Integrin signaling

Pathway network for the Integrin signaling SuperPath

Sources:

Reactome

Pathways in the Integrin signaling SuperPath

#	Name	Source	Genes
1	Integrin signaling	Reactome	AKT1 APBB1IP BCAR1 CRK CSK FGA FGB FGG FN1 GRB2 ITGA2B ITGB3 PDPK1 PTK2 PTPN1 RAP1A RAP1B RAPGEF3 RAPGEF4 RASGRP1 RASGRP2 SHC1 SOS1 SRC SYK TLN1 VWF (see all 27) (see less)
2	Platelet Aggregation (Plug Formation)	Reactome	ADRA2A ADRA2B ADRA2C AKT1 APBB1IP BCAR1 COL1A1 COL1A2 CRK CSK F2 FGA FGB FGG FN1 GP1BA GP1BB GP5 GP9 GRB2 ITGA2B ITGB3 MPL PDPK1 PTK2 PTPN1 RAP1A RAP1B RAPGEF3 RAPGEF4 RASGRP1 RASGRP2 SHC1 SOS1 SRC SYK THPO TLN1 VWF (see all 39) (see less)
3	p130Cas linkage to MAPK signaling for integrins	Reactome	APBB1IP BCAR1 CRK FGA FGB FGG FN1 ITGA2B ITGB3 PTK2 RAP1A RAP1B SRC TLN1 VWF (see all 15) (see less)
4	GRB2:SOS provides linkage to MAPK signaling for Integrins	Reactome	APBB1IP FGA FGB FGG FN1 GRB2 ITGA2B ITGB3 PTK2 RAP1A RAP1B SOS1 SRC TLN1 VWF (see all 15) (see less)

Gene overlap in member pathways for Integrin signaling SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	FGA	Fibrinogen Alpha Chain	Protein Coding	4
2	FGB	Fibrinogen Beta Chain	Protein Coding	4
3	FGG	Fibrinogen Gamma Chain	Protein Coding	4
4	FN1	Fibronectin 1	Protein Coding	4
5	ITGA2B	Integrin Subunit Alpha 2b	Protein Coding	4
6	ITGB3	Integrin Subunit Beta 3	Protein Coding	4
7	APBB1IP	Amyloid Beta Precursor Protein Binding Family B Member 1 Interacting Protein	Protein Coding	4
8	PTK2	Protein Tyrosine Kinase 2	Protein Coding	4
9	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	4
10	RAP1B	RAP1B, Member Of RAS Oncogene Family	Protein Coding	4
11	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	4
12	TLN1	Talin 1	Protein Coding	4
13	VWF	Von Willebrand Factor	Protein Coding	4
14	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	3
15	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	3
16	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	3
17	BCAR1	BCAR1 Scaffold Protein, Cas Family Member	Protein Coding	3
18	RASGRP1	RAS Guanyl Releasing Protein 1	Protein Coding	2
19	RASGRP2	RAS Guanyl Releasing Protein 2	Protein Coding	2
20	RAPGEF3	Rap Guanine Nucleotide Exchange Factor 3	Protein Coding	2
21	RAPGEF4	Rap Guanine Nucleotide Exchange Factor 4	Protein Coding	2
22	CSK	C-Terminal Src Kinase	Protein Coding	2
23	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	2
24	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	2
25	PTPN1	Protein Tyrosine Phosphatase Non-Receptor Type 1	Protein Coding	2
26	SHC1	SHC Adaptor Protein 1	Protein Coding	2
27	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	2
28	COL1A1	Collagen Type I Alpha 1 Chain	Protein Coding	1
29	COL1A2	Collagen Type I Alpha 2 Chain	Protein Coding	1
30	ADRA2A	Adrenoceptor Alpha 2A	Protein Coding	1
31	ADRA2B	Adrenoceptor Alpha 2B	Protein Coding	1
32	ADRA2C	Adrenoceptor Alpha 2C	Protein Coding	1
33	F2	Coagulation Factor II, Thrombin	Protein Coding	1
34	GP1BA	Glycoprotein Ib Platelet Subunit Alpha	Protein Coding	1
35	GP1BB	Glycoprotein Ib Platelet Subunit Beta	Protein Coding	1
36	GP5	Glycoprotein V Platelet	Protein Coding	1
37	GP9	Glycoprotein IX Platelet	Protein Coding	1
38	MPL	MPL Proto-Oncogene, Thrombopoietin Receptor	Protein Coding	1
39	THPO	Thrombopoietin	Protein Coding	1

Disorders associated with Integrin signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Thrombocytopenia	Enrichment	FGG, GP1BA, GP1BB, GP9, ITGA2B, ITGB3, MPL, SRC, THPO, VWF	16.00
2	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	GP1BA, GP1BB, ITGA2B, ITGB3	9.05
3	Dysfibrinogenemia, congenital	Enrichment	FGA, FGB, FGG	8.96
4	Familial dysfibrinogenemia	Enrichment	FGA, FGB, FGG	8.96
5	Familial hypofibrinogenemia	Enrichment	FGA, FGB, FGG	8.96
6	Afibrinogenemia, congenital	Enrichment	FGA, FGB, FGG	8.36
7	Autosomal dominant macrothrombocytopenia	Enrichment	GP1BA, GP1BB, ITGA2B, ITGB3	7.92
8	Bernard-soulier syndrome	Enrichment	GP1BA, GP1BB, GP9	6.66
9	Bleeding disorder, platelet-type, 16	Enrichment	ITGA2B, ITGB3	5.47
10	Osteoporosis	Enrichment	COL1A1, COL1A2, SRC	5.11
11	Ehlers-danlos syndrome, arthrochalasia type, 2	Enrichment	COL1A1, COL1A2	5.09
12	Congenital amegakaryocytic thrombocytopenia	Enrichment	MPL, THPO	5.09
13	Ehlers-danlos/osteogenesis imperfecta syndrome	Enrichment	COL1A1, COL1A2	5.09
14	Glanzmann thrombasthenia 1	Enrichment	ITGA2B, ITGB3	4.62
15	Dyskeratosis congenita, autosomal dominant 6	Enrichment	MPL, THPO	4.62
16	High bone mass osteogenesis imperfecta	Enrichment	COL1A1, COL1A2	4.62
17	Ehlers-danlos syndrome, arthrochalasia type, 1	Enrichment	COL1A1, COL1A2	4.32
18	Osteogenesis imperfecta with normal sclerae, dominant form	Enrichment	COL1A1, COL1A2	4.32
19	Ehlers-danlos syndrome, classic type, 1	Enrichment	COL1A1, COL1A2	3.92
20	Osteogenesis imperfecta, type i	Enrichment	COL1A1, COL1A2	3.92
21	Classic ehlers-danlos syndrome	Enrichment	COL1A1, COL1A2	3.92
22	Osteogenesis imperfecta, type ii	Enrichment	COL1A1, COL1A2	3.78
23	Thrombophilia due to thrombin defect	Enrichment	F2, FGA	3.78
24	Myelofibrosis	Enrichment	MPL, SRC	3.78
25	Essential thrombocythemia	Enrichment	MPL, THPO	3.78
26	Primary bone dysplasia	Enrichment	COL1A1, COL1A2	3.45
27	Osteochondrodysplasia	Enrichment	COL1A1, COL1A2	3.36
28	Osteogenesis imperfecta, type iv	Enrichment	COL1A1, COL1A2	3.21
29	Osteogenesis imperfecta, type iii	Enrichment	COL1A1, COL1A2	3.08
30	Von willebrand disease, type 1	Enrichment	VWF	2.96
31	Von willebrand disease, type 2	Enrichment	VWF	2.96
32	Von willebrand disease, type 3	Enrichment	VWF	2.96
33	Fetomaternal alloimmune thrombocytopenia 2	Enrichment	ITGA2B	2.96
34	Thrombocytopenia 11 with multiple congenital anomalies and dysmorphic facies	Enrichment	RAP1B	2.96
35	Thrombocytopenia 6	Enrichment	SRC	2.96
36	Von willebrand's disease	Enrichment	VWF	2.96
37	Congenital fibrinogen deficiency	Enrichment	FGG	2.96
38	Capillary leak syndrome	Enrichment	TLN1	2.96
39	Noonan syndrome 4	Enrichment	SOS1	2.96
40	Ehlers-danlos syndrome	Enrichment	COL1A1, COL1A2	2.87
41	Brittle bone disorder	Enrichment	COL1A1, COL1A2	2.71
42	Proteus syndrome	Enrichment	AKT1	2.70
43	Bleeding disorder, platelet-type, 18	Enrichment	RASGRP2	2.70
44	Immunodeficiency 64 with lymphoproliferation	Enrichment	RASGRP1	2.70
45	Immunodeficiency 82 with systemic inflammation	Enrichment	SYK	2.70
46	Cowden syndrome 6	Enrichment	AKT1	2.70
47	Colitis	Enrichment	SYK	2.70
48	Immunodeficiency 64	Enrichment	RASGRP1	2.70
49	Ebv-induced lymphoproliferative disease due to rasgrp1 deficiency	Enrichment	RASGRP1	2.70
50	Spondyloepimetaphyseal dysplasia, strudwick type	Enrichment	FN1	2.66
51	Spondylometaphyseal dysplasia, corner fracture type	Enrichment	FN1	2.66
52	Fibromatosis, gingival, 1	Enrichment	SOS1	2.66
53	Pulmonic stenosis	Enrichment	SOS1	2.66
54	Bernard-soulier syndrome, type a2, autosomal dominant	Enrichment	GP1BA	2.54
55	Ehlers-danlos syndrome, cardiac valvular type	Enrichment	COL1A2	2.54
56	Nonarteritic anterior ischemic optic neuropathy	Enrichment	GP1BA	2.54
57	Thrombocythemia 2	Enrichment	MPL	2.54
58	Von willebrand disease, platelet-type	Enrichment	GP1BA	2.54
59	Prothrombin deficiency, congenital	Enrichment	F2	2.54
60	Amegakaryocytic thrombocytopenia, congenital, 1	Enrichment	MPL	2.54
61	Amegakaryocytic thrombocytopenia, congenital, 2	Enrichment	THPO	2.54
62	Combined osteogenesis imperfecta and ehlers-danlos syndrome 2	Enrichment	COL1A2	2.54
63	Hereditary thrombocytosis with transverse limb defect	Enrichment	THPO	2.54
64	Pregnancy loss, recurrent 2	Enrichment	F2	2.54
65	Asphyxia neonatorum	Enrichment	COL1A1	2.54
66	Thrombocytopenia 9	Enrichment	THPO	2.54
67	Bernard-soulier syndrome type a2	Enrichment	GP1BA	2.54
68	Lipodystrophy, familial partial, type 8	Enrichment	ADRA2A	2.54
69	Prothrombin deficiency	Enrichment	F2	2.54
70	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3	2.48
71	Periventricular nodular heterotopia 1	Enrichment	VWF	2.48
72	Glomerulopathy with fibronectin deposits 2	Enrichment	FN1	2.48
73	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	2.48
74	Nuchal bleb, familial	Enrichment	SOS1	2.48
75	Arthritis	Enrichment	SYK	2.40
76	Gingival fibromatosis	Enrichment	SOS1	2.35
77	Amyloidosis, hereditary systemic 2	Enrichment	FGA	2.26
78	Glanzmann thrombasthenia 2	Enrichment	ITGB3	2.26
79	Epiphyseal dysplasia, multiple, 1	Enrichment	COL1A1	2.24
80	Bruck syndrome 1	Enrichment	COL1A2	2.24
81	Dermatofibrosarcoma protuberans	Enrichment	COL1A1	2.24
82	Combined osteogenesis imperfecta and ehlers-danlos syndrome 1	Enrichment	COL1A1	2.24
83	Stickler syndrome, type ii	Enrichment	COL1A1	2.24
84	Dentinogenesis imperfecta	Enrichment	COL1A2	2.24
85	Noonan syndrome 3	Enrichment	SOS1	2.11
86	Thrombocythemia 1	Enrichment	THPO	2.07
87	Caffey disease	Enrichment	COL1A1	2.07
88	Cerebral sinovenous thrombosis	Enrichment	F2	2.07
89	Spastic paraplegia 4, autosomal dominant	Enrichment	FGG	2.05
90	Breast cancer	Enrichment	AKT1, SHC1	2.01
91	Phenylketonuria	Enrichment	COL1A1	1.94
92	Breast adenocarcinoma	Enrichment	AKT1	1.92
93	Colorectal cancer	Enrichment	AKT1, SRC	1.89
94	Aortic valve disease 1	Enrichment	SOS1	1.85
95	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.81
96	Noonan syndrome and noonan-related syndrome	Enrichment	SOS1	1.78
97	Familial adult myoclonic epilepsy	Enrichment	ADRA2B	1.77
98	Keratoconus	Enrichment	COL1A1	1.77
99	Cowden syndrome	Enrichment	AKT1	1.75
100	Immune deficiency disease	Enrichment	SYK	1.66
101	Meningioma	Enrichment	AKT1	1.63
102	Myocardial infarction	Enrichment	ITGB3	1.62
103	Noonan syndrome 1	Enrichment	SOS1	1.60
104	Rasopathy	Enrichment	SOS1	1.55
105	Stroke, ischemic	Enrichment	F2	1.55
106	Digeorge syndrome	Enrichment	GP1BB	1.47
107	Nephrotic syndrome	Enrichment	FN1	1.33
108	Hereditary breast ovarian cancer syndrome	Enrichment	BCAR1	1.23
109	Type 2 diabetes mellitus	Enrichment	PTPN1	1.09
110	Hereditary breast carcinoma	Enrichment	AKT1	1.08
111	Cerebral palsy	Enrichment	F2	0.97
112	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	COL1A1	0.92
113	Hypertelorism	Enrichment	COL1A1	0.86
114	Ovarian cancer	Enrichment	AKT1	0.74

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Integrin signaling

Pathway Network for Integrin signaling

Pathway network for the Integrin signaling SuperPath

Member Pathways for Integrin signaling

Pathways in the Integrin signaling SuperPath

Gene overlap in member pathways for Integrin signaling SuperPath

Associated Genes for Integrin signaling

Associated Disorders for Integrin signaling

Disorders associated with Integrin signaling SuperPath

STRING Interaction Network for Integrin signaling

Sources for Integrin signaling