Integrin family cell surface interactions

Pathway network for the Integrin family cell surface interactions SuperPath

Sources:

PubChem
QIAGEN

Pathways in the Integrin family cell surface interactions SuperPath

#	Name	Source	Genes
1	Integrin family cell surface interactions	PubChem	ITGA1 ITGA10 ITGA11 ITGA2 ITGA2B ITGA3 ITGA4 ITGA5 ITGA6 ITGA7 ITGA8 ITGA9 ITGAD ITGAE ITGAL ITGAM ITGAV ITGAX ITGB1 ITGB2 ITGB3 ITGB4 ITGB5 ITGB6 ITGB7 ITGB8 (see all 26) (see less)
2	Phagocytosis of Microbes	QIAGEN	C3 CDC42 CLEC7A CR1 DIRAS3 FCER1A FCER1G FCER2 FCGR1A FCGR2A FCGR3B FN1 ITGA1 ITGA10 ITGA11 ITGA2 ITGA2B ITGA3 ITGA4 ITGA5 ITGA6 ITGA7 ITGA8 ITGA9 ITGAD ITGAE ITGAL ITGAM ITGAV ITGAX ITGB1 ITGB2 ITGB3 ITGB4 ITGB5 ITGB6 ITGB7 ITGB8 MARCO MRC1 MRC2 MSR1 PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLCB1 PLCB2 PLCB3 PLCB4 PLCD1 PLCD3 PLCD4 PLCE1 PLCG1 PLCG2 PLCZ1 PRKCA PRKCB PRKCD PRKCE PRKCZ RAC1 RAC2 RAC3 RHOA RHOB RHOC RHOD RHOG RHOH RND2 RND3 TLR1 TLR10 TLR2 TLR3 TLR4 TLR5 TLR6 TLR7 TLR8 TLR9 VTN (see all 85) (see less)
3	Plexin-D1 Signaling	PubChem	ARF6 IQSEC1 ITGA1 ITGA10 ITGA11 ITGA2 ITGA3 ITGA4 ITGA5 ITGA6 ITGA7 ITGA8 ITGA9 ITGAV ITGB1 NRP1 PIP5K1B PLXND1 RND2 RRAS SEMA3C SEMA3E SEMA4A VEGFA (see all 24) (see less)

Gene overlap in member pathways for Integrin family cell surface interactions SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ITGA7	Integrin Subunit Alpha 7	Protein Coding	3
2	ITGA3	Integrin Subunit Alpha 3	Protein Coding	3
3	ITGA11	Integrin Subunit Alpha 11	Protein Coding	3
4	ITGA8	Integrin Subunit Alpha 8	Protein Coding	3
5	ITGA4	Integrin Subunit Alpha 4	Protein Coding	3
6	ITGA6	Integrin Subunit Alpha 6	Protein Coding	3
7	ITGA9	Integrin Subunit Alpha 9	Protein Coding	3
8	ITGA2	Integrin Subunit Alpha 2	Protein Coding	3
9	ITGA5	Integrin Subunit Alpha 5	Protein Coding	3
10	ITGAV	Integrin Subunit Alpha V	Protein Coding	3
11	ITGA10	Integrin Subunit Alpha 10	Protein Coding	3
12	ITGB1	Integrin Subunit Beta 1	Protein Coding	3
13	ITGA1	Integrin Subunit Alpha 1	Protein Coding	3
14	ITGAX	Integrin Subunit Alpha X	Protein Coding	2
15	ITGAD	Integrin Subunit Alpha D	Protein Coding	2
16	ITGAE	Integrin Subunit Alpha E	Protein Coding	2
17	ITGB7	Integrin Subunit Beta 7	Protein Coding	2
18	ITGAL	Integrin Subunit Alpha L	Protein Coding	2
19	ITGB6	Integrin Subunit Beta 6	Protein Coding	2
20	ITGB8	Integrin Subunit Beta 8	Protein Coding	2
21	ITGAM	Integrin Subunit Alpha M	Protein Coding	2
22	ITGB2	Integrin Subunit Beta 2	Protein Coding	2
23	ITGB4	Integrin Subunit Beta 4	Protein Coding	2
24	ITGA2B	Integrin Subunit Alpha 2b	Protein Coding	2
25	ITGB5	Integrin Subunit Beta 5	Protein Coding	2
26	ITGB3	Integrin Subunit Beta 3	Protein Coding	2
27	RND2	Rho Family GTPase 2	Protein Coding	2
28	RHOA	Ras Homolog Family Member A	Protein Coding	1
29	RHOB	Ras Homolog Family Member B	Protein Coding	1
30	RHOC	Ras Homolog Family Member C	Protein Coding	1
31	RHOD	Ras Homolog Family Member D	Protein Coding	1
32	RND3	Rho Family GTPase 3	Protein Coding	1
33	RHOG	Ras Homolog Family Member G	Protein Coding	1
34	RHOH	Ras Homolog Family Member H	Protein Coding	1
35	DIRAS3	DIRAS Family GTPase 3	Protein Coding	1
36	C3	Complement C3	Protein Coding	1
37	CDC42	Cell Division Cycle 42	Protein Coding	1
38	CLEC7A	C-Type Lectin Domain Containing 7A	Protein Coding	1
39	CR1	Complement C3b/C4b Receptor 1 (Knops Blood Group)	Protein Coding	1
40	FCER1A	Fc Epsilon Receptor Ia	Protein Coding	1
41	FCER1G	Fc Epsilon Receptor Ig	Protein Coding	1
42	FCER2	Fc Epsilon Receptor II	Protein Coding	1
43	FCGR1A	Fc Gamma Receptor Ia	Protein Coding	1
44	FCGR2A	Fc Gamma Receptor IIa	Protein Coding	1
45	FCGR3B	Fc Gamma Receptor IIIb	Protein Coding	1
46	FN1	Fibronectin 1	Protein Coding	1
47	MARCO	Macrophage Receptor With Collagenous Structure	Protein Coding	1
48	MRC1	Mannose Receptor C-Type 1	Protein Coding	1
49	MRC2	Mannose Receptor C-Type 2	Protein Coding	1
50	MSR1	Macrophage Scavenger Receptor 1	Protein Coding	1
51	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	1
52	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
53	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
54	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	1
55	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	1
56	PLCB1	Phospholipase C Beta 1	Protein Coding	1
57	PLCB2	Phospholipase C Beta 2	Protein Coding	1
58	PLCB3	Phospholipase C Beta 3	Protein Coding	1
59	PLCB4	Phospholipase C Beta 4	Protein Coding	1
60	PLCD1	Phospholipase C Delta 1	Protein Coding	1
61	PLCD3	Phospholipase C Delta 3	Protein Coding	1
62	PLCD4	Phospholipase C Delta 4	Protein Coding	1
63	PLCE1	Phospholipase C Epsilon 1	Protein Coding	1
64	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
65	PLCG2	Phospholipase C Gamma 2	Protein Coding	1
66	PLCZ1	Phospholipase C Zeta 1	Protein Coding	1
67	PRKCA	Protein Kinase C Alpha	Protein Coding	1
68	PRKCB	Protein Kinase C Beta	Protein Coding	1
69	PRKCD	Protein Kinase C Delta	Protein Coding	1
70	PRKCE	Protein Kinase C Epsilon	Protein Coding	1
71	PRKCZ	Protein Kinase C Zeta	Protein Coding	1
72	RAC1	Rac Family Small GTPase 1	Protein Coding	1
73	RAC2	Rac Family Small GTPase 2	Protein Coding	1
74	RAC3	Rac Family Small GTPase 3	Protein Coding	1
75	TLR1	Toll Like Receptor 1	Protein Coding	1
76	TLR10	Toll Like Receptor 10	Protein Coding	1
77	TLR2	Toll Like Receptor 2	Protein Coding	1
78	TLR3	Toll Like Receptor 3	Protein Coding	1
79	TLR4	Toll Like Receptor 4	Protein Coding	1
80	TLR5	Toll Like Receptor 5	Protein Coding	1
81	TLR6	Toll Like Receptor 6	Protein Coding	1
82	TLR7	Toll Like Receptor 7	Protein Coding	1
83	TLR8	Toll Like Receptor 8	Protein Coding	1
84	TLR9	Toll Like Receptor 9	Protein Coding	1
85	VTN	Vitronectin	Protein Coding	1
86	SEMA3C	Semaphorin 3C	Protein Coding	1
87	IQSEC1	IQ Motif And Sec7 Domain ArfGEF 1	Protein Coding	1
88	PIP5K1B	Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Beta	Protein Coding	1
89	PLXND1	Plexin D1	Protein Coding	1
90	SEMA3E	Semaphorin 3E	Protein Coding	1
91	SEMA4A	Semaphorin 4A	Protein Coding	1
92	RRAS	RAS Related	Protein Coding	1
93	ARF6	ARF GTPase 6	Protein Coding	1
94	NRP1	Neuropilin 1	Protein Coding	1
95	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	1

Disorders associated with Integrin family cell surface interactions SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGA2, ITGA2B, ITGB3	6.90
2	Bleeding disorder, platelet-type, 16	Enrichment	ITGA2B, ITGB3	4.98
3	Epidermolysis bullosa, junctional 5b, with pyloric atresia	Enrichment	ITGA6, ITGB4	4.28
4	Glanzmann thrombasthenia 1	Enrichment	ITGA2B, ITGB3	4.13
5	Systemic lupus erythematosus	Enrichment	FCGR2A, FCGR3B, ITGAM, TLR7	4.00
6	Junctional epidermolysis bullosa	Enrichment	ITGA6, ITGB4	3.90
7	Autosomal dominant macrothrombocytopenia	Enrichment	ITGA2B, ITGB3	3.80
8	Cone-rod dystrophy 10	Enrichment	SEMA4A	2.75
9	Intellectual developmental disorder with short stature and behavioral abnormalities	Enrichment	IQSEC1	2.75
10	Retinitis pigmentosa 35	Enrichment	SEMA4A	2.75
11	Microvascular complications of diabetes 1	Enrichment	VEGFA	2.75
12	Fetomaternal alloimmune thrombocytopenia 3	Enrichment	ITGA2	2.75
13	Immune dysregulation, neurodevelopmental defects, and colitis	Enrichment	ITGAV	2.75
14	Systemic lupus erythematosus 6	Enrichment	ITGAM	2.72
15	Fetomaternal alloimmune thrombocytopenia 2	Enrichment	ITGA2B	2.72
16	Amelogenesis imperfecta, type ih	Enrichment	ITGB6	2.72
17	Nephrotic syndrome	Enrichment	FN1, ITGA3, PLCE1	2.61
18	Sveinsson chorioretinal atrophy	Enrichment	SEMA4A	2.45
19	Congenital heart defects, multiple types, 9	Enrichment	PLXND1	2.45
20	Epidermolysis bullosa, junctional 7, with interstitial lung disease and nephrotic syndrome	Enrichment	ITGA3	2.45
21	Thrombocytopenia	Enrichment	ITGA2B, ITGB3	2.42
22	Leukocyte adhesion deficiency, type i	Enrichment	ITGB2	2.42
23	Leukocyte adhesion deficiency, type iii	Enrichment	ITGB2	2.42
24	Epidermolysis bullosa, junctional 5a, intermediate	Enrichment	ITGB4	2.42
25	Localized junctional epidermolysis bullosa, non-herlitz type	Enrichment	ITGB4	2.42
26	Muscular dystrophy, congenital, due to integrin alpha-7 deficiency	Enrichment	ITGA7	2.28
27	Epidermolysis bullosa, junctional 6, with pyloric atresia	Enrichment	ITGA6	2.28
28	Hypogonadotropic hypogonadism 5 with or without anosmia	Enrichment	SEMA3E	2.28
29	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3	2.24
30	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	2.24
31	Alopecia - intellectual disability syndrome	Enrichment	ITGB6	2.24
32	Leprosy 3	Enrichment	TLR2	2.20
33	Legionnaire disease	Enrichment	TLR5	2.20
34	Immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis	Enrichment	RAC2	2.20
35	Hemolytic uremic syndrome, atypical 5	Enrichment	C3	2.20
36	Immunodeficiency 83 viral infections	Enrichment	TLR3	2.20
37	Nail disorder, nonsyndromic congenital, 3	Enrichment	PLCD1	2.20
38	Leprosy 5	Enrichment	TLR1	2.20
39	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.20
40	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.20
41	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	2.20
42	Neurodevelopmental disorder with structural brain anomalies and dysmorphic facies	Enrichment	RAC3	2.20
43	Short syndrome	Enrichment	PIK3R1	2.20
44	Immunodeficiency 74, covid19-related, x-linked	Enrichment	TLR7	2.20
45	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.20
46	Systemic lupus erythematosus 1	Enrichment	TLR5	2.20
47	X-linked immunodeficiency 74	Enrichment	TLR7	2.20
48	Auriculocondylar syndrome 2a	Enrichment	PLCB4	2.20
49	Systemic lupus erythematosus 17	Enrichment	TLR7	2.20
50	Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia	Enrichment	RAC2	2.20
51	Candidiasis, familial, 4	Enrichment	CLEC7A	2.20
52	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.20
53	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.20
54	Melioidosis	Enrichment	TLR5	2.20
55	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.20
56	Macular degeneration, age-related, 9	Enrichment	C3	2.20
57	Macular degeneration, age-related, 10	Enrichment	TLR4	2.20
58	Complement component 3 deficiency, autosomal recessive	Enrichment	C3	2.20
59	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.20
60	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.20
61	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.20
62	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.20
63	Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia	Enrichment	RAC2	2.20
64	Immunodeficiency 129	Enrichment	RHOH	2.20
65	Auriculocondylar syndrome 2b	Enrichment	PLCB4	2.20
66	Complement component 3 deficiency	Enrichment	C3	2.20
67	T-cell immunodeficiency with epidermodysplasia verruciformis	Enrichment	RHOH	2.20
68	Membranoproliferative glomerulonephritis	Enrichment	C3	2.20
69	Primary membranoproliferative glomerulonephritis	Enrichment	C3	2.20
70	Neonatal alloimmune neutropenia	Enrichment	FCGR3B	2.20
71	Infantile lad-like disease due to rac2 deficiency	Enrichment	RAC2	2.20
72	Reticular dysgenesis-like severe combined immunodeficiency	Enrichment	RAC2	2.20
73	Nocarh syndrome	Enrichment	CDC42	2.20
74	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.20
75	Rac2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndrome	Enrichment	RAC2	2.20
76	Cone-rod dystrophy 2	Enrichment	ITGA4, SEMA4A	2.20
77	Retinitis pigmentosa 26	Enrichment	ITGA4	2.15
78	Amelogenesis imperfecta, type iiia	Enrichment	ITGB6	2.12
79	Epidermolysis bullosa simplex 5c, with pyloric atresia	Enrichment	ITGB4	2.12
80	Multisystem inflammatory syndrome in children	Enrichment	TLR3, TLR6	2.08
81	Moebius syndrome	Enrichment	PLXND1	2.05
82	Epidermolysis bullosa	Enrichment	ITGA6	2.05
83	Persistent truncus arteriosus	Enrichment	PLXND1	2.05
84	Malaria	Enrichment	CR1, FCGR2A	2.05
85	Epidermolysis bullosa simplex 1c, localized	Enrichment	ITGB4	2.02
86	Glanzmann thrombasthenia 2	Enrichment	ITGB3	2.02
87	Aplasia cutis congenita	Enrichment	ITGB4	2.02
88	Epidermolysis bullosa, junctional 1a, intermediate	Enrichment	ITGB4	1.94
89	Junctional epidermolysis bullosa non-herlitz type	Enrichment	ITGB4	1.94
90	Spondyloepimetaphyseal dysplasia, strudwick type	Enrichment	FN1	1.90
91	Spondylometaphyseal dysplasia, corner fracture type	Enrichment	FN1	1.90
92	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	1.90
93	Spermatogenic failure 17	Enrichment	PLCZ1	1.90
94	Aspergillosis	Enrichment	CLEC7A	1.90
95	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.90
96	Leprosy 1	Enrichment	TLR6	1.90
97	Ocular melanoma	Enrichment	PLCB4	1.90
98	Immune system disease	Enrichment	CDC42	1.90
99	Epidermolysis bullosa simplex	Enrichment	ITGB4	1.87
100	Renal hypodysplasia/aplasia 1	Enrichment	ITGA8	1.85
101	Charge syndrome	Enrichment	SEMA3E	1.80
102	Renal agenesis, bilateral	Enrichment	ITGA8	1.80
103	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	TLR8	1.73
104	Glomerulopathy with fibronectin deposits 2	Enrichment	FN1	1.73
105	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3R1	1.73
106	Nephrotic syndrome, type 3	Enrichment	PLCE1	1.73
107	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.73
108	Immunodeficiency 14	Enrichment	PIK3R1	1.73
109	Genetic atypical hemolytic-uremic syndrome	Enrichment	C3	1.73
110	Amelogenesis imperfecta, type ie	Enrichment	ITGB6	1.72
111	Familial colorectal cancer type x	Enrichment	SEMA4A	1.71
112	Juvenile myelomonocytic leukemia	Enrichment	RRAS	1.68
113	Neural tube defects	Enrichment	ITGB1	1.64
114	Isolated macular dystrophy	Enrichment	ITGA4	1.61
115	Anemia, autoimmune hemolytic	Enrichment	TLR8	1.60
116	Auriculocondylar syndrome 1	Enrichment	PLCB4	1.60
117	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3R2	1.60
118	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	1.60
119	Barrett esophagus	Enrichment	MSR1	1.60
120	Developmental and epileptic encephalopathy 12	Enrichment	PLCB1	1.60
121	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.60
122	Congenital myopathy 4a, autosomal dominant	Enrichment	ITGA7	1.58
123	Multiple sclerosis	Enrichment	ITGB4	1.58
124	Herpes simplex virus encephalitis	Enrichment	TLR3	1.51
125	Cardiomyopathy, dilated, 1a	Enrichment	SEMA3E	1.44
126	Melanoma, uveal	Enrichment	PLCB4	1.43
127	Hemihyperplasia, isolated	Enrichment	RHOA	1.43
128	Chronic mucocutaneous candidiasis	Enrichment	CLEC7A	1.43
129	Atypical hemolytic uremic syndrome with complement gene abnormality	Enrichment	C3	1.43
130	Noonan syndrome 1	Enrichment	RRAS	1.40
131	Myocardial infarction	Enrichment	ITGB3	1.38
132	Skin disease	Enrichment	ITGB4	1.38
133	Overgrowth syndrome	Enrichment	PIK3R1	1.37
134	Hirschsprung disease 1	Enrichment	SEMA3C	1.30
135	Severe covid-19	Enrichment	ITGAV	1.30
136	Rheumatoid arthritis	Enrichment	TLR1	1.26
137	Nephrotic syndrome, type 1	Enrichment	PLCE1	1.26
138	Developmental and epileptic encephalopathy 14	Enrichment	PLCB1	1.26
139	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.26
140	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.22
141	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	1.11
142	Atypical hemolytic-uremic syndrome	Enrichment	C3	1.05
143	Hereditary retinal dystrophy	Enrichment	ITGA4, SEMA4A	1.03
144	Fundus dystrophy	Enrichment	ITGA4, SEMA4A	1.03
145	Autosomal recessive non-syndromic intellectual disability	Enrichment	IQSEC1	1.01
146	Colorectal cancer	Enrichment	PIK3R1, TLR2	0.99
147	Human immunodeficiency virus type 1	Enrichment	TLR3	0.97
148	Behcet syndrome	Enrichment	TLR4	0.95
149	Focal segmental glomerulosclerosis	Enrichment	PLCE1	0.93
150	Prostate cancer	Enrichment	MSR1	0.78
151	Cystic fibrosis	Enrichment	FCGR2A	0.74
152	Genetic steroid-resistant nephrotic syndrome	Enrichment	PLCE1	0.72
153	Benign epilepsy with centrotemporal spikes	Enrichment	PLCB1	0.64
154	Centralopathic epilepsy	Enrichment	PLCB1	0.62
155	West syndrome	Enrichment	PLCB1	0.62
156	Myeloma, multiple	Enrichment	PIK3R2	0.53
157	Retinitis pigmentosa	Enrichment	SEMA4A	0.50
158	Ovarian cancer	Enrichment	MSR1	0.33
159	Complex neurodevelopmental disorder	Enrichment	RAC3	0.27

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Integrin family cell surface interactions

Pathway Network for Integrin family cell surface interactions

Pathway network for the Integrin family cell surface interactions SuperPath

Member Pathways for Integrin family cell surface interactions

Pathways in the Integrin family cell surface interactions SuperPath

Gene overlap in member pathways for Integrin family cell surface interactions SuperPath

Associated Genes for Integrin family cell surface interactions

Associated Disorders for Integrin family cell surface interactions

Disorders associated with Integrin family cell surface interactions SuperPath

STRING Interaction Network for Integrin family cell surface interactions

Sources for Integrin family cell surface interactions