Integrin-linked kinase signaling

No Pathway Network information available for Integrin-linked kinase signaling

Pathways in the Integrin-linked kinase signaling SuperPath

#	Name	Source	Genes
1	Integrin-linked kinase signaling	PubChem	ACTN1 AKT1 ARHGEF6 ARHGEF7 AURKA CCND1 CDC37 CDC42 CKAP5 CREB1 CTNNB1 DIAPH1 ELMO2 GIT2 GSK3B HSP90AA1 ILK ILKAP IQGAP1 JUN LEF1 LIMS1 LIMS2 MYL9 NACA NCK2 PARP1 PARVA PARVB PARVG PPP1R12A PPP1R14A PPP1R14B PPP1R14C PXN RAC1 RHOG RICTOR RUVBL1 RUVBL2 SNAI1 TACC3 TNS1 XPO1 ZEB1 ZYX (see all 46) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ELMO2	Engulfment And Cell Motility 2	Protein Coding	1
2	NACA	Nascent Polypeptide Associated Complex Subunit Alpha	Protein Coding	1
3	TNS1	Tensin 1	Protein Coding	1
4	ILKAP	ILK Associated Serine/Threonine Phosphatase	Protein Coding	1
5	PARVG	Parvin Gamma	Protein Coding	1
6	GIT2	GIT ArfGAP 2	Protein Coding	1
7	PPP1R14C	Protein Phosphatase 1 Regulatory Inhibitor Subunit 14C	Protein Coding	1
8	PPP1R14B	Protein Phosphatase 1 Regulatory Inhibitor Subunit 14B	Protein Coding	1
9	ZYX	Zyxin	Protein Coding	1
10	LIMS2	LIM Zinc Finger Domain Containing 2	Protein Coding	1
11	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
12	LEF1	Lymphoid Enhancer Binding Factor 1	Protein Coding	1
13	MYL9	Myosin Light Chain 9	Protein Coding	1
14	RUVBL2	RuvB Like AAA ATPase 2	Protein Coding	1
15	AURKA	Aurora Kinase A	Protein Coding	1
16	PPP1R14A	Protein Phosphatase 1 Regulatory Inhibitor Subunit 14A	Protein Coding	1
17	PPP1R12A	Protein Phosphatase 1 Regulatory Subunit 12A	Protein Coding	1
18	RHOG	Ras Homolog Family Member G	Protein Coding	1
19	TACC3	Transforming Acidic Coiled-Coil Containing Protein 3	Protein Coding	1
20	CCND1	Cyclin D1	Protein Coding	1
21	XPO1	Exportin 1	Protein Coding	1
22	DIAPH1	Diaphanous Related Formin 1	Protein Coding	1
23	RICTOR	RPTOR Independent Companion Of MTOR Complex 2	Protein Coding	1
24	RUVBL1	RuvB Like AAA ATPase 1	Protein Coding	1
25	CDC37	Cell Division Cycle 37, HSP90 Cochaperone	Protein Coding	1
26	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
27	IQGAP1	IQ Motif Containing GTPase Activating Protein 1	Protein Coding	1
28	ARHGEF6	Rac/Cdc42 Guanine Nucleotide Exchange Factor 6	Protein Coding	1
29	LIMS1	LIM Zinc Finger Domain Containing 1	Protein Coding	1
30	ACTN1	Actinin Alpha 1	Protein Coding	1
31	PARVA	Parvin Alpha	Protein Coding	1
32	PARVB	Parvin Beta	Protein Coding	1
33	ILK	Integrin Linked Kinase	Protein Coding	1
34	PXN	Paxillin	Protein Coding	1
35	ZEB1	Zinc Finger E-Box Binding Homeobox 1	Protein Coding	1
36	SNAI1	Snail Family Transcriptional Repressor 1	Protein Coding	1
37	CTNNB1	Catenin Beta 1	Protein Coding	1
38	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
39	ARHGEF7	Rho Guanine Nucleotide Exchange Factor 7	Protein Coding	1
40	NCK2	NCK Adaptor Protein 2	Protein Coding	1
41	CDC42	Cell Division Cycle 42	Protein Coding	1
42	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
43	CKAP5	Cytoskeleton Associated Protein 5	Protein Coding	1
44	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	1
45	RAC1	Rac Family Small GTPase 1	Protein Coding	1
46	PARP1	Poly(ADP-Ribose) Polymerase 1	Protein Coding	1

Disorders associated with Integrin-linked kinase signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Colorectal cancer	Enrichment	AKT1, AURKA, CCND1, CTNNB1	3.68
2	Polycystic liver disease	Enrichment	CTNNB1, RUVBL1	2.83
3	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1, RUVBL1	2.83
4	Proteus syndrome	Enrichment	AKT1	2.47
5	Ramon syndrome	Enrichment	ELMO2	2.47
6	Deafness, autosomal dominant 1, with or without thrombocytopenia	Enrichment	DIAPH1	2.47
7	Ectodermal dysplasia 17 with or without limb malformations	Enrichment	LEF1	2.47
8	Vascular malformation, primary intraosseous	Enrichment	ELMO2	2.47
9	Intellectual developmental disorder, x-linked 46	Enrichment	ARHGEF6	2.47
10	Cowden syndrome 6	Enrichment	AKT1	2.47
11	Muscular dystrophy, autosomal recessive, with cardiomyopathy and triangular tongue	Enrichment	LIMS2	2.47
12	Bleeding disorder, platelet-type, 15	Enrichment	ACTN1	2.47
13	Seizures, cortical blindness, and microcephaly syndrome	Enrichment	DIAPH1	2.47
14	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.47
15	Diaph1-related sensorineural hearing loss-thrombocytopenia syndrome	Enrichment	DIAPH1	2.47
16	Primary intraosseous venous malformation	Enrichment	ELMO2	2.47
17	Adenoid ameloblastoma	Enrichment	CTNNB1	2.47
18	Nocarh syndrome	Enrichment	CDC42	2.47
19	Autosomal recessive limb-girdle muscular dystrophy type 2w	Enrichment	LIMS2	2.47
20	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.47
21	Microcystic stromal tumor	Enrichment	CTNNB1	2.47
22	Ectrodactyly and ectodermal dysplasia without cleft lip/palate	Enrichment	LEF1	2.17
23	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.17
24	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.17
25	Genitourinary and/or brain malformation syndrome	Enrichment	PPP1R12A	2.17
26	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.17
27	Immunodeficiency, common variable, 15	Enrichment	RUVBL1	2.17
28	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	2.17
29	Split hand-foot malformation	Enrichment	LEF1	2.17
30	Immune system disease	Enrichment	CDC42	2.17
31	Megacystis-microcolon-intestinal hypoperistalsis syndrome 4	Enrichment	MYL9	2.17
32	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.17
33	Teratoma	Enrichment	CTNNB1	2.17
34	Primary mediastinal large b-cell lymphoma	Enrichment	XPO1	2.17
35	Desmoid disease, hereditary	Enrichment	CTNNB1	1.99
36	Corneal dystrophy, posterior polymorphous, 3	Enrichment	ZEB1	1.99
37	Corneal dystrophy, fuchs endothelial, 6	Enrichment	ZEB1	1.99
38	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.99
39	Anus, imperforate	Enrichment	CTNNB1	1.99
40	Neurodevelopmental disorder with progressive spasticity and brain abnormalities	Enrichment	RUVBL1	1.99
41	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.99
42	Desmoid tumor	Enrichment	CTNNB1	1.99
43	Intraocular pressure quantitative trait locus	Enrichment	ZEB1	1.99
44	Melanoma of soft tissue	Enrichment	CREB1	1.99
45	Pilomatrixoma	Enrichment	CTNNB1	1.87
46	Alazami syndrome	Enrichment	CTNNB1	1.87
47	Mantle cell lymphoma	Enrichment	CCND1	1.87
48	Craniopharyngioma	Enrichment	CTNNB1	1.87
49	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.87
50	Corneal dystrophy	Enrichment	ZEB1	1.87
51	Myeloma, multiple	Enrichment	AURKA, CCND1	1.81
52	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.77
53	Von hippel-lindau syndrome	Enrichment	CCND1	1.77
54	Fuchs' endothelial dystrophy	Enrichment	ZEB1	1.77
55	Corneal dystrophy, posterior polymorphous, 1	Enrichment	ZEB1	1.70
56	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.70
57	Split-hand/foot malformation 1	Enrichment	LEF1	1.70
58	Moyamoya disease 1	Enrichment	DIAPH1	1.70
59	Pendred syndrome	Enrichment	DIAPH1	1.70
60	Adrenocortical carcinoma	Enrichment	CTNNB1	1.70
61	Breast adenocarcinoma	Enrichment	AKT1	1.70
62	Gallbladder cancer	Enrichment	CTNNB1	1.63
63	Breast cancer	Enrichment	AKT1, JUN	1.57
64	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.57
65	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.52
66	Adult hepatocellular carcinoma	Enrichment	CTNNB1	1.52
67	Cowden syndrome	Enrichment	AKT1	1.52
68	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.48
69	Autosomal dominant macrothrombocytopenia	Enrichment	ACTN1	1.48
70	Meningioma	Enrichment	AKT1	1.40
71	Ovarian cancer	Enrichment	AKT1, CTNNB1	1.34
72	Medulloblastoma	Enrichment	CTNNB1	1.33
73	Gliosarcoma	Enrichment	TACC3	1.28
74	Giant cell glioblastoma	Enrichment	TACC3	1.25
75	Microcephaly	Enrichment	CTNNB1, DIAPH1	1.19
76	Hepatoblastoma	Enrichment	CTNNB1	1.16
77	Hepatocellular carcinoma	Enrichment	CTNNB1	1.14
78	Auditory neuropathy	Enrichment	DIAPH1	1.07
79	Bladder cancer	Enrichment	CTNNB1	1.03
80	Non-syndromic x-linked intellectual disability	Enrichment	ARHGEF6	0.94
81	Epilepsy	Enrichment	DIAPH1	0.90
82	Hereditary breast carcinoma	Enrichment	AKT1	0.86
83	Thrombocytopenia	Enrichment	ACTN1	0.82
84	Primary ovarian insufficiency	Enrichment	RICTOR	0.74
85	Rare genetic deafness	Enrichment	DIAPH1	0.63
86	Congenital nervous system abnormality	Enrichment	CTNNB1	0.52
87	Nervous system disease	Enrichment	CTNNB1	0.52

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Integrin-linked kinase signaling

Pathway Network for Integrin-linked kinase signaling

Member Pathways for Integrin-linked kinase signaling

Pathways in the Integrin-linked kinase signaling SuperPath

Associated Genes for Integrin-linked kinase signaling

Associated Disorders for Integrin-linked kinase signaling

Disorders associated with Integrin-linked kinase signaling SuperPath

STRING Interaction Network for Integrin-linked kinase signaling

Sources for Integrin-linked kinase signaling