Integration of energy metabolism

Pathway network for the Integration of energy metabolism SuperPath

Sources:

Reactome
GeneGo (Thomson Reuters)

Pathways in the Integration of energy metabolism SuperPath

#	Name	Source	Genes
1	Integration of energy metabolism	Reactome	ABCC8 ACACA ACACB ACLY ACSL3 ACSL4 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADIPOQ ADIPOR1 ADIPOR2 ADRA2A ADRA2C AGPAT1 AHCYL1 AKAP5 CACNA1A CACNA1C CACNA1D CACNA1E CACNA2D2 CACNB2 CACNB3 CD36 CHRM3 FASN FFAR1 GCG GCGR GLP1R GNA11 GNA14 GNA15 GNAI1 GNAI2 GNAQ GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 INS IQGAP1 ITPR1 ITPR2 ITPR3 KCNB1 KCNC2 KCNG2 KCNJ11 KCNS3 MARCKS MLX MLXIPL PFKFB1 PKLR PLCB1 PLCB2 PLCB3 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PRKAA2 PRKAB2 PRKACA PRKACB PRKACG PRKAG2 PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA RAP1A RAPGEF3 RAPGEF4 SLC2A1 SLC2A2 SNAP25 STK11 STX1A STXBP1 SYT5 TALDO1 TKT VAMP2 (see all 108) (see less)
2	Regulation of insulin secretion	Reactome	ABCC8 ACSL3 ACSL4 ADCY5 ADCY6 ADCY8 ADRA2A ADRA2C AHCYL1 AKAP5 CACNA1A CACNA1C CACNA1D CACNA1E CACNA2D2 CACNB2 CACNB3 CD36 CHRM3 FFAR1 GCG GLP1R GNA11 GNA14 GNA15 GNAI1 GNAI2 GNAQ GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 INS IQGAP1 ITPR1 ITPR2 ITPR3 KCNB1 KCNC2 KCNG2 KCNJ11 KCNS3 MARCKS PLCB1 PLCB2 PLCB3 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA RAP1A RAPGEF3 RAPGEF4 SLC2A1 SLC2A2 SNAP25 STX1A STXBP1 SYT5 VAMP2 (see all 78) (see less)
3	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	Reactome	ADCY5 ADCY6 ADCY8 AKAP5 GCG GLP1R GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 IQGAP1 ITPR1 ITPR2 ITPR3 KCNB1 KCNC2 KCNG2 KCNS3 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B RAP1A RAPGEF3 RAPGEF4 (see all 42) (see less)
4	Free fatty acids regulate insulin secretion	Reactome	ACSL3 ACSL4 CD36 FFAR1 GNA11 GNA14 GNA15 GNAQ PLCB1 PLCB2 PLCB3 (see all 11) (see less)
5	Acetylcholine regulates insulin secretion	Reactome	CHRM3 GNA11 GNA14 GNA15 GNAQ MARCKS PLCB1 PLCB2 PLCB3 PRKCA (see all 10) (see less)
6	ChREBP activates metabolic gene expression	Reactome	ACACA ACACB ACLY AGPAT1 FASN MLX MLXIPL PKLR (see all 8) (see less)
7	Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	Reactome	FFAR1 GNA11 GNA14 GNA15 GNAQ PLCB1 PLCB2 PLCB3 (see all 8) (see less)
8	AMPK inhibits chREBP transcriptional activation activity	Reactome	ADIPOQ ADIPOR1 ADIPOR2 MLXIPL PRKAA2 PRKAB2 PRKAG2 STK11 (see all 8) (see less)
9	PP2A-mediated dephosphorylation of key metabolic factors	Reactome	MLXIPL PFKFB1 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D (see all 7) (see less)
10	PKA-mediated phosphorylation of key metabolic factors	Reactome	MLXIPL PFKFB1 PRKACA PRKACB PRKACG
11	Saturated fatty acid biosynthesis	GeneGo (Thomson Reuters)	ACACA ACACB FASN
12	Intracellular metabolism of fatty acids regulates insulin secretion	Reactome	ACSL3 ACSL4 CD36

Gene overlap in member pathways for Integration of energy metabolism SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PLCB1	Phospholipase C Beta 1	Protein Coding	5
2	GNA11	G Protein Subunit Alpha 11	Protein Coding	5
3	GNA15	G Protein Subunit Alpha 15	Protein Coding	5
4	GNAQ	G Protein Subunit Alpha Q	Protein Coding	5
5	MLXIPL	MLX Interacting Protein Like	Protein Coding	5
6	PLCB2	Phospholipase C Beta 2	Protein Coding	5
7	PLCB3	Phospholipase C Beta 3	Protein Coding	5
8	GNA14	G Protein Subunit Alpha 14	Protein Coding	5
9	ACSL3	Acyl-CoA Synthetase Long Chain Family Member 3	Protein Coding	4
10	ACSL4	Acyl-CoA Synthetase Long Chain Family Member 4	Protein Coding	4
11	FFAR1	Free Fatty Acid Receptor 1	Protein Coding	4
12	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	4
13	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	4
14	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	4
15	CD36	CD36 Molecule (CD36 Blood Group)	Protein Coding	4
16	RAPGEF3	Rap Guanine Nucleotide Exchange Factor 3	Protein Coding	3
17	GNB5	G Protein Subunit Beta 5	Protein Coding	3
18	RAPGEF4	Rap Guanine Nucleotide Exchange Factor 4	Protein Coding	3
19	ADCY5	Adenylate Cyclase 5	Protein Coding	3
20	ADCY6	Adenylate Cyclase 6	Protein Coding	3
21	CHRM3	Cholinergic Receptor Muscarinic 3	Protein Coding	3
22	ADCY8	Adenylate Cyclase 8	Protein Coding	3
23	FASN	Fatty Acid Synthase	Protein Coding	3
24	KCNG2	Potassium Voltage-Gated Channel Modifier Subfamily G Member 2	Protein Coding	3
25	GCG	Glucagon	Protein Coding	3
26	GLP1R	Glucagon Like Peptide 1 Receptor	Protein Coding	3
27	GNAS	GNAS Complex Locus	Protein Coding	3
28	GNB1	G Protein Subunit Beta 1	Protein Coding	3
29	GNB2	G Protein Subunit Beta 2	Protein Coding	3
30	GNB3	G Protein Subunit Beta 3	Protein Coding	3
31	GNG3	G Protein Subunit Gamma 3	Protein Coding	3
32	GNG4	G Protein Subunit Gamma 4	Protein Coding	3
33	GNG5	G Protein Subunit Gamma 5	Protein Coding	3
34	GNG7	G Protein Subunit Gamma 7	Protein Coding	3
35	GNG10	G Protein Subunit Gamma 10	Protein Coding	3
36	GNG11	G Protein Subunit Gamma 11	Protein Coding	3
37	GNGT1	G Protein Subunit Gamma Transducin 1	Protein Coding	3
38	GNGT2	G Protein Subunit Gamma Transducin 2	Protein Coding	3
39	ACACA	Acetyl-CoA Carboxylase Alpha	Protein Coding	3
40	ACACB	Acetyl-CoA Carboxylase Beta	Protein Coding	3
41	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	3
42	ITPR2	Inositol 1,4,5-Trisphosphate Receptor Type 2	Protein Coding	3
43	ITPR3	Inositol 1,4,5-Trisphosphate Receptor Type 3	Protein Coding	3
44	KCNB1	Potassium Voltage-Gated Channel Subfamily B Member 1	Protein Coding	3
45	KCNC2	Potassium Voltage-Gated Channel Subfamily C Member 2	Protein Coding	3
46	KCNS3	Potassium Voltage-Gated Channel Modifier Subfamily S Member 3	Protein Coding	3
47	MARCKS	Myristoylated Alanine Rich Protein Kinase C Substrate	Protein Coding	3
48	GNG13	G Protein Subunit Gamma 13	Protein Coding	3
49	PFKFB1	6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 1	Protein Coding	3
50	GNG2	G Protein Subunit Gamma 2	Protein Coding	3
51	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	3
52	PRKAR1B	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Beta	Protein Coding	3
53	PRKAR2A	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Alpha	Protein Coding	3
54	PRKAR2B	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Beta	Protein Coding	3
55	PRKCA	Protein Kinase C Alpha	Protein Coding	3
56	GNG12	G Protein Subunit Gamma 12	Protein Coding	3
57	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	3
58	GNB4	G Protein Subunit Beta 4	Protein Coding	3
59	IQGAP1	IQ Motif Containing GTPase Activating Protein 1	Protein Coding	3
60	GNG8	G Protein Subunit Gamma 8	Protein Coding	3
61	AKAP5	A-Kinase Anchoring Protein 5	Protein Coding	3
62	AGPAT1	1-Acylglycerol-3-Phosphate O-Acyltransferase 1	Protein Coding	2
63	AHCYL1	Adenosylhomocysteinase Like 1	Protein Coding	2
64	ADRA2A	Adrenoceptor Alpha 2A	Protein Coding	2
65	ADRA2C	Adrenoceptor Alpha 2C	Protein Coding	2
66	GNAI1	G Protein Subunit Alpha I1	Protein Coding	2
67	GNAI2	G Protein Subunit Alpha I2	Protein Coding	2
68	INS	Insulin	Protein Coding	2
69	KCNJ11	Potassium Inwardly Rectifying Channel Subfamily J Member 11	Protein Coding	2
70	ACLY	ATP Citrate Lyase	Protein Coding	2
71	ADIPOR1	Adiponectin Receptor 1	Protein Coding	2
72	PRKAG2	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2	Protein Coding	2
73	PKLR	Pyruvate Kinase L/R	Protein Coding	2
74	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	2
75	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	2
76	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	2
77	PPP2R1B	Protein Phosphatase 2 Scaffold Subunit Abeta	Protein Coding	2
78	PPP2R5D	Protein Phosphatase 2 Regulatory Subunit B''Delta	Protein Coding	2
79	PRKAA2	Protein Kinase AMP-Activated Catalytic Subunit Alpha 2	Protein Coding	2
80	PRKAB2	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 2	Protein Coding	2
81	SLC2A1	Solute Carrier Family 2 Member 1	Protein Coding	2
82	SLC2A2	Solute Carrier Family 2 Member 2	Protein Coding	2
83	SNAP25	Synaptosome Associated Protein 25	Protein Coding	2
84	STK11	Serine/Threonine Kinase 11	Protein Coding	2
85	STX1A	Syntaxin 1A	Protein Coding	2
86	STXBP1	Syntaxin Binding Protein 1	Protein Coding	2
87	ABCC8	ATP Binding Cassette Subfamily C Member 8	Protein Coding	2
88	VAMP2	Vesicle Associated Membrane Protein 2	Protein Coding	2
89	SYT5	Synaptotagmin 5	Protein Coding	2
90	MLX	MAX Dimerization Protein MLX	Protein Coding	2
91	CACNA1A	Calcium Voltage-Gated Channel Subunit Alpha1 A	Protein Coding	2
92	CACNA1C	Calcium Voltage-Gated Channel Subunit Alpha1 C	Protein Coding	2
93	CACNA1D	Calcium Voltage-Gated Channel Subunit Alpha1 D	Protein Coding	2
94	CACNA1E	Calcium Voltage-Gated Channel Subunit Alpha1 E	Protein Coding	2
95	CACNB2	Calcium Voltage-Gated Channel Auxiliary Subunit Beta 2	Protein Coding	2
96	CACNB3	Calcium Voltage-Gated Channel Auxiliary Subunit Beta 3	Protein Coding	2
97	ADIPOR2	Adiponectin Receptor 2	Protein Coding	2
98	CACNA2D2	Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 2	Protein Coding	2
99	ADIPOQ	Adiponectin, C1Q And Collagen Domain Containing	Protein Coding	2
100	ADCY1	Adenylate Cyclase 1	Protein Coding	1
101	ADCY2	Adenylate Cyclase 2	Protein Coding	1
102	ADCY3	Adenylate Cyclase 3	Protein Coding	1
103	ADCY7	Adenylate Cyclase 7	Protein Coding	1
104	ADCY9	Adenylate Cyclase 9	Protein Coding	1
105	ADCY4	Adenylate Cyclase 4	Protein Coding	1
106	GCGR	Glucagon Receptor	Protein Coding	1
107	TALDO1	Transaldolase 1	Protein Coding	1
108	TKT	Transketolase	Protein Coding	1

Disorders associated with Integration of energy metabolism SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Anastomosing haemangioma	Enrichment	GNA11, GNA14, GNAQ	9.80
2	Developmental and epileptic encephalopathy	Enrichment	CACNA1E, CACNA2D2, KCNB1, KCNC2, SNAP25, STXBP1	7.30
3	Phakomatosis cesioflammea	Enrichment	GNA11, GNAQ	6.52
4	Neonatal diabetes mellitus	Enrichment	ABCC8, INS, KCNJ11	6.14
5	Capillary malformations, congenital	Enrichment	GNA11, GNAQ	5.52
6	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	5.41
7	Melanoma, uveal	Enrichment	GNA11, GNAQ	5.34
8	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	GNAS, PRKAR1A	5.03
9	Permanent neonatal diabetes mellitus	Enrichment	ABCC8, INS, KCNJ11	5.00
10	Strabismus	Enrichment	CACNA1A, GNB1, SLC2A1, STXBP1	4.79
11	Neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures	Enrichment	CACNA1A, CACNA1C	4.01
12	Dend syndrome	Enrichment	ABCC8, KCNJ11	4.01
13	Maturity-onset diabetes of the young	Enrichment	ABCC8, INS, KCNJ11	3.71
14	Developmental and epileptic encephalopathy 2	Enrichment	CACNA1A, SNAP25	3.71
15	Acetyl-coa carboxylase-alpha deficiency	Enrichment	ACACA	3.66
16	Intellectual developmental disorder, x-linked 63	Enrichment	ACSL4	3.66
17	Coronary heart disease 7	Enrichment	CD36	3.66
18	Platelet glycoprotein iv deficiency	Enrichment	CD36	3.66
19	Transient neonatal diabetes mellitus	Enrichment	ABCC8, KCNJ11	3.49
20	Hypoglycemia	Enrichment	ABCC8, KCNJ11	3.49
21	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	3.43
22	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	3.43
23	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	3.43
24	Hyperinsulinemic hypoglycemia, familial, 1	Enrichment	ABCC8, KCNJ11	3.32
25	Nonsyndromic genetic hyperinsulinism	Enrichment	ABCC8, KCNJ11	3.32
26	Houge-janssens syndrome 2	Enrichment	PPP2R1A	3.29
27	Ppp2r1a-related neurodevelopmental disorder	Enrichment	PPP2R1A	3.29
28	Adenosine triphosphate, elevated, of erythrocytes	Enrichment	PKLR	3.23
29	Anemia, congenital, nonspherocytic hemolytic, 2	Enrichment	PKLR	3.23
30	Hypocalciuric hypercalcemia, familial, type ii	Enrichment	GNA11	3.23
31	Sturge-weber syndrome	Enrichment	GNAQ	3.23
32	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	3.23
33	Hypocalcemia, autosomal dominant 2	Enrichment	GNA11	3.23
34	Phakomatosis cesiomarmorata	Enrichment	GNA11	3.23
35	Kaposiform hemangioendothelioma	Enrichment	GNA14	3.23
36	Cardiomyopathy, familial hypertrophic, 6	Enrichment	PRKAG2	3.23
37	Glycogen storage disease of heart, lethal congenital	Enrichment	PRKAG2	3.23
38	Intestinal polyposis syndrome	Enrichment	STK11	3.23
39	Long qt syndrome 1	Enrichment	CACNA1C, ITPR3, SLC2A2	3.18
40	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	3.13
41	Fibrolamellar carcinoma	Enrichment	PRKACA	3.13
42	Amme complex	Enrichment	ACSL4	3.05
43	Blood platelet disease	Enrichment	CD36	3.05
44	Cerebral malaria	Enrichment	CD36	3.05
45	Alternating hemiplegia of childhood	Enrichment	CACNA1A, SLC2A1	3.05
46	Houge-janssens syndrome 1	Enrichment	PPP2R5D	2.99
47	Houge-janssens syndrome 3	Enrichment	PPP2CA	2.99
48	Ovarian dysgenesis 3	Enrichment	MLX	2.93
49	Cutis marmorata telangiectatica congenita	Enrichment	GNA11	2.93
50	Angioma, tufted	Enrichment	GNA14	2.93
51	Autosomal dominant hypocalcemia	Enrichment	GNA11	2.93
52	Peutz-jeghers syndrome	Enrichment	STK11	2.93
53	Cerebral palsy	Enrichment	CACNA1A, CACNA1C, GNB1	2.84
54	Diabetes mellitus	Enrichment	INS, KCNJ11	2.76
55	Takayasu arteritis	Enrichment	MLX	2.75
56	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	GNA11	2.75
57	Adiponectin deficiency	Enrichment	ADIPOQ	2.75
58	Testicular germ cell cancer	Enrichment	STK11	2.75
59	Testicular cancer	Enrichment	STK11	2.75
60	Apc-associated polyposis conditions	Enrichment	STK11	2.75
61	Type 2 diabetes mellitus	Enrichment	ABCC8, KCNJ11, SLC2A2	2.75
62	West syndrome	Enrichment	PLCB1, SLC2A1, STXBP1	2.69
63	Congenital long qt syndrome	Enrichment	ITPR3, SLC2A2	2.68
64	Prune belly syndrome	Enrichment	CHRM3	2.66
65	Stroke, ischemic	Enrichment	ACSL4	2.66
66	Developmental and epileptic encephalopathy 12	Enrichment	PLCB1	2.63
67	Familial adenomatous polyposis 1	Enrichment	STK11	2.53
68	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	STK11	2.53
69	Anhidrosis, isolated, with normal sweat glands	Enrichment	ITPR2	2.51
70	Acrodysostosis 1 with or without hormone resistance	Enrichment	PRKAR1A	2.51
71	Pseudohypoparathyroidism, type ic	Enrichment	GNAS	2.51
72	Carney complex, type 1	Enrichment	PRKAR1A	2.51
73	Osseous heteroplasia, progressive	Enrichment	GNAS	2.51
74	Dyskinesia with orofacial involvement, autosomal dominant	Enrichment	ADCY5	2.51
75	Acth-independent macronodular adrenal hyperplasia 1	Enrichment	GNAS	2.51
76	Neurodevelopmental disorder with hypotonia and dysmorphic facies	Enrichment	GNB2	2.51
77	Neurodevelopmental disorder with hyperkinetic movements and dyskinesia	Enrichment	ADCY5	2.51
78	Pituitary adenoma 3, multiple types	Enrichment	GNAS	2.51
79	Charcot-marie-tooth disease, demyelinating, type 1j	Enrichment	ITPR3	2.51
80	Developmental and epileptic encephalopathy 26	Enrichment	KCNB1	2.51
81	Myxoma, intracardiac	Enrichment	PRKAR1A	2.51
82	Dyskinesia with orofacial involvement, autosomal recessive	Enrichment	ADCY5	2.51
83	Lodder-merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia	Enrichment	GNB5	2.51
84	Charcot-marie-tooth disease, dominant intermediate f	Enrichment	GNB4	2.51
85	Developmental and epileptic encephalopathy 103	Enrichment	KCNC2	2.51
86	Disorders of gnas inactivation	Enrichment	GNAS	2.51
87	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.51
88	Sick sinus syndrome 4	Enrichment	GNB2	2.51
89	Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathy	Enrichment	ITPR3	2.51
90	Prkar1b-related neurodegenerative dementia with intermediate filaments	Enrichment	PRKAR1B	2.51
91	Monostotic fibrous dysplasia	Enrichment	GNAS	2.51
92	Mazabraud syndrome	Enrichment	GNAS	2.51
93	Klippel-trenaunay-weber syndrome	Enrichment	GNAQ	2.45
94	Testicular germ cell tumor	Enrichment	STK11	2.45
95	Undetermined early-onset epileptic encephalopathy	Enrichment	CACNA1A, KCNB1, KCNC2	2.39
96	Hemolytic anemia	Enrichment	PKLR	2.38
97	Malaria	Enrichment	CD36	2.29
98	Developmental and epileptic encephalopathy 14	Enrichment	PLCB1	2.28
99	Microcephaly	Enrichment	GNB1, SLC2A1, SNAP25, STXBP1	2.26
100	Hyperinsulinemic hypoglycemia, familial, 2	Enrichment	KCNJ11	2.24
101	Brugada syndrome 4	Enrichment	CACNB2	2.24
102	Stomatin-deficient cryohydrocytosis with neurologic defects	Enrichment	SLC2A1	2.24
103	Ventricular tachycardia, familial	Enrichment	GNAI2	2.24
104	Developmental and epileptic encephalopathy 117	Enrichment	SNAP25	2.24
105	Maturity-onset diabetes of the young, type 12	Enrichment	ABCC8	2.24
106	Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities	Enrichment	GNAI1	2.24
107	Diabetes mellitus, transient neonatal, 3	Enrichment	KCNJ11	2.24
108	Primary aldosteronism, seizures, and neurologic abnormalities	Enrichment	CACNA1D	2.24
109	Brugada syndrome 3	Enrichment	CACNA1C	2.24
110	Epilepsy, idiopathic generalized 12	Enrichment	SLC2A1	2.24
111	Sinoatrial node dysfunction and deafness	Enrichment	CACNA1D	2.24
112	Neurodevelopmental disorder with hypotonia and autistic features with or without hyperkinetic movements	Enrichment	VAMP2	2.24
113	Diabetes mellitus, permanent neonatal, 2	Enrichment	KCNJ11	2.24
114	Epilepsy with generalized tonic-clonic seizures	Enrichment	SNAP25	2.24
115	Maturity-onset diabetes of the young, type 13	Enrichment	KCNJ11	2.24
116	Autosomal dominant hyperinsulinism due to sur1 deficiency	Enrichment	ABCC8	2.24
117	Developmental and epileptic encephalopathy 69	Enrichment	CACNA1E	2.24
118	Lipodystrophy, familial partial, type 8	Enrichment	ADRA2A	2.24
119	Diazoxide-resistant focal hyperinsulinism due to sur1 deficiency	Enrichment	ABCC8	2.24
120	Congestive heart failure	Enrichment	ABCC8	2.24
121	Sporadic hemiplegic migraine	Enrichment	CACNA1A	2.24
122	Atypical timothy syndrome	Enrichment	CACNA1C	2.24
123	Epilepsy with myoclonic absences	Enrichment	SLC2A1	2.24
124	Aldosterone-producing adenoma with seizures and neurological abnormalities	Enrichment	CACNA1D	2.24
125	Intermediate dend syndrome	Enrichment	KCNJ11	2.24
126	Timothy syndrome type 2	Enrichment	CACNA1C	2.24
127	Diazoxide-resistant focal hyperinsulinism due to kir6.2 deficiency	Enrichment	KCNJ11	2.24
128	Timothy syndrome type 1	Enrichment	CACNA1C	2.24
129	Autosomal recessive hyperinsulinism due to sur1 deficiency	Enrichment	ABCC8	2.24
130	Hereditary cryohydrocytosis with reduced stomatin	Enrichment	SLC2A1	2.24
131	Cacna1c-related disorders	Enrichment	CACNA1C	2.24
132	Benign paroxysmal torticollis of infancy	Enrichment	CACNA1A	2.24
133	Autosomal dominant hyperinsulinism due to kir6.2 deficiency	Enrichment	KCNJ11	2.24
134	Autosomal recessive hyperinsulinism due to kir6.2 deficiency	Enrichment	KCNJ11	2.24
135	Melanoma	Enrichment	STK11	2.23
136	Spinocerebellar ataxia 29	Enrichment	ITPR1	2.21
137	Pseudohypoparathyroidism, type ia	Enrichment	GNAS	2.21
138	Amelogenesis imperfecta, type ig	Enrichment	PRKAR1A	2.21
139	Pseudopseudohypoparathyroidism	Enrichment	GNAS	2.21
140	Lethal congenital contracture syndrome 8	Enrichment	ADCY6	2.21
141	Night blindness, congenital stationary, type 1h	Enrichment	GNB3	2.21
142	Marbach-schaaf neurodevelopmental syndrome	Enrichment	PRKAR1B	2.21
143	Usher syndrome, type iv	Enrichment	PRKAR1A	2.21
144	Acrodysostosis	Enrichment	PRKAR1A	2.21
145	Pseudohypoparathyroidism	Enrichment	GNAS	2.21
146	Ciliary dyskinesia, primary, 18	Enrichment	PRKAR1B	2.21
147	Lodder-merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmia	Enrichment	GNB5	2.21
148	Isolated primary pigmented nodular adrenocortical disease	Enrichment	PRKAR1A	2.21
149	Acth-independent macronodular adrenal hyperplasia	Enrichment	GNAS	2.21
150	Cerebral visual impairment	Enrichment	GNB1	2.21
151	Lip and oral cavity carcinoma	Enrichment	STK11	2.15
152	Non-syndromic x-linked intellectual disability	Enrichment	ACSL4	2.10
153	Short stature, developmental delay, and congenital heart defects	Enrichment	TKT	2.10
154	Deafness, autosomal recessive 44	Enrichment	ADCY1	2.10
155	Mahvash disease	Enrichment	GCGR	2.10
156	Mccune-albright syndrome	Enrichment	GNAS	2.03
157	Gillespie syndrome	Enrichment	ITPR1	2.03
158	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	GNAS	2.03
159	Hypomyelination neuropathy-arthrogryposis syndrome	Enrichment	ADCY6	2.03
160	Wolff-parkinson-white syndrome	Enrichment	PRKAG2	2.03
161	Brugada syndrome	Enrichment	CACNA1C, CACNB2	2.01
162	Melanoma, cutaneous malignant 1	Enrichment	STK11	2.00
163	Fanconi-bickel syndrome	Enrichment	SLC2A2	1.94
164	Pituitary adenoma 4, acth-secreting	Enrichment	GNAI2	1.94
165	Dystonia 9	Enrichment	SLC2A1	1.94
166	Timothy syndrome	Enrichment	CACNA1C	1.94
167	Alternating hemiplegia of childhood 1	Enrichment	CACNA1A	1.94
168	Glut1 deficiency syndrome 1	Enrichment	SLC2A1	1.94
169	Diabetes mellitus, permanent neonatal, 1	Enrichment	KCNJ11	1.94
170	Hypoglycemia, leucine-induced	Enrichment	ABCC8	1.94
171	Maturity-onset diabetes of the young, type 10	Enrichment	INS	1.94
172	Diabetes mellitus, transient neonatal, 2	Enrichment	ABCC8	1.94
173	Long qt syndrome 8	Enrichment	CACNA1C	1.94
174	Hyperproinsulinemia	Enrichment	INS	1.94
175	Glucose transporter type 1 deficiency syndrome	Enrichment	SLC2A1	1.94
176	Diabetes mellitus, permanent neonatal, 3	Enrichment	ABCC8	1.94
177	Diabetes mellitus, permanent neonatal, 4	Enrichment	INS	1.94
178	Hypopituitarism	Enrichment	GNAI2	1.94
179	Congenital disorder of glycosylation, type iw, autosomal dominant	Enrichment	CACNA1D	1.94
180	9q33.3q34.11 microdeletion syndrome	Enrichment	STXBP1	1.94
181	Hyperinsulinism	Enrichment	KCNJ11	1.94
182	Progressive bulbar palsy	Enrichment	CACNA1A	1.94
183	Chorea, benign hereditary	Enrichment	ADCY5	1.91
184	Spastic paraplegia 17, autosomal dominant	Enrichment	GNG3	1.91
185	Pseudohypoparathyroidism, type ib	Enrichment	GNAS	1.91
186	Lipodystrophy, congenital generalized, type 2	Enrichment	GNG3	1.91
187	Carney complex variant	Enrichment	PRKAR1A	1.91
188	Spinocerebellar ataxia 15	Enrichment	ITPR1	1.91
189	Arrhythmogenic right ventricular dysplasia, familial, 10	Enrichment	PRKAR1A	1.91
190	Familial sick sinus syndrome	Enrichment	GNB2	1.91
191	Pancreatic cancer	Enrichment	STK11	1.83
192	Transaldolase deficiency	Enrichment	TALDO1	1.80
193	Body mass index quantitative trait locus 19	Enrichment	ADCY3	1.80
194	Lung cancer	Enrichment	PPP2R1B	1.79
195	Type 1 diabetes mellitus 2	Enrichment	INS	1.77
196	Van der woude syndrome 1	Enrichment	CACNA1E	1.77
197	Glut1 deficiency syndrome 2	Enrichment	SLC2A1	1.77
198	Chromosome 17q23.1-q23.2 deletion syndrome	Enrichment	SLC2A1	1.77
199	Hyperinsulinemic hypoglycemia	Enrichment	ABCC8	1.77
200	Hereditary episodic ataxia	Enrichment	CACNA1A	1.77
201	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	1.73
202	Adrenocortical carcinoma	Enrichment	PRKAR1A	1.73
203	Familial hypertrophic cardiomyopathy	Enrichment	PRKAG2	1.71
204	Brachydactyly	Enrichment	GNAS	1.67
205	Migraine, familial hemiplegic, 1	Enrichment	CACNA1A	1.64
206	Spinocerebellar ataxia 6	Enrichment	CACNA1A	1.64
207	Dermatitis, atopic	Enrichment	KCNJ11	1.64
208	Ventricular fibrillation, paroxysmal familial, 1	Enrichment	CACNA1C	1.64
209	Developmental and epileptic encephalopathy 4	Enrichment	STXBP1	1.64
210	Developmental and epileptic encephalopathy 42	Enrichment	CACNA1A	1.64
211	Cerebellar atrophy with seizures and variable developmental delay	Enrichment	CACNA2D2	1.64
212	Developmental and epileptic encephalopathy 52	Enrichment	CACNA1A	1.64
213	Newborn respiratory distress syndrome	Enrichment	ABCC8	1.64
214	Episodic ataxia	Enrichment	CACNA1A	1.64
215	Familial or sporadic hemiplegic migraine	Enrichment	CACNA1A	1.64
216	Benign epilepsy with centrotemporal spikes	Enrichment	PLCB1, SLC2A1	1.64
217	Spastic paraplegia 4, autosomal dominant	Enrichment	GNAS	1.61
218	Hypothyroidism	Enrichment	GNB1	1.61
219	Centralopathic epilepsy	Enrichment	PLCB1	1.60
220	Gastric cancer	Enrichment	STK11	1.60
221	Hypertrophic cardiomyopathy	Enrichment	PRKAG2	1.60
222	Primary hyperaldosteronism	Enrichment	GNAS	1.56
223	Episodic ataxia, type 2	Enrichment	CACNA1A	1.55
224	Heart conduction disease	Enrichment	CACNA1C	1.55
225	Polyhydramnios	Enrichment	ABCC8	1.55
226	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.47
227	Myelodysplastic syndrome	Enrichment	GNB1	1.47
228	Type 1 diabetes mellitus	Enrichment	INS	1.47
229	Hypertrichosis	Enrichment	KCNJ11	1.47
230	Spastic ataxia	Enrichment	ITPR1, STXBP1	1.43
231	Acute promyelocytic leukemia	Enrichment	PRKAR1A	1.40
232	Focal epilepsy	Enrichment	SNAP25	1.40
233	Paroxysmal dystonia	Enrichment	SLC2A1	1.40
234	Multiple sclerosis	Enrichment	ITPR1	1.37
235	Gastroesophageal reflux	Enrichment	ABCC8	1.35
236	Lennox-gastaut syndrome	Enrichment	CACNA1A	1.35
237	Difference of sex development	Enrichment	CACNA1A	1.35
238	Anterior segment dysgenesis	Enrichment	ITPR1	1.34
239	Myoclonic-atonic epilepsy	Enrichment	SLC2A1	1.30
240	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	CACNA1C	1.30
241	Hypertension, essential	Enrichment	GNB3	1.29
242	Cleft palate, isolated	Enrichment	GNB1	1.29
243	Body mass index quantitative trait locus 11	Enrichment	ADCY3, GNAS	1.22
244	Migraine with or without aura 1	Enrichment	CACNA1A	1.21
245	Atrial heart septal defect	Enrichment	ABCC8	1.21
246	Interatrial communication	Enrichment	ABCC8	1.21
247	Presynaptic congenital myasthenic syndromes	Enrichment	SNAP25	1.21
248	Complex neurodevelopmental disorder	Enrichment	PPP2CA	1.21
249	Autism	Enrichment	STX1A, STXBP1	1.19
250	Attention deficit-hyperactivity disorder	Enrichment	GNB5	1.18
251	Cardiac conduction defect	Enrichment	CACNA1C	1.17
252	Congenital stationary night blindness	Enrichment	GNB3	1.16
253	Stereotypic movement disorder	Enrichment	SNAP25	1.14
254	Inherited cancer-predisposing syndrome	Enrichment	STK11	1.12
255	Dystonia	Enrichment	GNB1	0.99
256	Williams-beuren syndrome	Enrichment	STX1A	0.96
257	Congenital nervous system abnormality	Enrichment	CACNA1A, GNB5	0.91
258	Nervous system disease	Enrichment	CACNA1A, GNB5	0.91
259	Cardiomyopathy, familial hypertrophic, 1	Enrichment	CACNA1C	0.89
260	Autism spectrum disorder	Enrichment	GNB1, STXBP1	0.89
261	Developmental and epileptic encephalopathy 1	Enrichment	SLC2A1	0.87
262	Auditory neuropathy	Enrichment	CACNA1A	0.86
263	Autosomal dominant non-syndromic intellectual disability	Enrichment	GNB1	0.84
264	Long qt syndrome	Enrichment	CACNA1C	0.79
265	Cystic fibrosis	Enrichment	STX1A	0.77
266	Epilepsy	Enrichment	SLC2A1	0.69
267	Breast cancer	Enrichment	GNG3	0.68
268	Primary ciliary dyskinesia	Enrichment	PRKAR1B	0.68
269	Optic atrophy plus syndrome	Enrichment	SNAP25	0.65
270	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	ADCY1	0.29

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Integration of energy metabolism

Pathway Network for Integration of energy metabolism

Pathway network for the Integration of energy metabolism SuperPath

Member Pathways for Integration of energy metabolism

Pathways in the Integration of energy metabolism SuperPath

Gene overlap in member pathways for Integration of energy metabolism SuperPath

Associated Genes for Integration of energy metabolism

Associated Disorders for Integration of energy metabolism

Disorders associated with Integration of energy metabolism SuperPath

STRING Interaction Network for Integration of energy metabolism

Sources for Integration of energy metabolism