Integrin-mediated cell adhesion

No Pathway Network information available for Integrin-mediated cell adhesion

Pathways in the Integrin-mediated cell adhesion SuperPath

#	Name	Source	Genes
1	Integrin-mediated cell adhesion	WikiPathways	AKT1 AKT2 AKT3 ARAF ARHGEF7 BCAR1 BRAF CAPN1 CAPN10 CAPN11 CAPN2 CAPN3 CAPN5 CAPN6 CAPN7 CAPN9 CAPNS1 CAV1 CAV2 CAV3 CDC42 CRK CSK DOCK1 FYN GIT2 GRB2 HRAS ILK ITGA1 ITGA10 ITGA11 ITGA2 ITGA2B ITGA3 ITGA4 ITGA5 ITGA6 ITGA7 ITGA8 ITGA9 ITGAD ITGAE ITGAL ITGAM ITGAV ITGAX ITGB1 ITGB2 ITGB3 ITGB4 ITGB5 ITGB6 ITGB7 ITGB8 MAP2K1 MAP2K2 MAP2K3 MAP2K5 MAP2K6 MAPK1 MAPK10 MAPK12 MAPK4 MAPK6 MAPK7 MIR34C MYLK2 MYPN PAK1 PAK2 PAK3 PAK4 PAK6 PDPK1 PIK3R2 PTK2 PXN RAC1 RAC2 RAC3 RAF1 RAP1A RAP1B RAPGEF1 RHO ROCK1 ROCK2 SELENOP SHC1 SHC3 SORBS1 SOS1 SRC TLN1 TNS1 VASP VAV2 VAV3 VCL ZYX (see all 101) (see less)
2	HGF Pathway	QIAGEN	AKT1 AKT2 AKT3 CDC42 CDK6 CDKN1B CRKL DOCK1 ELK1 ETS1 ETS2 FOS GAB1 GRB2 HGF HRAS ITGA1 ITGA10 ITGA11 ITGA2 ITGA2B ITGA3 ITGA4 ITGA5 ITGA6 ITGA7 ITGA8 ITGA9 ITGAD ITGAE ITGAL ITGAM ITGAV ITGAX ITGB1 ITGB2 ITGB3 ITGB4 ITGB5 ITGB6 ITGB7 ITGB8 JUN KRAS MAP2K1 MAP2K2 MAP2K4 MAP2K7 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAPK1 MAPK10 MAPK3 MAPK8 MAPK9 MET MRAS NRAS PAK1 PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLCG1 PLCG2 PRKCA PRKCB PRKCG PTGS2 PTK2 PTK2B PXN RAC1 RAF1 RAP1A RAP1B RAPGEF1 RB1 RRAS RRAS2 SOS1 SOS2 STAT3 (see all 86) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RAP1B	RAP1B, Member Of RAS Oncogene Family	Protein Coding	2
2	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	2
3	CDC42	Cell Division Cycle 42	Protein Coding	2
4	ITGA8	Integrin Subunit Alpha 8	Protein Coding	2
5	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	2
6	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	2
7	RAC1	Rac Family Small GTPase 1	Protein Coding	2
8	PXN	Paxillin	Protein Coding	2
9	PTK2	Protein Tyrosine Kinase 2	Protein Coding	2
10	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	2
11	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	2
12	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	2
13	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	2
14	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	2
15	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	2
16	ITGB8	Integrin Subunit Beta 8	Protein Coding	2
17	ITGB6	Integrin Subunit Beta 6	Protein Coding	2
18	ITGB5	Integrin Subunit Beta 5	Protein Coding	2
19	ITGB4	Integrin Subunit Beta 4	Protein Coding	2
20	ITGB3	Integrin Subunit Beta 3	Protein Coding	2
21	ITGB2	Integrin Subunit Beta 2	Protein Coding	2
22	ITGB1	Integrin Subunit Beta 1	Protein Coding	2
23	ITGAX	Integrin Subunit Alpha X	Protein Coding	2
24	ITGAV	Integrin Subunit Alpha V	Protein Coding	2
25	ITGAM	Integrin Subunit Alpha M	Protein Coding	2
26	ITGAL	Integrin Subunit Alpha L	Protein Coding	2
27	ITGA7	Integrin Subunit Alpha 7	Protein Coding	2
28	ITGA5	Integrin Subunit Alpha 5	Protein Coding	2
29	ITGA4	Integrin Subunit Alpha 4	Protein Coding	2
30	ITGA3	Integrin Subunit Alpha 3	Protein Coding	2
31	ITGA2B	Integrin Subunit Alpha 2b	Protein Coding	2
32	ITGA2	Integrin Subunit Alpha 2	Protein Coding	2
33	ITGA1	Integrin Subunit Alpha 1	Protein Coding	2
34	ITGA6	Integrin Subunit Alpha 6	Protein Coding	2
35	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	2
36	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	2
37	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	2
38	DOCK1	Dedicator Of Cytokinesis 1	Protein Coding	2
39	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	2
40	ITGA10	Integrin Subunit Alpha 10	Protein Coding	2
41	ITGB7	Integrin Subunit Beta 7	Protein Coding	2
42	ITGAE	Integrin Subunit Alpha E	Protein Coding	2
43	ITGAD	Integrin Subunit Alpha D	Protein Coding	2
44	ITGA9	Integrin Subunit Alpha 9	Protein Coding	2
45	RAPGEF1	Rap Guanine Nucleotide Exchange Factor 1	Protein Coding	2
46	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	2
47	ITGA11	Integrin Subunit Alpha 11	Protein Coding	2
48	GIT2	GIT ArfGAP 2	Protein Coding	1
49	BCAR1	BCAR1 Scaffold Protein, Cas Family Member	Protein Coding	1
50	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	1
51	CAV3	Caveolin 3	Protein Coding	1
52	CAV2	Caveolin 2	Protein Coding	1
53	CAV1	Caveolin 1	Protein Coding	1
54	MYLK2	Myosin Light Chain Kinase 2	Protein Coding	1
55	MYPN	Myopalladin	Protein Coding	1
56	CAPNS1	Calpain Small Subunit 1	Protein Coding	1
57	CAPN3	Calpain 3	Protein Coding	1
58	CAPN2	Calpain 2	Protein Coding	1
59	CAPN1	Calpain 1	Protein Coding	1
60	ZYX	Zyxin	Protein Coding	1
61	VCL	Vinculin	Protein Coding	1
62	VASP	Vasodilator Stimulated Phosphoprotein	Protein Coding	1
63	CAPN5	Calpain 5	Protein Coding	1
64	TLN1	Talin 1	Protein Coding	1
65	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
66	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
67	SHC1	SHC Adaptor Protein 1	Protein Coding	1
68	SELENOP	Selenoprotein P	Protein Coding	1
69	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	1
70	RHO	Rhodopsin	Protein Coding	1
71	RAC3	Rac Family Small GTPase 3	Protein Coding	1
72	RAC2	Rac Family Small GTPase 2	Protein Coding	1
73	PAK6	P21 (RAC1) Activated Kinase 6	Protein Coding	1
74	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	1
75	MAP2K5	Mitogen-Activated Protein Kinase Kinase 5	Protein Coding	1
76	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
77	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	1
78	MAPK6	Mitogen-Activated Protein Kinase 6	Protein Coding	1
79	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
80	PAK3	P21 (RAC1) Activated Kinase 3	Protein Coding	1
81	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	1
82	MIR34C	MicroRNA 34c	RNA Gene	1
83	ARAF	A-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
84	ILK	Integrin Linked Kinase	Protein Coding	1
85	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
86	CSK	C-Terminal Src Kinase	Protein Coding	1
87	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	1
88	CAPN10	Calpain 10	Protein Coding	1
89	VAV3	Vav Guanine Nucleotide Exchange Factor 3	Protein Coding	1
90	PAK4	P21 (RAC1) Activated Kinase 4	Protein Coding	1
91	ARHGEF7	Rho Guanine Nucleotide Exchange Factor 7	Protein Coding	1
92	CAPN11	Calpain 11	Protein Coding	1
93	CAPN9	Calpain 9	Protein Coding	1
94	SORBS1	Sorbin And SH3 Domain Containing 1	Protein Coding	1
95	CAPN6	Calpain 6	Protein Coding	1
96	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	1
97	TNS1	Tensin 1	Protein Coding	1
98	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	1
99	MAPK4	Mitogen-Activated Protein Kinase 4	Protein Coding	1
100	SHC3	SHC Adaptor Protein 3	Protein Coding	1
101	CAPN7	Calpain 7	Protein Coding	1
102	CDK6	Cyclin Dependent Kinase 6	Protein Coding	1
103	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1
104	CRKL	CRK Like Proto-Oncogene, Adaptor Protein	Protein Coding	1
105	ELK1	ETS Transcription Factor ELK1	Protein Coding	1
106	ETS1	ETS Proto-Oncogene 1, Transcription Factor	Protein Coding	1
107	ETS2	ETS Proto-Oncogene 2, Transcription Factor	Protein Coding	1
108	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
109	GAB1	GRB2 Associated Binding Protein 1	Protein Coding	1
110	HGF	Hepatocyte Growth Factor	Protein Coding	1
111	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
112	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
113	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1
114	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	1
115	MAP3K2	Mitogen-Activated Protein Kinase Kinase Kinase 2	Protein Coding	1
116	MAP3K3	Mitogen-Activated Protein Kinase Kinase Kinase 3	Protein Coding	1
117	MAP3K4	Mitogen-Activated Protein Kinase Kinase Kinase 4	Protein Coding	1
118	MAP3K5	Mitogen-Activated Protein Kinase Kinase Kinase 5	Protein Coding	1
119	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
120	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
121	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
122	MET	MET Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	1
123	MRAS	Muscle RAS Oncogene Homolog	Protein Coding	1
124	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	1
125	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	1
126	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
127	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	1
128	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	1
129	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
130	PLCG2	Phospholipase C Gamma 2	Protein Coding	1
131	PRKCA	Protein Kinase C Alpha	Protein Coding	1
132	PRKCB	Protein Kinase C Beta	Protein Coding	1
133	PRKCG	Protein Kinase C Gamma	Protein Coding	1
134	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	1
135	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	1
136	RB1	RB Transcriptional Corepressor 1	Protein Coding	1
137	RRAS	RAS Related	Protein Coding	1
138	RRAS2	RAS Related 2	Protein Coding	1
139	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	1
140	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1

Disorders associated with Integrin-mediated cell adhesion SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rasopathy	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, MRAS, NRAS, RAF1, RRAS2, SOS1, SOS2	16.00
2	Noonan syndrome 1	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, MRAS, NRAS, RAF1, RRAS, RRAS2, SOS1, SOS2	10.56
3	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1, SOS1	10.37
4	Noonan syndrome 3	Enrichment	HRAS, KRAS, RAF1, SOS1	7.28
5	Lung non-small cell carcinoma	Enrichment	HRAS, KRAS, MAP2K1, NRAS	6.32
6	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	6.01
7	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS, MAP2K1, MAP2K2	6.01
8	Cardiofaciocutaneous syndrome	Enrichment	KRAS, MAP2K1, MAP2K2	6.01
9	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGA2, ITGA2B, ITGB3	5.31
10	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS	5.07
11	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS, RAF1	4.87
12	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	4.40
13	Ovarian cancer	Enrichment	AKT1, CDKN1B, KRAS, MET, RB1, RRAS2	4.37
14	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS, RRAS	4.28
15	Pulmonic stenosis	Enrichment	BRAF, SOS1	4.26
16	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3, STAT3	3.93
17	Bleeding disorder, platelet-type, 16	Enrichment	ITGA2B, ITGB3	3.93
18	Langerhans cell histiocytosis	Enrichment	MAP2K1, NRAS	3.93
19	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	3.93
20	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3R2	3.63
21	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	CRKL, MAPK1	3.63
22	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	3.63
23	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	3.63
24	Noonan syndrome with multiple lentigines	Enrichment	BRAF, RAF1	3.49
25	Epidermolysis bullosa, junctional 5b, with pyloric atresia	Enrichment	ITGA6, ITGB4	3.23
26	Breast adenocarcinoma	Enrichment	AKT1, KRAS	3.23
27	Cardiomyopathy, familial hypertrophic, 1	Enrichment	CAV3, MYLK2, RAF1	3.14
28	Bladder cancer	Enrichment	HRAS, KRAS, RB1	3.10
29	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	3.10
30	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	3.09
31	Glanzmann thrombasthenia 1	Enrichment	ITGA2B, ITGB3	3.09
32	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, MAP2K1	3.09
33	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	3.09
34	Pilomyxoid astrocytoma	Enrichment	KRAS, RAF1	3.09
35	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	3.09
36	Arteriovenous malformation	Enrichment	HRAS, MAP2K1	2.86
37	Junctional epidermolysis bullosa	Enrichment	ITGA6, ITGB4	2.86
38	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1	2.76
39	Autosomal dominant macrothrombocytopenia	Enrichment	ITGA2B, ITGB3	2.76
40	Colorectal cancer	Enrichment	AKT1, MET, NRAS, PIK3R1	2.65
41	Lip and oral cavity carcinoma	Enrichment	HRAS, RB1	2.60
42	Dilated cardiomyopathy	Enrichment	BRAF, MYPN, RAF1, VCL	2.53
43	Lung cancer susceptibility 3	Enrichment	KRAS, RB1	2.46
44	Thrombocytopenia	Enrichment	ITGA2B, ITGB3, SRC	2.26
45	Creatine phosphokinase, elevated serum	Enrichment	CAPN3, CAV3	2.21
46	Isolated elevated serum creatine phosphokinase levels	Enrichment	CAPN3, CAV3	2.21
47	Proteus syndrome	Enrichment	AKT1	2.20
48	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.20
49	Oculoectodermal syndrome	Enrichment	KRAS	2.20
50	Systemic lupus erythematosus 6	Enrichment	ITGAM	2.20
51	Deafness, autosomal recessive 26	Enrichment	GAB1	2.20
52	Noonan syndrome 5	Enrichment	RAF1	2.20
53	Noonan syndrome 4	Enrichment	SOS1	2.20
54	Deafness, autosomal recessive 39	Enrichment	HGF	2.20
55	Melorheostosis, isolated	Enrichment	MAP2K1	2.20
56	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.20
57	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.20
58	Microcephaly 12, primary, autosomal recessive	Enrichment	CDK6	2.20
59	Melanosis, neurocutaneous	Enrichment	NRAS	2.20
60	Noonan syndrome 9	Enrichment	SOS2	2.20
61	Noonan syndrome 6	Enrichment	NRAS	2.20
62	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.20
63	Noonan syndrome 11	Enrichment	MRAS	2.20
64	Noonan syndrome 13	Enrichment	MAPK1	2.20
65	Short syndrome	Enrichment	PIK3R1	2.20
66	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.20
67	Fetomaternal alloimmune thrombocytopenia 2	Enrichment	ITGA2B	2.20
68	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.20
69	Osteofibrous dysplasia	Enrichment	MET	2.20
70	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.20
71	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.20
72	Deafness, autosomal recessive 97	Enrichment	MET	2.20
73	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.20
74	Spinocerebellar ataxia 14	Enrichment	PRKCG	2.20
75	Melorheostosis	Enrichment	MAP2K1	2.20
76	Neuroendocrine tumor	Enrichment	CDKN1B	2.20
77	Autism 9	Enrichment	MET	2.20
78	Leopard syndrome 2	Enrichment	RAF1	2.20
79	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.20
80	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.20
81	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.20
82	Thrombocytopenia 11 with multiple congenital anomalies and dysmorphic facies	Enrichment	RAP1B	2.20
83	Cowden syndrome 6	Enrichment	AKT1	2.20
84	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.20
85	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.20
86	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.20
87	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.20
88	Trigonitis	Enrichment	RAF1	2.20
89	Trilateral retinoblastoma	Enrichment	RB1	2.20
90	Arthrogryposis, distal, type 11	Enrichment	MET	2.20
91	Amelogenesis imperfecta, type ih	Enrichment	ITGB6	2.20
92	Capillary hemangioma	Enrichment	AKT3	2.20
93	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.20
94	Congenital pulmonary airway malformation	Enrichment	KRAS	2.20
95	Cerebral cavernous malformations 5	Enrichment	MAP3K3	2.20
96	Fetomaternal alloimmune thrombocytopenia 3	Enrichment	ITGA2	2.20
97	Immune dysregulation, neurodevelopmental defects, and colitis	Enrichment	ITGAV	2.20
98	Nocarh syndrome	Enrichment	CDC42	2.20
99	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.20
100	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.20
101	Verrucous hemangioma	Enrichment	MAP3K3	2.20
102	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.20
103	Neurocutaneous melanocytosis	Enrichment	NRAS	2.20
104	Temporomandibular joint anomaly	Enrichment	DOCK1	2.20
105	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.20
106	Lung oat cell carcinoma	Enrichment	RB1	2.20
107	Familial isolated dilated cardiomyopathy	Enrichment	MYPN, RAF1, VCL	2.14
108	Intellectual developmental disorder, x-linked 30	Enrichment	PAK3	2.13
109	Pallister-killian syndrome	Enrichment	ARAF	2.13
110	Night blindness, congenital stationary, autosomal dominant 1	Enrichment	RHO	2.13
111	Lipodystrophy, congenital generalized, type 3	Enrichment	CAV1	2.13
112	Immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis	Enrichment	RAC2	2.13
113	Noonan syndrome 7	Enrichment	BRAF	2.13
114	Leopard syndrome 3	Enrichment	BRAF	2.13
115	Pulmonary hypertension, primary, 3	Enrichment	CAV1	2.13
116	Vitreoretinopathy, neovascular inflammatory	Enrichment	CAPN5	2.13
117	Knobloch syndrome 2	Enrichment	PAK2	2.13
118	Neurodevelopmental disorder with structural brain anomalies and dysmorphic facies	Enrichment	RAC3	2.13
119	Pulmonary hypertension, primary, 6	Enrichment	CAPNS1	2.13
120	Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia	Enrichment	RAC2	2.13
121	Lipodystrophy, familial partial, type 7	Enrichment	CAV1	2.13
122	Cardiomyopathy, dilated, 1w	Enrichment	VCL	2.13
123	Lymphangioma	Enrichment	BRAF	2.13
124	Phace association	Enrichment	BRAF	2.13
125	Cardiomyopathy, familial hypertrophic, 15	Enrichment	VCL	2.13
126	Retinitis pigmentosa 4	Enrichment	RHO	2.13
127	Thrombocytopenia 6	Enrichment	SRC	2.13
128	Congenital myopathy 24	Enrichment	MYPN	2.13
129	Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia	Enrichment	RAC2	2.13
130	Polycystic ovary syndrome	Enrichment	CAPN10	2.13
131	Progressive muscular atrophy	Enrichment	CAPN3	2.13
132	Infantile lad-like disease due to rac2 deficiency	Enrichment	RAC2	2.13
133	Capillary leak syndrome	Enrichment	TLN1	2.13
134	Reticular dysgenesis-like severe combined immunodeficiency	Enrichment	RAC2	2.13
135	Syringocystadenoma papilliferum	Enrichment	BRAF	2.13
136	Ganglioglioma	Enrichment	BRAF	2.13
137	Nongerminomatous germ cell tumor	Enrichment	BRAF	2.13
138	Phace syndrome	Enrichment	BRAF	2.13
139	Qualitative or quantitative defects of calpain	Enrichment	CAPN3	2.13
140	Classic hairy cell leukemia	Enrichment	BRAF	2.13
141	Rac2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndrome	Enrichment	RAC2	2.13
142	Breast cancer	Enrichment	AKT1, JUN, KRAS	1.92
143	Leukocyte adhesion deficiency, type i	Enrichment	ITGB2	1.90
144	Fibromatosis, gingival, 1	Enrichment	SOS1	1.90
145	Costello syndrome	Enrichment	HRAS	1.90
146	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	1.90
147	Leukocyte adhesion deficiency, type iii	Enrichment	ITGB2	1.90
148	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	1.90
149	Chromosome 13q14 deletion syndrome	Enrichment	RB1	1.90
150	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	1.90
151	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.90
152	Epidermolysis bullosa, junctional 5a, intermediate	Enrichment	ITGB4	1.90
153	Noonan syndrome 12	Enrichment	RRAS2	1.90
154	Epidermolysis bullosa, junctional 7, with interstitial lung disease and nephrotic syndrome	Enrichment	ITGA3	1.90
155	Childhood hepatocellular carcinoma	Enrichment	MET	1.90
156	Senior-loken syndrome 7	Enrichment	AKT3	1.90
157	Papillary renal cell carcinoma	Enrichment	MET	1.90
158	Immune system disease	Enrichment	CDC42	1.90
159	Bardet-biedl syndrome 16	Enrichment	AKT3	1.90
160	Localized junctional epidermolysis bullosa, non-herlitz type	Enrichment	ITGB4	1.90
161	Familial retinoblastoma	Enrichment	RB1	1.90
162	Tafro syndrome	Enrichment	MAP2K2	1.90
163	Wooly hair nevus	Enrichment	HRAS	1.90
164	Scoliosis, isolated 1	Enrichment	MAPK7	1.83
165	Spastic paraplegia 76, autosomal recessive	Enrichment	CAPN1	1.83
166	Cardiomyopathy, dilated, 1kk	Enrichment	MYPN	1.83
167	Neuropathy, congenital hypomyelinating, 2	Enrichment	RHO	1.83
168	Optic disk drusen	Enrichment	RHO	1.83
169	Qualitative or quantitative defects of caveolin-3	Enrichment	CAV3	1.83
170	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	1.79
171	Lung cancer	Enrichment	KRAS, MET	1.76
172	Jacobsen syndrome	Enrichment	ETS1	1.72
173	Retinoblastoma	Enrichment	RB1	1.72
174	Nuchal bleb, familial	Enrichment	SOS1	1.72
175	Osteogenic sarcoma	Enrichment	RB1	1.72
176	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3R1	1.72
177	Muscular dystrophy, congenital, due to integrin alpha-7 deficiency	Enrichment	ITGA7	1.72
178	Woolly hair, autosomal recessive 3	Enrichment	RB1	1.72
179	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.72
180	Epidermolysis bullosa, junctional 6, with pyloric atresia	Enrichment	ITGA6	1.72
181	Hypotrichosis 8	Enrichment	RB1	1.72
182	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	1.72
183	Hyper ige syndrome	Enrichment	STAT3	1.72
184	Immunodeficiency 14	Enrichment	PIK3R1	1.72
185	Squamous cell carcinoma	Enrichment	RB1	1.72
186	Bone osteosarcoma	Enrichment	RB1	1.72
187	Spermatocytoma	Enrichment	HRAS	1.72
188	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	1.72
189	Alopecia - intellectual disability syndrome	Enrichment	ITGB6	1.72
190	Renal cell carcinoma	Enrichment	MET	1.72
191	Type 1 diabetes mellitus 2	Enrichment	CAPN10	1.65
192	Ataxia-telangiectasia	Enrichment	BRAF	1.65
193	Rippling muscle disease 2	Enrichment	CAV3	1.65
194	Long qt syndrome 9	Enrichment	CAV3	1.65
195	Myopathy, distal, tateyama type	Enrichment	CAV3	1.65
196	Muscular dystrophy, limb-girdle, autosomal dominant 4	Enrichment	CAPN3	1.65
197	Tethered spinal cord syndrome	Enrichment	BRAF	1.65
198	Autosomal recessive limb-girdle muscular dystrophy type 2a	Enrichment	CAPN3	1.65
199	Microcephaly 17, primary, autosomal recessive	Enrichment	RHO	1.65
200	Cap myopathy	Enrichment	MYPN	1.65
201	Familial hypertrophic cardiomyopathy	Enrichment	CAV3, RAF1	1.60
202	Amelogenesis imperfecta, type iiia	Enrichment	ITGB6	1.60
203	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.60
204	Small cell cancer of the lung	Enrichment	RB1	1.60
205	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.60
206	Epidermolysis bullosa simplex 5c, with pyloric atresia	Enrichment	ITGB4	1.60
207	Retinitis pigmentosa 26	Enrichment	ITGA4	1.60
208	Lynch syndrome 4	Enrichment	RB1	1.60
209	Congenital generalized lipodystrophy	Enrichment	FOS	1.60
210	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.60
211	Hereditary ataxia	Enrichment	PRKCG	1.60
212	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.60
213	Pilocytic astrocytoma	Enrichment	KRAS	1.60
214	Epidermolytic nevus	Enrichment	HRAS	1.60
215	Primary hyperparathyroidism	Enrichment	CDKN1B	1.60
216	Gingival fibromatosis	Enrichment	SOS1	1.60
217	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.60
218	Systemic lupus erythematosus	Enrichment	ETS1, ITGAM	1.60
219	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	1.58
220	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	1.53
221	Craniopharyngioma	Enrichment	BRAF	1.53
222	Newborn respiratory distress syndrome	Enrichment	BRAF	1.53
223	Knobloch syndrome	Enrichment	PAK2	1.53
224	Epidermolysis bullosa simplex 1c, localized	Enrichment	ITGB4	1.50
225	Glanzmann thrombasthenia 2	Enrichment	ITGB3	1.50
226	Epidermolysis bullosa	Enrichment	ITGA6	1.50
227	Histiocytoid hemangioma	Enrichment	FOS	1.50
228	Aplasia cutis congenita	Enrichment	ITGB4	1.50
229	Hemimegalencephaly	Enrichment	AKT3	1.50
230	Hereditary breast carcinoma	Enrichment	AKT1, KRAS	1.50
231	Retinal detachment	Enrichment	RHO	1.44
232	Knobloch syndrome 1	Enrichment	PAK2	1.44
233	Mosaic variegated aneuploidy syndrome 1	Enrichment	PAK6	1.44
234	Autosomal recessive limb-girdle muscular dystrophy type 2b	Enrichment	CAPN3	1.44
235	Night blindness	Enrichment	RHO	1.44
236	Diffuse cutaneous systemic sclerosis	Enrichment	CAV1	1.44
237	Epidermolysis bullosa, junctional 1a, intermediate	Enrichment	ITGB4	1.43
238	Junctional epidermolysis bullosa non-herlitz type	Enrichment	ITGB4	1.43
239	Lung squamous cell carcinoma	Enrichment	KRAS	1.43
240	Multiple endocrine neoplasia, type i	Enrichment	CDKN1B	1.36
241	Renal cell carcinoma, papillary, 1	Enrichment	MET	1.36
242	Gallbladder cancer	Enrichment	KRAS	1.36
243	Megacolon	Enrichment	AKT3	1.36
244	Epidermolysis bullosa simplex	Enrichment	ITGB4	1.36
245	Overgrowth syndrome	Enrichment	PIK3R1	1.36
246	Muscular dystrophy, limb-girdle, autosomal recessive 1	Enrichment	CAPN3	1.36
247	Wilms tumor 5	Enrichment	BRAF	1.36
248	Limited scleroderma	Enrichment	CAV1	1.36
249	Myeloma, multiple	Enrichment	KRAS, PIK3R2	1.31
250	Arthrogryposis, distal, type 1a	Enrichment	MET	1.30
251	Renal hypodysplasia/aplasia 1	Enrichment	ITGA8	1.30
252	Lennox-gastaut syndrome	Enrichment	MAPK10	1.30
253	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.30
254	Fundus albipunctatus	Enrichment	RHO	1.29
255	Myelofibrosis	Enrichment	SRC	1.29
256	Coats disease	Enrichment	RHO	1.29
257	Childhood-onset nemaline myopathy	Enrichment	MYPN	1.29
258	Familial isolated restrictive cardiomyopathy	Enrichment	MYPN	1.29
259	Inherited cancer-predisposing syndrome	Enrichment	CDKN1B, MET, RB1	1.29
260	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.25
261	Cowden syndrome	Enrichment	AKT1	1.25
262	Renal agenesis, bilateral	Enrichment	ITGA8	1.25
263	Myopathy, tubular aggregate, 1	Enrichment	CAV3	1.24
264	Lymphoma, non-hodgkin, familial	Enrichment	BRAF	1.24
265	Congenital muscular dystrophy	Enrichment	CAPN3	1.24
266	Mosaic variegated aneuploidy syndrome	Enrichment	PAK6	1.24
267	Amelogenesis imperfecta, type ie	Enrichment	ITGB6	1.21
268	Polymicrogyria	Enrichment	AKT3	1.21
269	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.21
270	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.19
271	Primary hyperaldosteronism	Enrichment	BRAF	1.19
272	Ventricular septal defect	Enrichment	BRAF	1.19
273	Limb-girdle muscular dystrophy	Enrichment	CAPN3	1.19
274	Specific learning disability	Enrichment	MAPK1	1.17
275	Nemaline myopathy	Enrichment	MYPN	1.14
276	Melanoma	Enrichment	BRAF	1.14
277	Meningioma	Enrichment	AKT1	1.13
278	Migraine with or without aura 1	Enrichment	CAPN3	1.10
279	Heritable pulmonary arterial hypertension	Enrichment	CAV1	1.10
280	Aortic valve disease 1	Enrichment	SOS1	1.10
281	Neural tube defects	Enrichment	ITGB1	1.10
282	Acute promyelocytic leukemia	Enrichment	STAT3	1.10
283	Protein-deficiency anemia	Enrichment	NRAS	1.10
284	Multiple sclerosis	Enrichment	ITGB4	1.07
285	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.07
286	Isolated macular dystrophy	Enrichment	ITGA4	1.07
287	Muscular dystrophy, limb-girdle, autosomal recessive 2	Enrichment	CAPN3	1.07
288	Renal cell carcinoma, nonpapillary	Enrichment	MET	1.04
289	Congenital myopathy 4a, autosomal dominant	Enrichment	ITGA7	1.04
290	Lynch syndrome	Enrichment	KRAS	1.04
291	Cone-rod dystrophy 2	Enrichment	ITGA4, RHO	1.04
292	Rhabdomyosarcoma	Enrichment	HRAS	1.01
293	Osteoporosis	Enrichment	SRC	1.00
294	Cataract	Enrichment	RHO	1.00
295	Wilms tumor 1	Enrichment	BRAF	0.97
296	Heart, malformation of	Enrichment	MAPK1	0.97
297	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	HGF, MET	0.96
298	Arteriovenous malformations of the brain	Enrichment	KRAS	0.94
299	Diffuse large b-cell lymphoma	Enrichment	STAT3	0.94
300	Melanoma, cutaneous malignant 1	Enrichment	BRAF	0.92
301	Dandy-walker syndrome	Enrichment	BRAF	0.92
302	Sudden infant death syndrome	Enrichment	CAV3	0.92
303	Hepatocellular carcinoma	Enrichment	MET	0.88
304	Myocardial infarction	Enrichment	ITGB3	0.88
305	Skin disease	Enrichment	ITGB4	0.88
306	Congenital myopathy	Enrichment	MYPN	0.88
307	Autosomal recessive limb-girdle muscular dystrophy	Enrichment	CAPN3	0.88
308	Pancreatic cancer	Enrichment	KRAS	0.83
309	Hydrops fetalis, nonimmune	Enrichment	HRAS	0.82
310	Congenital stationary night blindness	Enrichment	RHO	0.80
311	Muscular dystrophy	Enrichment	CAPN3	0.78
312	Severe covid-19	Enrichment	ITGAV	0.77
313	Primary autosomal recessive microcephaly	Enrichment	CDK6	0.73
314	Left ventricular noncompaction	Enrichment	RAF1	0.70
315	Long qt syndrome 1	Enrichment	CAV3	0.70
316	Long qt syndrome	Enrichment	CAV3	0.68
317	Microcephaly	Enrichment	MAPK1, PAK3	0.63
318	Type 2 diabetes mellitus	Enrichment	AKT2	0.63
319	Complex neurodevelopmental disorder	Enrichment	PAK3, RAC3	0.63
320	Gastric cancer	Enrichment	KRAS	0.62
321	Nephrotic syndrome	Enrichment	ITGA3	0.62
322	Myopathy	Enrichment	CAPN3	0.59
323	Sensorineural hearing loss	Enrichment	HGF	0.58
324	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	0.53
325	Autism spectrum disorder	Enrichment	MAP2K1	0.30
326	Hereditary retinal dystrophy	Enrichment	ITGA4, RHO	0.19
327	Fundus dystrophy	Enrichment	ITGA4, RHO	0.19
328	Retinitis pigmentosa	Enrichment	RHO	0.10

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Integrin-mediated cell adhesion

Pathway Network for Integrin-mediated cell adhesion

Member Pathways for Integrin-mediated cell adhesion

Pathways in the Integrin-mediated cell adhesion SuperPath

Associated Genes for Integrin-mediated cell adhesion

Associated Disorders for Integrin-mediated cell adhesion

Disorders associated with Integrin-mediated cell adhesion SuperPath

STRING Interaction Network for Integrin-mediated cell adhesion

Sources for Integrin-mediated cell adhesion