kallmann syndrome	Enrichment	FGF17, FGF8, FGFR1	4.27
38	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, PIK3R2	4.21
39	Saethre-chotzen syndrome	Enrichment	FGFR2, FGFR3	4.21
40	Hemifacial hyperplasia	Enrichment	FGFR2, FGFR3	3.99
41	Holoprosencephaly	Enrichment	FGF8, FGFR1	3.99
42	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	3.98
43	Renal tubular acidosis, distal, 3, with or without sensorineural hearing loss	Enrichment	ATP6V0A4, ATP6V1B1	3.97
44	Deafness, onychodystrophy, osteodystrophy, impaired intellectual development, and seizures syndrome	Enrichment	ATP6V1B2, ATP6V1C1	3.97
45	Maturity-onset diabetes of the young, type 10	Enrichment	INS	3.83
46	Hyperproinsulinemia	Enrichment	INS	3.83
47	Diabetes mellitus, permanent neonatal, 4	Enrichment	INS	3.83
48	Holoprosencephaly 1	Enrichment	FGF8, FGFR1	3.82
49	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	3.75
50	Breast adenocarcinoma	Enrichment	KRAS, PIK3CA	3.74
51	Hemihyperplasia, isolated	Enrichment	IGF2, PIK3CA	3.67
52	Type 1 diabetes mellitus 2	Enrichment	INS	3.66
53	46,xy disorder of sex development	Enrichment	FGFR3, INSR	3.64
54	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, PIK3CA	3.59
55	Gallbladder cancer	Enrichment	KRAS, PIK3CA	3.59
56	Pilomyxoid astrocytoma	Enrichment	FGFR1, KRAS	3.59
57	Neonatal diabetes mellitus	Enrichment	INS	3.53
58	Donohue syndrome	Enrichment	INSR	3.43
59	Hyperinsulinemic hypoglycemia, familial, 5	Enrichment	INSR	3.43
60	Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities	Enrichment	INSR	3.43
61	Diabetes mellitus, insulin-resistant, with acanthosis nigricans	Enrichment	INSR	3.43
62	Silver-russell syndrome due to maternal uniparental disomy of chromosome 7	Enrichment	GRB10	3.43
63	Arteriovenous malformation	Enrichment	HRAS, PIK3CA	3.36
64	Type 1 diabetes mellitus	Enrichment	INS	3.35
65	Gastric cancer	Enrichment	FGFR2, KRAS, PIK3CA	3.33
66	Oculoectodermal syndrome	Enrichment	KRAS	3.29
67	Noonan syndrome 4	Enrichment	SOS1	3.29
68	Melanosis, neurocutaneous	Enrichment	NRAS	3.29
69	Noonan syndrome 6	Enrichment	NRAS	3.29
70	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	3.29
71	Congenital pulmonary airway malformation	Enrichment	KRAS	3.29
72	Phakomatosis pigmentokeratotica	Enrichment	HRAS	3.29
73	Neurocutaneous melanocytosis	Enrichment	NRAS	3.29
74	Autosomal recessive distal renal tubular acidosis	Enrichment	ATP6V0A4, ATP6V1B1	3.27
75	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, PIK3CA	3.27
76	Permanent neonatal diabetes mellitus	Enrichment	INS	3.23
77	Hyperinsulinemic hypoglycemia, familial, 4	Enrichment	INSR	3.13
78	Noonan syndrome 13	Enrichment	MAPK1	3.13
79	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	FGF8, KLB, PTPN11	3.11
80	Lip and oral cavity carcinoma	Enrichment	HRAS, PIK3CA	3.10
81	Diabetes mellitus	Enrichment	INS	3.09
82	Specific learning disability	Enrichment	MAPK1, PTPN11	3.08
83	Fibromatosis, gingival, 1	Enrichment	SOS1	2.99
84	Costello syndrome	Enrichment	HRAS	2.99
85	Pulmonic stenosis	Enrichment	SOS1	2.99
86	Wooly hair nevus	Enrichment	HRAS	2.99
87	Breast cancer	Enrichment	KRAS, SHC1	2.98
88	Lung cancer susceptibility 3	Enrichment	FGF10, KRAS	2.96
89	Nk-cell enteropathy	Enrichment	IGF1R, PIK3CB	2.96
90	Gliosarcoma	Enrichment	FGFR1, FGFR3	2.92
91	Microform holoprosencephaly	Enrichment	FGF8, FGFR1	2.92
92	Lobar holoprosencephaly	Enrichment	FGF8, FGFR1	2.92
93	Lynch syndrome	Enrichment	KRAS, PIK3CA	2.90
94	Silver-russell syndrome 3	Enrichment	IGF2	2.88
95	Growth delay due to insulin-like growth factor type 1 deficiency	Enrichment	IGF1	2.88
96	Silver-russell syndrome due to an imprinting defect of 11p15	Enrichment	IGF2	2.88
97	Silver-russell syndrome due to 11p15 microduplication	Enrichment	IGF2	2.88
98	Giant cell glioblastoma	Enrichment	FGFR1, FGFR3	2.87
99	Maturity-onset diabetes of the young	Enrichment	INS	2.83
100	Semilobar holoprosencephaly	Enrichment	FGF8, FGFR1	2.82
101	Nuchal bleb, familial	Enrichment	SOS1	2.81
102	Langerhans cell histiocytosis	Enrichment	NRAS	2.81
103	Craniosynostosis	Enrichment	FGFR2, FGFR3	2.73
104	Growth delay due to insulin-like growth factor i resistance	Enrichment	IGF1R	2.70
105	Beckwith-wiedemann syndrome due to imprinting defect of 11p15	Enrichment	IGF2	2.70
106	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	2.69
107	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	2.69
108	Cardiofaciocutaneous syndrome	Enrichment	KRAS	2.69
109	Lung sarcomatoid carcinoma	Enrichment	KRAS	2.69
110	Pilocytic astrocytoma	Enrichment	KRAS	2.69
111	Epidermolytic nevus	Enrichment	HRAS	2.69
112	Gingival fibromatosis	Enrichment	SOS1	2.69
113	Endometrial cancer	Enrichment	FGFR2, PIK3CA	2.68
114	Cutis laxa	Enrichment	ATP6V0A2, ATP6V1E1	2.64
115	Silver-russell syndrome due to a point mutation	Enrichment	IGF2	2.58
116	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.53
117	Hypochondroplasia	Enrichment	FGFR3	2.49
118	Macrodactyly	Enrichment	PIK3CA	2.49
119	Beare-stevenson cutis gyrata syndrome	Enrichment	FGFR2	2.49
120	Osteoglophonic dysplasia	Enrichment	FGFR1	2.49
121	Metachondromatosis	Enrichment	PTPN11	2.49
122	Thanatophoric dysplasia, type i	Enrichment	FGFR3	2.49
123	Trigonocephaly 1	Enrichment	FGFR1	2.49
124	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.49
125	Muenke syndrome	Enrichment	FGFR3	2.49
126	Deafness, autosomal recessive 26	Enrichment	GAB1	2.49
127	Scaphocephaly, maxillary retrusion, and impaired intellectual development	Enrichment	FGFR2	2.49
128	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.49
129	Apert syndrome	Enrichment	FGFR2	2.49
130	Leopard syndrome 1	Enrichment	PTPN11	2.49
131	Cowden syndrome 5	Enrichment	PIK3CA	2.49
132	Thanatophoric dysplasia, type ii	Enrichment	FGFR3	2.49
133	Hypogonadotropic hypogonadism 20 with or without anosmia	Enrichment	FGF17	2.49
134	Camptodactyly, tall stature, and hearing loss syndrome	Enrichment	FGFR3	2.49
135	Aplasia of lacrimal and salivary glands	Enrichment	FGF10	2.49
136	Bent bone dysplasia syndrome 1	Enrichment	FGFR2	2.49
137	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.49
138	Tumoral calcinosis, hyperphosphatemic, familial, 3	Enrichment	KL	2.49
139	Short syndrome	Enrichment	PIK3R1	2.49
140	Metacarpal 4-5 fusion	Enrichment	FGF16	2.49
141	Lacrimoauriculodentodigital syndrome 3	Enrichment	FGF10	2.49
142	Familial isolated trichomegaly	Enrichment	FGF5	2.49
143	Crouzon syndrome with acanthosis nigricans	Enrichment	FGFR3	2.49
144	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.49
145	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.49
146	Multiple synostoses syndrome 3	Enrichment	FGF9	2.49
147	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.49
148	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.49
149	Acute myeloid leukemia with minimal differentiation	Enrichment	FLT3	2.49
150	Hypogonadotropic hypogonadism 6 with or without anosmia	Enrichment	FGF8	2.49
151	Achondroplasia, severe, with developmental delay and acanthosis nigricans	Enrichment	FGFR3	2.49
152	Tumoral calcinosis, hyperphosphatemic, familial, 2	Enrichment	FGF23	2.49
153	Hartsfield syndrome	Enrichment	FGFR1	2.49
154	Renal hypodysplasia/aplasia 2	Enrichment	FGF20	2.49
155	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.49
156	Lacrimoauriculodentodigital syndrome 2	Enrichment	FGFR3	2.49
157	Immunodeficiency 125	Enrichment	FLT3LG	2.49
158	Short-rib thoracic dysplasia 22 without polydactyly	Enrichment	FGF4	2.49
159	Hypospadias	Enrichment	PIK3CA	2.49
160	Rare venous malformation	Enrichment	PIK3CA	2.49
161	Diaphragmatic eventration	Enrichment	PIK3CA	2.49
162	Fgfr3-related chondrodysplasia	Enrichment	FGFR3	2.49
163	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.49
164	Camptodactyly-tall stature-scoliosis-hearing loss syndrome	Enrichment	FGFR3	2.49
165	Rare combined vascular malformation	Enrichment	PIK3CA	2.49
166	Cavernous lymphangioma	Enrichment	PIK3CA	2.49
167	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.49
168	Hartsfield-bixler-demyer syndrome	Enrichment	FGFR1	2.49
169	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.49
170	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.49
171	Non-syndromic unicoronal craniosynostosis	Enrichment	FGFR2	2.49
172	Interstitial lung disease specific to childhood	Enrichment	FGF10	2.49
173	Macrodactyly of toe	Enrichment	PIK3CA	2.49
174	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.49
175	Malignant astrocytoma	Enrichment	PTPN11	2.49
176	Hydrops fetalis, nonimmune	Enrichment	HRAS, PTPN11	2.42
177	Hypothyroidism, congenital, nongoitrous, 9	Enrichment	IRS4	2.42
178	Silver-russell syndrome 1	Enrichment	IGF2	2.33
179	Lung cancer	Enrichment	KRAS, PIK3CA	2.25
180	Deafness, congenital, with onychodystrophy, autosomal dominant	Enrichment	ATP6V1B2	2.22
181	Breasts and/or nipples, aplasia or hypoplasia of, 1	Enrichment	PTPRF	2.22
182	Cutis laxa, autosomal recessive, type iid	Enrichment	ATP6V1A	2.22
183	Ceroid lipofuscinosis, neuronal, 10	Enrichment	CTSD	2.22
184	Breasts and/or nipples, aplasia or hypoplasia of, 2	Enrichment	PTPRF	2.22
185	Zimmermann-laband syndrome 2	Enrichment	ATP6V1B2	2.22
186	Cutis laxa, autosomal recessive, type iic	Enrichment	ATP6V1E1	2.22
187	Developmental and epileptic encephalopathy 104	Enrichment	ATP6V0A1	2.22
188	Neurodevelopmental disorder with epilepsy and brain atrophy	Enrichment	ATP6V0A1	2.22
189	Epilepsy, early-onset, 3, with or without developmental delay	Enrichment	ATP6V0C	2.22
190	Autosomal dominant deafness - onychodystrophy syndrome	Enrichment	ATP6V1B2	2.22
191	Otodental dysplasia	Enrichment	FGF3	2.19
192	Trichomegaly	Enrichment	FGF5	2.19
193	Pulmonary hypoplasia, primary	Enrichment	FGF10	2.19
194	Cervical cancer	Enrichment	FGFR3	2.19
195	Vitamin d hydroxylation-deficient rickets, type 1b	Enrichment	PDE3B	2.19
196	Aural atresia, congenital	Enrichment	FGFR2	2.19
197	Deafness, congenital, with inner ear agenesis, microtia, and microdontia	Enrichment	FGF3	2.19
198	Noonan syndrome 8	Enrichment	PIK3CA	2.19
199	Antley-bixler syndrome without genital anomalies or disordered steroidogenesis	Enrichment	FGFR2	2.19
200	Werner syndrome	Enrichment	PTPN11	2.19
201	Split hand-foot malformation	Enrichment	FGFR2	2.19
202	Cervix carcinoma	Enrichment	FGFR3	2.19
203	Acute myeloid leukemia without maturation	Enrichment	FLT3	2.19
204	Interfrontal craniofaciosynostosis	Enrichment	FGFR1	2.19
205	Autosomal dominant nonsyndromic deafness	Enrichment	FGFR2	2.19
206	Mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2)	Enrichment	FLT3	2.19
207	Oculootodental syndrome	Enrichment	FGF3	2.19
208	Aortic valve disease 1	Enrichment	SOS1	2.17
209	Protein-deficiency anemia	Enrichment	NRAS	2.17
210	46,xy partial gonadal dysgenesis	Enrichment	SOS1	2.14
211	Rhabdomyosarcoma	Enrichment	HRAS	2.08
212	Achondroplasia	Enrichment	FGFR3	2.01
213	Hypogonadotropic hypogonadism 2 with or without anosmia	Enrichment	FGFR1	2.01
214	Larsen syndrome	Enrichment	FGFR3	2.01
215	Hypophosphatemic rickets, autosomal dominant	Enrichment	FGF23	2.01
216	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.01
217	Vitamin d hydroxylation-deficient rickets, type 1a	Enrichment	PDE3B	2.01
218	Chromosome 8p11 myeloproliferative syndrome	Enrichment	FGFR1	2.01
219	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.01
220	Hamartoma	Enrichment	FGFR3	2.01
221	Testicular germ cell cancer	Enrichment	FGFR3	2.01
222	Immunodeficiency 14	Enrichment	PIK3R1	2.01
223	Tricuspid valve insufficiency	Enrichment	PTPN11	2.01
224	Mixed phenotype acute leukemia with t	Enrichment	FLT3	2.01
225	Testicular cancer	Enrichment	FGFR3	2.01
226	Keratoacanthoma	Enrichment	PIK3CA	2.01
227	Arteriovenous malformations of the brain	Enrichment	KRAS	2.01
228	Wilms tumor 1	Enrichment	IGF2	2.00
229	Hereditary breast carcinoma	Enrichment	KRAS, PIK3CA	1.98
230	Beckwith-wiedemann syndrome	Enrichment	IGF2	1.93
231	Renal tubular acidosis, distal, 2, with progressive sensorineural hearing loss	Enrichment	ATP6V1B1	1.92
232	Wrinkly skin syndrome	Enrichment	ATP6V0A2	1.92
233	Developmental and epileptic encephalopathy 93	Enrichment	ATP6V1A	1.92
234	Osteopetrosis, autosomal recessive 1	Enrichment	TCIRG1	1.92
235	Renal tubular acidosis	Enrichment	ATP6V1B1	1.92
236	Childhood-onset epilepsy syndrome	Enrichment	ATP6V0C	1.92
237	Hypertelorism	Enrichment	FGFR2, PIK3CA	1.91
238	Pancreatic cancer	Enrichment	KRAS	1.89
239	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	1.89
240	Multiple synostoses syndrome	Enrichment	FGF9	1.89
241	Chronic myelomonocytic leukemia	Enrichment	FLT3	1.89
242	Cerebrovascular disease	Enrichment	PIK3CA	1.89
243	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.89
244	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	1.89
245	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.89
246	Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	Enrichment	FLT3	1.89
247	Non-syndromic bicoronal craniosynostosis	Enrichment	FGFR3	1.89
248	Glioma	Enrichment	FGFR2	1.89
249	Heart, malformation of	Enrichment	MAPK1	1.88
250	Capillary malformations, congenital	Enrichment	PIK3CA	1.79
251	Lymphoma	Enrichment	PTPN11	1.79
252	Acute myeloid leukemia with maturation	Enrichment	FLT3	1.79
253	Hemimegalencephaly	Enrichment	PIK3CA	1.79
254	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	FLT3	1.79
255	Primary hypereosinophilic syndrome	Enrichment	FGFR1	1.79
256	Zimmermann-laband syndrome 1	Enrichment	ATP6V1B2	1.74
257	Choreoacanthocytosis	Enrichment	TCIRG1	1.74
258	Cutis laxa, autosomal recessive, type iia	Enrichment	ATP6V0A2	1.74
259	Neutropenia, severe congenital, 1, autosomal dominant	Enrichment	TCIRG1	1.74
260	Dysosteosclerosis	Enrichment	TCIRG1	1.74
261	Osteopetrosis, autosomal recessive 6	Enrichment	TCIRG1	1.74
262	Atp6v0a2-related cutis laxa	Enrichment	ATP6V0A2	1.74
263	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.71
264	Cowden syndrome 1	Enrichment	PIK3CA	1.71
265	Split-hand/foot malformation 1	Enrichment	FGFR2	1.71
266	Testicular germ cell tumor	Enrichment	FGFR3	1.71
267	Patent ductus arteriosus	Enrichment	PTPN11	1.71
268	Overgrowth syndrome	Enrichment	PIK3R1	1.65
269	Hypophosphatemic rickets	Enrichment	FGF23	1.65
270	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	FLT3	1.65
271	Autosomal recessive osteopetrosis	Enrichment	TCIRG1	1.62
272	Intervertebral disc disease	Enrichment	CILP	1.56
273	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	1.55
274	Orofacial cleft 1	Enrichment	FGF10	1.54
275	Atypical chronic myeloid leukemia, bcr-abl1 negative	Enrichment	FLT3	1.54
276	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.54
277	Hypogonadotropic hypogonadism	Enrichment	FGFR1	1.54
278	Cowden syndrome	Enrichment	PIK3CA	1.54
279	Renal agenesis, bilateral	Enrichment	FGF20	1.54
280	Congenital disorder of glycosylation, type il	Enrichment	ATP6V0A2	1.52
281	Osteopetrosis	Enrichment	TCIRG1	1.52
282	Alg9-congenital disorder of glycosylation	Enrichment	ATP6V0A2	1.52
283	Autosomal dominant severe congenital neutropenia	Enrichment	TCIRG1	1.52
284	Meier-gorlin syndrome 1	Enrichment	FGFR2	1.50
285	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.50
286	Primary bone dysplasia	Enrichment	FGFR3	1.50
287	Pectus excavatum	Enrichment	PTPN11	1.45
288	Leukemia, acute lymphoblastic	Enrichment	FLT3	1.45
289	Osteochondrodysplasia	Enrichment	FGFR3	1.45
290	Epicanthus	Enrichment	PTPN11	1.42
291	Septooptic dysplasia	Enrichment	FGFR1	1.42
292	Renal hypodysplasia/aplasia 3	Enrichment	FGFR3	1.42
293	Meningioma	Enrichment	PIK3CA	1.42
294	Congenital long qt syndrome	Enrichment	PTPN11	1.42
295	Microcephaly	Enrichment	ATP6V0A1, MAPK1, PTPN11	1.42
296	Pulmonary disease, chronic obstructive	Enrichment	PDE3B	1.38
297	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	FGFR1	1.35
298	Immunodeficiency 47	Enrichment	ATP6AP1	1.32
299	Severe congenital neutropenia	Enrichment	TCIRG1	1.32
300	Hydrocephalus	Enrichment	FGFR2	1.32
301	Septopreoptic holoprosencephaly	Enrichment	FGF8	1.32
302	Midline interhemispheric variant of holoprosencephaly	Enrichment	FGF8	1.32
303	Ovarian cancer	Enrichment	KRAS, PIK3CA	1.30
304	Alobar holoprosencephaly	Enrichment	FGF8	1.27
305	Patent foramen ovale	Enrichment	PTPN11	1.25
306	Nephrocalcinosis	Enrichment	ATP6V1B1	1.23
307	Nephrolithiasis	Enrichment	ATP6V1B1	1.23
308	Hepatoblastoma	Enrichment	FGFR3	1.18
309	Hepatocellular carcinoma	Enrichment	PIK3CA	1.16
310	Tooth agenesis	Enrichment	FGFR1	1.16
311	Precursor t-cell acute lymphoblastic leukemia	Enrichment	FLT3	1.14
312	Scoliosis	Enrichment	PTPN11	1.12
313	Strabismus	Enrichment	PTPN11	1.08
314	Polydactyly, postaxial, type a1	Enrichment	ATP6V1B1	1.06
315	Neuronal ceroid lipofuscinosis	Enrichment	CTSD	1.06
316	Prostate cancer	Enrichment	PIK3CA	1.05
317	Long qt syndrome 1	Enrichment	PTPN11	1.03
318	Connective tissue disease	Enrichment	FGFR3	1.01
319	Hypertrophic cardiomyopathy	Enrichment	PTPN11	0.88
320	Thrombocytopenia	Enrichment	PTPN11	0.84
321	Non-syndromic x-linked intellectual disability	Enrichment	ATP6AP1	0.71
322	Sensorineural hearing loss	Enrichment	ATP6V0A4	0.60
323	Undetermined early-onset epileptic encephalopathy	Enrichment	ATP6V1A	0.54
324	Congenital nervous system abnormality	Enrichment	FGFR3	0.53
325	Nervous system disease	Enrichment	FGFR3	0.53
326	Autism spectrum disorder	Enrichment	PTPN11	0.52
327	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	0.46
328	Autism	Enrichment	ATP6V0A1	0.45
329	Rare genetic deafness	Enrichment	ATP6V1B1	0.42
330	Complex neurodevelopmental disorder	Enrichment	ATP6V0A1	0.28

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Insulin receptor signalling cascade

Pathway Network for Insulin receptor signalling cascade

Pathway network for the Insulin receptor signalling cascade SuperPath

Member Pathways for Insulin receptor signalling cascade

Pathways in the Insulin receptor signalling cascade SuperPath

Gene overlap in member pathways for Insulin receptor signalling cascade SuperPath

Associated Genes for Insulin receptor signalling cascade

Associated Disorders for Insulin receptor signalling cascade

Disorders associated with Insulin receptor signalling cascade SuperPath

STRING Interaction Network for Insulin receptor signalling cascade

Sources for Insulin receptor signalling cascade